Rattus norvegicus

3 known processes

Spon2

spondin 2, extracellular matrix protein

Spon2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to oxygen levels GO:0070482 265 0.148
macromolecular complex assembly GO:0065003 273 0.107
rna biosynthetic process GO:0032774 380 0.097
positive regulation of developmental process GO:0051094 283 0.095
programmed cell death GO:0012501 392 0.093
cellular response to endogenous stimulus GO:0071495 377 0.090
regulation of anatomical structure morphogenesis GO:0022603 141 0.083
transcription dna templated GO:0006351 377 0.076
rna metabolic process GO:0016070 406 0.076
positive regulation of multicellular organismal process GO:0051240 387 0.074
response to growth factor GO:0070848 189 0.071
nucleic acid templated transcription GO:0097659 379 0.068
protein oligomerization GO:0051259 191 0.060
behavior GO:0007610 205 0.058
regulation of programmed cell death GO:0043067 341 0.058
regulation of multicellular organismal development GO:2000026 376 0.057
immune system process GO:0002376 204 0.056
cellular response to organic cyclic compound GO:0071407 202 0.054
response to hypoxia GO:0001666 231 0.054
single organism reproductive process GO:0044702 297 0.053
cellular response to oxygen containing compound GO:1901701 386 0.053
response to estrogen GO:0043627 232 0.052
response to decreased oxygen levels GO:0036293 237 0.052
response to inorganic substance GO:0010035 377 0.051
positive regulation of immune system process GO:0002684 90 0.049
apoptotic process GO:0006915 381 0.048
blood vessel development GO:0001568 69 0.047
reproductive process GO:0022414 372 0.047
response to corticosteroid GO:0031960 235 0.045
regulation of transcription dna templated GO:0006355 374 0.044
response to temperature stimulus GO:0009266 94 0.043
response to extracellular stimulus GO:0009991 380 0.042
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.042
tissue development GO:0009888 252 0.042
cardiovascular system development GO:0072358 134 0.041
protein complex biogenesis GO:0070271 263 0.041
reproductive system development GO:0061458 128 0.040
regulation of rna metabolic process GO:0051252 391 0.040
regulation of secretion by cell GO:1903530 208 0.039
response to peptide GO:1901652 292 0.038
positive regulation of cell death GO:0010942 184 0.037
regulation of apoptotic process GO:0042981 335 0.037
circulatory system development GO:0072359 134 0.036
limb morphogenesis GO:0035108 4 0.036
negative regulation of multicellular organismal process GO:0051241 203 0.036
positive regulation of cell communication GO:0010647 271 0.035
kidney development GO:0001822 67 0.035
response to biotic stimulus GO:0009607 226 0.034
cellular response to growth factor stimulus GO:0071363 162 0.034
regulation of rna biosynthetic process GO:2001141 381 0.034
positive regulation of cell proliferation GO:0008284 249 0.033
cellular response to hormone stimulus GO:0032870 247 0.033
reproduction GO:0000003 245 0.032
positive regulation of signaling GO:0023056 270 0.032
proteolysis GO:0006508 175 0.032
positive regulation of gene expression GO:0010628 244 0.032
carboxylic acid metabolic process GO:0019752 289 0.032
positive regulation of signal transduction GO:0009967 175 0.032
regulation of signal transduction GO:0009966 318 0.032
metal ion transport GO:0030001 289 0.030
protein complex subunit organization GO:0071822 302 0.030
cellular response to lipid GO:0071396 201 0.030
macromolecular complex subunit organization GO:0043933 339 0.030
vasculature development GO:0001944 70 0.030
protein complex assembly GO:0006461 263 0.030
response to external biotic stimulus GO:0043207 221 0.029
positive regulation of rna biosynthetic process GO:1902680 197 0.029
angiogenesis GO:0001525 53 0.029
response to wounding GO:0009611 254 0.029
positive regulation of programmed cell death GO:0043068 157 0.028
positive regulation of transcription dna templated GO:0045893 197 0.028
cellular response to cytokine stimulus GO:0071345 127 0.028
regulation of nucleic acid templated transcription GO:1903506 380 0.027
vesicle mediated transport GO:0016192 181 0.027
negative regulation of cell differentiation GO:0045596 99 0.027
negative regulation of metabolic process GO:0009892 331 0.027
oxoacid metabolic process GO:0043436 290 0.027
negative regulation of programmed cell death GO:0043069 183 0.027
response to other organism GO:0051707 220 0.027
negative regulation of macromolecule metabolic process GO:0010605 260 0.027
regulation of cell differentiation GO:0045595 320 0.027
cellular response to acid chemical GO:0071229 75 0.026
response to molecule of bacterial origin GO:0002237 194 0.026
positive regulation of response to stimulus GO:0048584 285 0.026
response to nutrient levels GO:0031667 370 0.026
cation transport GO:0006812 382 0.026
cellular component movement GO:0006928 248 0.026
locomotion GO:0040011 237 0.026
response to cytokine GO:0034097 215 0.026
cellular ketone metabolic process GO:0042180 51 0.026
cell cell signaling GO:0007267 335 0.026
response to heat GO:0009408 60 0.026
response to metal ion GO:0010038 253 0.026
cellular response to stress GO:0033554 269 0.025
positive regulation of transport GO:0051050 245 0.025
transcription from rna polymerase ii promoter GO:0006366 252 0.025
response to alkaloid GO:0043279 132 0.025
neuron projection development GO:0031175 273 0.025
artery development GO:0060840 3 0.024
multicellular organism reproduction GO:0032504 233 0.024
protein phosphorylation GO:0006468 345 0.024
cellular response to extracellular stimulus GO:0031668 73 0.024
regulation of cell development GO:0060284 263 0.024
appendage morphogenesis GO:0035107 4 0.024
response to bacterium GO:0009617 200 0.024
cell projection organization GO:0030030 302 0.023
response to amino acid GO:0043200 75 0.023
positive regulation of rna metabolic process GO:0051254 203 0.023
response to nutrient GO:0007584 248 0.023
regulation of system process GO:0044057 208 0.022
blood circulation GO:0008015 183 0.022
protein heterooligomerization GO:0051291 89 0.022
positive regulation of cell differentiation GO:0045597 217 0.022
cellular component assembly GO:0022607 360 0.022
regulation of cell morphogenesis GO:0022604 77 0.022
response to oxidative stress GO:0006979 186 0.022
organic acid metabolic process GO:0006082 292 0.022
anatomical structure formation involved in morphogenesis GO:0048646 83 0.021
homeostatic process GO:0042592 331 0.021
response to lipopolysaccharide GO:0032496 191 0.021
regulation of neurogenesis GO:0050767 247 0.021
epithelium development GO:0060429 96 0.021
positive regulation of nucleic acid templated transcription GO:1903508 197 0.021
biological adhesion GO:0022610 110 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.021
positive regulation of secretion by cell GO:1903532 128 0.021
nitrogen compound transport GO:0071705 229 0.021
intracellular signal transduction GO:0035556 314 0.021
regulation of cellular localization GO:0060341 263 0.020
neuron differentiation GO:0030182 368 0.020
cell type specific apoptotic process GO:0097285 134 0.020
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.020
regeneration GO:0031099 163 0.020
positive regulation of cellular amine metabolic process GO:0033240 3 0.020
regulation of cellular amine metabolic process GO:0033238 8 0.019
secretion by cell GO:0032940 248 0.019
cellular response to fluid shear stress GO:0071498 4 0.019
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.019
response to ketone GO:1901654 182 0.019
aging GO:0007568 241 0.019
positive regulation of cell projection organization GO:0031346 111 0.019
developmental process involved in reproduction GO:0003006 159 0.019
regulation of homeostatic process GO:0032844 101 0.019
sex differentiation GO:0007548 113 0.019
cellular response to abiotic stimulus GO:0071214 85 0.019
wound healing GO:0042060 122 0.019
regulation of nervous system development GO:0051960 264 0.018
negative regulation of response to stimulus GO:0048585 155 0.018
positive regulation of phosphorus metabolic process GO:0010562 262 0.018
urogenital system development GO:0001655 78 0.018
multi organism reproductive process GO:0044703 262 0.018
positive regulation of biosynthetic process GO:0009891 319 0.018
response to acid chemical GO:0001101 222 0.018
cellular response to glucocorticoid stimulus GO:0071385 68 0.018
embryonic appendage morphogenesis GO:0035113 4 0.018
regulation of cellular amino acid metabolic process GO:0006521 2 0.018
protein autophosphorylation GO:0046777 66 0.018
cellular amine metabolic process GO:0044106 38 0.018
positive regulation of cell development GO:0010720 176 0.018
response to radiation GO:0009314 137 0.018
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.017
metanephric mesenchymal cell migration GO:0035789 2 0.017
response to hyperoxia GO:0055093 45 0.017
regulation of stem cell differentiation GO:2000736 2 0.017
negative regulation of gene expression GO:0010629 199 0.017
carbohydrate derivative metabolic process GO:1901135 346 0.017
positive regulation of phosphorylation GO:0042327 177 0.017
tissue remodeling GO:0048771 40 0.017
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.017
organ morphogenesis GO:0009887 75 0.017
positive regulation of endothelial cell migration GO:0010595 4 0.017
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.017
response to retinoic acid GO:0032526 63 0.017
response to vitamin GO:0033273 131 0.016
secretion GO:0046903 307 0.016
blood vessel morphogenesis GO:0048514 58 0.016
cellular response to external stimulus GO:0071496 118 0.016
positive regulation of nervous system development GO:0051962 178 0.016
response to peptide hormone GO:0043434 278 0.016
cell morphogenesis GO:0000902 142 0.016
circulatory system process GO:0003013 183 0.016
regulation of cellular component organization GO:0051128 368 0.016
anatomical structure morphogenesis GO:0009653 298 0.016
gastrulation GO:0007369 2 0.016
negative regulation of cellular biosynthetic process GO:0031327 161 0.016
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.016
positive regulation of smooth muscle cell migration GO:0014911 27 0.016
sexual reproduction GO:0019953 148 0.015
female pregnancy GO:0007565 122 0.015
negative regulation of cell communication GO:0010648 158 0.015
prostate gland epithelium morphogenesis GO:0060740 2 0.015
mesoderm development GO:0007498 2 0.015
nucleoside metabolic process GO:0009116 179 0.015
formation of primary germ layer GO:0001704 1 0.015
cellular component biogenesis GO:0044085 368 0.015
regulation of response to stress GO:0080134 126 0.015
gamete generation GO:0007276 124 0.015
cellular response to oxygen levels GO:0071453 60 0.015
brain development GO:0007420 247 0.015
monovalent inorganic cation transport GO:0015672 172 0.015
development of primary female sexual characteristics GO:0046545 56 0.015
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.015
central nervous system development GO:0007417 311 0.015
regulation of defense response GO:0031347 68 0.015
gliogenesis GO:0042063 93 0.015
regulation of metal ion transport GO:0010959 118 0.015
regulation of secretion GO:0051046 224 0.014
neuron development GO:0048666 286 0.014
regulation of cell projection organization GO:0031344 175 0.014
regulation of phosphorus metabolic process GO:0051174 349 0.014
cellular amino acid metabolic process GO:0006520 107 0.014
regulation of locomotion GO:0040012 148 0.014
negative regulation of developmental process GO:0051093 125 0.014
epithelial cell differentiation GO:0030855 71 0.014
response to transforming growth factor beta GO:0071559 46 0.014
ion homeostasis GO:0050801 212 0.014
negative regulation of rna metabolic process GO:0051253 123 0.014
protein localization GO:0008104 191 0.014
female sex differentiation GO:0046660 59 0.014
negative regulation of biosynthetic process GO:0009890 168 0.014
negative regulation of rna biosynthetic process GO:1902679 118 0.014
response to reactive oxygen species GO:0000302 120 0.014
dna metabolic process GO:0006259 96 0.014
negative regulation of apoptotic process GO:0043066 181 0.014
positive regulation of secretion GO:0051047 140 0.014
negative regulation of nucleic acid templated transcription GO:1903507 117 0.014
ovulation cycle GO:0042698 67 0.014
multi multicellular organism process GO:0044706 138 0.014
negative regulation of signaling GO:0023057 157 0.013
catabolic process GO:0009056 351 0.013
regulation of ion transport GO:0043269 245 0.013
enzyme linked receptor protein signaling pathway GO:0007167 116 0.013
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.013
positive regulation of cellular biosynthetic process GO:0031328 295 0.013
response to tumor necrosis factor GO:0034612 56 0.013
regulation of immune response GO:0050776 55 0.013
renal system development GO:0072001 67 0.013
small gtpase mediated signal transduction GO:0007264 36 0.013
regulation of protein metabolic process GO:0051246 289 0.013
transmembrane transport GO:0055085 412 0.013
positive regulation of calcium ion transport GO:0051928 36 0.013
regulation of cell motility GO:2000145 131 0.013
development of primary sexual characteristics GO:0045137 107 0.013
single organism carbohydrate metabolic process GO:0044723 118 0.013
positive regulation of cellular protein metabolic process GO:0032270 167 0.013
s shaped body morphogenesis GO:0072050 2 0.013
positive regulation of molecular function GO:0044093 230 0.013
positive regulation of protein phosphorylation GO:0001934 135 0.013
gonad development GO:0008406 104 0.013
amine metabolic process GO:0009308 38 0.013
macromolecule localization GO:0033036 252 0.013
regulation of cytokine production GO:0001817 56 0.013
mesenchymal cell proliferation GO:0010463 4 0.013
multicellular organism growth GO:0035264 1 0.013
regulation of molecular function GO:0065009 398 0.013
cytoplasmic transport GO:0016482 115 0.013
organophosphate metabolic process GO:0019637 370 0.012
defense response to gram negative bacterium GO:0050829 3 0.012
regulation of cell proliferation GO:0042127 359 0.012
chemical homeostasis GO:0048878 292 0.012
growth GO:0040007 165 0.012
ras protein signal transduction GO:0007265 29 0.012
regulation of immunoglobulin production GO:0002637 4 0.012
regulation of canonical wnt signaling pathway GO:0060828 4 0.012
regulation of cellular ketone metabolic process GO:0010565 27 0.012
single organism biosynthetic process GO:0044711 342 0.012
regulation of catalytic activity GO:0050790 304 0.012
hormone secretion GO:0046879 115 0.012
organ regeneration GO:0031100 101 0.012
response to activity GO:0014823 73 0.012
regulation of synaptic transmission GO:0050804 141 0.012
ion transmembrane transport GO:0034220 365 0.012
synaptic transmission GO:0007268 235 0.012
localization of cell GO:0051674 202 0.012
multicellular organismal homeostasis GO:0048871 49 0.012
muscle structure development GO:0061061 87 0.012
cellular response to steroid hormone stimulus GO:0071383 93 0.012
regulation of peptide transport GO:0090087 87 0.012
ribonucleotide metabolic process GO:0009259 231 0.012
response to mechanical stimulus GO:0009612 134 0.012
nucleobase containing small molecule metabolic process GO:0055086 316 0.012
regulation of blood vessel size GO:0050880 89 0.011
regulation of intracellular signal transduction GO:1902531 218 0.011
vascular process in circulatory system GO:0003018 96 0.011
divalent metal ion transport GO:0070838 132 0.011
response to ethanol GO:0045471 162 0.011
regulation of immune system process GO:0002682 123 0.011
response to estradiol GO:0032355 164 0.011
salivary gland development GO:0007431 3 0.011
salivary gland morphogenesis GO:0007435 1 0.011
positive regulation of synaptic plasticity GO:0031915 3 0.011
neurological system process GO:0050877 219 0.011
signal release GO:0023061 145 0.011
cellular catabolic process GO:0044248 295 0.011
response to fibroblast growth factor GO:0071774 29 0.011
hepatocyte proliferation GO:0072574 3 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.011
regulation of phosphate metabolic process GO:0019220 349 0.011
single organism membrane organization GO:0044802 74 0.011
cellular response to nitrogen compound GO:1901699 210 0.011
negative regulation of cellular metabolic process GO:0031324 281 0.011
neuronal action potential GO:0019228 35 0.011
digestive system development GO:0055123 41 0.011
cellular response to nutrient levels GO:0031669 60 0.011
response to monosaccharide GO:0034284 159 0.011
muscle system process GO:0003012 115 0.011
regulation of response to external stimulus GO:0032101 106 0.011
regulation of cell migration GO:0030334 128 0.011
positive regulation of intracellular signal transduction GO:1902533 138 0.011
cellular component morphogenesis GO:0032989 155 0.011
regulation of growth GO:0040008 105 0.011
positive regulation of cellular component organization GO:0051130 200 0.011
cellular response to tumor necrosis factor GO:0071356 46 0.011
positive regulation of cell migration GO:0030335 96 0.011
cellular homeostasis GO:0019725 252 0.010
membrane organization GO:0061024 94 0.010
purine ribonucleoside metabolic process GO:0046128 168 0.010
leukocyte migration GO:0050900 38 0.010
regulation of neuron differentiation GO:0045664 208 0.010
anterior posterior pattern specification GO:0009952 1 0.010
organelle organization GO:0006996 266 0.010
response to ionizing radiation GO:0010212 59 0.010
intracellular transport GO:0046907 185 0.010
negative regulation of cell development GO:0010721 82 0.010
female gonad development GO:0008585 53 0.010
reactive oxygen species metabolic process GO:0072593 37 0.010
ribose phosphate metabolic process GO:0019693 235 0.010
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.010
cytokine production GO:0001816 61 0.010
negative regulation of cell death GO:0060548 229 0.010
sodium ion transport GO:0006814 82 0.010

Spon2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.042
nervous system disease DOID:863 0 0.042
sensory system disease DOID:0050155 0 0.026