Rattus norvegicus

0 known processes

Nkx2-4

NK2 homeobox 4

Nkx2-4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
response to corticosteroid GO:0031960 235 0.228
response to glucocorticoid GO:0051384 223 0.114
cellular lipid metabolic process GO:0044255 208 0.110
regulation of cellular localization GO:0060341 263 0.101
response to nutrient levels GO:0031667 370 0.093
response to estrogen GO:0043627 232 0.087
cellular response to lipid GO:0071396 201 0.083
positive regulation of protein metabolic process GO:0051247 178 0.080
multicellular organism reproduction GO:0032504 233 0.078
cellular response to organonitrogen compound GO:0071417 197 0.078
response to oxygen levels GO:0070482 265 0.071
multi organism reproductive process GO:0044703 262 0.068
lipid metabolic process GO:0006629 283 0.064
positive regulation of cell communication GO:0010647 271 0.064
regulation of molecular function GO:0065009 398 0.061
response to bacterium GO:0009617 200 0.060
response to decreased oxygen levels GO:0036293 237 0.058
regulation of transcription dna templated GO:0006355 374 0.057
cellular response to steroid hormone stimulus GO:0071383 93 0.056
positive regulation of developmental process GO:0051094 283 0.055
intracellular signal transduction GO:0035556 314 0.052
regulation of hormone levels GO:0010817 187 0.051
positive regulation of signaling GO:0023056 270 0.051
positive regulation of gene expression GO:0010628 244 0.050
transcription dna templated GO:0006351 377 0.048
regulation of phosphorus metabolic process GO:0051174 349 0.048
rna biosynthetic process GO:0032774 380 0.047
cell migration GO:0016477 197 0.047
regulation of rna metabolic process GO:0051252 391 0.044
response to peptide hormone GO:0043434 278 0.044
localization of cell GO:0051674 202 0.044
response to peptide GO:1901652 292 0.044
cellular component movement GO:0006928 248 0.043
multicellular organismal reproductive process GO:0048609 233 0.042
response to acid chemical GO:0001101 222 0.042
cellular response to organic cyclic compound GO:0071407 202 0.042
response to hypoxia GO:0001666 231 0.041
regulation of cellular protein metabolic process GO:0032268 267 0.040
positive regulation of molecular function GO:0044093 230 0.040
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.040
transcription from rna polymerase ii promoter GO:0006366 252 0.038
cation transport GO:0006812 382 0.038
carboxylic acid metabolic process GO:0019752 289 0.038
cellular cation homeostasis GO:0030003 180 0.038
secretion GO:0046903 307 0.037
positive regulation of multicellular organismal process GO:0051240 387 0.036
positive regulation of biosynthetic process GO:0009891 319 0.036
reproductive process GO:0022414 372 0.036
regulation of nucleic acid templated transcription GO:1903506 380 0.036
regulation of rna biosynthetic process GO:2001141 381 0.036
cellular response to glucocorticoid stimulus GO:0071385 68 0.035
response to ketone GO:1901654 182 0.034
positive regulation of cell differentiation GO:0045597 217 0.034
nucleic acid templated transcription GO:0097659 379 0.034
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.033
regulation of cell motility GO:2000145 131 0.033
amine metabolic process GO:0009308 38 0.033
regulation of protein modification process GO:0031399 194 0.033
hormone transport GO:0009914 121 0.032
positive regulation of cell proliferation GO:0008284 249 0.032
central nervous system development GO:0007417 311 0.032
wnt signaling pathway planar cell polarity pathway GO:0060071 2 0.032
regulation of catalytic activity GO:0050790 304 0.032
cellular response to hormone stimulus GO:0032870 247 0.032
cellular response to endogenous stimulus GO:0071495 377 0.032
chemical homeostasis GO:0048878 292 0.032
reproduction GO:0000003 245 0.031
cellular response to stress GO:0033554 269 0.031
positive regulation of response to stimulus GO:0048584 285 0.031
metestrus GO:0060210 1 0.030
response to growth factor GO:0070848 189 0.030
cellular response to corticosteroid stimulus GO:0071384 69 0.030
regulation of protein metabolic process GO:0051246 289 0.030
cellular response to oxygen containing compound GO:1901701 386 0.030
enzyme linked receptor protein signaling pathway GO:0007167 116 0.030
rna metabolic process GO:0016070 406 0.029
organelle organization GO:0006996 266 0.029
signal release GO:0023061 145 0.029
positive regulation of cell migration GO:0030335 96 0.029
ion homeostasis GO:0050801 212 0.029
positive regulation of intracellular signal transduction GO:1902533 138 0.029
organic acid metabolic process GO:0006082 292 0.028
response to inorganic substance GO:0010035 377 0.028
cellular amine metabolic process GO:0044106 38 0.028
cell motility GO:0048870 202 0.028
gamete generation GO:0007276 124 0.028
positive regulation of rna metabolic process GO:0051254 203 0.028
response to external biotic stimulus GO:0043207 221 0.028
negative regulation of gene expression GO:0010629 199 0.028
regulation of cell projection size GO:0032536 1 0.028
cellular ketone metabolic process GO:0042180 51 0.026
positive regulation of transcription dna templated GO:0045893 197 0.026
single organism biosynthetic process GO:0044711 342 0.025
positive regulation of cellular biosynthetic process GO:0031328 295 0.025
response to other organism GO:0051707 220 0.025
cellular response to oxidative stress GO:0034599 76 0.024
regulation of hormone secretion GO:0046883 106 0.024
response to biotic stimulus GO:0009607 226 0.024
cellular response to peptide GO:1901653 133 0.024
negative regulation of cell death GO:0060548 229 0.024
locomotion GO:0040011 237 0.024
oxoacid metabolic process GO:0043436 290 0.023
negative regulation of macromolecule metabolic process GO:0010605 260 0.023
positive regulation of protein phosphorylation GO:0001934 135 0.022
regulation of phosphorylation GO:0042325 248 0.022
regulation of cell proliferation GO:0042127 359 0.022
intracellular transport GO:0046907 185 0.022
sexual reproduction GO:0019953 148 0.022
response to nutrient GO:0007584 248 0.022
circulatory system process GO:0003013 183 0.022
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.022
organic hydroxy compound metabolic process GO:1901615 115 0.021
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.021
positive regulation of cell motility GO:2000147 97 0.021
response to oxidative stress GO:0006979 186 0.021
fatty acid metabolic process GO:0006631 99 0.021
positive regulation of cellular component movement GO:0051272 102 0.020
cellular response to peptide hormone stimulus GO:0071375 120 0.020
negative regulation of apoptotic process GO:0043066 181 0.020
positive regulation of neurogenesis GO:0050769 165 0.020
homeostatic process GO:0042592 331 0.019
negative regulation of cellular metabolic process GO:0031324 281 0.019
regulation of phosphate metabolic process GO:0019220 349 0.019
positive regulation of nucleic acid templated transcription GO:1903508 197 0.019
negative regulation of programmed cell death GO:0043069 183 0.019
secretion by cell GO:0032940 248 0.019
muscle system process GO:0003012 115 0.019
negative regulation of biosynthetic process GO:0009890 168 0.019
activation of protein kinase activity GO:0032147 47 0.018
positive regulation of cellular amine metabolic process GO:0033240 3 0.018
cellular response to growth factor stimulus GO:0071363 162 0.018
regulation of secretion by cell GO:1903530 208 0.018
cellular amino acid metabolic process GO:0006520 107 0.018
single organism organelle organization GO:1902589 180 0.018
regulation of cellular amine metabolic process GO:0033238 8 0.018
lipid biosynthetic process GO:0008610 128 0.018
negative regulation of metabolic process GO:0009892 331 0.018
cell cell signaling GO:0007267 335 0.018
response to alkaloid GO:0043279 132 0.018
positive regulation of rna biosynthetic process GO:1902680 197 0.018
glycerolipid metabolic process GO:0046486 67 0.017
male gamete generation GO:0048232 99 0.017
defense response to gram positive bacterium GO:0050830 2 0.017
metal ion homeostasis GO:0055065 186 0.017
regulation of kinase activity GO:0043549 117 0.017
response to metal ion GO:0010038 253 0.017
response to vitamin GO:0033273 131 0.017
small molecule biosynthetic process GO:0044283 124 0.017
response to wounding GO:0009611 254 0.017
response to extracellular stimulus GO:0009991 380 0.017
cation homeostasis GO:0055080 195 0.017
cytosolic calcium ion homeostasis GO:0051480 140 0.017
alcohol metabolic process GO:0006066 77 0.017
regulation of cell migration GO:0030334 128 0.017
amide transport GO:0042886 105 0.017
peptide transport GO:0015833 97 0.016
regulation of nervous system development GO:0051960 264 0.016
regulation of muscle system process GO:0090257 79 0.016
cytoplasmic transport GO:0016482 115 0.016
positive regulation of nervous system development GO:0051962 178 0.016
positive regulation of protein serine threonine kinase activity GO:0071902 52 0.016
transmission of nerve impulse GO:0019226 42 0.016
regulation of multicellular organismal development GO:2000026 376 0.016
regulation of immune system process GO:0002682 123 0.016
immune response GO:0006955 104 0.016
cellular calcium ion homeostasis GO:0006874 160 0.016
divalent inorganic cation homeostasis GO:0072507 165 0.016
cellular macromolecule localization GO:0070727 122 0.016
urogenital system development GO:0001655 78 0.016
anatomical structure morphogenesis GO:0009653 298 0.016
single organism intracellular transport GO:1902582 166 0.016
regulation of system process GO:0044057 208 0.016
proteolysis GO:0006508 175 0.015
nitrogen compound transport GO:0071705 229 0.015
negative regulation of secretion GO:0051048 82 0.015
positive regulation of cellular protein metabolic process GO:0032270 167 0.015
response to monosaccharide GO:0034284 159 0.015
regulation of transferase activity GO:0051338 123 0.015
regulation of locomotion GO:0040012 148 0.015
regulation of neurological system process GO:0031644 43 0.015
calcium ion homeostasis GO:0055074 162 0.015
non canonical wnt signaling pathway GO:0035567 3 0.015
regulation of protein phosphorylation GO:0001932 183 0.015
apoptotic process GO:0006915 381 0.014
negative regulation of transport GO:0051051 136 0.014
spermatogenesis GO:0007283 99 0.014
regulation of cellular amino acid metabolic process GO:0006521 2 0.014
hormone secretion GO:0046879 115 0.014
neurological system process GO:0050877 219 0.014
response to carbohydrate GO:0009743 183 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.014
positive regulation of protein modification process GO:0031401 142 0.014
negative regulation of secretion by cell GO:1903531 72 0.014
negative regulation of neuron death GO:1901215 69 0.014
positive regulation of phosphorus metabolic process GO:0010562 262 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.014
response to transition metal nanoparticle GO:1990267 122 0.014
response to estradiol GO:0032355 164 0.014
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.014
cellular response to reactive oxygen species GO:0034614 55 0.014
response to insulin GO:0032868 133 0.013
single organism reproductive process GO:0044702 297 0.013
neuron projection development GO:0031175 273 0.013
protein phosphorylation GO:0006468 345 0.013
brain development GO:0007420 247 0.013
regeneration GO:0031099 163 0.013
retinal metabolic process GO:0042574 3 0.013
response to ethanol GO:0045471 162 0.013
positive regulation of neuron differentiation GO:0045666 126 0.013
cellular component assembly GO:0022607 360 0.013
growth GO:0040007 165 0.013
regulation of cellular ketone metabolic process GO:0010565 27 0.013
regulation of apoptotic process GO:0042981 335 0.013
negative regulation of signaling GO:0023057 157 0.013
gliogenesis GO:0042063 93 0.013
cellular response to external stimulus GO:0071496 118 0.013
sequestering of calcium ion GO:0051208 8 0.013
cellular component morphogenesis GO:0032989 155 0.013
macromolecule localization GO:0033036 252 0.013
negative regulation of molecular function GO:0044092 133 0.013
negative regulation of cellular protein metabolic process GO:0032269 106 0.013
response to activity GO:0014823 73 0.012
positive regulation of locomotion GO:0040017 102 0.012
peptide hormone secretion GO:0030072 84 0.012
inorganic ion transmembrane transport GO:0098660 229 0.012
cellular response to abiotic stimulus GO:0071214 85 0.012
cellular homeostasis GO:0019725 252 0.012
insulin like growth factor receptor signaling pathway GO:0048009 3 0.012
regulation of secretion GO:0051046 224 0.012
rhythmic process GO:0048511 156 0.012
response to amino acid GO:0043200 75 0.012
defense response to gram negative bacterium GO:0050829 3 0.012
cellular catabolic process GO:0044248 295 0.012
female pregnancy GO:0007565 122 0.012
response to transforming growth factor beta GO:0071559 46 0.012
multi multicellular organism process GO:0044706 138 0.012
immune system process GO:0002376 204 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
second messenger mediated signaling GO:0019932 51 0.012
axis specification GO:0009798 4 0.012
insulin secretion GO:0030073 69 0.012
metal ion transport GO:0030001 289 0.012
blood circulation GO:0008015 183 0.012
organic anion transport GO:0015711 132 0.012
negative regulation of cell communication GO:0010648 158 0.012
regulation of cell development GO:0060284 263 0.012
regulation of lipid metabolic process GO:0019216 68 0.012
aging GO:0007568 241 0.012
catabolic process GO:0009056 351 0.012
gland development GO:0048732 155 0.012
defense response GO:0006952 194 0.012
response to toxic substance GO:0009636 133 0.012
regulation of peptide transport GO:0090087 87 0.012
neuron differentiation GO:0030182 368 0.012
response to nicotine GO:0035094 51 0.011
positive regulation of response to external stimulus GO:0032103 51 0.011
positive regulation of mapk cascade GO:0043410 92 0.011
regulation of neurogenesis GO:0050767 247 0.011
steroid metabolic process GO:0008202 73 0.011
monocarboxylic acid metabolic process GO:0032787 152 0.011
cellular divalent inorganic cation homeostasis GO:0072503 162 0.011
cellular response to insulin stimulus GO:0032869 81 0.011
positive regulation of phosphorylation GO:0042327 177 0.011
cellular ion homeostasis GO:0006873 184 0.011
positive regulation of transferase activity GO:0051347 81 0.011
biological adhesion GO:0022610 110 0.011
chromosome segregation GO:0007059 2 0.011
cellular response to acid chemical GO:0071229 75 0.011
sequestering of metal ion GO:0051238 9 0.011
tissue development GO:0009888 252 0.011
regulation of neuron death GO:1901214 115 0.011
regulation of cell differentiation GO:0045595 320 0.011
positive regulation of signal transduction GO:0009967 175 0.011
positive regulation of endothelial cell migration GO:0010595 4 0.011
molting cycle GO:0042303 3 0.011
cellular component biogenesis GO:0044085 368 0.011
regulation of ion transport GO:0043269 245 0.011
regulation of establishment of planar polarity GO:0090175 2 0.011
regulation of membrane potential GO:0042391 110 0.011
multicellular organismal homeostasis GO:0048871 49 0.011
cardiovascular system development GO:0072358 134 0.010
head development GO:0060322 247 0.010
positive regulation of cell development GO:0010720 176 0.010
spindle organization GO:0007051 2 0.010
negative regulation of protein metabolic process GO:0051248 114 0.010
regulation of homeostatic process GO:0032844 101 0.010
multicellular organismal signaling GO:0035637 44 0.010
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.010
negative regulation of cell proliferation GO:0008285 119 0.010
neuron death GO:0070997 127 0.010
regulation of protein kinase activity GO:0045859 105 0.010
action potential GO:0001508 54 0.010
positive regulation of kinase activity GO:0033674 77 0.010
ion transmembrane transport GO:0034220 365 0.010
transmembrane transport GO:0055085 412 0.010

Nkx2-4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org