Rattus norvegicus

29 known processes

Chek2

CHK2 checkpoint homolog (S. pombe)

(Aliases: Rad53,Chk2)

Chek2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
g protein coupled receptor signaling pathway GO:0007186 242 0.133
regulation of phosphorus metabolic process GO:0051174 349 0.095
cellular amino acid metabolic process GO:0006520 107 0.088
regulation of molecular function GO:0065009 398 0.075
single organism intracellular transport GO:1902582 166 0.070
single organism catabolic process GO:0044712 283 0.059
nucleoside phosphate metabolic process GO:0006753 283 0.056
immune system process GO:0002376 204 0.055
response to extracellular stimulus GO:0009991 380 0.054
regulation of kinase activity GO:0043549 117 0.051
reproductive process GO:0022414 372 0.047
multi organism reproductive process GO:0044703 262 0.046
apoptotic process GO:0006915 381 0.046
positive regulation of cellular protein metabolic process GO:0032270 167 0.045
programmed cell death GO:0012501 392 0.045
positive regulation of multicellular organismal process GO:0051240 387 0.045
carboxylic acid metabolic process GO:0019752 289 0.044
macromolecule localization GO:0033036 252 0.044
regulation of catalytic activity GO:0050790 304 0.043
organelle organization GO:0006996 266 0.043
positive regulation of cell death GO:0010942 184 0.042
response to nutrient levels GO:0031667 370 0.042
establishment of protein localization GO:0045184 141 0.042
regulation of protein metabolic process GO:0051246 289 0.041
response to molecule of bacterial origin GO:0002237 194 0.040
intracellular signal transduction GO:0035556 314 0.039
positive regulation of phosphorus metabolic process GO:0010562 262 0.039
positive regulation of catalytic activity GO:0043085 184 0.038
regulation of programmed cell death GO:0043067 341 0.038
regulation of cellular amine metabolic process GO:0033238 8 0.038
catabolic process GO:0009056 351 0.037
amine metabolic process GO:0009308 38 0.036
positive regulation of phosphorylation GO:0042327 177 0.036
positive regulation of phosphate metabolic process GO:0045937 262 0.035
regulation of cellular amino acid metabolic process GO:0006521 2 0.034
negative regulation of neutrophil apoptotic process GO:0033030 3 0.034
response to other organism GO:0051707 220 0.033
cellular catabolic process GO:0044248 295 0.033
oxoacid metabolic process GO:0043436 290 0.032
purine nucleoside metabolic process GO:0042278 169 0.032
positive regulation of cell communication GO:0010647 271 0.032
regulation of cellular component organization GO:0051128 368 0.032
purine ribonucleoside metabolic process GO:0046128 168 0.032
positive regulation of response to stimulus GO:0048584 285 0.031
regulation of cellular protein metabolic process GO:0032268 267 0.031
aging GO:0007568 241 0.029
cellular ketone metabolic process GO:0042180 51 0.029
organic substance catabolic process GO:1901575 316 0.028
nucleobase containing small molecule metabolic process GO:0055086 316 0.028
single organism biosynthetic process GO:0044711 342 0.028
cellular amine metabolic process GO:0044106 38 0.027
cellular modified amino acid metabolic process GO:0006575 61 0.027
regulation of secretion by cell GO:1903530 208 0.027
nucleoside metabolic process GO:0009116 179 0.026
cellular homeostasis GO:0019725 252 0.026
positive regulation of transport GO:0051050 245 0.025
positive regulation of cellular biosynthetic process GO:0031328 295 0.025
lipid metabolic process GO:0006629 283 0.025
nucleotide metabolic process GO:0009117 279 0.025
protein localization GO:0008104 191 0.025
regulation of protein phosphorylation GO:0001932 183 0.024
positive regulation of cellular component organization GO:0051130 200 0.024
positive regulation of programmed cell death GO:0043068 157 0.024
regulation of cell proliferation GO:0042127 359 0.023
organophosphate metabolic process GO:0019637 370 0.023
negative regulation of metabolic process GO:0009892 331 0.023
chemical homeostasis GO:0048878 292 0.023
organic acid metabolic process GO:0006082 292 0.023
response to external biotic stimulus GO:0043207 221 0.023
response to oxygen levels GO:0070482 265 0.023
organophosphate catabolic process GO:0046434 148 0.023
glycosyl compound metabolic process GO:1901657 182 0.023
response to decreased oxygen levels GO:0036293 237 0.022
dephosphorylation GO:0016311 98 0.022
response to lipopolysaccharide GO:0032496 191 0.022
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.021
negative regulation of cellular metabolic process GO:0031324 281 0.021
ribonucleoside metabolic process GO:0009119 174 0.021
purine ribonucleotide catabolic process GO:0009154 136 0.021
ribose phosphate metabolic process GO:0019693 235 0.021
inflammatory response GO:0006954 150 0.020
positive regulation of cell proliferation GO:0008284 249 0.020
intracellular transport GO:0046907 185 0.020
immune effector process GO:0002252 53 0.020
nucleoside triphosphate catabolic process GO:0009143 123 0.019
reactive oxygen species metabolic process GO:0072593 37 0.019
regulation of hydrolase activity GO:0051336 143 0.019
regulation of apoptotic process GO:0042981 335 0.019
ribonucleotide metabolic process GO:0009259 231 0.019
response to growth factor GO:0070848 189 0.019
immune response GO:0006955 104 0.019
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
cellular response to growth factor stimulus GO:0071363 162 0.018
regulation of protein modification process GO:0031399 194 0.018
regulation of mesenchymal cell proliferation GO:0010464 4 0.018
positive regulation of protein metabolic process GO:0051247 178 0.018
negative regulation of cell differentiation GO:0045596 99 0.018
metal ion homeostasis GO:0055065 186 0.018
regulation of protein kinase activity GO:0045859 105 0.018
regulation of cell migration GO:0030334 128 0.018
glycerolipid metabolic process GO:0046486 67 0.018
cation transport GO:0006812 382 0.018
negative regulation of nervous system development GO:0051961 79 0.018
positive regulation of signal transduction GO:0009967 175 0.018
sexual reproduction GO:0019953 148 0.018
cellular response to endogenous stimulus GO:0071495 377 0.018
protein phosphorylation GO:0006468 345 0.018
nucleobase containing compound catabolic process GO:0034655 152 0.018
purine containing compound metabolic process GO:0072521 253 0.017
regulation of transferase activity GO:0051338 123 0.017
negative regulation of protein metabolic process GO:0051248 114 0.017
organophosphate biosynthetic process GO:0090407 143 0.017
positive regulation of the force of heart contraction by norepinephrine GO:0003061 1 0.017
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.017
heterocycle catabolic process GO:0046700 167 0.017
macromolecular complex assembly GO:0065003 273 0.017
organic cyclic compound catabolic process GO:1901361 175 0.017
regulation of reactive oxygen species metabolic process GO:2000377 26 0.017
response to peptide hormone GO:0043434 278 0.017
response to bacterium GO:0009617 200 0.017
glycosyl compound catabolic process GO:1901658 126 0.017
regulation of cellular ketone metabolic process GO:0010565 27 0.017
cellular chemical homeostasis GO:0055082 247 0.016
positive regulation of immune system process GO:0002684 90 0.016
response to nutrient GO:0007584 248 0.016
small gtpase mediated signal transduction GO:0007264 36 0.016
cell adhesion GO:0007155 110 0.016
regulation of multicellular organismal development GO:2000026 376 0.016
negative regulation of molecular function GO:0044092 133 0.016
positive regulation of organelle organization GO:0010638 48 0.016
guanosine containing compound metabolic process GO:1901068 74 0.016
regulation of phosphorylation GO:0042325 248 0.016
angiogenesis GO:0001525 53 0.016
positive regulation of biosynthetic process GO:0009891 319 0.016
single organism organelle organization GO:1902589 180 0.016
negative regulation of programmed cell death GO:0043069 183 0.016
regulation of cytokine production GO:0001817 56 0.016
t cell tolerance induction GO:0002517 3 0.016
negative regulation of cellular protein metabolic process GO:0032269 106 0.016
small molecule catabolic process GO:0044282 59 0.015
biological adhesion GO:0022610 110 0.015
nucleoside phosphate catabolic process GO:1901292 140 0.015
purine nucleoside triphosphate catabolic process GO:0009146 122 0.015
regulation of intracellular signal transduction GO:1902531 218 0.015
proteolysis GO:0006508 175 0.015
response to biotic stimulus GO:0009607 226 0.015
regulation of vesicle mediated transport GO:0060627 81 0.015
vesicle mediated transport GO:0016192 181 0.015
multicellular organism reproduction GO:0032504 233 0.015
synaptic transmission GO:0007268 235 0.015
regulation of cellular localization GO:0060341 263 0.015
response to hypoxia GO:0001666 231 0.015
macromolecular complex subunit organization GO:0043933 339 0.015
regulation of cell differentiation GO:0045595 320 0.015
regulation of immune system process GO:0002682 123 0.015
negative regulation of macromolecule metabolic process GO:0010605 260 0.015
cell migration GO:0016477 197 0.014
regulation of response to stress GO:0080134 126 0.014
regulation of cellular catabolic process GO:0031329 101 0.014
cytokine production GO:0001816 61 0.014
negative regulation of cell development GO:0010721 82 0.014
regulation of phosphate metabolic process GO:0019220 349 0.014
positive regulation of cellular component biogenesis GO:0044089 55 0.014
multicellular organism growth GO:0035264 1 0.014
negative regulation of multicellular organismal process GO:0051241 203 0.014
female pregnancy GO:0007565 122 0.014
positive regulation of tolerance induction GO:0002645 1 0.014
peptidyl amino acid modification GO:0018193 126 0.014
gtp catabolic process GO:0006184 71 0.014
positive regulation of protein phosphorylation GO:0001934 135 0.014
single organism reproductive process GO:0044702 297 0.014
phospholipid metabolic process GO:0006644 61 0.014
cardiovascular system development GO:0072358 134 0.014
negative regulation of catalytic activity GO:0043086 103 0.013
regulation of immune response GO:0050776 55 0.013
reproduction GO:0000003 245 0.013
positive regulation of secretion GO:0051047 140 0.013
cellular lipid metabolic process GO:0044255 208 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
cellular component assembly GO:0022607 360 0.013
response to ethanol GO:0045471 162 0.013
positive regulation of molecular function GO:0044093 230 0.013
positive regulation of developmental process GO:0051094 283 0.013
carbohydrate derivative metabolic process GO:1901135 346 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.013
organ regeneration GO:0031100 101 0.013
regeneration GO:0031099 163 0.013
purine containing compound catabolic process GO:0072523 138 0.013
gamete generation GO:0007276 124 0.013
positive regulation of mapk cascade GO:0043410 92 0.013
calcium ion homeostasis GO:0055074 162 0.012
cellular response to oxygen containing compound GO:1901701 386 0.012
cellular macromolecule localization GO:0070727 122 0.012
purine ribonucleotide metabolic process GO:0009150 227 0.012
guanosine containing compound catabolic process GO:1901069 71 0.012
response to cytokine GO:0034097 215 0.012
cellular nitrogen compound catabolic process GO:0044270 163 0.012
negative regulation of cellular component organization GO:0051129 83 0.012
cytoplasmic transport GO:0016482 115 0.012
jak stat cascade GO:0007259 26 0.012
regulation of synaptic transmission GO:0050804 141 0.012
cation homeostasis GO:0055080 195 0.012
positive regulation of protein modification process GO:0031401 142 0.012
homeostatic process GO:0042592 331 0.012
reactive oxygen species biosynthetic process GO:1903409 8 0.012
organic acid catabolic process GO:0016054 49 0.012
cell cycle process GO:0022402 57 0.012
cellular component biogenesis GO:0044085 368 0.012
calcium ion transport GO:0006816 131 0.012
regulation of catabolic process GO:0009894 113 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
rhythmic process GO:0048511 156 0.012
cell cycle GO:0007049 101 0.012
multicellular organismal reproductive process GO:0048609 233 0.011
negative regulation of developmental process GO:0051093 125 0.011
positive regulation of protein kinase activity GO:0045860 73 0.011
regulation of homeostatic process GO:0032844 101 0.011
organ formation GO:0048645 3 0.011
cellular response to external stimulus GO:0071496 118 0.011
protein complex assembly GO:0006461 263 0.011
nucleotide biosynthetic process GO:0009165 98 0.011
regulation of intracellular transport GO:0032386 65 0.011
sex differentiation GO:0007548 113 0.011
calcium mediated signaling GO:0019722 23 0.011
response to peptide GO:1901652 292 0.011
acute inflammatory response GO:0002526 58 0.011
hepaticobiliary system development GO:0061008 90 0.011
negative regulation of homeostatic process GO:0032845 47 0.011
divalent inorganic cation transport GO:0072511 134 0.011
protein transport GO:0015031 132 0.011
aromatic compound catabolic process GO:0019439 168 0.011
regulation of signal transduction GO:0009966 318 0.011
ribonucleoside triphosphate metabolic process GO:0009199 141 0.011
multi multicellular organism process GO:0044706 138 0.011
response to estrogen GO:0043627 232 0.011
mapk cascade GO:0000165 140 0.011
ion transmembrane transport GO:0034220 365 0.011
carboxylic acid catabolic process GO:0046395 49 0.011
embryonic skeletal system development GO:0048706 3 0.011
nucleoside catabolic process GO:0009164 126 0.011
dna metabolic process GO:0006259 96 0.011
positive regulation of immune response GO:0050778 42 0.011
embryonic pattern specification GO:0009880 1 0.011
angioblast cell migration GO:0035476 1 0.011
positive regulation of cell development GO:0010720 176 0.010
adaptive immune response GO:0002250 14 0.010
secretion GO:0046903 307 0.010
response to wounding GO:0009611 254 0.010
reactive nitrogen species metabolic process GO:2001057 1 0.010
metanephric tubule development GO:0072170 4 0.010
defense response GO:0006952 194 0.010
purine nucleotide metabolic process GO:0006163 229 0.010
regulation of defense response GO:0031347 68 0.010
positive regulation of cell projection organization GO:0031346 111 0.010
response to transforming growth factor beta GO:0071559 46 0.010
negative regulation of apoptotic process GO:0043066 181 0.010
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.010
purine ribonucleoside catabolic process GO:0046130 124 0.010
nucleotide catabolic process GO:0009166 139 0.010
negative regulation of neurogenesis GO:0050768 78 0.010
negative regulation of cell proliferation GO:0008285 119 0.010
cellular protein localization GO:0034613 122 0.010

Chek2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 0 0.017
disease of anatomical entity DOID:7 0 0.017
nervous system disease DOID:863 0 0.017
disease of cellular proliferation DOID:14566 0 0.015
cancer DOID:162 0 0.010
organ system cancer DOID:0050686 0 0.010
cardiovascular system disease DOID:1287 0 0.010
disease of metabolism DOID:0014667 0 0.010