Rattus norvegicus

0 known processes

Otx2

orthodenticle homeobox 2

Otx2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organophosphate metabolic process GO:0019637 370 0.210
regulation of phosphorus metabolic process GO:0051174 349 0.080
cellular lipid metabolic process GO:0044255 208 0.062
lipid metabolic process GO:0006629 283 0.062
g protein coupled receptor signaling pathway GO:0007186 242 0.058
purine nucleotide metabolic process GO:0006163 229 0.057
regulation of molecular function GO:0065009 398 0.050
carbohydrate derivative metabolic process GO:1901135 346 0.049
transmembrane transport GO:0055085 412 0.049
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.042
Fly
positive regulation of gene expression GO:0010628 244 0.039
Human Mouse Worm Fly
single organism biosynthetic process GO:0044711 342 0.038
neuron differentiation GO:0030182 368 0.038
Human Mouse Worm Fly
negative regulation of transport GO:0051051 136 0.038
regulation of catecholamine secretion GO:0050433 32 0.038
catabolic process GO:0009056 351 0.038
reproductive process GO:0022414 372 0.037
head development GO:0060322 247 0.037
Zebrafish Mouse Fly
nucleotide metabolic process GO:0009117 279 0.036
rna biosynthetic process GO:0032774 380 0.033
Human Mouse Worm Fly
nucleobase containing small molecule metabolic process GO:0055086 316 0.032
ribose phosphate metabolic process GO:0019693 235 0.032
rhythmic process GO:0048511 156 0.032
intracellular signal transduction GO:0035556 314 0.031
blood circulation GO:0008015 183 0.030
purine containing compound metabolic process GO:0072521 253 0.029
regulation of nucleic acid templated transcription GO:1903506 380 0.029
Human Mouse Worm Fly
single organism catabolic process GO:0044712 283 0.028
regulation of hormone levels GO:0010817 187 0.028
organophosphate biosynthetic process GO:0090407 143 0.027
central nervous system development GO:0007417 311 0.027
Zebrafish Mouse Fly
cellular component biogenesis GO:0044085 368 0.027
Human
regulation of rna biosynthetic process GO:2001141 381 0.027
Human Mouse Worm Fly
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.026
Human Mouse Worm Fly
developmental process involved in reproduction GO:0003006 159 0.026
cellular amine metabolic process GO:0044106 38 0.026
organic substance catabolic process GO:1901575 316 0.026
carbohydrate derivative catabolic process GO:1901136 147 0.026
negative regulation of rna metabolic process GO:0051253 123 0.025
Fly
positive regulation of intracellular signal transduction GO:1902533 138 0.025
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.025
cellular ion homeostasis GO:0006873 184 0.025
cellular calcium ion homeostasis GO:0006874 160 0.025
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.025
Fly
neuron development GO:0048666 286 0.025
Human Fly
organonitrogen compound biosynthetic process GO:1901566 167 0.024
purine ribonucleotide metabolic process GO:0009150 227 0.024
hormone transport GO:0009914 121 0.024
cellular catabolic process GO:0044248 295 0.024
single organism reproductive process GO:0044702 297 0.023
tissue development GO:0009888 252 0.023
Zebrafish Mouse Fly
multicellular organismal reproductive process GO:0048609 233 0.023
glycerolipid metabolic process GO:0046486 67 0.023
apoptotic process GO:0006915 381 0.023
amine metabolic process GO:0009308 38 0.023
organonitrogen compound catabolic process GO:1901565 179 0.022
transcription from rna polymerase ii promoter GO:0006366 252 0.022
Human Mouse Worm Fly
phototransduction visible light GO:0007603 2 0.022
negative regulation of cellular metabolic process GO:0031324 281 0.022
Fly
positive regulation of cell proliferation GO:0008284 249 0.022
positive regulation of rna metabolic process GO:0051254 203 0.022
Human Mouse Worm Fly
regulation of ion transmembrane transport GO:0034765 121 0.021
inorganic ion transmembrane transport GO:0098660 229 0.021
growth GO:0040007 165 0.021
ribonucleotide metabolic process GO:0009259 231 0.021
negative regulation of cellular biosynthetic process GO:0031327 161 0.021
Fly
cellular response to oxygen containing compound GO:1901701 386 0.021
Zebrafish
response to monosaccharide GO:0034284 159 0.021
regulation of phosphorylation GO:0042325 248 0.021
positive regulation of cell death GO:0010942 184 0.021
organic hydroxy compound metabolic process GO:1901615 115 0.021
regulation of phosphate metabolic process GO:0019220 349 0.021
brain development GO:0007420 247 0.020
Zebrafish Mouse Fly
inorganic cation transmembrane transport GO:0098662 202 0.020
ribonucleotide biosynthetic process GO:0009260 85 0.020
eye morphogenesis GO:0048592 4 0.020
Mouse Fly
circulatory system process GO:0003013 183 0.020
cellular homeostasis GO:0019725 252 0.020
regulation of programmed cell death GO:0043067 341 0.020
regulation of nucleotide metabolic process GO:0006140 117 0.019
hormone secretion GO:0046879 115 0.019
organ morphogenesis GO:0009887 75 0.019
Mouse Fly
sex differentiation GO:0007548 113 0.019
regulation of purine nucleotide metabolic process GO:1900542 115 0.019
organophosphate catabolic process GO:0046434 148 0.019
regulation of transporter activity GO:0032409 50 0.019
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.019
Human Mouse Worm Fly
nucleoside phosphate metabolic process GO:0006753 283 0.019
single organism carbohydrate metabolic process GO:0044723 118 0.019
negative regulation of macromolecule metabolic process GO:0010605 260 0.019
Fly
sodium ion transmembrane transport GO:0035725 67 0.018
gland development GO:0048732 155 0.018
regulation of intracellular signal transduction GO:1902531 218 0.018
purine nucleotide catabolic process GO:0006195 136 0.018
behavior GO:0007610 205 0.018
Worm
cellular chemical homeostasis GO:0055082 247 0.018
nucleobase containing compound catabolic process GO:0034655 152 0.018
alcohol metabolic process GO:0006066 77 0.018
camp metabolic process GO:0046058 63 0.018
rna metabolic process GO:0016070 406 0.018
Human Mouse Worm Fly
response to nutrient levels GO:0031667 370 0.017
response to peptide GO:1901652 292 0.017
axis specification GO:0009798 4 0.017
Mouse
heterocycle catabolic process GO:0046700 167 0.017
response to extracellular stimulus GO:0009991 380 0.017
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.017
Fly
negative regulation of gene expression GO:0010629 199 0.017
Fly
cellular ketone metabolic process GO:0042180 51 0.017
male sex differentiation GO:0046661 64 0.016
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.016
Fly
regulation of signal transduction GO:0009966 318 0.016
positive regulation of molecular function GO:0044093 230 0.016
cellular metal ion homeostasis GO:0006875 172 0.016
response to metal ion GO:0010038 253 0.016
organ formation GO:0048645 3 0.016
response to ethanol GO:0045471 162 0.016
development of primary sexual characteristics GO:0045137 107 0.016
purine ribonucleotide biosynthetic process GO:0009152 81 0.016
cellular response to organonitrogen compound GO:0071417 197 0.016
carbohydrate derivative biosynthetic process GO:1901137 124 0.016
reproductive system development GO:0061458 128 0.016
response to radiation GO:0009314 137 0.016
positive regulation of rna biosynthetic process GO:1902680 197 0.016
Human Mouse Worm Fly
organelle organization GO:0006996 266 0.016
Fly
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.016
Human Mouse Worm Fly
ribonucleoside triphosphate metabolic process GO:0009199 141 0.016
regulation of cyclic nucleotide biosynthetic process GO:0030802 45 0.016
purine ribonucleoside metabolic process GO:0046128 168 0.016
negative regulation of transcription dna templated GO:0045892 116 0.016
Fly
cellular response to peptide hormone stimulus GO:0071375 120 0.016
purine ribonucleotide catabolic process GO:0009154 136 0.016
regulation of rna metabolic process GO:0051252 391 0.015
Human Mouse Worm Fly
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
secretion by cell GO:0032940 248 0.015
positive regulation of phosphate metabolic process GO:0045937 262 0.015
reproductive structure development GO:0048608 128 0.015
gonad development GO:0008406 104 0.015
phospholipid metabolic process GO:0006644 61 0.015
response to ketone GO:1901654 182 0.015
metal ion transport GO:0030001 289 0.015
oxidation reduction process GO:0055114 304 0.015
macromolecular complex subunit organization GO:0043933 339 0.015
Human
purine containing compound biosynthetic process GO:0072522 85 0.015
regulation of peptide transport GO:0090087 87 0.015
organic hydroxy compound biosynthetic process GO:1901617 51 0.015
regulation of erk1 and erk2 cascade GO:0070372 41 0.015
calcium ion transmembrane transport GO:0070588 70 0.015
forebrain development GO:0030900 98 0.015
Mouse
carboxylic acid metabolic process GO:0019752 289 0.015
chemical homeostasis GO:0048878 292 0.014
response to camp GO:0051591 91 0.014
nucleoside phosphate catabolic process GO:1901292 140 0.014
negative regulation of metabolic process GO:0009892 331 0.014
Fly
regulation of secretion GO:0051046 224 0.014
regulation of cellular amino acid metabolic process GO:0006521 2 0.014
single organism behavior GO:0044708 130 0.014
Worm
regulation of cellular ketone metabolic process GO:0010565 27 0.014
cellular carbohydrate metabolic process GO:0044262 72 0.014
heart morphogenesis GO:0003007 3 0.014
regulation of metal ion transport GO:0010959 118 0.014
retina morphogenesis in camera type eye GO:0060042 1 0.014
multi organism reproductive process GO:0044703 262 0.014
nucleoside phosphate biosynthetic process GO:1901293 102 0.014
positive regulation of cell communication GO:0010647 271 0.014
ribonucleoside metabolic process GO:0009119 174 0.014
negative regulation of molecular function GO:0044092 133 0.014
cation transmembrane transport GO:0098655 263 0.014
positive regulation of cellular biosynthetic process GO:0031328 295 0.014
Human Mouse Worm Fly
cytosolic calcium ion homeostasis GO:0051480 140 0.014
protein complex subunit organization GO:0071822 302 0.014
Human
cellular response to hormone stimulus GO:0032870 247 0.014
nucleic acid templated transcription GO:0097659 379 0.013
Human Mouse Worm Fly
ovulation cycle process GO:0022602 50 0.013
negative regulation of nucleic acid templated transcription GO:1903507 117 0.013
Fly
cellular nitrogen compound catabolic process GO:0044270 163 0.013
guanosine containing compound metabolic process GO:1901068 74 0.013
response to glucocorticoid GO:0051384 223 0.013
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.013
Fly
regulation of transcription dna templated GO:0006355 374 0.013
Human Mouse Worm Fly
purine containing compound catabolic process GO:0072523 138 0.013
sodium ion transport GO:0006814 82 0.013
negative regulation of biosynthetic process GO:0009890 168 0.013
Fly
embryonic appendage morphogenesis GO:0035113 4 0.013
nucleoside metabolic process GO:0009116 179 0.013
positive regulation of phosphorus metabolic process GO:0010562 262 0.013
regulation of multicellular organismal development GO:2000026 376 0.013
Mouse Fly
monovalent inorganic cation transport GO:0015672 172 0.013
oxoacid metabolic process GO:0043436 290 0.012
embryonic limb morphogenesis GO:0030326 4 0.012
regulation of cellular amine metabolic process GO:0033238 8 0.012
calcium ion homeostasis GO:0055074 162 0.012
regulation of secretion by cell GO:1903530 208 0.012
positive regulation of nucleotide metabolic process GO:0045981 91 0.012
sensory organ development GO:0007423 74 0.012
Zebrafish Mouse Fly
cell cell signaling involved in cell fate commitment GO:0045168 2 0.012
cyclic nucleotide metabolic process GO:0009187 80 0.012
cellular response to lipid GO:0071396 201 0.012
aromatic compound catabolic process GO:0019439 168 0.012
vesicle mediated transport GO:0016192 181 0.012
sensory perception GO:0007600 101 0.012
Worm
cation transport GO:0006812 382 0.012
camp biosynthetic process GO:0006171 47 0.012
regeneration GO:0031099 163 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
response to wounding GO:0009611 254 0.012
adult locomotory behavior GO:0008344 4 0.012
developmental growth GO:0048589 100 0.012
cyclic nucleotide biosynthetic process GO:0009190 63 0.012
regulation of protein metabolic process GO:0051246 289 0.012
organic acid metabolic process GO:0006082 292 0.012
sequestering of metal ion GO:0051238 9 0.012
peptide transport GO:0015833 97 0.011
camera type eye morphogenesis GO:0048593 2 0.011
regulation of vesicle mediated transport GO:0060627 81 0.011
regulation of apoptotic process GO:0042981 335 0.011
regulation of peptide secretion GO:0002791 82 0.011
limb morphogenesis GO:0035108 4 0.011
nucleotide catabolic process GO:0009166 139 0.011
regulation of neuron death GO:1901214 115 0.011
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.011
Human Mouse Worm Fly
cell cell signaling GO:0007267 335 0.011
response to reactive oxygen species GO:0000302 120 0.011
hormone metabolic process GO:0042445 69 0.011
positive regulation of protein metabolic process GO:0051247 178 0.011
regulation of protein phosphorylation GO:0001932 183 0.011
response to organophosphorus GO:0046683 102 0.011
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 27 0.011
peptide hormone secretion GO:0030072 84 0.011
gliogenesis GO:0042063 93 0.011
endocrine system development GO:0035270 30 0.011
reproduction GO:0000003 245 0.011
embryonic axis specification GO:0000578 1 0.011
Mouse
intracellular transport GO:0046907 185 0.011
positive regulation of catalytic activity GO:0043085 184 0.011
cellular component movement GO:0006928 248 0.011
Human
purine nucleoside metabolic process GO:0042278 169 0.011
amide transport GO:0042886 105 0.011
ribonucleoside catabolic process GO:0042454 126 0.011
positive regulation of biosynthetic process GO:0009891 319 0.011
Human Mouse Worm Fly
cell migration GO:0016477 197 0.011
response to purine containing compound GO:0014074 126 0.011
neuromuscular process GO:0050905 2 0.011
regulation of insulin secretion GO:0050796 65 0.011
negative regulation of secretion GO:0051048 82 0.011
programmed cell death GO:0012501 392 0.011
regulation of neurogenesis GO:0050767 247 0.010
Fly
response to peptide hormone GO:0043434 278 0.010
negative regulation of signaling GO:0023057 157 0.010
regulation of cell differentiation GO:0045595 320 0.010
Fly
response to light stimulus GO:0009416 52 0.010
neural crest cell development GO:0014032 2 0.010
gastrulation GO:0007369 2 0.010
Mouse
heart development GO:0007507 72 0.010
gtp metabolic process GO:0046039 72 0.010
sequestering of calcium ion GO:0051208 8 0.010
carbohydrate metabolic process GO:0005975 130 0.010
cellular response to nitrogen compound GO:1901699 210 0.010
cell fate determination GO:0001709 2 0.010
Mouse
small gtpase mediated signal transduction GO:0007264 36 0.010
nucleotide biosynthetic process GO:0009165 98 0.010
development of primary female sexual characteristics GO:0046545 56 0.010
regulation of gtp catabolic process GO:0033124 58 0.010
regulation of protein modification process GO:0031399 194 0.010
gtp catabolic process GO:0006184 71 0.010
regulation of cell development GO:0060284 263 0.010
Fly

Otx2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
retinal disease DOID:5679 0 0.079
sensory system disease DOID:0050155 0 0.079
Human
disease of anatomical entity DOID:7 0 0.079
Human
eye and adnexa disease DOID:1492 0 0.079
Human
nervous system disease DOID:863 0 0.079
Human
eye disease DOID:5614 0 0.079
Human
retinal degeneration DOID:8466 0 0.069
retinitis pigmentosa DOID:10584 0 0.046
disease of metabolism DOID:0014667 0 0.017
cone rod dystrophy DOID:0050572 0 0.015
central nervous system disease DOID:331 0 0.012