Rattus norvegicus

0 known processes

Nkd2

naked cuticle homolog 2 (Drosophila)

Nkd2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of nucleic acid templated transcription GO:1903506 380 0.083
response to extracellular stimulus GO:0009991 380 0.070
anatomical structure morphogenesis GO:0009653 298 0.060
neuron differentiation GO:0030182 368 0.058
cell projection organization GO:0030030 302 0.056
transcription from rna polymerase ii promoter GO:0006366 252 0.056
transcription dna templated GO:0006351 377 0.055
intracellular signal transduction GO:0035556 314 0.053
regulation of molecular function GO:0065009 398 0.053
regulation of rna metabolic process GO:0051252 391 0.053
programmed cell death GO:0012501 392 0.052
central nervous system development GO:0007417 311 0.051
response to nutrient levels GO:0031667 370 0.051
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.050
rna metabolic process GO:0016070 406 0.049
positive regulation of multicellular organismal process GO:0051240 387 0.049
regulation of intracellular signal transduction GO:1902531 218 0.047
single organism organelle organization GO:1902589 180 0.047
positive regulation of gene expression GO:0010628 244 0.047
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.046
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.044
regulation of cell proliferation GO:0042127 359 0.044
organelle organization GO:0006996 266 0.043
reproductive process GO:0022414 372 0.041
negative regulation of macromolecule metabolic process GO:0010605 260 0.040
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.039
negative regulation of metabolic process GO:0009892 331 0.039
apoptotic process GO:0006915 381 0.038
negative regulation of cellular metabolic process GO:0031324 281 0.038
regulation of cellular protein metabolic process GO:0032268 267 0.038
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.035
regulation of rna biosynthetic process GO:2001141 381 0.035
nucleic acid templated transcription GO:0097659 379 0.034
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.034
cellular catabolic process GO:0044248 295 0.034
regulation of protein metabolic process GO:0051246 289 0.033
protein phosphorylation GO:0006468 345 0.032
regulation of catalytic activity GO:0050790 304 0.032
monovalent inorganic cation transport GO:0015672 172 0.032
cation transport GO:0006812 382 0.032
positive regulation of developmental process GO:0051094 283 0.032
transmembrane transport GO:0055085 412 0.031
rna biosynthetic process GO:0032774 380 0.031
heterocycle catabolic process GO:0046700 167 0.031
single organism biosynthetic process GO:0044711 342 0.031
regulation of phosphorylation GO:0042325 248 0.031
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.031
negative regulation of cellular biosynthetic process GO:0031327 161 0.030
cellular component movement GO:0006928 248 0.030
regulation of phosphorus metabolic process GO:0051174 349 0.030
cellular response to stress GO:0033554 269 0.030
positive regulation of cell communication GO:0010647 271 0.029
regulation of multicellular organismal development GO:2000026 376 0.029
cellular component morphogenesis GO:0032989 155 0.029
regulation of cellular amino acid metabolic process GO:0006521 2 0.029
regulation of cell differentiation GO:0045595 320 0.028
regulation of cellular component organization GO:0051128 368 0.028
positive regulation of biosynthetic process GO:0009891 319 0.028
positive regulation of nucleic acid templated transcription GO:1903508 197 0.028
cellular response to hormone stimulus GO:0032870 247 0.027
positive regulation of cell differentiation GO:0045597 217 0.027
positive regulation of rna metabolic process GO:0051254 203 0.026
localization of cell GO:0051674 202 0.026
regulation of protein modification process GO:0031399 194 0.026
positive regulation of catalytic activity GO:0043085 184 0.026
cellular nitrogen compound catabolic process GO:0044270 163 0.026
organophosphate metabolic process GO:0019637 370 0.026
regulation of programmed cell death GO:0043067 341 0.026
regulation of signal transduction GO:0009966 318 0.026
cell projection morphogenesis GO:0048858 123 0.025
negative regulation of apoptotic process GO:0043066 181 0.025
metal ion transport GO:0030001 289 0.025
positive regulation of phosphorus metabolic process GO:0010562 262 0.025
positive regulation of rna biosynthetic process GO:1902680 197 0.025
protein complex subunit organization GO:0071822 302 0.025
positive regulation of cellular component organization GO:0051130 200 0.025
inorganic ion transmembrane transport GO:0098660 229 0.024
negative regulation of gene expression GO:0010629 199 0.024
aging GO:0007568 241 0.024
response to growth factor GO:0070848 189 0.024
cellular amine metabolic process GO:0044106 38 0.024
response to inorganic substance GO:0010035 377 0.024
aromatic compound catabolic process GO:0019439 168 0.024
small gtpase mediated signal transduction GO:0007264 36 0.024
nucleotide metabolic process GO:0009117 279 0.024
negative regulation of rna metabolic process GO:0051253 123 0.023
ribose phosphate metabolic process GO:0019693 235 0.023
regulation of phosphate metabolic process GO:0019220 349 0.023
purine ribonucleotide metabolic process GO:0009150 227 0.023
carbohydrate derivative metabolic process GO:1901135 346 0.023
regulation of anatomical structure morphogenesis GO:0022603 141 0.023
positive regulation of protein metabolic process GO:0051247 178 0.023
positive regulation of nervous system development GO:0051962 178 0.023
cell part morphogenesis GO:0032990 123 0.023
actin cytoskeleton organization GO:0030036 73 0.023
single organism catabolic process GO:0044712 283 0.022
brain development GO:0007420 247 0.022
regulation of apoptotic process GO:0042981 335 0.022
ion homeostasis GO:0050801 212 0.022
cell migration GO:0016477 197 0.022
positive regulation of cell proliferation GO:0008284 249 0.022
ras protein signal transduction GO:0007265 29 0.022
regulation of transcription dna templated GO:0006355 374 0.022
positive regulation of phosphorylation GO:0042327 177 0.022
positive regulation of cellular biosynthetic process GO:0031328 295 0.022
positive regulation of phosphate metabolic process GO:0045937 262 0.022
regulation of neuron projection development GO:0010975 161 0.022
positive regulation of intracellular signal transduction GO:1902533 138 0.021
cell motility GO:0048870 202 0.021
positive regulation of transcription dna templated GO:0045893 197 0.021
purine containing compound metabolic process GO:0072521 253 0.021
cell morphogenesis GO:0000902 142 0.021
catabolic process GO:0009056 351 0.021
cellular component assembly GO:0022607 360 0.021
nucleobase containing compound catabolic process GO:0034655 152 0.021
organic cyclic compound catabolic process GO:1901361 175 0.021
cellular chemical homeostasis GO:0055082 247 0.021
regulation of protein kinase activity GO:0045859 105 0.021
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.021
cytoskeleton organization GO:0007010 111 0.021
negative regulation of rna biosynthetic process GO:1902679 118 0.021
cation transmembrane transport GO:0098655 263 0.021
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.020
regulation of neuron differentiation GO:0045664 208 0.020
regulation of transferase activity GO:0051338 123 0.020
response to oxygen levels GO:0070482 265 0.020
response to peptide GO:1901652 292 0.020
macromolecular complex assembly GO:0065003 273 0.020
positive regulation of cell projection organization GO:0031346 111 0.020
nucleoside phosphate metabolic process GO:0006753 283 0.020
neuron projection morphogenesis GO:0048812 122 0.020
negative regulation of cell death GO:0060548 229 0.020
regeneration GO:0031099 163 0.020
purine ribonucleotide catabolic process GO:0009154 136 0.020
purine nucleoside metabolic process GO:0042278 169 0.020
neuron projection development GO:0031175 273 0.020
single organism reproductive process GO:0044702 297 0.020
regulation of cell development GO:0060284 263 0.020
nucleobase containing small molecule metabolic process GO:0055086 316 0.020
cell morphogenesis involved in differentiation GO:0000904 119 0.020
amine metabolic process GO:0009308 38 0.020
neuron development GO:0048666 286 0.019
cellular response to growth factor stimulus GO:0071363 162 0.019
cardiovascular system development GO:0072358 134 0.019
cellular response to peptide GO:1901653 133 0.019
ribonucleotide catabolic process GO:0009261 136 0.019
positive regulation of cellular protein metabolic process GO:0032270 167 0.019
regulation of cellular amine metabolic process GO:0033238 8 0.019
regulation of protein phosphorylation GO:0001932 183 0.019
actin filament based process GO:0030029 86 0.019
response to other organism GO:0051707 220 0.019
macromolecule localization GO:0033036 252 0.019
negative regulation of molecular function GO:0044092 133 0.019
regulation of neuron death GO:1901214 115 0.019
positive regulation of cell development GO:0010720 176 0.019
regulation of metal ion transport GO:0010959 118 0.019
cellular ketone metabolic process GO:0042180 51 0.019
secretion GO:0046903 307 0.019
response to nutrient GO:0007584 248 0.019
cellular component biogenesis GO:0044085 368 0.019
cellular response to oxygen containing compound GO:1901701 386 0.019
purine containing compound catabolic process GO:0072523 138 0.019
regulation of cellular ketone metabolic process GO:0010565 27 0.018
response to bacterium GO:0009617 200 0.018
response to wounding GO:0009611 254 0.018
nucleoside triphosphate metabolic process GO:0009141 144 0.018
negative regulation of biosynthetic process GO:0009890 168 0.018
positive regulation of molecular function GO:0044093 230 0.018
regulation of kinase activity GO:0043549 117 0.018
regulation of cell projection organization GO:0031344 175 0.018
cation homeostasis GO:0055080 195 0.018
tissue development GO:0009888 252 0.018
response to purine containing compound GO:0014074 126 0.018
negative regulation of transcription dna templated GO:0045892 116 0.017
cellular response to endogenous stimulus GO:0071495 377 0.017
chemical homeostasis GO:0048878 292 0.017
negative regulation of programmed cell death GO:0043069 183 0.017
organic acid metabolic process GO:0006082 292 0.017
macromolecular complex subunit organization GO:0043933 339 0.017
organic substance catabolic process GO:1901575 316 0.017
positive regulation of response to stimulus GO:0048584 285 0.017
blood circulation GO:0008015 183 0.017
protein complex biogenesis GO:0070271 263 0.017
response to hypoxia GO:0001666 231 0.017
nucleoside catabolic process GO:0009164 126 0.017
positive regulation of neurogenesis GO:0050769 165 0.017
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.017
muscle structure development GO:0061061 87 0.016
locomotion GO:0040011 237 0.016
multi organism reproductive process GO:0044703 262 0.016
cellular response to nitrogen compound GO:1901699 210 0.016
heart morphogenesis GO:0003007 3 0.016
organonitrogen compound catabolic process GO:1901565 179 0.016
positive regulation of protein modification process GO:0031401 142 0.016
regulation of neurogenesis GO:0050767 247 0.016
oxoacid metabolic process GO:0043436 290 0.016
cellular response to external stimulus GO:0071496 118 0.016
nucleoside phosphate catabolic process GO:1901292 140 0.016
circulatory system process GO:0003013 183 0.016
regulation of cellular catabolic process GO:0031329 101 0.016
nucleoside metabolic process GO:0009116 179 0.016
positive regulation of signal transduction GO:0009967 175 0.016
carbohydrate derivative catabolic process GO:1901136 147 0.015
negative regulation of multicellular organismal process GO:0051241 203 0.015
response to decreased oxygen levels GO:0036293 237 0.015
intracellular transport GO:0046907 185 0.015
ribonucleoside triphosphate metabolic process GO:0009199 141 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
ribonucleoside metabolic process GO:0009119 174 0.015
purine nucleotide metabolic process GO:0006163 229 0.015
purine nucleotide catabolic process GO:0006195 136 0.015
proteolysis GO:0006508 175 0.015
circulatory system development GO:0072359 134 0.015
inorganic cation transmembrane transport GO:0098662 202 0.015
positive regulation of protein phosphorylation GO:0001934 135 0.015
regulation of nervous system development GO:0051960 264 0.015
purine nucleoside triphosphate metabolic process GO:0009144 141 0.015
cellular amino acid metabolic process GO:0006520 107 0.015
head development GO:0060322 247 0.015
negative regulation of nucleic acid templated transcription GO:1903507 117 0.015
cellular response to lipid GO:0071396 201 0.015
cellular response to organic cyclic compound GO:0071407 202 0.015
anatomical structure formation involved in morphogenesis GO:0048646 83 0.015
response to acid chemical GO:0001101 222 0.014
regulation of nucleotide metabolic process GO:0006140 117 0.014
glycosyl compound metabolic process GO:1901657 182 0.014
ribonucleotide metabolic process GO:0009259 231 0.014
nucleotide catabolic process GO:0009166 139 0.014
regulation of canonical wnt signaling pathway GO:0060828 4 0.014
immune system process GO:0002376 204 0.014
purine ribonucleoside metabolic process GO:0046128 168 0.014
positive regulation of neuron projection development GO:0010976 99 0.014
regulation of cellular localization GO:0060341 263 0.014
wound healing GO:0042060 122 0.014
cellular response to insulin stimulus GO:0032869 81 0.014
cell cell signaling GO:0007267 335 0.014
sex differentiation GO:0007548 113 0.014
positive regulation of neuron differentiation GO:0045666 126 0.014
secretion by cell GO:0032940 248 0.013
response to peptide hormone GO:0043434 278 0.013
regulation of catabolic process GO:0009894 113 0.013
purine ribonucleoside catabolic process GO:0046130 124 0.013
muscle system process GO:0003012 115 0.013
neuron death GO:0070997 127 0.013
cardiac ventricle development GO:0003231 1 0.013
regulation of purine nucleotide metabolic process GO:1900542 115 0.013
multicellular organismal reproductive process GO:0048609 233 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
axis specification GO:0009798 4 0.013
nucleoside triphosphate catabolic process GO:0009143 123 0.013
cellular metal ion homeostasis GO:0006875 172 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.013
bmp signaling pathway GO:0030509 4 0.013
positive regulation of protein kinase activity GO:0045860 73 0.013
negative regulation of phosphate metabolic process GO:0045936 80 0.013
negative regulation of signaling GO:0023057 157 0.012
response to molecule of bacterial origin GO:0002237 194 0.012
ion transmembrane transport GO:0034220 365 0.012
response to estrogen GO:0043627 232 0.012
anterior posterior pattern specification GO:0009952 1 0.012
response to glucocorticoid GO:0051384 223 0.012
cardiac chamber development GO:0003205 1 0.012
response to temperature stimulus GO:0009266 94 0.012
eye morphogenesis GO:0048592 4 0.012
regulation of stem cell differentiation GO:2000736 2 0.012
defense response GO:0006952 194 0.012
protein localization GO:0008104 191 0.012
cell type specific apoptotic process GO:0097285 134 0.012
cellular response to cytokine stimulus GO:0071345 127 0.012
lipid metabolic process GO:0006629 283 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
cell cell signaling involved in cell fate commitment GO:0045168 2 0.012
forebrain development GO:0030900 98 0.012
cell adhesion GO:0007155 110 0.012
negative regulation of cell communication GO:0010648 158 0.012
purine nucleoside catabolic process GO:0006152 124 0.012
reproductive structure development GO:0048608 128 0.012
organophosphate catabolic process GO:0046434 148 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.012
guanosine containing compound catabolic process GO:1901069 71 0.012
response to oxidative stress GO:0006979 186 0.012
regulation of mapk cascade GO:0043408 116 0.012
cellular calcium ion homeostasis GO:0006874 160 0.012
regulation of proteasomal protein catabolic process GO:0061136 4 0.012
vasculature development GO:0001944 70 0.011
gtp metabolic process GO:0046039 72 0.011
response to estradiol GO:0032355 164 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 53 0.011
spermatogenesis GO:0007283 99 0.011
mapk cascade GO:0000165 140 0.011
response to corticosteroid GO:0031960 235 0.011
response to external biotic stimulus GO:0043207 221 0.011
metal ion homeostasis GO:0055065 186 0.011
tube development GO:0035295 89 0.011
reactive oxygen species metabolic process GO:0072593 37 0.011
carboxylic acid metabolic process GO:0019752 289 0.011
ribonucleoside triphosphate catabolic process GO:0009203 122 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.011
positive regulation of signaling GO:0023056 270 0.011
regulation of hydrolase activity GO:0051336 143 0.011
multicellular organism reproduction GO:0032504 233 0.011
peptidyl amino acid modification GO:0018193 126 0.011
negative regulation of protein metabolic process GO:0051248 114 0.011
glycosyl compound catabolic process GO:1901658 126 0.011
reproduction GO:0000003 245 0.011
cellular protein localization GO:0034613 122 0.011
regulation of nucleoside metabolic process GO:0009118 66 0.011
developmental process involved in reproduction GO:0003006 159 0.011
regulation of membrane potential GO:0042391 110 0.011
positive regulation of kinase activity GO:0033674 77 0.011
limb morphogenesis GO:0035108 4 0.011
negative regulation of cell differentiation GO:0045596 99 0.011
g protein coupled receptor signaling pathway GO:0007186 242 0.011
cellular cation homeostasis GO:0030003 180 0.010
negative regulation of canonical wnt signaling pathway GO:0090090 4 0.010
cellular response to steroid hormone stimulus GO:0071383 93 0.010
gastrulation GO:0007369 2 0.010
gliogenesis GO:0042063 93 0.010
positive regulation of mapk cascade GO:0043410 92 0.010
regulation of immune system process GO:0002682 123 0.010
gamete generation GO:0007276 124 0.010
regulation of organelle organization GO:0033043 80 0.010
negative regulation of response to stimulus GO:0048585 155 0.010
growth GO:0040007 165 0.010
neuron apoptotic process GO:0051402 88 0.010
regulation of blood circulation GO:1903522 110 0.010
protein oligomerization GO:0051259 191 0.010
positive regulation of cellular catabolic process GO:0031331 71 0.010
dendrite development GO:0016358 72 0.010
regulation of ion transport GO:0043269 245 0.010
muscle contraction GO:0006936 88 0.010
response to lipopolysaccharide GO:0032496 191 0.010
positive regulation of cell death GO:0010942 184 0.010
neurological system process GO:0050877 219 0.010
regulation of map kinase activity GO:0043405 53 0.010
positive regulation of transferase activity GO:0051347 81 0.010
rho protein signal transduction GO:0007266 11 0.010
urogenital system development GO:0001655 78 0.010
single organism intracellular transport GO:1902582 166 0.010
protein complex assembly GO:0006461 263 0.010
cellular response to extracellular stimulus GO:0031668 73 0.010

Nkd2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 0 0.054
disease of anatomical entity DOID:7 0 0.054
nervous system disease DOID:863 0 0.016
muscular disease DOID:0080000 0 0.012
central nervous system disease DOID:331 0 0.012
muscle tissue disease DOID:66 0 0.012
connective tissue disease DOID:65 0 0.010
myopathy DOID:423 0 0.010
bone disease DOID:0080001 0 0.010