Rattus norvegicus

43 known processes

Cfb

complement factor B

(Aliases: Bf,MGC94594,Da1-24)

Cfb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
complement activation GO:0006956 11 0.995
immune response GO:0006955 104 0.846
protein activation cascade GO:0072376 12 0.822
immune effector process GO:0002252 53 0.517
negative regulation of innate immune response GO:0045824 4 0.495
response to nutrient levels GO:0031667 370 0.466
coagulation GO:0050817 28 0.362
positive regulation of immune system process GO:0002684 90 0.360
positive regulation of immune response GO:0050778 42 0.319
regulation of immune response GO:0050776 55 0.318
inflammatory response GO:0006954 150 0.291
innate immune response GO:0045087 35 0.291
positive regulation of multicellular organismal process GO:0051240 387 0.284
blood coagulation GO:0007596 26 0.280
regulation of immune system process GO:0002682 123 0.275
response to ketone GO:1901654 182 0.272
immune system process GO:0002376 204 0.231
positive regulation of response to stimulus GO:0048584 285 0.229
regulation of protein metabolic process GO:0051246 289 0.228
wound healing GO:0042060 122 0.225
regulation of cellular protein metabolic process GO:0032268 267 0.214
response to corticosteroid GO:0031960 235 0.209
response to wounding GO:0009611 254 0.207
regulation of phosphate metabolic process GO:0019220 349 0.203
response to external biotic stimulus GO:0043207 221 0.202
intracellular signal transduction GO:0035556 314 0.199
regulation of multicellular organismal development GO:2000026 376 0.175
response to biotic stimulus GO:0009607 226 0.174
homeostatic process GO:0042592 331 0.173
leukocyte mediated immunity GO:0002443 28 0.147
activation of immune response GO:0002253 26 0.146
positive regulation of developmental process GO:0051094 283 0.140
response to nutrient GO:0007584 248 0.133
organic acid metabolic process GO:0006082 292 0.127
positive regulation of cell communication GO:0010647 271 0.120
hemostasis GO:0007599 26 0.119
regulation of body fluid levels GO:0050878 90 0.119
acute phase response GO:0006953 20 0.115
regulation of developmental growth GO:0048638 45 0.105
positive regulation of phosphorus metabolic process GO:0010562 262 0.105
response to glucocorticoid GO:0051384 223 0.105
humoral immune response GO:0006959 12 0.103
monocarboxylic acid metabolic process GO:0032787 152 0.099
oxoacid metabolic process GO:0043436 290 0.097
regulation of phosphorylation GO:0042325 248 0.093
immune system development GO:0002520 41 0.092
cell projection organization GO:0030030 302 0.091
regulation of phosphorus metabolic process GO:0051174 349 0.090
response to metal ion GO:0010038 253 0.089
positive regulation of signaling GO:0023056 270 0.087
response to extracellular stimulus GO:0009991 380 0.087
reproductive process GO:0022414 372 0.086
protein maturation GO:0051604 68 0.083
negative regulation of cellular protein metabolic process GO:0032269 106 0.080
programmed cell death GO:0012501 392 0.077
positive regulation of nervous system development GO:0051962 178 0.075
liver development GO:0001889 90 0.075
response to magnesium ion GO:0032026 20 0.074
negative regulation of cellular metabolic process GO:0031324 281 0.073
positive regulation of blood coagulation GO:0030194 4 0.072
response to inorganic substance GO:0010035 377 0.070
regulation of defense response GO:0031347 68 0.070
cellular response to lipid GO:0071396 201 0.069
regulation of signal transduction GO:0009966 318 0.068
negative regulation of multicellular organismal process GO:0051241 203 0.067
cellular amino acid metabolic process GO:0006520 107 0.067
response to interleukin 1 GO:0070555 55 0.067
protein phosphorylation GO:0006468 345 0.066
positive regulation of signal transduction GO:0009967 175 0.065
regulation of tolerance induction dependent upon immune response GO:0002652 1 0.065
positive regulation of phosphate metabolic process GO:0045937 262 0.063
gland development GO:0048732 155 0.062
response to other organism GO:0051707 220 0.062
positive regulation of erk1 and erk2 cascade GO:0070374 29 0.061
regulation of protein modification process GO:0031399 194 0.059
response to organophosphorus GO:0046683 102 0.059
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.058
regulation of cellular component organization GO:0051128 368 0.058
positive regulation of protein metabolic process GO:0051247 178 0.058
response to estradiol GO:0032355 164 0.058
regulation of cell development GO:0060284 263 0.056
positive regulation of cell development GO:0010720 176 0.054
response to camp GO:0051591 91 0.053
immunoglobulin mediated immune response GO:0016064 4 0.052
regulation of innate immune response GO:0045088 15 0.052
negative regulation of macromolecule metabolic process GO:0010605 260 0.050
response to bacterium GO:0009617 200 0.050
regulation of growth GO:0040008 105 0.049
cellular component biogenesis GO:0044085 368 0.048
multicellular organismal signaling GO:0035637 44 0.048
regulation of cellular amine metabolic process GO:0033238 8 0.048
regulation of molecular function GO:0065009 398 0.048
cellular response to stress GO:0033554 269 0.048
response to purine containing compound GO:0014074 126 0.047
negative regulation of gene expression GO:0010629 199 0.047
positive regulation of tolerance induction dependent upon immune response GO:0002654 1 0.046
behavior GO:0007610 205 0.046
chemical homeostasis GO:0048878 292 0.046
cellular amine metabolic process GO:0044106 38 0.046
proteolysis GO:0006508 175 0.045
cellular ketone metabolic process GO:0042180 51 0.045
sexual reproduction GO:0019953 148 0.044
carboxylic acid metabolic process GO:0019752 289 0.043
peptidyl amino acid modification GO:0018193 126 0.043
negative regulation of metabolic process GO:0009892 331 0.042
response to cytokine GO:0034097 215 0.042
b cell mediated immunity GO:0019724 4 0.042
amine metabolic process GO:0009308 38 0.041
regulation of cell activation GO:0050865 50 0.041
cellular response to oxygen containing compound GO:1901701 386 0.041
response to decreased oxygen levels GO:0036293 237 0.040
regulation of hormone levels GO:0010817 187 0.040
neurological system process GO:0050877 219 0.040
cellular component assembly GO:0022607 360 0.039
transmission of nerve impulse GO:0019226 42 0.039
negative regulation of developmental process GO:0051093 125 0.039
metal ion homeostasis GO:0055065 186 0.039
regulation of cellular ketone metabolic process GO:0010565 27 0.038
positive regulation of hydrolase activity GO:0051345 86 0.037
response to lipopolysaccharide GO:0032496 191 0.037
signal transduction by phosphorylation GO:0023014 144 0.037
regulation of cellular amino acid metabolic process GO:0006521 2 0.037
tissue development GO:0009888 252 0.037
negative regulation of humoral immune response GO:0002921 4 0.036
regulation of response to stress GO:0080134 126 0.035
cellular response to corticosteroid stimulus GO:0071384 69 0.035
cellular response to interleukin 1 GO:0071347 37 0.035
negative regulation of molecular function GO:0044092 133 0.034
regulation of neurogenesis GO:0050767 247 0.034
response to acid chemical GO:0001101 222 0.033
response to interferon gamma GO:0034341 20 0.033
regulation of response to wounding GO:1903034 69 0.032
cellular chemical homeostasis GO:0055082 247 0.032
neuron projection development GO:0031175 273 0.032
tolerance induction GO:0002507 5 0.032
positive regulation of protein phosphorylation GO:0001934 135 0.032
rna metabolic process GO:0016070 406 0.032
single organism behavior GO:0044708 130 0.032
reactive nitrogen species metabolic process GO:2001057 1 0.032
negative regulation of cell communication GO:0010648 158 0.031
response to fatty acid GO:0070542 65 0.031
lipid biosynthetic process GO:0008610 128 0.031
response to progesterone GO:0032570 48 0.031
anterior posterior pattern specification GO:0009952 1 0.031
regulation of catalytic activity GO:0050790 304 0.031
macromolecular complex subunit organization GO:0043933 339 0.030
regulation of intracellular signal transduction GO:1902531 218 0.030
positive regulation of hemostasis GO:1900048 4 0.030
positive regulation of phosphorylation GO:0042327 177 0.030
cellular response to cytokine stimulus GO:0071345 127 0.029
regulation of system process GO:0044057 208 0.029
cell projection morphogenesis GO:0048858 123 0.029
positive regulation of cell differentiation GO:0045597 217 0.029
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.028
organelle organization GO:0006996 266 0.028
negative regulation of viral process GO:0048525 4 0.028
regulation of rna metabolic process GO:0051252 391 0.028
rna biosynthetic process GO:0032774 380 0.028
neuron development GO:0048666 286 0.027
protein oligomerization GO:0051259 191 0.027
regulation of programmed cell death GO:0043067 341 0.027
cellular component movement GO:0006928 248 0.027
single organism biosynthetic process GO:0044711 342 0.027
regeneration GO:0031099 163 0.026
erk1 and erk2 cascade GO:0070371 48 0.026
chemosensory behavior GO:0007635 2 0.026
regulation of immune effector process GO:0002697 32 0.026
response to molecule of bacterial origin GO:0002237 194 0.026
regulation of protein phosphorylation GO:0001932 183 0.026
lung development GO:0030324 43 0.026
negative regulation of catalytic activity GO:0043086 103 0.026
tube development GO:0035295 89 0.025
positive regulation of cellular component organization GO:0051130 200 0.025
respiratory system development GO:0060541 45 0.025
regulation of protein maturation GO:1903317 50 0.024
defense response GO:0006952 194 0.024
regulation of cell projection organization GO:0031344 175 0.024
multicellular organism reproduction GO:0032504 233 0.024
localization of cell GO:0051674 202 0.024
multicellular organismal reproductive process GO:0048609 233 0.023
blood coagulation fibrin clot formation GO:0072378 1 0.023
positive regulation of neuron projection development GO:0010976 99 0.023
protein complex subunit organization GO:0071822 302 0.023
regulation of catabolic process GO:0009894 113 0.023
positive regulation of intracellular signal transduction GO:1902533 138 0.023
regulation of mapk cascade GO:0043408 116 0.023
cellular homeostasis GO:0019725 252 0.023
regulation of nucleic acid templated transcription GO:1903506 380 0.023
macromolecular complex assembly GO:0065003 273 0.023
regulation of erk1 and erk2 cascade GO:0070372 41 0.022
cation transport GO:0006812 382 0.022
reactive oxygen species metabolic process GO:0072593 37 0.022
monocarboxylic acid biosynthetic process GO:0072330 48 0.022
lipid localization GO:0010876 62 0.021
positive regulation of cell projection organization GO:0031346 111 0.021
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.021
developmental process involved in reproduction GO:0003006 159 0.021
single organism organelle organization GO:1902589 180 0.021
reactive oxygen species biosynthetic process GO:1903409 8 0.021
multi organism reproductive process GO:0044703 262 0.021
cation homeostasis GO:0055080 195 0.021
cytoskeleton organization GO:0007010 111 0.021
regulation of transcription dna templated GO:0006355 374 0.021
regulation of cell migration GO:0030334 128 0.020
negative regulation of immune system process GO:0002683 39 0.020
viral genome replication GO:0019079 2 0.020
viral transcription GO:0019083 2 0.020
carboxylic acid biosynthetic process GO:0046394 83 0.020
small molecule biosynthetic process GO:0044283 124 0.020
response to peptide hormone GO:0043434 278 0.020
apoptotic process GO:0006915 381 0.020
ras protein signal transduction GO:0007265 29 0.020
positive regulation of cell death GO:0010942 184 0.020
positive regulation of catalytic activity GO:0043085 184 0.020
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.020
positive regulation of cellular biosynthetic process GO:0031328 295 0.019
regulation of cell differentiation GO:0045595 320 0.019
regulation of tolerance induction to nonself antigen GO:0002655 1 0.019
metal ion transport GO:0030001 289 0.019
renal system development GO:0072001 67 0.019
ion homeostasis GO:0050801 212 0.019
nucleobase containing small molecule metabolic process GO:0055086 316 0.019
positive regulation of mapk cascade GO:0043410 92 0.019
lipid transport GO:0006869 61 0.019
neuron differentiation GO:0030182 368 0.019
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
protein complex biogenesis GO:0070271 263 0.018
regulation of locomotion GO:0040012 148 0.018
acute inflammatory response GO:0002526 58 0.018
developmental growth GO:0048589 100 0.018
fatty acid derivative metabolic process GO:1901568 38 0.018
fatty acid biosynthetic process GO:0006633 33 0.018
carbohydrate homeostasis GO:0033500 75 0.018
aging GO:0007568 241 0.018
locomotion GO:0040011 237 0.018
positive regulation of cellular protein metabolic process GO:0032270 167 0.018
multi multicellular organism process GO:0044706 138 0.018
organophosphate metabolic process GO:0019637 370 0.018
catabolic process GO:0009056 351 0.017
cellular response to acid chemical GO:0071229 75 0.017
positive regulation of neuron differentiation GO:0045666 126 0.017
nucleoside metabolic process GO:0009116 179 0.017
purine nucleotide metabolic process GO:0006163 229 0.017
macromolecule localization GO:0033036 252 0.017
protein complex assembly GO:0006461 263 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
regulation of serine type peptidase activity GO:1902571 1 0.017
positive regulation of coagulation GO:0050820 5 0.017
regulation of blood circulation GO:1903522 110 0.017
cellular metal ion homeostasis GO:0006875 172 0.017
regulation of anatomical structure size GO:0090066 135 0.017
regulation of rna biosynthetic process GO:2001141 381 0.017
cellular response to biotic stimulus GO:0071216 59 0.017
response to dexamethasone GO:0071548 49 0.017
antigen processing and presentation GO:0019882 2 0.017
rhythmic process GO:0048511 156 0.016
organic substance catabolic process GO:1901575 316 0.016
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003340 2 0.016
negative regulation of cell differentiation GO:0045596 99 0.016
negative regulation of phosphorus metabolic process GO:0010563 80 0.016
cellular response to metal ion GO:0071248 55 0.016
cellular response to gonadotropin stimulus GO:0071371 17 0.016
single organism reproductive process GO:0044702 297 0.016
cellular ion homeostasis GO:0006873 184 0.016
positive regulation of gene expression GO:0010628 244 0.016
response to oxygen levels GO:0070482 265 0.016
regulation of neuron differentiation GO:0045664 208 0.015
nucleic acid templated transcription GO:0097659 379 0.015
icosanoid biosynthetic process GO:0046456 18 0.015
regulation of apoptotic process GO:0042981 335 0.015
purine ribonucleotide metabolic process GO:0009150 227 0.015
purine containing compound metabolic process GO:0072521 253 0.015
positive regulation of response to wounding GO:1903036 34 0.015
reproduction GO:0000003 245 0.015
protein localization GO:0008104 191 0.015
circadian rhythm GO:0007623 88 0.015
head development GO:0060322 247 0.015
negative regulation of phosphate metabolic process GO:0045936 80 0.015
regulation of hydrolase activity GO:0051336 143 0.015
eye morphogenesis GO:0048592 4 0.015
organ regeneration GO:0031100 101 0.015
intracellular transport GO:0046907 185 0.015
lipid metabolic process GO:0006629 283 0.015
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.014
gonad development GO:0008406 104 0.014
regulation of cytoskeleton organization GO:0051493 49 0.014
negative regulation of proteolysis GO:0045861 41 0.014
regulation of peptidase activity GO:0052547 55 0.014
regulation of actin filament based process GO:0032970 42 0.014
response to cobalt ion GO:0032025 12 0.014
regulation of nervous system development GO:0051960 264 0.014
heart development GO:0007507 72 0.014
negative regulation of cellular component organization GO:0051129 83 0.014
neuronal action potential GO:0019228 35 0.014
axis specification GO:0009798 4 0.014
viral gene expression GO:0019080 2 0.014
negative regulation of epithelial cell migration GO:0010633 4 0.014
ribonucleoside metabolic process GO:0009119 174 0.014
cellular lipid metabolic process GO:0044255 208 0.014
circulatory system process GO:0003013 183 0.014
cellular catabolic process GO:0044248 295 0.014
defense response to gram negative bacterium GO:0050829 3 0.014
response to hypoxia GO:0001666 231 0.014
fatty acid metabolic process GO:0006631 99 0.013
cellular response to nitrogen compound GO:1901699 210 0.013
intracellular protein transport GO:0006886 79 0.013
spindle organization GO:0007051 2 0.013
positive regulation of cell activation GO:0050867 34 0.013
regulation of proteolysis GO:0030162 66 0.013
fibrinolysis GO:0042730 2 0.013
positive regulation of neurogenesis GO:0050769 165 0.013
cellular response to extracellular stimulus GO:0031668 73 0.013
protein transport GO:0015031 132 0.013
negative regulation of immune response GO:0050777 15 0.013
mapk cascade GO:0000165 140 0.013
regulation of response to external stimulus GO:0032101 106 0.013
secretion GO:0046903 307 0.013
organic anion transport GO:0015711 132 0.013
regulation of neuron projection development GO:0010975 161 0.013
cellular response to hormone stimulus GO:0032870 247 0.013
regulation of reactive oxygen species metabolic process GO:2000377 26 0.013
cellular cation homeostasis GO:0030003 180 0.013
amide transport GO:0042886 105 0.012
negative regulation of endopeptidase activity GO:0010951 36 0.012
cellular response to external stimulus GO:0071496 118 0.012
cytoplasmic transport GO:0016482 115 0.012
ion transmembrane transport GO:0034220 365 0.012
unsaturated fatty acid biosynthetic process GO:0006636 21 0.012
positive regulation of developmental growth GO:0048639 29 0.012
protein processing GO:0016485 68 0.012
organonitrogen compound catabolic process GO:1901565 179 0.012
cell cell signaling GO:0007267 335 0.012
peptidyl tyrosine modification GO:0018212 72 0.012
response to monosaccharide GO:0034284 159 0.012
anatomical structure morphogenesis GO:0009653 298 0.012
cellular response to nutrient levels GO:0031669 60 0.012
cellular macromolecule catabolic process GO:0044265 29 0.012
response to transition metal nanoparticle GO:1990267 122 0.012
olfactory learning GO:0008355 1 0.012
response to glucose GO:0009749 136 0.012
defense response to gram positive bacterium GO:0050830 2 0.012
positive regulation of molecular function GO:0044093 230 0.012
regulation of kinase activity GO:0043549 117 0.012
endocytosis GO:0006897 84 0.012
heterocycle catabolic process GO:0046700 167 0.012
positive regulation of tolerance induction GO:0002645 1 0.011
negative regulation of viral genome replication GO:0045071 1 0.011
blood circulation GO:0008015 183 0.011
positive regulation of growth GO:0045927 55 0.011
single organism intracellular transport GO:1902582 166 0.011
regulation of muscle system process GO:0090257 79 0.011
negative regulation of peptidase activity GO:0010466 38 0.011
response to hexose GO:0009746 144 0.011
cellular response to endogenous stimulus GO:0071495 377 0.011
reproductive structure development GO:0048608 128 0.011
muscle tissue development GO:0060537 58 0.011
cell morphogenesis involved in differentiation GO:0000904 119 0.011
biological adhesion GO:0022610 110 0.011
gamete generation GO:0007276 124 0.011
regulation of cellular localization GO:0060341 263 0.011
response to gonadotropin GO:0034698 34 0.011
negative regulation of signaling GO:0023057 157 0.011
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.011
regulation of transferase activity GO:0051338 123 0.011
anion transport GO:0006820 178 0.011
cellular response to organic cyclic compound GO:0071407 202 0.011
development of primary male sexual characteristics GO:0046546 59 0.011
male sex differentiation GO:0046661 64 0.011
embryonic pattern specification GO:0009880 1 0.011
muscle system process GO:0003012 115 0.011
spermatogenesis GO:0007283 99 0.011
brain development GO:0007420 247 0.010
positive regulation of protein modification process GO:0031401 142 0.010
antigen processing and presentation of peptide antigen GO:0048002 2 0.010
regulation of cell proliferation GO:0042127 359 0.010
nucleoside phosphate metabolic process GO:0006753 283 0.010
development of primary sexual characteristics GO:0045137 107 0.010
peptide secretion GO:0002790 86 0.010
negative regulation of protein processing GO:0010955 47 0.010
response to peptide GO:1901652 292 0.010
sex differentiation GO:0007548 113 0.010
respiratory tube development GO:0030323 43 0.010
cellular response to inorganic substance GO:0071241 65 0.010
carbohydrate derivative metabolic process GO:1901135 346 0.010
establishment of protein localization GO:0045184 141 0.010
negative regulation of cellular amine metabolic process GO:0033239 3 0.010
nuclear transport GO:0051169 49 0.010
response to ethanol GO:0045471 162 0.010
cellular response to camp GO:0071320 26 0.010
positive regulation of cell proliferation GO:0008284 249 0.010
negative regulation of protein metabolic process GO:0051248 114 0.010
cellular response to iron ion starvation GO:0010106 1 0.010
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.010
response to axon injury GO:0048678 59 0.010
glycosyl compound metabolic process GO:1901657 182 0.010

Cfb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.039
disease of anatomical entity DOID:7 0 0.031
integumentary system disease DOID:16 0 0.031
inherited metabolic disorder DOID:655 0 0.023
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
vascular disease DOID:178 0 0.013
cardiovascular system disease DOID:1287 0 0.013