Rattus norvegicus

29 known processes

Nradd

neurotrophin receptor associated death domain

(Aliases: PLAIDD)

Nradd biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
transcription dna templated GO:0006351 377 0.336
metestrus GO:0060210 1 0.205
regulation of osteoblast differentiation GO:0045667 14 0.179
tissue development GO:0009888 252 0.170
cellular response to biotic stimulus GO:0071216 59 0.162
localization of cell GO:0051674 202 0.140
cell motility GO:0048870 202 0.139
reproductive process GO:0022414 372 0.138
taxis GO:0042330 67 0.129
response to radiation GO:0009314 137 0.127
positive regulation of cell proliferation GO:0008284 249 0.125
epidermis development GO:0008544 11 0.124
hair cycle process GO:0022405 2 0.122
metal ion homeostasis GO:0055065 186 0.119
epithelium development GO:0060429 96 0.118
gland development GO:0048732 155 0.116
rna biosynthetic process GO:0032774 380 0.116
response to other organism GO:0051707 220 0.114
regulation of canonical wnt signaling pathway GO:0060828 4 0.114
positive regulation of cell differentiation GO:0045597 217 0.114
rna metabolic process GO:0016070 406 0.111
response to wounding GO:0009611 254 0.107
regulation of cell proliferation GO:0042127 359 0.107
locomotion GO:0040011 237 0.107
regulation of cell differentiation GO:0045595 320 0.106
cell migration GO:0016477 197 0.105
negative regulation of osteoblast differentiation GO:0045668 2 0.101
regulation of rna metabolic process GO:0051252 391 0.101
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.099
organic acid metabolic process GO:0006082 292 0.097
regulation of molecular function GO:0065009 398 0.096
apoptotic process GO:0006915 381 0.096
regulation of programmed cell death GO:0043067 341 0.095
response to corticosteroid GO:0031960 235 0.094
negative regulation of cell death GO:0060548 229 0.087
regulation of cell projection size GO:0032536 1 0.087
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.086
carboxylic acid metabolic process GO:0019752 289 0.085
nucleic acid templated transcription GO:0097659 379 0.084
neuron development GO:0048666 286 0.083
cellular response to oxygen containing compound GO:1901701 386 0.081
eye morphogenesis GO:0048592 4 0.079
negative regulation of cell proliferation GO:0008285 119 0.079
anterior posterior pattern specification GO:0009952 1 0.079
anatomical structure morphogenesis GO:0009653 298 0.077
regulation of cytokine biosynthetic process GO:0042035 3 0.074
cytokine production GO:0001816 61 0.073
cellular response to lipid GO:0071396 201 0.072
cellular response to hormone stimulus GO:0032870 247 0.071
limb morphogenesis GO:0035108 4 0.071
negative regulation of biosynthetic process GO:0009890 168 0.071
cell projection morphogenesis GO:0048858 123 0.071
lipid metabolic process GO:0006629 283 0.068
response to bacterium GO:0009617 200 0.068
response to estrogen GO:0043627 232 0.067
embryonic appendage morphogenesis GO:0035113 4 0.065
cellular response to stress GO:0033554 269 0.064
regulation of transcription dna templated GO:0006355 374 0.063
regulation of nucleic acid templated transcription GO:1903506 380 0.063
cell projection organization GO:0030030 302 0.063
endocrine system development GO:0035270 30 0.061
positive regulation of response to stimulus GO:0048584 285 0.059
response to biotic stimulus GO:0009607 226 0.059
defense response GO:0006952 194 0.058
regulation of multicellular organismal development GO:2000026 376 0.058
neuron differentiation GO:0030182 368 0.057
purine nucleotide metabolic process GO:0006163 229 0.053
positive regulation of protein metabolic process GO:0051247 178 0.053
response to acid chemical GO:0001101 222 0.052
embryonic limb morphogenesis GO:0030326 4 0.052
amine metabolic process GO:0009308 38 0.051
negative regulation of cellular biosynthetic process GO:0031327 161 0.051
cytokine biosynthetic process GO:0042089 3 0.050
intracellular signal transduction GO:0035556 314 0.050
wnt signaling pathway planar cell polarity pathway GO:0060071 2 0.049
anatomical structure formation involved in morphogenesis GO:0048646 83 0.048
response to peptide hormone GO:0043434 278 0.047
wnt signaling pathway calcium modulating pathway GO:0007223 1 0.047
negative regulation of macromolecule metabolic process GO:0010605 260 0.046
neuron projection morphogenesis GO:0048812 122 0.046
renal filtration GO:0097205 10 0.046
tongue morphogenesis GO:0043587 3 0.045
negative regulation of multicellular organismal process GO:0051241 203 0.045
molting cycle process GO:0022404 2 0.044
vasculature development GO:0001944 70 0.044
positive regulation of cellular biosynthetic process GO:0031328 295 0.044
wound healing GO:0042060 122 0.043
regulation of immune system process GO:0002682 123 0.043
neural crest cell differentiation GO:0014033 2 0.043
bmp signaling pathway GO:0030509 4 0.043
brain development GO:0007420 247 0.042
non canonical wnt signaling pathway GO:0035567 3 0.042
programmed cell death GO:0012501 392 0.042
negative regulation of cellular metabolic process GO:0031324 281 0.041
response to estradiol GO:0032355 164 0.041
response to oxygen levels GO:0070482 265 0.041
cell part morphogenesis GO:0032990 123 0.041
positive regulation of gene expression GO:0010628 244 0.040
carbohydrate derivative metabolic process GO:1901135 346 0.040
positive regulation of secretion GO:0051047 140 0.040
embryonic skeletal system development GO:0048706 3 0.038
cellular response to external stimulus GO:0071496 118 0.037
osteoblast differentiation GO:0001649 26 0.036
regulation of anatomical structure morphogenesis GO:0022603 141 0.036
positive regulation of rna metabolic process GO:0051254 203 0.036
regulation of phosphorus metabolic process GO:0051174 349 0.036
negative regulation of cell differentiation GO:0045596 99 0.036
cellular amino acid metabolic process GO:0006520 107 0.036
regulation of signal transduction GO:0009966 318 0.036
cellular component movement GO:0006928 248 0.035
regulation of cellular amino acid metabolic process GO:0006521 2 0.035
positive regulation of cellular component movement GO:0051272 102 0.035
regulation of cytokine production GO:0001817 56 0.035
cell morphogenesis GO:0000902 142 0.034
positive regulation of nucleic acid templated transcription GO:1903508 197 0.034
transformation of host cell by virus GO:0019087 4 0.034
appendage morphogenesis GO:0035107 4 0.033
positive regulation of cellular amine metabolic process GO:0033240 3 0.033
tube development GO:0035295 89 0.033
gliogenesis GO:0042063 93 0.031
multi organism reproductive process GO:0044703 262 0.031
single organism intracellular transport GO:1902582 166 0.031
cellular ketone metabolic process GO:0042180 51 0.031
regulation of establishment of planar polarity GO:0090175 2 0.030
glomerular filtration GO:0003094 10 0.030
positive regulation of multicellular organismal process GO:0051240 387 0.030
cellular response to reactive oxygen species GO:0034614 55 0.030
tube formation GO:0035148 3 0.030
molting cycle GO:0042303 3 0.029
negative regulation of rna metabolic process GO:0051253 123 0.029
positive regulation of developmental process GO:0051094 283 0.029
divalent inorganic cation homeostasis GO:0072507 165 0.029
regulation of rna biosynthetic process GO:2001141 381 0.029
positive regulation of biosynthetic process GO:0009891 319 0.029
response to interleukin 1 GO:0070555 55 0.029
regulation of cellular component movement GO:0051270 150 0.029
cellular response to steroid hormone stimulus GO:0071383 93 0.028
regulation of cellular amine metabolic process GO:0033238 8 0.028
cellular response to cytokine stimulus GO:0071345 127 0.028
cellular component morphogenesis GO:0032989 155 0.028
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.028
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.028
oxoacid metabolic process GO:0043436 290 0.028
negative regulation of signal transduction GO:0009968 83 0.028
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 13 0.028
response to molecule of bacterial origin GO:0002237 194 0.027
acute inflammatory response GO:0002526 58 0.027
chemical homeostasis GO:0048878 292 0.027
regulation of phosphate metabolic process GO:0019220 349 0.027
regulation of cellular ketone metabolic process GO:0010565 27 0.027
female pregnancy GO:0007565 122 0.027
immune system process GO:0002376 204 0.027
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.027
prostate gland epithelium morphogenesis GO:0060740 2 0.026
response to ionizing radiation GO:0010212 59 0.026
regulation of hydrolase activity GO:0051336 143 0.026
regulation of protein metabolic process GO:0051246 289 0.026
cellular response to lipopolysaccharide GO:0071222 55 0.026
skin morphogenesis GO:0043589 2 0.026
development of primary sexual characteristics GO:0045137 107 0.026
multi multicellular organism process GO:0044706 138 0.026
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.025
organ morphogenesis GO:0009887 75 0.025
response to external biotic stimulus GO:0043207 221 0.025
hindlimb morphogenesis GO:0035137 2 0.025
carboxylic acid biosynthetic process GO:0046394 83 0.025
regulation of cellular protein metabolic process GO:0032268 267 0.024
positive regulation of transcription dna templated GO:0045893 197 0.024
cytokine secretion GO:0050663 15 0.024
regulation of intracellular signal transduction GO:1902531 218 0.024
multicellular organismal reproductive process GO:0048609 233 0.024
immune response GO:0006955 104 0.024
axon development GO:0061564 96 0.024
cellular amine metabolic process GO:0044106 38 0.023
male sex differentiation GO:0046661 64 0.023
regulation of protein phosphorylation GO:0001932 183 0.023
regulation of apoptotic process GO:0042981 335 0.023
learning or memory GO:0007611 90 0.023
negative regulation of nucleic acid templated transcription GO:1903507 117 0.023
cellular response to alcohol GO:0097306 87 0.023
endothelial cell proliferation GO:0001935 20 0.023
positive regulation of cytokine production GO:0001819 42 0.023
negative regulation of gene expression GO:0010629 199 0.023
wnt signaling pathway GO:0016055 17 0.022
positive regulation of mast cell activation GO:0033005 4 0.022
positive regulation of cell communication GO:0010647 271 0.022
negative regulation of transcription dna templated GO:0045892 116 0.022
regulation of metanephros development GO:0072215 4 0.022
chemotaxis GO:0006935 66 0.022
purine ribonucleotide metabolic process GO:0009150 227 0.022
regulation of glomerular filtration GO:0003093 9 0.022
fatty acid derivative metabolic process GO:1901568 38 0.022
neural crest cell development GO:0014032 2 0.022
positive regulation of neuron differentiation GO:0045666 126 0.021
cellular metal ion homeostasis GO:0006875 172 0.021
positive regulation of cytokine biosynthetic process GO:0042108 1 0.021
transcription from rna polymerase ii promoter GO:0006366 252 0.021
cellular response to acid chemical GO:0071229 75 0.021
regulation of cell motility GO:2000145 131 0.021
negative regulation of rna biosynthetic process GO:1902679 118 0.021
prostate gland morphogenesis GO:0060512 2 0.021
connective tissue development GO:0061448 33 0.021
negative regulation of programmed cell death GO:0043069 183 0.021
positive regulation of apoptotic process GO:0043065 154 0.021
macromolecular complex subunit organization GO:0043933 339 0.020
response to transition metal nanoparticle GO:1990267 122 0.020
positive regulation of phosphate metabolic process GO:0045937 262 0.020
biological adhesion GO:0022610 110 0.020
regulation of cellular response to stress GO:0080135 49 0.020
response to cytokine GO:0034097 215 0.020
protein localization GO:0008104 191 0.020
positive regulation of biomineral tissue development GO:0070169 4 0.020
regulation of cell development GO:0060284 263 0.020
establishment of tissue polarity GO:0007164 2 0.020
cytoplasmic transport GO:0016482 115 0.020
regulation of neuron differentiation GO:0045664 208 0.020
response to glucocorticoid GO:0051384 223 0.019
cellular calcium ion homeostasis GO:0006874 160 0.019
neurological system process GO:0050877 219 0.019
regulation of interleukin 6 production GO:0032675 12 0.019
hepaticobiliary system development GO:0061008 90 0.019
hair cycle GO:0042633 3 0.019
multicellular organism growth GO:0035264 1 0.019
single organism biosynthetic process GO:0044711 342 0.019
steroid metabolic process GO:0008202 73 0.018
regulation of phosphorylation GO:0042325 248 0.018
neuron projection development GO:0031175 273 0.018
cellular response to molecule of bacterial origin GO:0071219 56 0.018
negative regulation of canonical wnt signaling pathway GO:0090090 4 0.018
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.018
single organism reproductive process GO:0044702 297 0.018
positive regulation of locomotion GO:0040017 102 0.018
cellular response to nitrogen compound GO:1901699 210 0.018
negative regulation of metabolic process GO:0009892 331 0.018
negative regulation of viral process GO:0048525 4 0.018
diet induced thermogenesis GO:0002024 1 0.018
cellular response to retinoic acid GO:0071300 27 0.018
vasculogenesis GO:0001570 3 0.018
central nervous system development GO:0007417 311 0.018
g protein coupled receptor signaling pathway GO:0007186 242 0.017
regulation of epithelial cell proliferation GO:0050678 49 0.017
positive regulation of transport GO:0051050 245 0.017
organic acid biosynthetic process GO:0016053 83 0.017
nucleobase containing small molecule metabolic process GO:0055086 316 0.017
cellular response to tumor necrosis factor GO:0071356 46 0.017
positive regulation of secretion by cell GO:1903532 128 0.017
neuronal action potential GO:0019228 35 0.017
tissue morphogenesis GO:0048729 22 0.017
inflammatory response GO:0006954 150 0.017
macromolecule localization GO:0033036 252 0.017
establishment of planar polarity GO:0001736 1 0.017
lymphocyte chemotaxis GO:0048247 3 0.016
fatty acid metabolic process GO:0006631 99 0.016
positive regulation of signal transduction GO:0009967 175 0.016
regulation of angiogenesis GO:0045765 39 0.016
intracellular transport GO:0046907 185 0.016
synaptic transmission GO:0007268 235 0.016
regulation of bmp signaling pathway GO:0030510 2 0.016
regulation of neurogenesis GO:0050767 247 0.016
regulation of catalytic activity GO:0050790 304 0.016
response to growth factor GO:0070848 189 0.016
positive regulation of neuron projection development GO:0010976 99 0.016
enzyme linked receptor protein signaling pathway GO:0007167 116 0.016
negative regulation of signaling GO:0023057 157 0.016
neutrophil chemotaxis GO:0030593 11 0.016
negative regulation of cell communication GO:0010648 158 0.016
positive regulation of cellular protein metabolic process GO:0032270 167 0.016
respiratory system development GO:0060541 45 0.015
embryonic hindlimb morphogenesis GO:0035116 2 0.015
positive regulation of interleukin 1 beta secretion GO:0050718 3 0.015
camera type eye morphogenesis GO:0048593 2 0.015
liver development GO:0001889 90 0.015
mesenchymal to epithelial transition GO:0060231 3 0.015
negative regulation of apoptotic process GO:0043066 181 0.015
protein complex biogenesis GO:0070271 263 0.015
embryonic pattern specification GO:0009880 1 0.015
blood vessel development GO:0001568 69 0.015
cellular response to oxidative stress GO:0034599 76 0.015
regulation of cytokine secretion GO:0050707 11 0.015
positive regulation of programmed cell death GO:0043068 157 0.015
regulation of cell migration GO:0030334 128 0.015
morphogenesis of a polarized epithelium GO:0001738 1 0.015
regulation of response to stress GO:0080134 126 0.015
t cell chemotaxis GO:0010818 2 0.015
cellular component assembly GO:0022607 360 0.015
multicellular organismal water homeostasis GO:0050891 4 0.015
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.015
axis specification GO:0009798 4 0.015
homeostatic process GO:0042592 331 0.015
cardiovascular system development GO:0072358 134 0.014
regulation of interleukin 8 production GO:0032677 2 0.014
positive regulation of phosphorylation GO:0042327 177 0.014
antigen receptor mediated signaling pathway GO:0050851 1 0.014
skeletal system development GO:0001501 41 0.014
macromolecular complex assembly GO:0065003 273 0.014
cellular lipid metabolic process GO:0044255 208 0.014
circulatory system development GO:0072359 134 0.014
protein oligomerization GO:0051259 191 0.014
positive regulation of epithelial cell proliferation GO:0050679 32 0.014
positive regulation of rna biosynthetic process GO:1902680 197 0.014
positive regulation of molecular function GO:0044093 230 0.014
positive regulation of neurogenesis GO:0050769 165 0.014
regulation of secretion by cell GO:1903530 208 0.014
angiogenesis GO:0001525 53 0.014
glial cell differentiation GO:0010001 65 0.014
spermatogenesis GO:0007283 99 0.014
g protein coupled receptor internalization GO:0002031 3 0.014
response to light stimulus GO:0009416 52 0.014
regulation of wnt signaling pathway GO:0030111 8 0.013
response to peptide GO:1901652 292 0.013
cellular response to endogenous stimulus GO:0071495 377 0.013
triglyceride homeostasis GO:0070328 2 0.013
negative regulation of developmental process GO:0051093 125 0.013
positive regulation of signaling GO:0023056 270 0.013
cell morphogenesis involved in differentiation GO:0000904 119 0.013
regulation of stem cell proliferation GO:0072091 14 0.013
response to anoxia GO:0034059 4 0.013
positive regulation of nervous system development GO:0051962 178 0.013
reproduction GO:0000003 245 0.013
keratinocyte differentiation GO:0030216 2 0.013
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.013
mesenchymal cell proliferation GO:0010463 4 0.013
neural crest cell migration GO:0001755 1 0.013
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.013
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016339 3 0.013
cytokine mediated signaling pathway GO:0019221 43 0.013
response to oxidative stress GO:0006979 186 0.013
cellular response to growth factor stimulus GO:0071363 162 0.013
urogenital system development GO:0001655 78 0.013
cellular modified amino acid metabolic process GO:0006575 61 0.013
secretion GO:0046903 307 0.013
regulation of nervous system development GO:0051960 264 0.013
renal system development GO:0072001 67 0.013
positive regulation of intracellular signal transduction GO:1902533 138 0.013
response to metal ion GO:0010038 253 0.013
embryonic skeletal system morphogenesis GO:0048704 3 0.012
positive regulation of cell activation GO:0050867 34 0.012
icosanoid biosynthetic process GO:0046456 18 0.012
head development GO:0060322 247 0.012
positive regulation of interleukin 1 beta production GO:0032731 6 0.012
regulation of endothelial cell proliferation GO:0001936 18 0.012
glomerular mesangial cell proliferation GO:0072110 4 0.012
establishment of protein localization to organelle GO:0072594 44 0.012
response to alkaloid GO:0043279 132 0.012
lipid biosynthetic process GO:0008610 128 0.012
hematopoietic progenitor cell differentiation GO:0002244 2 0.012
negative regulation of response to stimulus GO:0048585 155 0.012
myeloid leukocyte migration GO:0097529 20 0.012
positive regulation of fibroblast proliferation GO:0048146 15 0.012
gonad development GO:0008406 104 0.012
cell adhesion GO:0007155 110 0.012
regulation of defense response GO:0031347 68 0.012
defense response to gram negative bacterium GO:0050829 3 0.012
leukocyte chemotaxis GO:0030595 22 0.012
positive regulation of adiponectin secretion GO:0070165 1 0.012
response to mechanical stimulus GO:0009612 134 0.012
cell fate determination GO:0001709 2 0.012
cellular protein localization GO:0034613 122 0.012
positive regulation of mesenchymal cell proliferation GO:0002053 4 0.012
cell activation GO:0001775 97 0.012
vesicle mediated transport GO:0016192 181 0.012
positive regulation of phosphorus metabolic process GO:0010562 262 0.012
secretion by cell GO:0032940 248 0.011
cellular divalent inorganic cation homeostasis GO:0072503 162 0.011
cellular macromolecule localization GO:0070727 122 0.011
hair follicle development GO:0001942 2 0.011
myeloid leukocyte activation GO:0002274 36 0.011
fibroblast proliferation GO:0048144 22 0.011
chronic inflammatory response GO:0002544 16 0.011
leukotriene biosynthetic process GO:0019370 3 0.011
response to extracellular stimulus GO:0009991 380 0.011
palate development GO:0060021 2 0.011
positive regulation of cell motility GO:2000147 97 0.011
regulation of leukocyte activation GO:0002694 45 0.011
nucleoside metabolic process GO:0009116 179 0.011
peptidyl amino acid modification GO:0018193 126 0.011
organic substance catabolic process GO:1901575 316 0.011
coenzyme metabolic process GO:0006732 86 0.011
ensheathment of neurons GO:0007272 40 0.011
interleukin 1 beta secretion GO:0050702 3 0.011
lung development GO:0030324 43 0.011
protein localization to organelle GO:0033365 57 0.011
dendrite development GO:0016358 72 0.011
response to temperature stimulus GO:0009266 94 0.011
reproductive system development GO:0061458 128 0.011
morphogenesis of embryonic epithelium GO:0016331 3 0.011
muscle cell differentiation GO:0042692 52 0.011
positive regulation of protein modification process GO:0031401 142 0.011
unsaturated fatty acid metabolic process GO:0033559 39 0.011
positive regulation of protein localization to nucleus GO:1900182 15 0.011
regulation of locomotion GO:0040012 148 0.011
aging GO:0007568 241 0.011
peptidyl tyrosine modification GO:0018212 72 0.011
asymmetric stem cell division GO:0098722 2 0.011
sex differentiation GO:0007548 113 0.010
metal ion transport GO:0030001 289 0.010
pyridine containing compound metabolic process GO:0072524 32 0.010
forebrain development GO:0030900 98 0.010
cellular chemical homeostasis GO:0055082 247 0.010
prostate gland development GO:0030850 9 0.010
regulation of response to wounding GO:1903034 69 0.010
negative regulation of kidney development GO:0090185 2 0.010
response to gamma radiation GO:0010332 24 0.010
negative regulation of molecular function GO:0044092 133 0.010
granulocyte chemotaxis GO:0071621 15 0.010
embryo development GO:0009790 49 0.010
positive regulation of immune response GO:0050778 42 0.010

Nradd disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 0 0.055
disease of anatomical entity DOID:7 0 0.055
eye and adnexa disease DOID:1492 0 0.055
nervous system disease DOID:863 0 0.055
integumentary system disease DOID:16 0 0.023
gastrointestinal system disease DOID:77 0 0.020
eye disease DOID:5614 0 0.019