Rattus norvegicus

51 known processes

Cdc42bpa

CDC42 binding protein kinase alpha

(Aliases: Pk428,Mrck)

Cdc42bpa biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
intracellular signal transduction GO:0035556 314 0.241
regulation of transcription dna templated GO:0006355 374 0.155
protein phosphorylation GO:0006468 345 0.138
transcription dna templated GO:0006351 377 0.131
rna metabolic process GO:0016070 406 0.130
cell migration GO:0016477 197 0.120
positive regulation of cellular component organization GO:0051130 200 0.107
programmed cell death GO:0012501 392 0.098
nucleic acid templated transcription GO:0097659 379 0.098
regulation of protein phosphorylation GO:0001932 183 0.090
regulation of phosphate metabolic process GO:0019220 349 0.084
regulation of multicellular organismal development GO:2000026 376 0.084
anatomical structure morphogenesis GO:0009653 298 0.083
transcription from rna polymerase ii promoter GO:0006366 252 0.083
regulation of phosphorus metabolic process GO:0051174 349 0.080
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.079
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.076
cellular component movement GO:0006928 248 0.076
regulation of signal transduction GO:0009966 318 0.075
rna biosynthetic process GO:0032774 380 0.075
cellular component biogenesis GO:0044085 368 0.074
Fly
apoptotic process GO:0006915 381 0.074
neuron development GO:0048666 286 0.073
Fly
regulation of cellular component organization GO:0051128 368 0.070
Fly
regulation of apoptotic process GO:0042981 335 0.070
cell projection organization GO:0030030 302 0.070
negative regulation of gene expression GO:0010629 199 0.067
regulation of catalytic activity GO:0050790 304 0.067
negative regulation of metabolic process GO:0009892 331 0.067
regulation of rna biosynthetic process GO:2001141 381 0.067
regulation of cellular protein metabolic process GO:0032268 267 0.062
regulation of molecular function GO:0065009 398 0.059
single organism reproductive process GO:0044702 297 0.058
regulation of nucleic acid templated transcription GO:1903506 380 0.058
regulation of protein metabolic process GO:0051246 289 0.056
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.056
organelle organization GO:0006996 266 0.055
vesicle mediated transport GO:0016192 181 0.054
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.051
regulation of neuron differentiation GO:0045664 208 0.050
organic substance catabolic process GO:1901575 316 0.049
localization of cell GO:0051674 202 0.049
cell motility GO:0048870 202 0.049
neuron differentiation GO:0030182 368 0.049
Fly
tissue development GO:0009888 252 0.049
response to nutrient levels GO:0031667 370 0.048
reproduction GO:0000003 245 0.048
multicellular organism reproduction GO:0032504 233 0.047
multi organism reproductive process GO:0044703 262 0.047
brain development GO:0007420 247 0.047
regulation of dendrite development GO:0050773 59 0.046
mesoderm development GO:0007498 2 0.046
single organism catabolic process GO:0044712 283 0.046
catabolic process GO:0009056 351 0.045
head development GO:0060322 247 0.044
multicellular organismal reproductive process GO:0048609 233 0.044
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.043
regulation of rna metabolic process GO:0051252 391 0.042
negative regulation of cell proliferation GO:0008285 119 0.042
central nervous system development GO:0007417 311 0.042
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.041
regulation of anatomical structure morphogenesis GO:0022603 141 0.041
regulation of cell development GO:0060284 263 0.040
synaptic transmission GO:0007268 235 0.039
neuron projection development GO:0031175 273 0.039
positive regulation of gene expression GO:0010628 244 0.039
small gtpase mediated signal transduction GO:0007264 36 0.039
cell morphogenesis GO:0000902 142 0.039
positive regulation of signaling GO:0023056 270 0.039
cellular component assembly GO:0022607 360 0.038
Fly
reproductive process GO:0022414 372 0.038
cellular catabolic process GO:0044248 295 0.037
negative regulation of signaling GO:0023057 157 0.037
positive regulation of biosynthetic process GO:0009891 319 0.037
secretion GO:0046903 307 0.037
regulation of phosphorylation GO:0042325 248 0.037
regulation of protein modification process GO:0031399 194 0.037
macromolecular complex assembly GO:0065003 273 0.036
Fly
response to hypoxia GO:0001666 231 0.036
gastrulation GO:0007369 2 0.036
regulation of programmed cell death GO:0043067 341 0.035
positive regulation of transport GO:0051050 245 0.035
negative regulation of cellular metabolic process GO:0031324 281 0.035
cellular component morphogenesis GO:0032989 155 0.035
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.035
positive regulation of cellular biosynthetic process GO:0031328 295 0.035
nucleoside triphosphate catabolic process GO:0009143 123 0.035
positive regulation of cell communication GO:0010647 271 0.034
cell type specific apoptotic process GO:0097285 134 0.034
negative regulation of multicellular organismal process GO:0051241 203 0.034
response to decreased oxygen levels GO:0036293 237 0.033
cellular response to stress GO:0033554 269 0.033
neuron apoptotic process GO:0051402 88 0.032
response to extracellular stimulus GO:0009991 380 0.032
ras protein signal transduction GO:0007265 29 0.032
Rat
locomotion GO:0040011 237 0.032
regulation of neuron projection development GO:0010975 161 0.032
regulation of cell differentiation GO:0045595 320 0.032
regulation of cellular amino acid metabolic process GO:0006521 2 0.032
axonogenesis GO:0007409 71 0.031
cell projection morphogenesis GO:0048858 123 0.031
positive regulation of rna biosynthetic process GO:1902680 197 0.031
aromatic compound catabolic process GO:0019439 168 0.031
negative regulation of response to stimulus GO:0048585 155 0.031
regulation of cellular amine metabolic process GO:0033238 8 0.031
organophosphate metabolic process GO:0019637 370 0.031
regulation of nervous system development GO:0051960 264 0.030
regulation of cellular ketone metabolic process GO:0010565 27 0.030
response to oxygen levels GO:0070482 265 0.030
negative regulation of programmed cell death GO:0043069 183 0.030
negative regulation of cell communication GO:0010648 158 0.030
positive regulation of response to stimulus GO:0048584 285 0.029
cellular amino acid metabolic process GO:0006520 107 0.029
positive regulation of signal transduction GO:0009967 175 0.029
nucleotide catabolic process GO:0009166 139 0.029
sexual reproduction GO:0019953 148 0.029
circulatory system development GO:0072359 134 0.029
cell part morphogenesis GO:0032990 123 0.028
positive regulation of nucleic acid templated transcription GO:1903508 197 0.028
signal release GO:0023061 145 0.028
nucleobase containing small molecule metabolic process GO:0055086 316 0.028
anterior posterior pattern specification GO:0009952 1 0.028
negative regulation of molecular function GO:0044092 133 0.028
regulation of neurogenesis GO:0050767 247 0.027
nucleobase containing compound catabolic process GO:0034655 152 0.027
carbohydrate derivative catabolic process GO:1901136 147 0.027
cation homeostasis GO:0055080 195 0.027
cellular nitrogen compound catabolic process GO:0044270 163 0.027
macromolecular complex subunit organization GO:0043933 339 0.027
Fly
positive regulation of transcription dna templated GO:0045893 197 0.027
regulation of intracellular signal transduction GO:1902531 218 0.027
cellular amine metabolic process GO:0044106 38 0.027
positive regulation of neurogenesis GO:0050769 165 0.026
vesicle localization GO:0051648 33 0.026
purine nucleotide catabolic process GO:0006195 136 0.026
embryonic skeletal system morphogenesis GO:0048704 3 0.026
vasculature development GO:0001944 70 0.025
cellular ketone metabolic process GO:0042180 51 0.025
nucleoside phosphate catabolic process GO:1901292 140 0.025
ribonucleotide catabolic process GO:0009261 136 0.025
organophosphate catabolic process GO:0046434 148 0.025
negative regulation of developmental process GO:0051093 125 0.025
embryonic skeletal system development GO:0048706 3 0.025
organelle localization GO:0051640 55 0.025
Mouse
regulation of cell projection organization GO:0031344 175 0.025
actin filament based process GO:0030029 86 0.025
male mating behavior GO:0060179 3 0.024
negative regulation of cellular biosynthetic process GO:0031327 161 0.024
regulation of kinase activity GO:0043549 117 0.024
secretion by cell GO:0032940 248 0.024
negative regulation of apoptotic process GO:0043066 181 0.024
positive regulation of nervous system development GO:0051962 178 0.024
ribose phosphate metabolic process GO:0019693 235 0.024
positive regulation of cellular amine metabolic process GO:0033240 3 0.024
synaptic growth at neuromuscular junction GO:0051124 1 0.023
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.023
regulation of small gtpase mediated signal transduction GO:0051056 48 0.023
organic cyclic compound catabolic process GO:1901361 175 0.023
heterocycle catabolic process GO:0046700 167 0.023
positive regulation of programmed cell death GO:0043068 157 0.023
amine metabolic process GO:0009308 38 0.023
establishment of vesicle localization GO:0051650 31 0.023
regulation of protein kinase activity GO:0045859 105 0.023
negative regulation of cell death GO:0060548 229 0.022
negative regulation of nucleic acid templated transcription GO:1903507 117 0.022
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.022
formation of primary germ layer GO:0001704 1 0.022
response to growth factor GO:0070848 189 0.022
vasculogenesis GO:0001570 3 0.022
reproductive system development GO:0061458 128 0.022
regulation of neuron apoptotic process GO:0043523 83 0.022
nucleotide metabolic process GO:0009117 279 0.022
epithelium development GO:0060429 96 0.022
positive regulation of cellular protein metabolic process GO:0032270 167 0.022
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.021
growth GO:0040007 165 0.021
negative regulation of macromolecule metabolic process GO:0010605 260 0.021
response to nutrient GO:0007584 248 0.021
axon development GO:0061564 96 0.021
positive regulation of molecular function GO:0044093 230 0.021
negative regulation of catalytic activity GO:0043086 103 0.021
positive regulation of developmental process GO:0051094 283 0.021
carbohydrate derivative metabolic process GO:1901135 346 0.021
macromolecule localization GO:0033036 252 0.021
axis specification GO:0009798 4 0.021
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.020
positive regulation of neuron projection development GO:0010976 99 0.020
regulation of cellular catabolic process GO:0031329 101 0.020
gland development GO:0048732 155 0.020
dendrite morphogenesis GO:0048813 43 0.020
positive regulation of apoptotic process GO:0043065 154 0.020
regulation of cell proliferation GO:0042127 359 0.020
protein autophosphorylation GO:0046777 66 0.020
cytoskeleton organization GO:0007010 111 0.020
positive regulation of cell development GO:0010720 176 0.020
positive regulation of rna metabolic process GO:0051254 203 0.020
negative regulation of rna biosynthetic process GO:1902679 118 0.020
nucleoside metabolic process GO:0009116 179 0.020
cellular response to oxygen containing compound GO:1901701 386 0.020
positive regulation of cell differentiation GO:0045597 217 0.019
regulation of cell morphogenesis GO:0022604 77 0.019
cellular response to growth factor stimulus GO:0071363 162 0.019
synaptic vesicle endocytosis GO:0048488 4 0.019
negative regulation of protein metabolic process GO:0051248 114 0.019
nucleoside triphosphate metabolic process GO:0009141 144 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.019
purine nucleoside metabolic process GO:0042278 169 0.019
glycosyl compound catabolic process GO:1901658 126 0.019
response to metal ion GO:0010038 253 0.019
bmp signaling pathway GO:0030509 4 0.019
response to wounding GO:0009611 254 0.019
purine containing compound metabolic process GO:0072521 253 0.019
neural crest cell development GO:0014032 2 0.019
single organism cellular localization GO:1902580 102 0.018
cytoskeleton dependent cytokinesis GO:0061640 2 0.018
negative regulation of rna metabolic process GO:0051253 123 0.018
single organism membrane organization GO:0044802 74 0.018
regulation of secretion by cell GO:1903530 208 0.018
negative regulation of biosynthetic process GO:0009890 168 0.018
negative regulation of cellular protein metabolic process GO:0032269 106 0.018
positive regulation of phosphate metabolic process GO:0045937 262 0.017
inorganic cation transmembrane transport GO:0098662 202 0.017
organic acid metabolic process GO:0006082 292 0.017
positive regulation of neuron differentiation GO:0045666 126 0.017
proteolysis GO:0006508 175 0.017
developmental growth GO:0048589 100 0.017
adult locomotory behavior GO:0008344 4 0.017
peptidyl amino acid modification GO:0018193 126 0.017
neuron death GO:0070997 127 0.017
blood vessel morphogenesis GO:0048514 58 0.017
purine containing compound catabolic process GO:0072523 138 0.017
positive regulation of cell proliferation GO:0008284 249 0.017
ribonucleoside triphosphate metabolic process GO:0009199 141 0.017
regulation of transferase activity GO:0051338 123 0.017
embryo development GO:0009790 49 0.017
response to hydrogen peroxide GO:0042542 89 0.017
synaptic vesicle transport GO:0048489 23 0.017
regulation of neuron death GO:1901214 115 0.017
single organism organelle organization GO:1902589 180 0.016
response to estrogen GO:0043627 232 0.016
positive regulation of protein phosphorylation GO:0001934 135 0.016
nitrogen compound transport GO:0071705 229 0.016
tube formation GO:0035148 3 0.016
synaptic vesicle localization GO:0097479 24 0.016
cell cell signaling GO:0007267 335 0.016
protein complex subunit organization GO:0071822 302 0.016
Fly
neuron projection morphogenesis GO:0048812 122 0.016
cardiovascular system development GO:0072358 134 0.016
rhythmic process GO:0048511 156 0.016
regulation of secretion GO:0051046 224 0.016
divalent inorganic cation homeostasis GO:0072507 165 0.016
homeostatic process GO:0042592 331 0.016
regulation of hydrolase activity GO:0051336 143 0.016
response to acid chemical GO:0001101 222 0.016
dendrite development GO:0016358 72 0.016
positive regulation of cell projection organization GO:0031346 111 0.016
purine ribonucleotide catabolic process GO:0009154 136 0.016
regulation of dendrite morphogenesis GO:0048814 33 0.016
positive regulation of cell death GO:0010942 184 0.016
positive regulation of phosphorus metabolic process GO:0010562 262 0.016
microtubule organizing center organization GO:0031023 1 0.015
negative regulation of signal transduction GO:0009968 83 0.015
epithelial cell differentiation GO:0030855 71 0.015
neural crest cell differentiation GO:0014033 2 0.015
protein oligomerization GO:0051259 191 0.015
regulation of synaptic transmission GO:0050804 141 0.015
gamete generation GO:0007276 124 0.015
negative regulation of transcription dna templated GO:0045892 116 0.015
developmental process involved in reproduction GO:0003006 159 0.015
spermatogenesis GO:0007283 99 0.015
development of primary sexual characteristics GO:0045137 107 0.015
response to biotic stimulus GO:0009607 226 0.015
protein complex assembly GO:0006461 263 0.015
Fly
regulation of cellular localization GO:0060341 263 0.015
transmission of nerve impulse GO:0019226 42 0.015
neuronal action potential GO:0019228 35 0.015
regulation of peptide hormone secretion GO:0090276 80 0.015
anatomical structure formation involved in morphogenesis GO:0048646 83 0.015
morphogenesis of embryonic epithelium GO:0016331 3 0.015
cellular homeostasis GO:0019725 252 0.015
peptidyl serine phosphorylation GO:0018105 33 0.015
mesoderm morphogenesis GO:0048332 1 0.015
nucleoside catabolic process GO:0009164 126 0.015
cell adhesion GO:0007155 110 0.015
cellular chemical homeostasis GO:0055082 247 0.014
response to peptide GO:1901652 292 0.014
purine ribonucleotide metabolic process GO:0009150 227 0.014
ion transmembrane transport GO:0034220 365 0.014
cell morphogenesis involved in differentiation GO:0000904 119 0.014
cellular response to reactive oxygen species GO:0034614 55 0.014
multicellular organismal signaling GO:0035637 44 0.014
cellular cation homeostasis GO:0030003 180 0.014
rho protein signal transduction GO:0007266 11 0.014
Rat
cell growth GO:0016049 104 0.014
regulation of response to stress GO:0080134 126 0.014
regulation of mapk cascade GO:0043408 116 0.014
camera type eye development GO:0043010 48 0.014
regulation of cellular component biogenesis GO:0044087 86 0.014
Fly
membrane organization GO:0061024 94 0.014
positive regulation of multicellular organismal process GO:0051240 387 0.014
mitotic spindle organization GO:0007052 2 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.014
regulation of vesicle mediated transport GO:0060627 81 0.014
gonad development GO:0008406 104 0.013
developmental growth involved in morphogenesis GO:0060560 33 0.013
response to glucose GO:0009749 136 0.013
eye morphogenesis GO:0048592 4 0.013
eye development GO:0001654 50 0.013
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.013
establishment of tissue polarity GO:0007164 2 0.013
positive regulation of protein metabolic process GO:0051247 178 0.013
organ morphogenesis GO:0009887 75 0.013
cation transport GO:0006812 382 0.013
response to monosaccharide GO:0034284 159 0.013
protein complex biogenesis GO:0070271 263 0.013
Fly
insulin secretion GO:0030073 69 0.013
axon cargo transport GO:0008088 1 0.013
response to external biotic stimulus GO:0043207 221 0.013
purine nucleoside triphosphate metabolic process GO:0009144 141 0.013
hormone secretion GO:0046879 115 0.013
reproductive structure development GO:0048608 128 0.013
regulation of bmp signaling pathway GO:0030510 2 0.013
regulation of hormone levels GO:0010817 187 0.013
cellular macromolecular complex assembly GO:0034622 58 0.013
Fly
establishment of organelle localization GO:0051656 37 0.013
Mouse
axis elongation GO:0003401 2 0.013
glycosyl compound metabolic process GO:1901657 182 0.013
positive regulation of focal adhesion assembly GO:0051894 2 0.013
spindle organization GO:0007051 2 0.013
actin cytoskeleton organization GO:0030036 73 0.013
purine nucleoside catabolic process GO:0006152 124 0.013
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.013
regulation of axonogenesis GO:0050770 37 0.013
positive regulation of intracellular signal transduction GO:1902533 138 0.013
cellular response to organic cyclic compound GO:0071407 202 0.013
response to oxidative stress GO:0006979 186 0.012
purine ribonucleoside catabolic process GO:0046130 124 0.012
response to hexose GO:0009746 144 0.012
response to peptide hormone GO:0043434 278 0.012
metal ion homeostasis GO:0055065 186 0.012
cellular response to nitrogen compound GO:1901699 210 0.012
positive regulation of phosphorylation GO:0042327 177 0.012
cellular metal ion homeostasis GO:0006875 172 0.012
male gamete generation GO:0048232 99 0.012
tube development GO:0035295 89 0.012
purine ribonucleoside metabolic process GO:0046128 168 0.012
blood vessel development GO:0001568 69 0.012
single organism biosynthetic process GO:0044711 342 0.012
response to inorganic substance GO:0010035 377 0.012
cellular response to endogenous stimulus GO:0071495 377 0.012
response to carbohydrate GO:0009743 183 0.012
cell cycle GO:0007049 101 0.012
regulation of canonical wnt signaling pathway GO:0060828 4 0.012
hormone transport GO:0009914 121 0.012
heart morphogenesis GO:0003007 3 0.012
wound healing GO:0042060 122 0.012
ribonucleoside metabolic process GO:0009119 174 0.012
carboxylic acid metabolic process GO:0019752 289 0.012
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 4 0.012
action potential GO:0001508 54 0.012
ribonucleoside catabolic process GO:0042454 126 0.012
lipid modification GO:0030258 52 0.012
forebrain development GO:0030900 98 0.012
positive regulation of catalytic activity GO:0043085 184 0.012
regulation of epithelial cell differentiation GO:0030856 12 0.012
germ cell migration GO:0008354 1 0.012
chemical homeostasis GO:0048878 292 0.012
circadian rhythm GO:0007623 88 0.012
peptide hormone secretion GO:0030072 84 0.012
embryonic pattern specification GO:0009880 1 0.012
cellular macromolecule localization GO:0070727 122 0.011
regulation of cell motility GO:2000145 131 0.011
actin filament based movement GO:0030048 16 0.011
regulation of cell cycle GO:0051726 73 0.011
regulation of cell migration GO:0030334 128 0.011
purine nucleotide metabolic process GO:0006163 229 0.011
neuromuscular synaptic transmission GO:0007274 2 0.011
negative regulation of neuron apoptotic process GO:0043524 45 0.011
ribonucleoside triphosphate catabolic process GO:0009203 122 0.011
glandular epithelial cell differentiation GO:0002067 4 0.011
positive regulation of transferase activity GO:0051347 81 0.011
muscle structure development GO:0061061 87 0.011
intracellular transport GO:0046907 185 0.011
mapk cascade GO:0000165 140 0.011
regulation of growth GO:0040008 105 0.011
cell cycle checkpoint GO:0000075 2 0.011
cellular response to oxygen levels GO:0071453 60 0.011
neurotransmitter secretion GO:0007269 33 0.011
response to alkaloid GO:0043279 132 0.011
dna integrity checkpoint GO:0031570 2 0.011
mesoderm formation GO:0001707 1 0.011
positive regulation of protein modification process GO:0031401 142 0.011
behavior GO:0007610 205 0.011
regulation of insulin secretion GO:0050796 65 0.011
centrosome organization GO:0051297 1 0.011
cytokinetic process GO:0032506 1 0.011
oxoacid metabolic process GO:0043436 290 0.011
regulation of synaptic plasticity GO:0048167 70 0.011
regulation of catabolic process GO:0009894 113 0.011
nucleoside phosphate metabolic process GO:0006753 283 0.011
cardiac conduction GO:0061337 2 0.011
cellular divalent inorganic cation homeostasis GO:0072503 162 0.011
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.011
peptidyl serine modification GO:0018209 34 0.010
immune response GO:0006955 104 0.010
transforming growth factor beta receptor complex assembly GO:0007181 2 0.010
sex differentiation GO:0007548 113 0.010
positive regulation of mapk cascade GO:0043410 92 0.010
aging GO:0007568 241 0.010
response to vitamin GO:0033273 131 0.010
inorganic ion transmembrane transport GO:0098660 229 0.010
endocytosis GO:0006897 84 0.010
circulatory system process GO:0003013 183 0.010
neuromuscular process GO:0050905 2 0.010
negative regulation of heart growth GO:0061117 3 0.010
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.010
response to other organism GO:0051707 220 0.010
circadian regulation of gene expression GO:0032922 3 0.010
reactive oxygen species biosynthetic process GO:1903409 8 0.010
organonitrogen compound catabolic process GO:1901565 179 0.010

Cdc42bpa disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.047
nervous system disease DOID:863 0 0.047
cancer DOID:162 0 0.034
disease of cellular proliferation DOID:14566 0 0.034
organ system cancer DOID:0050686 0 0.034
disease of metabolism DOID:0014667 0 0.014
gastrointestinal system cancer DOID:3119 0 0.013
central nervous system disease DOID:331 0 0.012
inherited metabolic disorder DOID:655 0 0.012
neuromuscular disease DOID:440 0 0.011
neuropathy DOID:870 0 0.011