Rattus norvegicus

113 known processes

Chek1

CHK1 checkpoint homolog (S. pombe)

Chek1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to stress GO:0033554 269 0.084
cell cycle GO:0007049 101 0.049
cell projection organization GO:0030030 302 0.048
double strand break repair GO:0006302 1 0.045
Human
macromolecular complex subunit organization GO:0043933 339 0.043
Human Mouse
regulation of protein metabolic process GO:0051246 289 0.043
Mouse
tetrahydrofolate metabolic process GO:0046653 9 0.042
nucleic acid templated transcription GO:0097659 379 0.042
Mouse
response to oxygen levels GO:0070482 265 0.041
cellular component biogenesis GO:0044085 368 0.041
programmed cell death GO:0012501 392 0.039
Zebrafish
negative regulation of metabolic process GO:0009892 331 0.039
macromolecule localization GO:0033036 252 0.038
cellular response to oxygen containing compound GO:1901701 386 0.036
single organism biosynthetic process GO:0044711 342 0.036
apoptotic process GO:0006915 381 0.036
Zebrafish
single organism reproductive process GO:0044702 297 0.035
anatomical structure morphogenesis GO:0009653 298 0.034
cellular component assembly GO:0022607 360 0.034
multicellular organismal reproductive process GO:0048609 233 0.033
multi organism reproductive process GO:0044703 262 0.033
rna metabolic process GO:0016070 406 0.032
Mouse
cell cycle checkpoint GO:0000075 2 0.032
Human Zebrafish Mouse
protein phosphorylation GO:0006468 345 0.031
oxoacid metabolic process GO:0043436 290 0.030
chromosome segregation GO:0007059 2 0.030
cell cycle process GO:0022402 57 0.030
response to inorganic substance GO:0010035 377 0.030
negative regulation of macromolecule metabolic process GO:0010605 260 0.030
neuron differentiation GO:0030182 368 0.030
intracellular signal transduction GO:0035556 314 0.030
Zebrafish
cellular amino acid metabolic process GO:0006520 107 0.029
multicellular organism reproduction GO:0032504 233 0.029
rna biosynthetic process GO:0032774 380 0.029
Mouse
regulation of cellular component organization GO:0051128 368 0.029
Human Mouse
protein complex subunit organization GO:0071822 302 0.029
organelle organization GO:0006996 266 0.028
Human Mouse
response to decreased oxygen levels GO:0036293 237 0.028
response to metal ion GO:0010038 253 0.028
rhythmic process GO:0048511 156 0.028
regulation of transcription dna templated GO:0006355 374 0.027
Mouse
reproductive process GO:0022414 372 0.027
regulation of programmed cell death GO:0043067 341 0.026
response to hypoxia GO:0001666 231 0.026
transcription from rna polymerase ii promoter GO:0006366 252 0.026
Mouse
negative regulation of gene expression GO:0010629 199 0.025
reproduction GO:0000003 245 0.025
regulation of rna metabolic process GO:0051252 391 0.025
Mouse
response to estradiol GO:0032355 164 0.025
head development GO:0060322 247 0.025
regulation of cellular protein metabolic process GO:0032268 267 0.024
Mouse
developmental process involved in reproduction GO:0003006 159 0.024
negative regulation of cellular metabolic process GO:0031324 281 0.024
macromolecular complex assembly GO:0065003 273 0.024
tissue development GO:0009888 252 0.023
regulation of rna biosynthetic process GO:2001141 381 0.023
Mouse
secretion GO:0046903 307 0.023
central nervous system development GO:0007417 311 0.023
locomotion GO:0040011 237 0.023
regulation of cell cycle GO:0051726 73 0.023
cellular amine metabolic process GO:0044106 38 0.023
positive regulation of cell proliferation GO:0008284 249 0.022
homeostatic process GO:0042592 331 0.022
regulation of phosphorylation GO:0042325 248 0.022
regulation of nucleic acid templated transcription GO:1903506 380 0.022
Mouse
aging GO:0007568 241 0.022
neuron development GO:0048666 286 0.021
regulation of phosphorus metabolic process GO:0051174 349 0.021
response to peptide hormone GO:0043434 278 0.021
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.021
Mouse
response to estrogen GO:0043627 232 0.020
dna integrity checkpoint GO:0031570 2 0.020
Human Zebrafish Mouse
peptidyl amino acid modification GO:0018193 126 0.020
Human Mouse
regulation of cellular amino acid metabolic process GO:0006521 2 0.020
regulation of cell proliferation GO:0042127 359 0.020
Mouse
folic acid containing compound metabolic process GO:0006760 10 0.020
amine metabolic process GO:0009308 38 0.020
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.020
Mouse
positive regulation of cellular biosynthetic process GO:0031328 295 0.020
Mouse
protein complex biogenesis GO:0070271 263 0.019
response to transition metal nanoparticle GO:1990267 122 0.019
carboxylic acid metabolic process GO:0019752 289 0.019
regulation of molecular function GO:0065009 398 0.019
regulation of mrna splicing via spliceosome GO:0048024 3 0.019
positive regulation of response to stimulus GO:0048584 285 0.019
regulation of cell differentiation GO:0045595 320 0.019
positive regulation of protein metabolic process GO:0051247 178 0.018
response to corticosteroid GO:0031960 235 0.018
proteolysis GO:0006508 175 0.018
regulation of apoptotic process GO:0042981 335 0.018
cellular catabolic process GO:0044248 295 0.018
centrosome organization GO:0051297 1 0.018
Human
cellular response to organonitrogen compound GO:0071417 197 0.018
regulation of cellular amine metabolic process GO:0033238 8 0.018
negative regulation of protein metabolic process GO:0051248 114 0.018
brain development GO:0007420 247 0.017
reproductive system development GO:0061458 128 0.017
transcription dna templated GO:0006351 377 0.017
Mouse
negative regulation of apoptotic process GO:0043066 181 0.017
positive regulation of gene expression GO:0010628 244 0.017
Mouse
organic substance catabolic process GO:1901575 316 0.017
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.017
single organism organelle organization GO:1902589 180 0.017
Human Mouse
regulation of cellular ketone metabolic process GO:0010565 27 0.017
cellular component movement GO:0006928 248 0.016
cellular response to endogenous stimulus GO:0071495 377 0.016
chemical homeostasis GO:0048878 292 0.016
response to nutrient levels GO:0031667 370 0.016
positive regulation of multicellular organismal process GO:0051240 387 0.016
response to carbohydrate GO:0009743 183 0.016
metaphase anaphase transition of cell cycle GO:0044784 1 0.016
negative regulation of programmed cell death GO:0043069 183 0.016
response to growth factor GO:0070848 189 0.016
regulation of multicellular organismal development GO:2000026 376 0.016
response to ketone GO:1901654 182 0.016
centrosome cycle GO:0007098 1 0.016
Human
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.015
protein complex assembly GO:0006461 263 0.015
negative regulation of cell death GO:0060548 229 0.015
positive regulation of rna metabolic process GO:0051254 203 0.015
Mouse
regulation of phosphate metabolic process GO:0019220 349 0.015
cell cell signaling GO:0007267 335 0.015
response to radiation GO:0009314 137 0.015
Mouse
response to acid chemical GO:0001101 222 0.015
pteridine containing compound metabolic process GO:0042558 14 0.015
organic acid metabolic process GO:0006082 292 0.015
negative regulation of cellular protein metabolic process GO:0032269 106 0.015
regulation of nervous system development GO:0051960 264 0.015
development of primary sexual characteristics GO:0045137 107 0.015
cellular ketone metabolic process GO:0042180 51 0.015
alpha amino acid biosynthetic process GO:1901607 23 0.015
dna metabolic process GO:0006259 96 0.015
catabolic process GO:0009056 351 0.015
positive regulation of phosphate metabolic process GO:0045937 262 0.015
response to peptide GO:1901652 292 0.015
reproductive structure development GO:0048608 128 0.015
alpha amino acid metabolic process GO:1901605 71 0.015
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.015
Mouse
regulation of catalytic activity GO:0050790 304 0.014
regulation of neurogenesis GO:0050767 247 0.014
nucleobase containing small molecule metabolic process GO:0055086 316 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.014
regulation of protein phosphorylation GO:0001932 183 0.014
neuron projection development GO:0031175 273 0.014
sex differentiation GO:0007548 113 0.014
regulation of cell development GO:0060284 263 0.014
rna localization GO:0006403 4 0.014
protein localization GO:0008104 191 0.014
mitotic sister chromatid separation GO:0051306 1 0.014
nucleoside phosphate metabolic process GO:0006753 283 0.014
response to extracellular stimulus GO:0009991 380 0.014
regulation of proteasomal protein catabolic process GO:0061136 4 0.014
regulation of anatomical structure morphogenesis GO:0022603 141 0.014
cellular response to organic cyclic compound GO:0071407 202 0.014
response to alkaloid GO:0043279 132 0.014
axis specification GO:0009798 4 0.013
nitrogen compound transport GO:0071705 229 0.013
eye morphogenesis GO:0048592 4 0.013
regulation of cellular localization GO:0060341 263 0.013
response to glucocorticoid GO:0051384 223 0.013
positive regulation of apoptotic process GO:0043065 154 0.013
cellular response to growth factor stimulus GO:0071363 162 0.013
cellular response to lipid GO:0071396 201 0.013
secretion by cell GO:0032940 248 0.013
positive regulation of developmental process GO:0051094 283 0.013
negative regulation of phosphorus metabolic process GO:0010563 80 0.013
response to nutrient GO:0007584 248 0.013
positive regulation of programmed cell death GO:0043068 157 0.013
positive regulation of cellular protein metabolic process GO:0032270 167 0.013
regulation of signal transduction GO:0009966 318 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
gonad development GO:0008406 104 0.013
defense response GO:0006952 194 0.013
protein oligomerization GO:0051259 191 0.012
cellular chemical homeostasis GO:0055082 247 0.012
negative regulation of biosynthetic process GO:0009890 168 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
negative regulation of cell communication GO:0010648 158 0.012
cellular modified amino acid biosynthetic process GO:0042398 18 0.012
response to purine containing compound GO:0014074 126 0.012
positive regulation of rna biosynthetic process GO:1902680 197 0.012
Mouse
regulation of sister chromatid segregation GO:0033045 1 0.012
sexual reproduction GO:0019953 148 0.012
cytoplasmic transport GO:0016482 115 0.012
positive regulation of molecular function GO:0044093 230 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.012
gamete generation GO:0007276 124 0.012
maintenance of location GO:0051235 17 0.012
microtubule organizing center organization GO:0031023 1 0.012
Human
positive regulation of cellular amine metabolic process GO:0033240 3 0.012
regulation of response to stress GO:0080134 126 0.012
Human
response to lipopolysaccharide GO:0032496 191 0.012
positive regulation of phosphorus metabolic process GO:0010562 262 0.012
spermatogenesis GO:0007283 99 0.012
metaphase anaphase transition of mitotic cell cycle GO:0007091 1 0.012
cellular cation homeostasis GO:0030003 180 0.012
purine containing compound metabolic process GO:0072521 253 0.012
response to oxidative stress GO:0006979 186 0.012
response to molecule of bacterial origin GO:0002237 194 0.011
intracellular transport GO:0046907 185 0.011
response to toxic substance GO:0009636 133 0.011
nucleotide metabolic process GO:0009117 279 0.011
cellular homeostasis GO:0019725 252 0.011
cellular nitrogen compound catabolic process GO:0044270 163 0.011
ovulation cycle GO:0042698 67 0.011
transmembrane transport GO:0055085 412 0.011
response to ethanol GO:0045471 162 0.011
regulation of organelle organization GO:0033043 80 0.011
Human Mouse
regulation of cell projection organization GO:0031344 175 0.011
dna recombination GO:0006310 3 0.011
Human
purine ribonucleotide metabolic process GO:0009150 227 0.011
embryo development GO:0009790 49 0.011
positive regulation of phosphorylation GO:0042327 177 0.011
positive regulation of nucleic acid templated transcription GO:1903508 197 0.011
Mouse
mitotic cell cycle checkpoint GO:0007093 1 0.011
Zebrafish
positive regulation of cellular component organization GO:0051130 200 0.011
chromatin modification GO:0016568 33 0.011
Human Mouse
positive regulation of cell differentiation GO:0045597 217 0.011
mitotic cell cycle phase transition GO:0044772 20 0.011
negative regulation of signaling GO:0023057 157 0.011
negative regulation of cellular component organization GO:0051129 83 0.011
Human
positive regulation of transcription dna templated GO:0045893 197 0.011
Mouse
cofactor metabolic process GO:0051186 95 0.010
sister chromatid segregation GO:0000819 1 0.010
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.010
Mouse
negative regulation of nucleic acid templated transcription GO:1903507 117 0.010
tube development GO:0035295 89 0.010
behavior GO:0007610 205 0.010
positive regulation of biosynthetic process GO:0009891 319 0.010
Mouse
synaptic transmission GO:0007268 235 0.010
regulation of protein modification process GO:0031399 194 0.010
Mouse
male gamete generation GO:0048232 99 0.010
ion homeostasis GO:0050801 212 0.010
anterior posterior pattern specification GO:0009952 1 0.010

Chek1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
disease of anatomical entity DOID:7 0 0.012
nervous system disease DOID:863 0 0.012
organ system cancer DOID:0050686 0 0.011