Rattus norvegicus

0 known processes

Trex2

three prime repair exonuclease 2

(Aliases: RGD1562245)

Trex2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of cell communication GO:0010647 271 0.130
response to inorganic substance GO:0010035 377 0.122
regulation of phosphate metabolic process GO:0019220 349 0.116
cellular component biogenesis GO:0044085 368 0.096
response to acid chemical GO:0001101 222 0.093
regulation of cell proliferation GO:0042127 359 0.093
wound healing GO:0042060 122 0.083
single organism reproductive process GO:0044702 297 0.081
positive regulation of cell proliferation GO:0008284 249 0.080
response to glucocorticoid GO:0051384 223 0.078
response to extracellular stimulus GO:0009991 380 0.070
regulation of cell differentiation GO:0045595 320 0.065
regulation of apoptotic process GO:0042981 335 0.064
signal transduction by phosphorylation GO:0023014 144 0.063
macromolecular complex subunit organization GO:0043933 339 0.060
regulation of system process GO:0044057 208 0.058
regulation of molecular function GO:0065009 398 0.058
response to oxygen levels GO:0070482 265 0.058
response to nutrient levels GO:0031667 370 0.057
regulation of programmed cell death GO:0043067 341 0.057
intracellular signal transduction GO:0035556 314 0.056
positive regulation of developmental process GO:0051094 283 0.054
anatomical structure morphogenesis GO:0009653 298 0.054
cellular response to oxygen containing compound GO:1901701 386 0.053
reproductive process GO:0022414 372 0.050
tissue development GO:0009888 252 0.049
metal ion transport GO:0030001 289 0.049
sensory perception GO:0007600 101 0.048
response to carbohydrate GO:0009743 183 0.047
neurological system process GO:0050877 219 0.042
circulatory system process GO:0003013 183 0.042
cellular component assembly GO:0022607 360 0.041
tongue morphogenesis GO:0043587 3 0.041
negative regulation of transport GO:0051051 136 0.041
cellular response to lipid GO:0071396 201 0.041
regulation of protein localization GO:0032880 81 0.041
response to estrogen GO:0043627 232 0.040
regulation of intracellular signal transduction GO:1902531 218 0.040
regulation of protein metabolic process GO:0051246 289 0.040
positive regulation of phosphorylation GO:0042327 177 0.039
response to nutrient GO:0007584 248 0.039
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.038
response to estradiol GO:0032355 164 0.038
small molecule biosynthetic process GO:0044283 124 0.038
response to hexose GO:0009746 144 0.038
aging GO:0007568 241 0.038
amine metabolic process GO:0009308 38 0.037
rhythmic process GO:0048511 156 0.037
neuron projection development GO:0031175 273 0.037
positive regulation of multicellular organismal process GO:0051240 387 0.037
negative regulation of apoptotic process GO:0043066 181 0.036
multicellular organismal reproductive process GO:0048609 233 0.036
regulation of phosphorylation GO:0042325 248 0.036
cellular amine metabolic process GO:0044106 38 0.036
response to wounding GO:0009611 254 0.036
response to corticosteroid GO:0031960 235 0.036
developmental process involved in reproduction GO:0003006 159 0.036
positive regulation of molecular function GO:0044093 230 0.036
positive regulation of signaling GO:0023056 270 0.035
macromolecular complex assembly GO:0065003 273 0.035
response to oxidative stress GO:0006979 186 0.035
regulation of catalytic activity GO:0050790 304 0.035
wnt signaling pathway planar cell polarity pathway GO:0060071 2 0.035
negative regulation of cell proliferation GO:0008285 119 0.035
regulation of phosphorus metabolic process GO:0051174 349 0.035
response to decreased oxygen levels GO:0036293 237 0.033
negative regulation of macromolecule metabolic process GO:0010605 260 0.033
cellular response to stress GO:0033554 269 0.032
regulation of signal transduction GO:0009966 318 0.032
protein complex biogenesis GO:0070271 263 0.032
negative regulation of programmed cell death GO:0043069 183 0.032
multicellular organism reproduction GO:0032504 233 0.032
positive regulation of phosphate metabolic process GO:0045937 262 0.032
regulation of cellular component organization GO:0051128 368 0.031
negative regulation of cell communication GO:0010648 158 0.030
cellular response to steroid hormone stimulus GO:0071383 93 0.030
cellular response to organic cyclic compound GO:0071407 202 0.030
positive regulation of phosphorus metabolic process GO:0010562 262 0.029
positive regulation of catalytic activity GO:0043085 184 0.029
protein localization GO:0008104 191 0.029
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.029
ion transmembrane transport GO:0034220 365 0.029
negative regulation of gene expression GO:0010629 199 0.029
positive regulation of protein phosphorylation GO:0001934 135 0.028
ion homeostasis GO:0050801 212 0.028
head development GO:0060322 247 0.028
protein complex subunit organization GO:0071822 302 0.028
homeostatic process GO:0042592 331 0.028
cellular ketone metabolic process GO:0042180 51 0.028
inorganic ion transmembrane transport GO:0098660 229 0.028
regulation of protein phosphorylation GO:0001932 183 0.028
enzyme linked receptor protein signaling pathway GO:0007167 116 0.028
circulatory system development GO:0072359 134 0.028
blood circulation GO:0008015 183 0.028
monovalent inorganic cation transport GO:0015672 172 0.027
positive regulation of gene expression GO:0010628 244 0.027
regulation of multicellular organismal development GO:2000026 376 0.026
regulation of cellular localization GO:0060341 263 0.026
reproductive system development GO:0061458 128 0.026
cell projection organization GO:0030030 302 0.026
regulation of establishment of planar polarity GO:0090175 2 0.026
regulation of cellular protein metabolic process GO:0032268 267 0.026
positive regulation of response to stimulus GO:0048584 285 0.026
secretion GO:0046903 307 0.026
reproductive structure development GO:0048608 128 0.026
organic acid metabolic process GO:0006082 292 0.026
multi organism reproductive process GO:0044703 262 0.026
ribonucleoside metabolic process GO:0009119 174 0.026
positive regulation of transport GO:0051050 245 0.025
fibrinolysis GO:0042730 2 0.025
carboxylic acid biosynthetic process GO:0046394 83 0.025
neuron differentiation GO:0030182 368 0.025
protein complex assembly GO:0006461 263 0.025
carboxylic acid metabolic process GO:0019752 289 0.025
chemical homeostasis GO:0048878 292 0.025
response to retinoic acid GO:0032526 63 0.025
cellular response to glucocorticoid stimulus GO:0071385 68 0.025
response to growth factor GO:0070848 189 0.025
regulation of protein modification process GO:0031399 194 0.025
establishment of tissue polarity GO:0007164 2 0.025
regulation of cellular amino acid metabolic process GO:0006521 2 0.025
cellular chemical homeostasis GO:0055082 247 0.025
programmed cell death GO:0012501 392 0.024
cation transport GO:0006812 382 0.024
negative regulation of cell death GO:0060548 229 0.024
ribose phosphate metabolic process GO:0019693 235 0.024
rna metabolic process GO:0016070 406 0.024
protein oligomerization GO:0051259 191 0.024
single organism catabolic process GO:0044712 283 0.024
ovulation cycle process GO:0022602 50 0.023
regulation of cellular amine metabolic process GO:0033238 8 0.023
regulation of anatomical structure size GO:0090066 135 0.023
alcohol metabolic process GO:0006066 77 0.023
heart process GO:0003015 57 0.023
regulation of ion transport GO:0043269 245 0.023
single organism biosynthetic process GO:0044711 342 0.022
cellular response to acid chemical GO:0071229 75 0.022
response to glucose GO:0009749 136 0.022
brain development GO:0007420 247 0.022
regulation of neuron projection development GO:0010975 161 0.022
positive regulation of cell death GO:0010942 184 0.022
regulation of mapk cascade GO:0043408 116 0.022
developmental growth GO:0048589 100 0.022
response to metal ion GO:0010038 253 0.022
response to ketone GO:1901654 182 0.022
cellular nitrogen compound catabolic process GO:0044270 163 0.022
Human
synaptic transmission GO:0007268 235 0.022
blood vessel development GO:0001568 69 0.022
nucleotide metabolic process GO:0009117 279 0.022
proteolysis GO:0006508 175 0.021
response to reactive oxygen species GO:0000302 120 0.021
negative regulation of metabolic process GO:0009892 331 0.021
positive regulation of programmed cell death GO:0043068 157 0.021
kidney development GO:0001822 67 0.021
cytosolic calcium ion homeostasis GO:0051480 140 0.021
apoptotic process GO:0006915 381 0.021
cellular response to endogenous stimulus GO:0071495 377 0.021
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.021
reproduction GO:0000003 245 0.021
nucleoside phosphate metabolic process GO:0006753 283 0.021
response to monosaccharide GO:0034284 159 0.020
cell cell signaling GO:0007267 335 0.020
regulation of anatomical structure morphogenesis GO:0022603 141 0.020
regulation of cellular ketone metabolic process GO:0010565 27 0.020
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.020
vascular process in circulatory system GO:0003018 96 0.020
organ regeneration GO:0031100 101 0.020
positive regulation of cellular biosynthetic process GO:0031328 295 0.020
muscle system process GO:0003012 115 0.020
regulation of hydrolase activity GO:0051336 143 0.020
action potential GO:0001508 54 0.020
regulation of rna biosynthetic process GO:2001141 381 0.019
urogenital system development GO:0001655 78 0.019
heart morphogenesis GO:0003007 3 0.019
vasoconstriction GO:0042310 54 0.019
nucleobase containing small molecule metabolic process GO:0055086 316 0.019
regulation of kinase activity GO:0043549 117 0.019
ribonucleotide metabolic process GO:0009259 231 0.019
hormone secretion GO:0046879 115 0.019
regulation of protein kinase activity GO:0045859 105 0.019
positive regulation of protein metabolic process GO:0051247 178 0.019
sexual reproduction GO:0019953 148 0.019
positive regulation of biosynthetic process GO:0009891 319 0.019
cellular response to nitrogen compound GO:1901699 210 0.019
negative regulation of protein metabolic process GO:0051248 114 0.019
regulation of neuron differentiation GO:0045664 208 0.019
cardiovascular system development GO:0072358 134 0.019
organophosphate catabolic process GO:0046434 148 0.019
cellular calcium ion homeostasis GO:0006874 160 0.019
negative regulation of cellular metabolic process GO:0031324 281 0.018
negative regulation of signaling GO:0023057 157 0.018
ovulation cycle GO:0042698 67 0.018
response to peptide GO:1901652 292 0.018
regulation of transferase activity GO:0051338 123 0.018
divalent inorganic cation homeostasis GO:0072507 165 0.018
carbohydrate derivative metabolic process GO:1901135 346 0.018
embryonic hindlimb morphogenesis GO:0035116 2 0.018
organonitrogen compound catabolic process GO:1901565 179 0.018
regulation of nervous system development GO:0051960 264 0.018
smooth muscle cell proliferation GO:0048659 77 0.018
purine containing compound metabolic process GO:0072521 253 0.018
regulation of secretion by cell GO:1903530 208 0.018
glycosyl compound metabolic process GO:1901657 182 0.018
neuron development GO:0048666 286 0.018
response to hypoxia GO:0001666 231 0.018
cellular response to hormone stimulus GO:0032870 247 0.018
gland development GO:0048732 155 0.018
positive regulation of apoptotic process GO:0043065 154 0.018
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.018
actin filament based process GO:0030029 86 0.018
cellular response to peptide GO:1901653 133 0.017
organophosphate metabolic process GO:0019637 370 0.017
immune system process GO:0002376 204 0.017
ras protein signal transduction GO:0007265 29 0.017
metestrus GO:0060210 1 0.017
regulation of cell projection organization GO:0031344 175 0.017
regulation of neurogenesis GO:0050767 247 0.017
response to vitamin GO:0033273 131 0.017
secretion by cell GO:0032940 248 0.017
heart contraction GO:0060047 57 0.017
positive regulation of signal transduction GO:0009967 175 0.017
epithelial cell differentiation GO:0030855 71 0.017
response to alkaloid GO:0043279 132 0.017
regulation of smooth muscle cell proliferation GO:0048660 75 0.017
epithelium development GO:0060429 96 0.017
cellular amino acid metabolic process GO:0006520 107 0.017
gamete generation GO:0007276 124 0.017
regulation of blood vessel size GO:0050880 89 0.017
cellular catabolic process GO:0044248 295 0.017
Human
organic substance catabolic process GO:1901575 316 0.017
Human
cytoskeleton organization GO:0007010 111 0.017
anatomical structure formation involved in morphogenesis GO:0048646 83 0.017
macromolecule localization GO:0033036 252 0.017
cellular divalent inorganic cation homeostasis GO:0072503 162 0.017
regulation of membrane potential GO:0042391 110 0.017
positive regulation of ion transport GO:0043270 94 0.016
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.016
negative regulation of molecular function GO:0044092 133 0.016
ribonucleoside catabolic process GO:0042454 126 0.016
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
epithelial cell proliferation GO:0050673 54 0.016
purine ribonucleotide metabolic process GO:0009150 227 0.016
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.016
growth GO:0040007 165 0.016
nucleobase containing compound catabolic process GO:0034655 152 0.016
Human
single organism organelle organization GO:1902589 180 0.016
small gtpase mediated signal transduction GO:0007264 36 0.016
regulation of ion transmembrane transporter activity GO:0032412 48 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.015
purine ribonucleoside metabolic process GO:0046128 168 0.015
sex differentiation GO:0007548 113 0.015
organelle organization GO:0006996 266 0.015
purine ribonucleotide catabolic process GO:0009154 136 0.015
purine nucleotide metabolic process GO:0006163 229 0.015
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.015
regulation of transcription dna templated GO:0006355 374 0.015
non canonical wnt signaling pathway GO:0035567 3 0.015
spermatogenesis GO:0007283 99 0.015
positive regulation of mapk cascade GO:0043410 92 0.015
organic cyclic compound catabolic process GO:1901361 175 0.015
Human
regulation of metal ion transport GO:0010959 118 0.015
gastrulation GO:0007369 2 0.015
positive regulation of protein modification process GO:0031401 142 0.015
response to peptide hormone GO:0043434 278 0.015
negative regulation of developmental process GO:0051093 125 0.015
positive regulation of rna biosynthetic process GO:1902680 197 0.014
oxoacid metabolic process GO:0043436 290 0.014
transcription from rna polymerase ii promoter GO:0006366 252 0.014
monocarboxylic acid biosynthetic process GO:0072330 48 0.014
behavior GO:0007610 205 0.014
regulation of plasminogen activation GO:0010755 2 0.014
establishment of protein localization GO:0045184 141 0.014
organic hydroxy compound metabolic process GO:1901615 115 0.014
cellular homeostasis GO:0019725 252 0.014
purine nucleoside metabolic process GO:0042278 169 0.014
regulation of cell development GO:0060284 263 0.014
cellular response to corticosteroid stimulus GO:0071384 69 0.014
axis specification GO:0009798 4 0.014
inorganic cation transmembrane transport GO:0098662 202 0.014
mapk cascade GO:0000165 140 0.014
actin cytoskeleton organization GO:0030036 73 0.013
regulation of blood pressure GO:0008217 83 0.013
hematopoietic progenitor cell differentiation GO:0002244 2 0.013
regulation of vasoconstriction GO:0019229 44 0.013
rna biosynthetic process GO:0032774 380 0.013
regulation of blood circulation GO:1903522 110 0.013
single organism intracellular transport GO:1902582 166 0.013
mesoderm development GO:0007498 2 0.013
neuronal action potential GO:0019228 35 0.013
glucose homeostasis GO:0042593 75 0.013
regulation of rna metabolic process GO:0051252 391 0.013
gonad development GO:0008406 104 0.013
insulin like growth factor receptor signaling pathway GO:0048009 3 0.013
regulation of transporter activity GO:0032409 50 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.013
regulation of epithelial cell proliferation GO:0050678 49 0.013
metal ion homeostasis GO:0055065 186 0.013
regulation of cell cycle GO:0051726 73 0.013
regulation of transmembrane transport GO:0034762 122 0.013
cellular response to alcohol GO:0097306 87 0.013
negative regulation of cellular protein metabolic process GO:0032269 106 0.013
vasculature development GO:0001944 70 0.013
calcium ion homeostasis GO:0055074 162 0.012
regulation of ion transmembrane transport GO:0034765 121 0.012
regulation of body fluid levels GO:0050878 90 0.012
nucleoside metabolic process GO:0009116 179 0.012
positive regulation of nervous system development GO:0051962 178 0.012
establishment of planar polarity GO:0001736 1 0.012
development of primary sexual characteristics GO:0045137 107 0.012
positive regulation of blood coagulation GO:0030194 4 0.012
negative regulation of ion transport GO:0043271 51 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.012
negative regulation of fibrinolysis GO:0051918 2 0.012
nucleic acid templated transcription GO:0097659 379 0.012
positive regulation of neuron differentiation GO:0045666 126 0.012
response to molecule of bacterial origin GO:0002237 194 0.012
positive regulation of cellular protein metabolic process GO:0032270 167 0.012
lipid metabolic process GO:0006629 283 0.012
regulation of cell projection size GO:0032536 1 0.012
cellular metal ion homeostasis GO:0006875 172 0.012
positive regulation of cell projection organization GO:0031346 111 0.012
organophosphate biosynthetic process GO:0090407 143 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.012
central nervous system development GO:0007417 311 0.011
organic acid biosynthetic process GO:0016053 83 0.011
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.011
cellular response to growth factor stimulus GO:0071363 162 0.011
muscle contraction GO:0006936 88 0.011
positive regulation of nucleic acid templated transcription GO:1903508 197 0.011
negative regulation of multicellular organismal process GO:0051241 203 0.011
positive regulation of transferase activity GO:0051347 81 0.011
muscle cell proliferation GO:0033002 84 0.011
cellular response to oxidative stress GO:0034599 76 0.011
cation transmembrane transport GO:0098655 263 0.011
cellular response to metal ion GO:0071248 55 0.011
negative regulation of cell differentiation GO:0045596 99 0.011
protein transport GO:0015031 132 0.011
negative regulation of biosynthetic process GO:0009890 168 0.011
negative regulation of cellular biosynthetic process GO:0031327 161 0.011
response to transition metal nanoparticle GO:1990267 122 0.011
cellular ion homeostasis GO:0006873 184 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.011
positive regulation of rna metabolic process GO:0051254 203 0.011
morphogenesis of a polarized epithelium GO:0001738 1 0.011
cellular component morphogenesis GO:0032989 155 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
cellular cation homeostasis GO:0030003 180 0.011
cytoplasmic transport GO:0016482 115 0.011
cellular lipid metabolic process GO:0044255 208 0.011
glycosyl compound catabolic process GO:1901658 126 0.011
liver development GO:0001889 90 0.011
male gamete generation GO:0048232 99 0.011
regulation of secretion GO:0051046 224 0.010
nucleoside triphosphate catabolic process GO:0009143 123 0.010
regulation of nucleotide metabolic process GO:0006140 117 0.010
cation homeostasis GO:0055080 195 0.010
regulation of cell motility GO:2000145 131 0.010
catabolic process GO:0009056 351 0.010
Human
ribonucleoside triphosphate metabolic process GO:0009199 141 0.010
fatty acid biosynthetic process GO:0006633 33 0.010
regulation of tube size GO:0035150 89 0.010
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.010
regulation of muscle system process GO:0090257 79 0.010
positive regulation of cellular component organization GO:0051130 200 0.010
positive regulation of intracellular signal transduction GO:1902533 138 0.010
plasminogen activation GO:0031639 2 0.010
protein phosphorylation GO:0006468 345 0.010
response to nicotine GO:0035094 51 0.010
forebrain development GO:0030900 98 0.010
regulation of homeostatic process GO:0032844 101 0.010

Trex2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.012
musculoskeletal system disease DOID:17 0 0.012
nervous system disease DOID:863 0 0.010