Rattus norvegicus

43 known processes

Klk6

kallikrein related-peptidase 6

(Aliases: Prss9)

Klk6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to purine containing compound GO:0014074 126 0.267
response to decreased oxygen levels GO:0036293 237 0.253
response to corticosteroid GO:0031960 235 0.251
cellular response to lipid GO:0071396 201 0.187
response to oxygen levels GO:0070482 265 0.184
response to hypoxia GO:0001666 231 0.171
response to metal ion GO:0010038 253 0.146
acute phase response GO:0006953 20 0.138
immune system process GO:0002376 204 0.134
response to other organism GO:0051707 220 0.126
defense response GO:0006952 194 0.105
apoptotic process GO:0006915 381 0.097
cellular response to organonitrogen compound GO:0071417 197 0.094
response to nutrient GO:0007584 248 0.093
Rat
central nervous system development GO:0007417 311 0.090
positive regulation of response to stimulus GO:0048584 285 0.086
Human
protein complex subunit organization GO:0071822 302 0.075
response to transition metal nanoparticle GO:1990267 122 0.074
regulation of cellular component organization GO:0051128 368 0.074
glial cell development GO:0021782 19 0.073
response to nutrient levels GO:0031667 370 0.073
Rat
macromolecular complex assembly GO:0065003 273 0.072
response to estrogen GO:0043627 232 0.071
cellular component movement GO:0006928 248 0.070
protein complex biogenesis GO:0070271 263 0.068
regulation of programmed cell death GO:0043067 341 0.066
cellular lipid metabolic process GO:0044255 208 0.066
action potential GO:0001508 54 0.064
gliogenesis GO:0042063 93 0.063
regulation of neurotransmitter levels GO:0001505 42 0.062
negative regulation of nervous system development GO:0051961 79 0.059
response to lipopolysaccharide GO:0032496 191 0.058
negative regulation of cell development GO:0010721 82 0.056
negative regulation of apoptotic process GO:0043066 181 0.056
renal system development GO:0072001 67 0.055
chemical homeostasis GO:0048878 292 0.054
response to cytokine GO:0034097 215 0.054
catabolic process GO:0009056 351 0.053
intermediate filament bundle assembly GO:0045110 1 0.051
regulation of nervous system development GO:0051960 264 0.048
regulation of synaptic plasticity GO:0048167 70 0.048
protein homooligomerization GO:0051260 91 0.048
response to peptide GO:1901652 292 0.048
response to molecule of bacterial origin GO:0002237 194 0.046
response to external biotic stimulus GO:0043207 221 0.046
glial cell differentiation GO:0010001 65 0.045
metal ion transport GO:0030001 289 0.044
macromolecular complex subunit organization GO:0043933 339 0.043
regulation of locomotion GO:0040012 148 0.043
protein complex assembly GO:0006461 263 0.042
cellular response to oxygen containing compound GO:1901701 386 0.042
organic anion transport GO:0015711 132 0.041
cellular component assembly GO:0022607 360 0.041
hormone metabolic process GO:0042445 69 0.041
dicarboxylic acid transport GO:0006835 34 0.040
circulatory system process GO:0003013 183 0.040
Rat
epithelial cell differentiation GO:0030855 71 0.040
biological adhesion GO:0022610 110 0.040
single organism reproductive process GO:0044702 297 0.039
response to inorganic substance GO:0010035 377 0.038
multicellular organismal signaling GO:0035637 44 0.036
cell cell signaling GO:0007267 335 0.036
programmed cell death GO:0012501 392 0.036
positive regulation of cell death GO:0010942 184 0.036
cellular response to organic cyclic compound GO:0071407 202 0.036
cellular response to nitrogen compound GO:1901699 210 0.035
response to retinoic acid GO:0032526 63 0.035
multicellular organismal homeostasis GO:0048871 49 0.035
response to hexose GO:0009746 144 0.034
muscle contraction GO:0006936 88 0.034
response to toxic substance GO:0009636 133 0.034
response to peptide hormone GO:0043434 278 0.033
monovalent inorganic cation transport GO:0015672 172 0.033
regulation of cell development GO:0060284 263 0.033
cell motility GO:0048870 202 0.033
response to acid chemical GO:0001101 222 0.032
blood circulation GO:0008015 183 0.032
Rat
response to extracellular stimulus GO:0009991 380 0.031
Rat
protein oligomerization GO:0051259 191 0.031
cellular homeostasis GO:0019725 252 0.031
synaptic transmission GO:0007268 235 0.030
astrocyte development GO:0014002 4 0.030
cellular response to extracellular stimulus GO:0031668 73 0.030
positive regulation of catalytic activity GO:0043085 184 0.030
regulation of apoptotic process GO:0042981 335 0.030
protein phosphorylation GO:0006468 345 0.029
glucose homeostasis GO:0042593 75 0.029
actin filament based process GO:0030029 86 0.029
response to bacterium GO:0009617 200 0.029
neurotransmitter transport GO:0006836 42 0.029
cellular component biogenesis GO:0044085 368 0.029
regulation of system process GO:0044057 208 0.029
Rat
regulation of membrane potential GO:0042391 110 0.029
brain development GO:0007420 247 0.029
regulation of cellular protein metabolic process GO:0032268 267 0.028
amine metabolic process GO:0009308 38 0.028
alcohol metabolic process GO:0006066 77 0.028
head development GO:0060322 247 0.028
negative regulation of neurogenesis GO:0050768 78 0.028
neuron projection development GO:0031175 273 0.028
neurological system process GO:0050877 219 0.028
heart process GO:0003015 57 0.027
cellular response to cytokine stimulus GO:0071345 127 0.027
regulation of cell differentiation GO:0045595 320 0.027
cellular amine metabolic process GO:0044106 38 0.027
response to radiation GO:0009314 137 0.027
positive regulation of cell communication GO:0010647 271 0.027
Human
positive regulation of apoptotic process GO:0043065 154 0.027
calcium ion homeostasis GO:0055074 162 0.026
muscle system process GO:0003012 115 0.026
cation transport GO:0006812 382 0.026
organonitrogen compound biosynthetic process GO:1901566 167 0.026
response to carbohydrate GO:0009743 183 0.026
response to fatty acid GO:0070542 65 0.026
response to organophosphorus GO:0046683 102 0.025
regulation of blood circulation GO:1903522 110 0.025
Rat
transmission of nerve impulse GO:0019226 42 0.025
sensory perception of pain GO:0019233 73 0.025
cellular cation homeostasis GO:0030003 180 0.025
positive regulation of immune system process GO:0002684 90 0.025
carboxylic acid transport GO:0046942 115 0.025
regulation of synaptic transmission GO:0050804 141 0.025
cellular catabolic process GO:0044248 295 0.024
response to alkaloid GO:0043279 132 0.024
cellular response to peptide GO:1901653 133 0.024
cellular response to hormone stimulus GO:0032870 247 0.024
positive regulation of developmental process GO:0051094 283 0.024
negative regulation of neuron differentiation GO:0045665 62 0.024
cellular amino acid metabolic process GO:0006520 107 0.024
neuron differentiation GO:0030182 368 0.024
positive regulation of nervous system development GO:0051962 178 0.024
negative regulation of cell communication GO:0010648 158 0.024
neuron development GO:0048666 286 0.024
amino acid transmembrane transport GO:0003333 33 0.024
inflammatory response GO:0006954 150 0.023
immune response GO:0006955 104 0.023
positive regulation of cell development GO:0010720 176 0.023
tissue development GO:0009888 252 0.023
astrocyte differentiation GO:0048708 19 0.023
regulation of neural precursor cell proliferation GO:2000177 16 0.023
multi organism reproductive process GO:0044703 262 0.022
cellular response to fluid shear stress GO:0071498 4 0.022
saliva secretion GO:0046541 3 0.022
response to monosaccharide GO:0034284 159 0.022
cell projection organization GO:0030030 302 0.022
inorganic cation transmembrane transport GO:0098662 202 0.022
rna biosynthetic process GO:0032774 380 0.022
homeostatic process GO:0042592 331 0.022
sensory perception GO:0007600 101 0.022
ion transmembrane transport GO:0034220 365 0.022
cellular response to acid chemical GO:0071229 75 0.022
transcription dna templated GO:0006351 377 0.022
neuronal action potential GO:0019228 35 0.022
response to mercury ion GO:0046689 15 0.021
regulation of cell migration GO:0030334 128 0.021
response to glucocorticoid GO:0051384 223 0.021
response to zinc ion GO:0010043 39 0.021
anion transport GO:0006820 178 0.021
immune effector process GO:0002252 53 0.021
cardiac muscle cell contraction GO:0086003 10 0.021
lipid biosynthetic process GO:0008610 128 0.021
regulation of anatomical structure size GO:0090066 135 0.020
Rat
regulation of secretion by cell GO:1903530 208 0.020
negative regulation of programmed cell death GO:0043069 183 0.020
signal release GO:0023061 145 0.020
cellular chemical homeostasis GO:0055082 247 0.020
single organism behavior GO:0044708 130 0.020
positive regulation of neurogenesis GO:0050769 165 0.020
positive regulation of cellular protein metabolic process GO:0032270 167 0.020
cellular response to endogenous stimulus GO:0071495 377 0.020
cellular hormone metabolic process GO:0034754 49 0.020
regulation of protein modification process GO:0031399 194 0.020
organic substance catabolic process GO:1901575 316 0.020
regulation of blood vessel size GO:0050880 89 0.019
Rat
neurotransmitter uptake GO:0001504 3 0.019
protein localization GO:0008104 191 0.019
response to tumor necrosis factor GO:0034612 56 0.019
cell migration GO:0016477 197 0.019
cellular ion homeostasis GO:0006873 184 0.019
intermediate filament cytoskeleton organization GO:0045104 3 0.019
regulation of rna biosynthetic process GO:2001141 381 0.019
aging GO:0007568 241 0.019
regulation of immunoglobulin production GO:0002637 4 0.019
cellular response to external stimulus GO:0071496 118 0.019
cellular response to stress GO:0033554 269 0.019
response to vitamin GO:0033273 131 0.018
regeneration GO:0031099 163 0.018
regulation of heart contraction GO:0008016 48 0.018
neural crest cell differentiation GO:0014033 2 0.018
cation homeostasis GO:0055080 195 0.018
positive regulation of response to external stimulus GO:0032103 51 0.018
positive regulation of cell differentiation GO:0045597 217 0.018
epithelium development GO:0060429 96 0.018
secretion GO:0046903 307 0.018
multicellular organism reproduction GO:0032504 233 0.018
organic acid transport GO:0015849 116 0.018
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.018
negative regulation of synaptic transmission gabaergic GO:0032229 6 0.018
acute inflammatory response GO:0002526 58 0.017
positive regulation of defense response GO:0031349 37 0.017
positive regulation of signaling GO:0023056 270 0.017
Human
detection of calcium ion GO:0005513 1 0.017
regulation of smooth muscle cell migration GO:0014910 36 0.017
cellular response to tumor necrosis factor GO:0071356 46 0.017
response to ketone GO:1901654 182 0.016
cytosolic calcium ion homeostasis GO:0051480 140 0.016
negative regulation of cellular metabolic process GO:0031324 281 0.016
single organism biosynthetic process GO:0044711 342 0.016
regulation of neuron projection development GO:0010975 161 0.016
cellular response to retinoic acid GO:0071300 27 0.016
divalent inorganic cation homeostasis GO:0072507 165 0.016
regulation of multicellular organismal development GO:2000026 376 0.016
cardiac muscle contraction GO:0060048 27 0.016
regulation of hydrolase activity GO:0051336 143 0.016
regulation of cellular amino acid metabolic process GO:0006521 2 0.016
positive regulation of molecular function GO:0044093 230 0.015
secretion by cell GO:0032940 248 0.015
ion homeostasis GO:0050801 212 0.015
cellular response to peptide hormone stimulus GO:0071375 120 0.015
regulation of cellular amine metabolic process GO:0033238 8 0.015
regulation of ion transport GO:0043269 245 0.015
regulation of canonical wnt signaling pathway GO:0060828 4 0.015
negative regulation of signaling GO:0023057 157 0.015
detection of stimulus GO:0051606 24 0.015
smooth muscle contraction GO:0006939 37 0.015
peptidyl amino acid modification GO:0018193 126 0.015
vesicle mediated transport GO:0016192 181 0.015
regulation of behavior GO:0050795 61 0.015
female pregnancy GO:0007565 122 0.015
heart contraction GO:0060047 57 0.015
negative regulation of nucleic acid templated transcription GO:1903507 117 0.015
negative regulation of metabolic process GO:0009892 331 0.014
response to cgmp GO:0070305 3 0.014
regulation of cell proliferation GO:0042127 359 0.014
anatomical structure homeostasis GO:0060249 29 0.014
positive regulation of myeloid leukocyte differentiation GO:0002763 7 0.014
gonad development GO:0008406 104 0.014
urinary tract smooth muscle contraction GO:0014848 4 0.014
regulation of smooth muscle cell proliferation GO:0048660 75 0.014
regulation of anatomical structure morphogenesis GO:0022603 141 0.014
negative regulation of response to stimulus GO:0048585 155 0.014
intracellular transport GO:0046907 185 0.014
cellular lipid catabolic process GO:0044242 37 0.014
regulation of immune system process GO:0002682 123 0.014
amide transport GO:0042886 105 0.014
positive regulation of programmed cell death GO:0043068 157 0.014
regulation of neurological system process GO:0031644 43 0.014
cellular response to glucocorticoid stimulus GO:0071385 68 0.014
regulation of neurotransmitter uptake GO:0051580 1 0.014
peristalsis GO:0030432 2 0.014
ossification GO:0001503 70 0.014
t cell migration GO:0072678 2 0.014
reproductive structure development GO:0048608 128 0.014
regulation of inflammatory response GO:0050727 48 0.013
regulation of cellular component movement GO:0051270 150 0.013
gamete generation GO:0007276 124 0.013
cellular calcium ion homeostasis GO:0006874 160 0.013
l glutamate import GO:0051938 2 0.013
positive regulation of gamma aminobutyric acid secretion GO:0014054 4 0.013
positive regulation of catecholamine secretion GO:0033605 13 0.013
b cell activation involved in immune response GO:0002312 1 0.013
kidney development GO:0001822 67 0.013
ribose phosphate biosynthetic process GO:0046390 87 0.013
organic acid metabolic process GO:0006082 292 0.013
regulation of response to external stimulus GO:0032101 106 0.013
carbohydrate derivative biosynthetic process GO:1901137 124 0.013
neuron neuron synaptic transmission GO:0007270 60 0.013
reproductive process GO:0022414 372 0.013
glycerolipid metabolic process GO:0046486 67 0.013
response to activity GO:0014823 73 0.013
morphogenesis of embryonic epithelium GO:0016331 3 0.013
localization of cell GO:0051674 202 0.013
intermediate filament based process GO:0045103 3 0.013
potassium ion transmembrane transport GO:0071805 71 0.013
carboxylic acid metabolic process GO:0019752 289 0.013
regulation of hormone secretion GO:0046883 106 0.013
response to insulin GO:0032868 133 0.013
cellular ketone metabolic process GO:0042180 51 0.013
sensory organ development GO:0007423 74 0.012
multicellular organism growth GO:0035264 1 0.012
immunoglobulin mediated immune response GO:0016064 4 0.012
cytoskeleton organization GO:0007010 111 0.012
response to camp GO:0051591 91 0.012
carbohydrate derivative metabolic process GO:1901135 346 0.012
regulation of neurogenesis GO:0050767 247 0.012
negative regulation of cell death GO:0060548 229 0.012
negative regulation of glutamate secretion GO:0014050 9 0.012
organ regeneration GO:0031100 101 0.012
cellular response to hexose stimulus GO:0071331 65 0.012
positive regulation of phosphorus metabolic process GO:0010562 262 0.012
sexual reproduction GO:0019953 148 0.012
chemotaxis GO:0006935 66 0.012
negative regulation of multicellular organismal process GO:0051241 203 0.012
regulation of ossification GO:0030278 32 0.012
positive regulation of cytokine production GO:0001819 42 0.012
regulation of response to wounding GO:1903034 69 0.012
phospholipid metabolic process GO:0006644 61 0.012
multicellular organismal reproductive process GO:0048609 233 0.012
locomotion GO:0040011 237 0.012
regulation of rna metabolic process GO:0051252 391 0.012
negative regulation of cell differentiation GO:0045596 99 0.012
response to estradiol GO:0032355 164 0.012
positive regulation of cell motility GO:2000147 97 0.012
actin filament based movement GO:0030048 16 0.012
response to glucose GO:0009749 136 0.011
regulation of sensory perception of pain GO:0051930 29 0.011
sequestering of metal ion GO:0051238 9 0.011
positive regulation of inflammatory response GO:0050729 24 0.011
neural precursor cell proliferation GO:0061351 23 0.011
circadian rhythm GO:0007623 88 0.011
rhythmic behavior GO:0007622 24 0.011
copulation GO:0007620 17 0.011
g protein coupled receptor signaling pathway GO:0007186 242 0.011
Human
innate immune response GO:0045087 35 0.011
cellular response to growth factor stimulus GO:0071363 162 0.011
regulation of muscle contraction GO:0006937 53 0.011
regulation of signal transduction GO:0009966 318 0.011
Human
cell adhesion GO:0007155 110 0.011
oxoacid metabolic process GO:0043436 290 0.011
excretion GO:0007588 24 0.011
cerebellar granule cell precursor proliferation GO:0021930 1 0.011
b cell mediated immunity GO:0019724 4 0.011
prostate gland epithelium morphogenesis GO:0060740 2 0.011
protein kinase c activating g protein coupled receptor signaling pathway GO:0007205 12 0.011
ensheathment of neurons GO:0007272 40 0.011
cellular protein complex assembly GO:0043623 44 0.011
positive regulation of cell projection organization GO:0031346 111 0.011
cellular response to carbohydrate stimulus GO:0071322 72 0.011
detection of temperature stimulus involved in sensory perception of pain GO:0050965 4 0.011
multi multicellular organism process GO:0044706 138 0.011
organic cyclic compound catabolic process GO:1901361 175 0.011
positive regulation of cellular biosynthetic process GO:0031328 295 0.011
regulation of molecular function GO:0065009 398 0.011
intermediate filament organization GO:0045109 1 0.011
cellular amino acid biosynthetic process GO:0008652 32 0.011
regulation of catalytic activity GO:0050790 304 0.011
regulation of muscle system process GO:0090257 79 0.011
positive regulation of multicellular organismal process GO:0051240 387 0.011
Rat
myeloid leukocyte migration GO:0097529 20 0.011
myelination GO:0042552 39 0.011
cellular response to monosaccharide stimulus GO:0071326 67 0.011
response to oxidative stress GO:0006979 186 0.011
regulation of hormone levels GO:0010817 187 0.011
regulation of map kinase activity GO:0043405 53 0.010
defense response to gram negative bacterium GO:0050829 3 0.010
single organism catabolic process GO:0044712 283 0.010
glycerophospholipid metabolic process GO:0006650 47 0.010
membrane organization GO:0061024 94 0.010
anatomical structure morphogenesis GO:0009653 298 0.010
cellular response to glucose stimulus GO:0071333 65 0.010
positive regulation of organic acid transport GO:0032892 22 0.010
circulatory system development GO:0072359 134 0.010
spermatogenesis GO:0007283 99 0.010
response to ph GO:0009268 27 0.010
endomembrane system organization GO:0010256 48 0.010
male gamete generation GO:0048232 99 0.010
hormone transport GO:0009914 121 0.010
regulation of saliva secretion GO:0046877 3 0.010
proteolysis GO:0006508 175 0.010
metal ion homeostasis GO:0055065 186 0.010
neural crest cell development GO:0014032 2 0.010

Klk6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 0 0.044
disease of anatomical entity DOID:7 0 0.044
eye and adnexa disease DOID:1492 0 0.044
nervous system disease DOID:863 0 0.044
eye disease DOID:5614 0 0.044
retinal disease DOID:5679 0 0.033
gastrointestinal system disease DOID:77 0 0.030
musculoskeletal system disease DOID:17 0 0.021
retinal degeneration DOID:8466 0 0.019
connective tissue disease DOID:65 0 0.012
vascular disease DOID:178 0 0.011
cardiovascular system disease DOID:1287 0 0.011
central nervous system disease DOID:331 0 0.010