Rattus norvegicus

92 known processes

Map2k3

mitogen activated protein kinase kinase 3

Map2k3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
apoptotic process GO:0006915 381 0.126
Rat
regulation of apoptotic process GO:0042981 335 0.116
Rat
programmed cell death GO:0012501 392 0.108
Rat
negative regulation of apoptotic process GO:0043066 181 0.088
organic acid metabolic process GO:0006082 292 0.085
protein complex assembly GO:0006461 263 0.080
negative regulation of programmed cell death GO:0043069 183 0.079
regulation of rna metabolic process GO:0051252 391 0.074
Human
cellular amino acid metabolic process GO:0006520 107 0.070
regulation of transcription dna templated GO:0006355 374 0.068
Human
regulation of programmed cell death GO:0043067 341 0.066
Rat
intracellular signal transduction GO:0035556 314 0.065
Mouse Rat
regulation of nucleic acid templated transcription GO:1903506 380 0.063
Human
negative regulation of cell death GO:0060548 229 0.063
regulation of phosphorus metabolic process GO:0051174 349 0.058
protein phosphorylation GO:0006468 345 0.055
response to oxygen levels GO:0070482 265 0.054
regulation of signal transduction GO:0009966 318 0.054
Mouse Rat
aging GO:0007568 241 0.053
protein complex subunit organization GO:0071822 302 0.051
rna biosynthetic process GO:0032774 380 0.048
Human
carbohydrate metabolic process GO:0005975 130 0.048
carboxylic acid metabolic process GO:0019752 289 0.048
regulation of protein modification process GO:0031399 194 0.046
oxidation reduction process GO:0055114 304 0.046
response to inorganic substance GO:0010035 377 0.046
macromolecular complex assembly GO:0065003 273 0.045
cation transmembrane transport GO:0098655 263 0.044
protein heterooligomerization GO:0051291 89 0.043
oxoacid metabolic process GO:0043436 290 0.042
cellular ketone metabolic process GO:0042180 51 0.042
tissue development GO:0009888 252 0.042
Rat
positive regulation of developmental process GO:0051094 283 0.041
circulatory system process GO:0003013 183 0.040
Mouse
regulation of cellular ketone metabolic process GO:0010565 27 0.040
reproductive process GO:0022414 372 0.040
Rat
transcription from rna polymerase ii promoter GO:0006366 252 0.038
ion transmembrane transport GO:0034220 365 0.038
regulation of rna biosynthetic process GO:2001141 381 0.038
Human
multicellular organism growth GO:0035264 1 0.037
positive regulation of cellular biosynthetic process GO:0031328 295 0.036
Human Rat
macromolecule localization GO:0033036 252 0.035
Rat
transcription dna templated GO:0006351 377 0.035
Human
cellular component assembly GO:0022607 360 0.034
protein oligomerization GO:0051259 191 0.034
regulation of cellular amino acid metabolic process GO:0006521 2 0.034
regulation of molecular function GO:0065009 398 0.032
Human Mouse Rat
cellular response to stress GO:0033554 269 0.032
Rat
response to wounding GO:0009611 254 0.032
negative regulation of metabolic process GO:0009892 331 0.032
carbohydrate derivative metabolic process GO:1901135 346 0.031
rna metabolic process GO:0016070 406 0.031
Human
inorganic ion transmembrane transport GO:0098660 229 0.031
inorganic cation transmembrane transport GO:0098662 202 0.031
nucleic acid templated transcription GO:0097659 379 0.031
Human
positive regulation of gene expression GO:0010628 244 0.030
Human
regulation of catalytic activity GO:0050790 304 0.030
Human Mouse Rat
positive regulation of biosynthetic process GO:0009891 319 0.029
negative regulation of cellular metabolic process GO:0031324 281 0.029
regulation of cellular amine metabolic process GO:0033238 8 0.029
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.029
Human Rat
mapk cascade GO:0000165 140 0.028
Mouse Rat
protein complex biogenesis GO:0070271 263 0.028
response to decreased oxygen levels GO:0036293 237 0.028
regulation of phosphorylation GO:0042325 248 0.028
amine metabolic process GO:0009308 38 0.027
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.027
positive regulation of rna metabolic process GO:0051254 203 0.027
Human
central nervous system development GO:0007417 311 0.027
transmembrane transport GO:0055085 412 0.026
cellular component biogenesis GO:0044085 368 0.026
nucleobase containing small molecule metabolic process GO:0055086 316 0.026
cellular amine metabolic process GO:0044106 38 0.026
single organism reproductive process GO:0044702 297 0.025
Rat
macromolecular complex subunit organization GO:0043933 339 0.025
cellular protein localization GO:0034613 122 0.025
negative regulation of phosphorus metabolic process GO:0010563 80 0.025
single organism biosynthetic process GO:0044711 342 0.024
cellular response to organonitrogen compound GO:0071417 197 0.024
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.024
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.024
Human Rat
heart process GO:0003015 57 0.024
Mouse
positive regulation of cell differentiation GO:0045597 217 0.024
positive regulation of catalytic activity GO:0043085 184 0.024
Human Mouse Rat
response to metal ion GO:0010038 253 0.023
response to oxidative stress GO:0006979 186 0.023
response to estrogen GO:0043627 232 0.023
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.023
response to biotic stimulus GO:0009607 226 0.023
positive regulation of molecular function GO:0044093 230 0.023
Human Mouse Rat
response to hypoxia GO:0001666 231 0.023
regulation of intracellular signal transduction GO:1902531 218 0.023
Mouse Rat
regulation of cell differentiation GO:0045595 320 0.022
cellular response to oxygen containing compound GO:1901701 386 0.022
single organism intracellular transport GO:1902582 166 0.022
single organism carbohydrate metabolic process GO:0044723 118 0.022
response to growth factor GO:0070848 189 0.022
tube development GO:0035295 89 0.022
cellular response to organic cyclic compound GO:0071407 202 0.022
reactive oxygen species metabolic process GO:0072593 37 0.022
gastrulation GO:0007369 2 0.021
response to extracellular stimulus GO:0009991 380 0.021
brain development GO:0007420 247 0.021
response to reactive oxygen species GO:0000302 120 0.021
behavior GO:0007610 205 0.021
negative regulation of macromolecule metabolic process GO:0010605 260 0.021
positive regulation of cellular protein metabolic process GO:0032270 167 0.021
metal ion transport GO:0030001 289 0.021
cofactor metabolic process GO:0051186 95 0.021
organelle organization GO:0006996 266 0.021
regulation of protein phosphorylation GO:0001932 183 0.021
cell cycle checkpoint GO:0000075 2 0.021
protein localization GO:0008104 191 0.021
cellular response to cytokine stimulus GO:0071345 127 0.021
regulation of phosphate metabolic process GO:0019220 349 0.020
monovalent inorganic cation transport GO:0015672 172 0.020
regulation of multicellular organismal development GO:2000026 376 0.020
intracellular transport GO:0046907 185 0.020
positive regulation of phosphorylation GO:0042327 177 0.020
anatomical structure morphogenesis GO:0009653 298 0.020
secretion by cell GO:0032940 248 0.020
single organism cellular localization GO:1902580 102 0.020
neuron differentiation GO:0030182 368 0.020
positive regulation of transcription dna templated GO:0045893 197 0.020
Human
head development GO:0060322 247 0.020
nucleotide metabolic process GO:0009117 279 0.020
cellular glucan metabolic process GO:0006073 23 0.020
positive regulation of multicellular organismal process GO:0051240 387 0.020
response to cytokine GO:0034097 215 0.020
regulation of mapk cascade GO:0043408 116 0.020
Mouse Rat
glycogen metabolic process GO:0005977 23 0.019
regulation of cellular protein metabolic process GO:0032268 267 0.019
blood circulation GO:0008015 183 0.019
Mouse
defense response GO:0006952 194 0.019
Mouse
regulation of cellular localization GO:0060341 263 0.019
nucleoside phosphate metabolic process GO:0006753 283 0.019
organophosphate metabolic process GO:0019637 370 0.019
muscle system process GO:0003012 115 0.019
Mouse Rat
response to hydrogen peroxide GO:0042542 89 0.019
regulation of ion transport GO:0043269 245 0.019
Rat
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
signal transduction by phosphorylation GO:0023014 144 0.019
Mouse Rat
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.019
positive regulation of rna biosynthetic process GO:1902680 197 0.019
Human
negative regulation of biosynthetic process GO:0009890 168 0.018
neuron development GO:0048666 286 0.018
regulation of cell development GO:0060284 263 0.018
locomotion GO:0040011 237 0.018
cellular response to nitrogen compound GO:1901699 210 0.018
negative regulation of molecular function GO:0044092 133 0.018
membrane organization GO:0061024 94 0.018
regulation of cell proliferation GO:0042127 359 0.018
organonitrogen compound biosynthetic process GO:1901566 167 0.017
regulation of kinase activity GO:0043549 117 0.017
Human Mouse Rat
regulation of nervous system development GO:0051960 264 0.017
single organism organelle organization GO:1902589 180 0.017
regulation of secretion by cell GO:1903530 208 0.017
nucleoside metabolic process GO:0009116 179 0.017
regulation of cytokine production GO:0001817 56 0.017
Mouse
response to peptide GO:1901652 292 0.017
negative regulation of signaling GO:0023057 157 0.017
multi organism reproductive process GO:0044703 262 0.017
regulation of blood circulation GO:1903522 110 0.017
cellular response to endogenous stimulus GO:0071495 377 0.017
regulation of secretion GO:0051046 224 0.017
Rat
negative regulation of response to stimulus GO:0048585 155 0.016
establishment of protein localization GO:0045184 141 0.016
positive regulation of cellular component organization GO:0051130 200 0.016
positive regulation of cell death GO:0010942 184 0.016
Rat
small molecule biosynthetic process GO:0044283 124 0.016
nitrogen compound transport GO:0071705 229 0.016
regulation of protein metabolic process GO:0051246 289 0.016
response to bacterium GO:0009617 200 0.016
response to ethanol GO:0045471 162 0.016
tumor necrosis factor mediated signaling pathway GO:0033209 4 0.016
glycosyl compound metabolic process GO:1901657 182 0.016
cellular macromolecule localization GO:0070727 122 0.016
carboxylic acid transport GO:0046942 115 0.016
Rat
negative regulation of gene expression GO:0010629 199 0.016
negative regulation of rna biosynthetic process GO:1902679 118 0.016
response to molecule of bacterial origin GO:0002237 194 0.016
single organism membrane organization GO:0044802 74 0.016
heart development GO:0007507 72 0.015
regulation of proteasomal protein catabolic process GO:0061136 4 0.015
negative regulation of phosphate metabolic process GO:0045936 80 0.015
lipid biosynthetic process GO:0008610 128 0.015
neuron projection development GO:0031175 273 0.015
secretion GO:0046903 307 0.015
Rat
response to acid chemical GO:0001101 222 0.015
purine nucleotide metabolic process GO:0006163 229 0.015
ribose phosphate metabolic process GO:0019693 235 0.015
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.015
heart contraction GO:0060047 57 0.015
Mouse
cellular chemical homeostasis GO:0055082 247 0.015
protein targeting GO:0006605 61 0.015
cation transport GO:0006812 382 0.015
positive regulation of protein metabolic process GO:0051247 178 0.015
organophosphate biosynthetic process GO:0090407 143 0.015
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.014
cellular polysaccharide metabolic process GO:0044264 23 0.014
purine ribonucleoside metabolic process GO:0046128 168 0.014
positive regulation of protein modification process GO:0031401 142 0.014
negative regulation of catalytic activity GO:0043086 103 0.014
positive regulation of phosphorus metabolic process GO:0010562 262 0.014
regulation of response to external stimulus GO:0032101 106 0.014
negative regulation of nucleic acid templated transcription GO:1903507 117 0.014
positive regulation of phosphate metabolic process GO:0045937 262 0.014
kidney development GO:0001822 67 0.014
lipid metabolic process GO:0006629 283 0.014
coenzyme metabolic process GO:0006732 86 0.014
cellular carbohydrate metabolic process GO:0044262 72 0.014
wound healing GO:0042060 122 0.014
carboxylic acid biosynthetic process GO:0046394 83 0.014
single organism catabolic process GO:0044712 283 0.014
muscle contraction GO:0006936 88 0.014
Mouse
response to external biotic stimulus GO:0043207 221 0.014
regulation of cell projection organization GO:0031344 175 0.014
muscle tissue development GO:0060537 58 0.014
Rat
regulation of neurogenesis GO:0050767 247 0.014
intracellular protein transport GO:0006886 79 0.013
protein transport GO:0015031 132 0.013
dna integrity checkpoint GO:0031570 2 0.013
purine nucleoside metabolic process GO:0042278 169 0.013
ion homeostasis GO:0050801 212 0.013
response to radiation GO:0009314 137 0.013
anion transport GO:0006820 178 0.013
Rat
positive regulation of cell proliferation GO:0008284 249 0.013
homeostatic process GO:0042592 331 0.013
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.013
dephosphorylation GO:0016311 98 0.013
organic acid transport GO:0015849 116 0.013
Rat
cell projection organization GO:0030030 302 0.013
lipid storage GO:0019915 1 0.013
circulatory system development GO:0072359 134 0.013
regulation of protein localization GO:0032880 81 0.013
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.013
regulation of neuron differentiation GO:0045664 208 0.013
peptidyl amino acid modification GO:0018193 126 0.013
reproduction GO:0000003 245 0.013
Rat
regulation of cellular component organization GO:0051128 368 0.013
chemical homeostasis GO:0048878 292 0.013
regulation of transferase activity GO:0051338 123 0.012
Human Mouse Rat
cation homeostasis GO:0055080 195 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.012
protein localization to nucleus GO:0034504 39 0.012
cellular lipid metabolic process GO:0044255 208 0.012
g protein coupled receptor signaling pathway GO:0007186 242 0.012
purine containing compound metabolic process GO:0072521 253 0.012
amide transport GO:0042886 105 0.012
positive regulation of neurogenesis GO:0050769 165 0.012
multicellular organism reproduction GO:0032504 233 0.012
Rat
signal release GO:0023061 145 0.012
negative regulation of cell communication GO:0010648 158 0.012
organic hydroxy compound metabolic process GO:1901615 115 0.012
negative regulation of multicellular organismal process GO:0051241 203 0.012
regulation of muscle system process GO:0090257 79 0.012
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.012
renal system development GO:0072001 67 0.012
cellular response to peptide GO:1901653 133 0.012
heart morphogenesis GO:0003007 3 0.012
positive regulation of cell development GO:0010720 176 0.012
regulation of anatomical structure morphogenesis GO:0022603 141 0.012
respiratory gaseous exchange GO:0007585 4 0.012
multicellular organismal reproductive process GO:0048609 233 0.012
Rat
positive regulation of nervous system development GO:0051962 178 0.012
response to nutrient GO:0007584 248 0.012
response to vitamin GO:0033273 131 0.012
negative regulation of rna metabolic process GO:0051253 123 0.012
divalent inorganic cation homeostasis GO:0072507 165 0.012
anterior posterior pattern specification GO:0009952 1 0.012
embryonic pattern specification GO:0009880 1 0.012
respiratory system process GO:0003016 3 0.012
response to glucocorticoid GO:0051384 223 0.012
negative regulation of transcription dna templated GO:0045892 116 0.012
cytoplasmic transport GO:0016482 115 0.012
regulation of system process GO:0044057 208 0.012
response to other organism GO:0051707 220 0.012
negative regulation of protein metabolic process GO:0051248 114 0.011
reproductive system development GO:0061458 128 0.011
positive regulation of signaling GO:0023056 270 0.011
Mouse Rat
ribonucleoside metabolic process GO:0009119 174 0.011
regulation of neuron projection development GO:0010975 161 0.011
regulation of hormone levels GO:0010817 187 0.011
axis specification GO:0009798 4 0.011
protein localization to organelle GO:0033365 57 0.011
catabolic process GO:0009056 351 0.011
lipid localization GO:0010876 62 0.011
Rat
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.011
striated muscle contraction GO:0006941 44 0.011
Mouse
anion transmembrane transport GO:0098656 77 0.011
reproductive structure development GO:0048608 128 0.011
regulation of cell migration GO:0030334 128 0.011
regulation of hydrolase activity GO:0051336 143 0.011
muscle organ morphogenesis GO:0048644 1 0.011
organic anion transport GO:0015711 132 0.011
Rat
cell cell signaling GO:0007267 335 0.011
cellular homeostasis GO:0019725 252 0.011
regulation of cell motility GO:2000145 131 0.011
small gtpase mediated signal transduction GO:0007264 36 0.011
sodium ion transport GO:0006814 82 0.011
metal ion homeostasis GO:0055065 186 0.011
cellular component movement GO:0006928 248 0.011
cellular divalent inorganic cation homeostasis GO:0072503 162 0.011
regulation of cellular component movement GO:0051270 150 0.011
epithelium development GO:0060429 96 0.011
ras protein signal transduction GO:0007265 29 0.010
developmental process involved in reproduction GO:0003006 159 0.010
positive regulation of protein phosphorylation GO:0001934 135 0.010
cytokine production GO:0001816 61 0.010
Mouse
cellular response to oxidative stress GO:0034599 76 0.010
positive regulation of signal transduction GO:0009967 175 0.010
Mouse Rat
peptidyl tyrosine modification GO:0018212 72 0.010
positive regulation of immunoglobulin production GO:0002639 4 0.010
regeneration GO:0031099 163 0.010
alcohol metabolic process GO:0006066 77 0.010
positive regulation of nucleic acid templated transcription GO:1903508 197 0.010
Human
regulation of response to wounding GO:1903034 69 0.010

Map2k3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 0 0.049
muscular disease DOID:0080000 0 0.049
muscular dystrophy DOID:9884 0 0.049
disease of anatomical entity DOID:7 0 0.049
musculoskeletal system disease DOID:17 0 0.049
muscle tissue disease DOID:66 0 0.049
nervous system disease DOID:863 0 0.035
cardiovascular system disease DOID:1287 0 0.028
heart disease DOID:114 0 0.014
cardiomyopathy DOID:0050700 0 0.014
intrinsic cardiomyopathy DOID:0060036 0 0.012
central nervous system disease DOID:331 0 0.012
disease of metabolism DOID:0014667 0 0.012
neuromuscular disease DOID:440 0 0.011
charcot marie tooth disease DOID:10595 0 0.011
neuropathy DOID:870 0 0.011
skin disease DOID:37 0 0.010
integumentary system disease DOID:16 0 0.010