Rattus norvegicus

83 known processes

Map2k2

mitogen activated protein kinase kinase 2

(Aliases: Prkmk2)

Map2k2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
macromolecular complex subunit organization GO:0043933 339 0.284
Yeast Rat
positive regulation of signal transduction GO:0009967 175 0.277
protein complex biogenesis GO:0070271 263 0.252
Rat
positive regulation of cell communication GO:0010647 271 0.201
regulation of molecular function GO:0065009 398 0.154
cellular component assembly GO:0022607 360 0.147
Rat
regulation of cellular component organization GO:0051128 368 0.132
Yeast
response to wounding GO:0009611 254 0.125
Rat
single organism organelle organization GO:1902589 180 0.124
Yeast Rat
intracellular signal transduction GO:0035556 314 0.119
organonitrogen compound biosynthetic process GO:1901566 167 0.115
positive regulation of ruffle assembly GO:1900029 1 0.108
positive regulation of cellular component biogenesis GO:0044089 55 0.107
regulation of phosphate metabolic process GO:0019220 349 0.106
positive regulation of response to stimulus GO:0048584 285 0.103
regulation of phosphorus metabolic process GO:0051174 349 0.099
neuron differentiation GO:0030182 368 0.098
Rat
reproduction GO:0000003 245 0.097
Yeast Worm Fly
peptide biosynthetic process GO:0043043 3 0.095
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.094
Rat
programmed cell death GO:0012501 392 0.090
Worm
positive regulation of intracellular signal transduction GO:1902533 138 0.087
positive regulation of cellular amine metabolic process GO:0033240 3 0.086
protein complex assembly GO:0006461 263 0.083
Rat
cellular response to stress GO:0033554 269 0.082
Yeast
negative regulation of phosphorus metabolic process GO:0010563 80 0.081
rna biosynthetic process GO:0032774 380 0.077
Rat
mitotic cell cycle GO:0000278 49 0.077
Rat
mitotic cell cycle process GO:1903047 35 0.076
Rat
positive regulation of signaling GO:0023056 270 0.075
oxidation reduction process GO:0055114 304 0.071
cytoskeleton organization GO:0007010 111 0.071
Yeast
neurological system process GO:0050877 219 0.069
cell cycle GO:0007049 101 0.069
Rat
positive regulation of cellular component organization GO:0051130 200 0.068
negative regulation of response to stimulus GO:0048585 155 0.067
negative regulation of macromolecule metabolic process GO:0010605 260 0.067
response to mineralocorticoid GO:0051385 49 0.063
regulation of immune response GO:0050776 55 0.062
regulation of catalytic activity GO:0050790 304 0.059
regulation of signal transduction GO:0009966 318 0.058
heart contraction GO:0060047 57 0.058
response to ketone GO:1901654 182 0.056
negative regulation of cellular metabolic process GO:0031324 281 0.056
organelle organization GO:0006996 266 0.055
Yeast Rat
metal ion transport GO:0030001 289 0.055
cellular amide metabolic process GO:0043603 44 0.055
negative regulation of phosphate metabolic process GO:0045936 80 0.054
regulation of multicellular organismal development GO:2000026 376 0.054
response to estradiol GO:0032355 164 0.054
regulation of apoptotic process GO:0042981 335 0.054
spindle organization GO:0007051 2 0.053
regulation of cell migration GO:0030334 128 0.052
Rat
multi organism reproductive process GO:0044703 262 0.052
Yeast Fly
catabolic process GO:0009056 351 0.052
Yeast Rat Worm
regulation of intracellular signal transduction GO:1902531 218 0.052
regulation of cell proliferation GO:0042127 359 0.051
organic substance catabolic process GO:1901575 316 0.051
Rat Worm
negative regulation of metabolic process GO:0009892 331 0.051
cation transport GO:0006812 382 0.051
regulation of cellular amine metabolic process GO:0033238 8 0.050
peptide metabolic process GO:0006518 32 0.050
single organism cellular localization GO:1902580 102 0.049
Yeast Rat
regulation of nucleotide catabolic process GO:0030811 65 0.049
Rat
positive regulation of nervous system development GO:0051962 178 0.049
multicellular organism growth GO:0035264 1 0.047
response to extracellular stimulus GO:0009991 380 0.047
locomotion GO:0040011 237 0.047
Mouse Rat Fly
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.046
Rat
deoxyribonucleoside monophosphate metabolic process GO:0009162 6 0.046
positive regulation of monooxygenase activity GO:0032770 5 0.045
single organism catabolic process GO:0044712 283 0.045
Yeast Rat
response to corticosterone GO:0051412 40 0.045
neuron death GO:0070997 127 0.045
head development GO:0060322 247 0.044
reproductive process GO:0022414 372 0.044
Yeast Worm Fly
positive regulation of oxidoreductase activity GO:0051353 7 0.044
positive regulation of cellular component movement GO:0051272 102 0.043
Mouse Rat
positive regulation of cellular biosynthetic process GO:0031328 295 0.042
Rat
positive regulation of cell proliferation GO:0008284 249 0.041
single organism reproductive process GO:0044702 297 0.041
Worm Fly
regulation of neurogenesis GO:0050767 247 0.041
mitotic spindle organization GO:0007052 2 0.041
immune response GO:0006955 104 0.041
carbohydrate derivative metabolic process GO:1901135 346 0.041
Rat
multicellular organism reproduction GO:0032504 233 0.041
Fly
cellular amine metabolic process GO:0044106 38 0.040
organic acid metabolic process GO:0006082 292 0.040
neuron apoptotic process GO:0051402 88 0.039
organic cyclic compound catabolic process GO:1901361 175 0.039
Rat
regulation of nervous system development GO:0051960 264 0.039
regulation of nucleoside metabolic process GO:0009118 66 0.039
Rat
multicellular organismal reproductive process GO:0048609 233 0.038
Fly
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.038
cellular catabolic process GO:0044248 295 0.038
Yeast Rat
regulation of neuron differentiation GO:0045664 208 0.038
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 5 0.038
axis specification GO:0009798 4 0.037
Fly
protein phosphorylation GO:0006468 345 0.037
response to starvation GO:0042594 59 0.037
apoptotic process GO:0006915 381 0.037
Worm
positive regulation of rna metabolic process GO:0051254 203 0.037
Rat
protein oligomerization GO:0051259 191 0.037
Rat
cellular amino acid metabolic process GO:0006520 107 0.036
gamete generation GO:0007276 124 0.036
Fly
heart process GO:0003015 57 0.036
nucleobase containing compound catabolic process GO:0034655 152 0.036
Rat
small molecule catabolic process GO:0044282 59 0.036
positive regulation of organelle organization GO:0010638 48 0.036
regulation of purine nucleotide metabolic process GO:1900542 115 0.035
Rat
purine nucleoside metabolic process GO:0042278 169 0.035
Rat
regulation of system process GO:0044057 208 0.035
Rat
rna metabolic process GO:0016070 406 0.035
Rat
nucleobase containing small molecule metabolic process GO:0055086 316 0.034
Rat
positive regulation of gene expression GO:0010628 244 0.034
Rat
nucleotide metabolic process GO:0009117 279 0.034
Rat
cellular glucan metabolic process GO:0006073 23 0.034
brain development GO:0007420 247 0.033
response to estrogen GO:0043627 232 0.033
negative regulation of cellular protein metabolic process GO:0032269 106 0.032
positive regulation of cell migration GO:0030335 96 0.032
Rat
blood circulation GO:0008015 183 0.032
Rat
regulation of cell projection organization GO:0031344 175 0.032
regulation of protein metabolic process GO:0051246 289 0.032
central nervous system development GO:0007417 311 0.031
deoxyribose phosphate metabolic process GO:0019692 9 0.030
divalent metal ion transport GO:0070838 132 0.030
regulation of gtpase activity GO:0043087 57 0.030
Rat
behavior GO:0007610 205 0.030
amine metabolic process GO:0009308 38 0.030
sexual reproduction GO:0019953 148 0.029
Yeast Fly
regulation of apoptotic signaling pathway GO:2001233 13 0.029
response to nutrient levels GO:0031667 370 0.029
response to glucocorticoid GO:0051384 223 0.029
Rat
immune system process GO:0002376 204 0.029
Fly
positive regulation of developmental process GO:0051094 283 0.029
negative regulation of molecular function GO:0044092 133 0.029
transcription dna templated GO:0006351 377 0.028
Rat
regulation of mrna splicing via spliceosome GO:0048024 3 0.028
cellular response to nutrient levels GO:0031669 60 0.028
positive regulation of cytoskeleton organization GO:0051495 26 0.028
regulation of nucleic acid templated transcription GO:1903506 380 0.028
Rat
macroautophagy GO:0016236 4 0.028
regulation of programmed cell death GO:0043067 341 0.028
protein heterooligomerization GO:0051291 89 0.028
Rat
regulation of neurotransmitter levels GO:0001505 42 0.028
heterocycle catabolic process GO:0046700 167 0.028
Rat
deoxyribonucleotide biosynthetic process GO:0009263 6 0.028
regulation of response to wounding GO:1903034 69 0.028
regulation of catabolic process GO:0009894 113 0.027
Rat
cellular ketone metabolic process GO:0042180 51 0.027
positive regulation of nucleic acid templated transcription GO:1903508 197 0.027
Rat
regulation of phosphorylation GO:0042325 248 0.027
response to corticosteroid GO:0031960 235 0.027
Rat
response to temperature stimulus GO:0009266 94 0.027
Yeast
positive regulation of synaptic transmission GO:0050806 62 0.027
cellular protein complex assembly GO:0043623 44 0.027
positive regulation of erk1 and erk2 cascade GO:0070374 29 0.027
Fly
regulation of rna metabolic process GO:0051252 391 0.026
Rat
regulation of kinase activity GO:0043549 117 0.026
positive regulation of cell motility GO:2000147 97 0.026
Mouse Rat
regulation of cellular amino acid metabolic process GO:0006521 2 0.026
regulation of blood circulation GO:1903522 110 0.026
Rat
2 deoxyribonucleotide biosynthetic process GO:0009265 6 0.026
oxoacid metabolic process GO:0043436 290 0.026
regulation of response to stress GO:0080134 126 0.026
Yeast
developmental growth GO:0048589 100 0.025
regulation of cell cycle GO:0051726 73 0.025
aromatic compound catabolic process GO:0019439 168 0.025
Rat
transcription from rna polymerase ii promoter GO:0006366 252 0.025
Rat
aging GO:0007568 241 0.025
Worm
regulation of protein kinase activity GO:0045859 105 0.025
positive regulation of hydrolase activity GO:0051345 86 0.024
Rat
regulation of neuron death GO:1901214 115 0.024
cell motility GO:0048870 202 0.024
Mouse Rat Fly
positive regulation of neuron differentiation GO:0045666 126 0.024
regulation of ion transport GO:0043269 245 0.024
response to acid chemical GO:0001101 222 0.024
microtubule cytoskeleton organization GO:0000226 25 0.024
regulation of purine nucleotide catabolic process GO:0033121 65 0.024
Rat
regulation of nitric oxide synthase activity GO:0050999 8 0.024
cell cell signaling GO:0007267 335 0.023
positive regulation of membrane potential GO:0045838 16 0.023
nucleic acid templated transcription GO:0097659 379 0.023
Rat
intraspecies interaction between organisms GO:0051703 15 0.023
positive regulation of phosphate metabolic process GO:0045937 262 0.023
single organism biosynthetic process GO:0044711 342 0.022
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.022
regulation of cellular ketone metabolic process GO:0010565 27 0.022
regulation of response to external stimulus GO:0032101 106 0.022
sensory perception GO:0007600 101 0.022
regulation of neuron apoptotic process GO:0043523 83 0.022
stress activated protein kinase signaling cascade GO:0031098 37 0.022
positive regulation of cell differentiation GO:0045597 217 0.022
regulation of immune system process GO:0002682 123 0.022
gastrulation GO:0007369 2 0.022
ribose phosphate biosynthetic process GO:0046390 87 0.022
g protein coupled receptor signaling pathway GO:0007186 242 0.022
Yeast
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.021
Rat
multi multicellular organism process GO:0044706 138 0.021
positive regulation of rna biosynthetic process GO:1902680 197 0.021
Rat
epithelial cell proliferation GO:0050673 54 0.021
defense response GO:0006952 194 0.021
intracellular protein transport GO:0006886 79 0.021
Yeast
regulation of growth GO:0040008 105 0.021
ribonucleotide metabolic process GO:0009259 231 0.021
Rat
positive regulation of cellular protein metabolic process GO:0032270 167 0.021
protein complex subunit organization GO:0071822 302 0.021
Yeast Rat
response to activity GO:0014823 73 0.021
regulation of heart contraction GO:0008016 48 0.021
secondary metabolite catabolic process GO:0090487 1 0.021
carbohydrate derivative biosynthetic process GO:1901137 124 0.021
regulation of transcription dna templated GO:0006355 374 0.020
Rat
macromolecular complex assembly GO:0065003 273 0.020
Rat
reactive nitrogen species metabolic process GO:2001057 1 0.020
regulation of microtubule polymerization or depolymerization GO:0031110 12 0.020
hair follicle development GO:0001942 2 0.020
negative regulation of cell cycle phase transition GO:1901988 4 0.020
glycosyl compound metabolic process GO:1901657 182 0.020
Rat
regulation of cellular component biogenesis GO:0044087 86 0.019
homeostatic process GO:0042592 331 0.019
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.019
Rat
regulation of protein modification process GO:0031399 194 0.019
intracellular transport GO:0046907 185 0.019
Yeast Rat
regulation of organelle organization GO:0033043 80 0.019
calcium ion transport GO:0006816 131 0.019
negative regulation of neuron death GO:1901215 69 0.019
positive regulation of kinase activity GO:0033674 77 0.019
negative regulation of protein phosphorylation GO:0001933 44 0.019
regulation of cellular component movement GO:0051270 150 0.019
Mouse Rat
cell migration GO:0016477 197 0.019
Rat Fly
negative regulation of response to nutrient levels GO:0032108 7 0.019
purine ribonucleotide biosynthetic process GO:0009152 81 0.018
regulation of cellular catabolic process GO:0031329 101 0.018
Rat
pentose metabolic process GO:0019321 8 0.018
negative regulation of gene expression GO:0010629 199 0.018
negative regulation of protein modification process GO:0031400 52 0.018
organonitrogen compound catabolic process GO:1901565 179 0.018
Rat
regulation of epithelial cell proliferation GO:0050678 49 0.018
nucleoside phosphate metabolic process GO:0006753 283 0.018
Rat
regulation of hydrolase activity GO:0051336 143 0.018
Rat
developmental process involved in reproduction GO:0003006 159 0.018
Worm Fly
circulatory system process GO:0003013 183 0.018
Rat
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.018
Rat
regulation of cellular response to stress GO:0080135 49 0.018
Yeast
receptor localization to synapse GO:0097120 2 0.018
apoptotic signaling pathway GO:0097190 27 0.017
regulation of cell development GO:0060284 263 0.017
sequestering of metal ion GO:0051238 9 0.017
single organism carbohydrate metabolic process GO:0044723 118 0.017
response to vitamin GO:0033273 131 0.017
ribose phosphate metabolic process GO:0019693 235 0.017
Rat
positive regulation of locomotion GO:0040017 102 0.017
Mouse Rat
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.017
positive regulation of cyclic nucleotide metabolic process GO:0030801 37 0.017
amide biosynthetic process GO:0043604 10 0.016
circulatory system development GO:0072359 134 0.016
positive regulation of transcription dna templated GO:0045893 197 0.016
Rat
positive regulation of cell death GO:0010942 184 0.016
regulation of anatomical structure size GO:0090066 135 0.016
Rat
regulation of monooxygenase activity GO:0032768 8 0.016
adenylate cyclase activating g protein coupled receptor signaling pathway GO:0007189 24 0.016
nucleoside phosphate catabolic process GO:1901292 140 0.016
Rat
positive regulation of biosynthetic process GO:0009891 319 0.016
Rat
cell projection organization GO:0030030 302 0.015
Rat
cell type specific apoptotic process GO:0097285 134 0.015
purine nucleotide metabolic process GO:0006163 229 0.015
Rat
positive regulation of gtpase activity GO:0043547 47 0.015
Rat
negative regulation of rna splicing GO:0033119 3 0.015
purine nucleotide biosynthetic process GO:0006164 83 0.015
calcium ion homeostasis GO:0055074 162 0.015
negative regulation of cell death GO:0060548 229 0.015
cellular component biogenesis GO:0044085 368 0.015
Rat
negative regulation of signaling GO:0023057 157 0.015
regulation of protein complex assembly GO:0043254 33 0.015
regulation of cell differentiation GO:0045595 320 0.015
positive regulation of ion transport GO:0043270 94 0.015
divalent inorganic cation transport GO:0072511 134 0.015
regulation of map kinase activity GO:0043405 53 0.015
growth GO:0040007 165 0.015
Yeast
organophosphate catabolic process GO:0046434 148 0.015
Rat
reactive oxygen species biosynthetic process GO:1903409 8 0.015
nucleotide catabolic process GO:0009166 139 0.014
Rat
regulation of vesicle mediated transport GO:0060627 81 0.014
regulation of cellular protein metabolic process GO:0032268 267 0.014
axon development GO:0061564 96 0.014
negative regulation of signal transduction GO:0009968 83 0.014
lipid modification GO:0030258 52 0.014
single organism nuclear import GO:1902593 35 0.014
Yeast
microtubule based process GO:0007017 36 0.014
Rat
regulation of cytoskeleton organization GO:0051493 49 0.014
cellular response to extracellular stimulus GO:0031668 73 0.014
monosaccharide metabolic process GO:0005996 61 0.014
negative regulation of protein metabolic process GO:0051248 114 0.014
positive regulation of cell development GO:0010720 176 0.014
positive regulation of neurogenesis GO:0050769 165 0.014
response to decreased oxygen levels GO:0036293 237 0.014
positive regulation of cyclase activity GO:0031281 15 0.014
regulation of rna biosynthetic process GO:2001141 381 0.014
Rat
negative regulation of innate immune response GO:0045824 4 0.013
protein localization GO:0008104 191 0.013
Yeast
camp metabolic process GO:0046058 63 0.013
negative regulation of neuron apoptotic process GO:0043524 45 0.013
negative regulation of cell communication GO:0010648 158 0.013
female pregnancy GO:0007565 122 0.013
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 2 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.013
transmembrane transport GO:0055085 412 0.013
actin filament based process GO:0030029 86 0.013
Yeast
regulation of transferase activity GO:0051338 123 0.013
nucleotide biosynthetic process GO:0009165 98 0.013
purine containing compound biosynthetic process GO:0072522 85 0.013
purine containing compound metabolic process GO:0072521 253 0.013
Rat
positive regulation of cell projection organization GO:0031346 111 0.013
regulation of cell motility GO:2000145 131 0.013
Mouse Rat
response to inorganic substance GO:0010035 377 0.012
positive regulation of catalytic activity GO:0043085 184 0.012
regulation of cyclase activity GO:0031279 21 0.012
positive regulation of neuron projection development GO:0010976 99 0.012
ion homeostasis GO:0050801 212 0.012
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.012
negative regulation of purine nucleotide metabolic process GO:1900543 23 0.012
cell growth GO:0016049 104 0.012
Yeast
negative regulation of phosphorylation GO:0042326 57 0.012
regulation of synaptic transmission GO:0050804 141 0.012
response to ethanol GO:0045471 162 0.012
feeding behavior GO:0007631 53 0.012
response to toxic substance GO:0009636 133 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.012
Rat
organophosphate metabolic process GO:0019637 370 0.012
Rat
response to fatty acid GO:0070542 65 0.012
hair cycle process GO:0022405 2 0.012
purine nucleoside triphosphate catabolic process GO:0009146 122 0.012
Rat
triglyceride homeostasis GO:0070328 2 0.012
macromolecule localization GO:0033036 252 0.012
Yeast
regulation of ras protein signal transduction GO:0046578 45 0.012
Rat Fly
nucleoside phosphate biosynthetic process GO:1901293 102 0.012
regulation of blood vessel endothelial cell migration GO:0043535 4 0.012
eye development GO:0001654 50 0.012
positive regulation of protein metabolic process GO:0051247 178 0.012
regulation of cell cycle process GO:0010564 31 0.011
negative regulation of ras gtpase activity GO:0034261 2 0.011
regulation of mapk cascade GO:0043408 116 0.011
adult locomotory behavior GO:0008344 4 0.011
response to external biotic stimulus GO:0043207 221 0.011
regulation of dna metabolic process GO:0051052 60 0.011
glycosaminoglycan biosynthetic process GO:0006024 4 0.011
cellular nitrogen compound catabolic process GO:0044270 163 0.011
Rat
cyclic nucleotide biosynthetic process GO:0009190 63 0.011
sensory organ development GO:0007423 74 0.011
guanosine containing compound catabolic process GO:1901069 71 0.011
Rat
establishment of protein localization GO:0045184 141 0.011
Yeast
nadp metabolic process GO:0006739 13 0.011
cation homeostasis GO:0055080 195 0.011
synaptic transmission GO:0007268 235 0.011
transformation of host cell by virus GO:0019087 4 0.011
response to electrical stimulus GO:0051602 56 0.011
sulfur compound biosynthetic process GO:0044272 19 0.011
cellular carbohydrate metabolic process GO:0044262 72 0.011
regulation of smooth muscle cell proliferation GO:0048660 75 0.011
cell adhesion GO:0007155 110 0.011
Rat
acetate ester metabolic process GO:1900619 4 0.011
response to hydrogen peroxide GO:0042542 89 0.011
positive regulation of response to wounding GO:1903036 34 0.011
negative regulation of apoptotic process GO:0043066 181 0.011
response to peptide GO:1901652 292 0.011
protein targeting to nucleus GO:0044744 35 0.011
Yeast
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.011
neuron development GO:0048666 286 0.010
Rat
visual perception GO:0007601 3 0.010
response to heat GO:0009408 60 0.010
Yeast
carbohydrate derivative catabolic process GO:1901136 147 0.010
Rat
secretion by cell GO:0032940 248 0.010
potassium ion transport GO:0006813 97 0.010
purine ribonucleoside metabolic process GO:0046128 168 0.010
Rat
metal ion homeostasis GO:0055065 186 0.010
nuclear transport GO:0051169 49 0.010
Yeast
gtp catabolic process GO:0006184 71 0.010
Rat
positive regulation of cellular catabolic process GO:0031331 71 0.010
Rat
phenol containing compound metabolic process GO:0018958 30 0.010
cellular response to alcohol GO:0097306 87 0.010
neuronal action potential GO:0019228 35 0.010
purine ribonucleotide catabolic process GO:0009154 136 0.010
Rat
negative regulation of catalytic activity GO:0043086 103 0.010
positive regulation of epithelial cell proliferation GO:0050679 32 0.010

Map2k2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
endocrine gland cancer DOID:170 0 0.127
cancer DOID:162 0 0.127
disease of cellular proliferation DOID:14566 0 0.127
organ system cancer DOID:0050686 0 0.127
thyroid carcinoma DOID:3963 0 0.010
thyroid cancer DOID:1781 0 0.010