Rattus norvegicus

0 known processes

Top3a

topoisomerase (DNA) III alpha

Top3a biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of rna metabolic process GO:0051252 391 0.058
regulation of nucleic acid templated transcription GO:1903506 380 0.058
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.057
regulation of phosphorus metabolic process GO:0051174 349 0.052
regulation of rna biosynthetic process GO:2001141 381 0.051
single organism biosynthetic process GO:0044711 342 0.051
regulation of phosphate metabolic process GO:0019220 349 0.051
tube development GO:0035295 89 0.049
regulation of phosphorylation GO:0042325 248 0.044
positive regulation of developmental process GO:0051094 283 0.044
cellular response to stress GO:0033554 269 0.043
Fly
regulation of signal transduction GO:0009966 318 0.043
rna biosynthetic process GO:0032774 380 0.042
cellular response to endogenous stimulus GO:0071495 377 0.041
cellular response to hormone stimulus GO:0032870 247 0.041
rna metabolic process GO:0016070 406 0.040
nucleic acid templated transcription GO:0097659 379 0.040
cellular component movement GO:0006928 248 0.039
regulation of molecular function GO:0065009 398 0.039
organic acid metabolic process GO:0006082 292 0.038
negative regulation of biosynthetic process GO:0009890 168 0.038
cell projection organization GO:0030030 302 0.037
positive regulation of biosynthetic process GO:0009891 319 0.037
positive regulation of phosphate metabolic process GO:0045937 262 0.037
cell migration GO:0016477 197 0.036
cellular component biogenesis GO:0044085 368 0.036
protein phosphorylation GO:0006468 345 0.036
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.035
negative regulation of metabolic process GO:0009892 331 0.035
regulation of cellular amino acid metabolic process GO:0006521 2 0.035
programmed cell death GO:0012501 392 0.035
regulation of transcription dna templated GO:0006355 374 0.035
cellular amino acid metabolic process GO:0006520 107 0.034
negative regulation of macromolecule metabolic process GO:0010605 260 0.034
positive regulation of cellular biosynthetic process GO:0031328 295 0.034
intracellular signal transduction GO:0035556 314 0.034
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.033
regulation of cellular amine metabolic process GO:0033238 8 0.033
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.033
positive regulation of rna biosynthetic process GO:1902680 197 0.032
positive regulation of nucleic acid templated transcription GO:1903508 197 0.032
regulation of neurogenesis GO:0050767 247 0.032
apoptotic process GO:0006915 381 0.032
macromolecule localization GO:0033036 252 0.031
single organism reproductive process GO:0044702 297 0.031
regulation of cellular ketone metabolic process GO:0010565 27 0.031
cellular component assembly GO:0022607 360 0.031
positive regulation of gene expression GO:0010628 244 0.030
cellular ketone metabolic process GO:0042180 51 0.030
positive regulation of rna metabolic process GO:0051254 203 0.029
anatomical structure morphogenesis GO:0009653 298 0.029
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.029
carboxylic acid metabolic process GO:0019752 289 0.029
response to carbohydrate GO:0009743 183 0.029
negative regulation of cellular metabolic process GO:0031324 281 0.028
positive regulation of molecular function GO:0044093 230 0.028
response to hypoxia GO:0001666 231 0.027
response to inorganic substance GO:0010035 377 0.026
cofactor metabolic process GO:0051186 95 0.026
organophosphate metabolic process GO:0019637 370 0.026
oxoacid metabolic process GO:0043436 290 0.026
multi organism reproductive process GO:0044703 262 0.025
regulation of cell development GO:0060284 263 0.025
response to estrogen GO:0043627 232 0.025
negative regulation of signaling GO:0023057 157 0.025
regulation of cell differentiation GO:0045595 320 0.024
positive regulation of multicellular organismal process GO:0051240 387 0.024
regulation of programmed cell death GO:0043067 341 0.024
regulation of cell proliferation GO:0042127 359 0.024
negative regulation of gene expression GO:0010629 199 0.024
regulation of cellular component movement GO:0051270 150 0.024
amine metabolic process GO:0009308 38 0.024
carbohydrate derivative metabolic process GO:1901135 346 0.023
positive regulation of cell development GO:0010720 176 0.023
cellular amine metabolic process GO:0044106 38 0.023
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.023
cell cell signaling GO:0007267 335 0.023
negative regulation of response to stimulus GO:0048585 155 0.023
regulation of catalytic activity GO:0050790 304 0.022
anterior posterior pattern specification GO:0009952 1 0.022
response to nutrient levels GO:0031667 370 0.022
regulation of purine nucleotide metabolic process GO:1900542 115 0.022
positive regulation of nervous system development GO:0051962 178 0.022
positive regulation of neurogenesis GO:0050769 165 0.022
positive regulation of cellular amine metabolic process GO:0033240 3 0.022
cellular response to oxygen containing compound GO:1901701 386 0.021
transcription dna templated GO:0006351 377 0.021
multicellular organism reproduction GO:0032504 233 0.021
negative regulation of multicellular organismal process GO:0051241 203 0.021
response to oxygen levels GO:0070482 265 0.021
positive regulation of phosphorus metabolic process GO:0010562 262 0.021
macromolecular complex assembly GO:0065003 273 0.021
regulation of nervous system development GO:0051960 264 0.021
regulation of intracellular signal transduction GO:1902531 218 0.021
positive regulation of transcription dna templated GO:0045893 197 0.021
cell motility GO:0048870 202 0.020
response to insulin GO:0032868 133 0.020
embryonic pattern specification GO:0009880 1 0.020
central nervous system development GO:0007417 311 0.020
reproductive process GO:0022414 372 0.020
response to extracellular stimulus GO:0009991 380 0.020
negative regulation of cell communication GO:0010648 158 0.020
response to decreased oxygen levels GO:0036293 237 0.019
neuron projection development GO:0031175 273 0.019
multicellular organism growth GO:0035264 1 0.019
cell morphogenesis involved in differentiation GO:0000904 119 0.019
ribose phosphate metabolic process GO:0019693 235 0.019
cellular response to organonitrogen compound GO:0071417 197 0.019
nucleobase containing small molecule metabolic process GO:0055086 316 0.019
nucleotide metabolic process GO:0009117 279 0.019
localization of cell GO:0051674 202 0.019
small gtpase mediated signal transduction GO:0007264 36 0.019
developmental process involved in reproduction GO:0003006 159 0.019
purine nucleotide metabolic process GO:0006163 229 0.019
protein complex biogenesis GO:0070271 263 0.019
neuron development GO:0048666 286 0.018
negative regulation of rna metabolic process GO:0051253 123 0.018
neuron differentiation GO:0030182 368 0.018
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.018
positive regulation of cell proliferation GO:0008284 249 0.018
nucleoside phosphate metabolic process GO:0006753 283 0.018
positive regulation of phosphorylation GO:0042327 177 0.018
axis specification GO:0009798 4 0.018
regulation of protein modification process GO:0031399 194 0.018
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.018
positive regulation of cell projection organization GO:0031346 111 0.018
negative regulation of molecular function GO:0044092 133 0.017
response to ethanol GO:0045471 162 0.017
regulation of cell migration GO:0030334 128 0.017
regulation of peptide transport GO:0090087 87 0.017
hepaticobiliary system development GO:0061008 90 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
multicellular organismal reproductive process GO:0048609 233 0.017
macromolecular complex subunit organization GO:0043933 339 0.017
transcription from rna polymerase ii promoter GO:0006366 252 0.017
positive regulation of protein phosphorylation GO:0001934 135 0.017
regulation of anatomical structure morphogenesis GO:0022603 141 0.016
positive regulation of cellular component organization GO:0051130 200 0.016
response to glucocorticoid GO:0051384 223 0.016
enzyme linked receptor protein signaling pathway GO:0007167 116 0.016
response to monosaccharide GO:0034284 159 0.016
female pregnancy GO:0007565 122 0.016
head development GO:0060322 247 0.016
positive regulation of cell differentiation GO:0045597 217 0.016
nucleoside metabolic process GO:0009116 179 0.016
positive regulation of protein modification process GO:0031401 142 0.016
locomotion GO:0040011 237 0.016
positive regulation of cell death GO:0010942 184 0.016
glycosyl compound metabolic process GO:1901657 182 0.016
response to estradiol GO:0032355 164 0.016
cellular response to nitrogen compound GO:1901699 210 0.016
gastrulation GO:0007369 2 0.015
lipid metabolic process GO:0006629 283 0.015
cellular response to reactive oxygen species GO:0034614 55 0.015
response to metal ion GO:0010038 253 0.015
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.015
ras protein signal transduction GO:0007265 29 0.015
gland development GO:0048732 155 0.015
regulation of cellular localization GO:0060341 263 0.015
homeostatic process GO:0042592 331 0.015
response to hexose GO:0009746 144 0.015
sexual reproduction GO:0019953 148 0.015
organonitrogen compound biosynthetic process GO:1901566 167 0.015
negative regulation of protein metabolic process GO:0051248 114 0.015
cation transport GO:0006812 382 0.015
positive regulation of neuron projection development GO:0010976 99 0.014
coenzyme metabolic process GO:0006732 86 0.014
cellular lipid metabolic process GO:0044255 208 0.014
regulation of protein phosphorylation GO:0001932 183 0.014
reproduction GO:0000003 245 0.014
peptidyl amino acid modification GO:0018193 126 0.014
positive regulation of apoptotic process GO:0043065 154 0.014
response to glucose GO:0009749 136 0.014
brain development GO:0007420 247 0.014
purine ribonucleotide catabolic process GO:0009154 136 0.014
regulation of cellular protein metabolic process GO:0032268 267 0.014
carbohydrate derivative biosynthetic process GO:1901137 124 0.014
positive regulation of catalytic activity GO:0043085 184 0.014
negative regulation of cellular protein metabolic process GO:0032269 106 0.014
single organism intracellular transport GO:1902582 166 0.014
purine ribonucleotide metabolic process GO:0009150 227 0.014
reproductive structure development GO:0048608 128 0.014
negative regulation of transcription dna templated GO:0045892 116 0.014
carbohydrate homeostasis GO:0033500 75 0.014
regulation of locomotion GO:0040012 148 0.014
response to peptide GO:1901652 292 0.014
negative regulation of nucleic acid templated transcription GO:1903507 117 0.014
regulation of cell projection organization GO:0031344 175 0.014
response to wounding GO:0009611 254 0.014
Fly
response to acid chemical GO:0001101 222 0.014
olfactory learning GO:0008355 1 0.013
response to growth factor GO:0070848 189 0.013
negative regulation of catalytic activity GO:0043086 103 0.013
intracellular transport GO:0046907 185 0.013
response to lipopolysaccharide GO:0032496 191 0.013
cellular response to insulin stimulus GO:0032869 81 0.013
regulation of protein metabolic process GO:0051246 289 0.013
regulation of kinase activity GO:0043549 117 0.013
reactive oxygen species metabolic process GO:0072593 37 0.013
positive regulation of response to stimulus GO:0048584 285 0.013
purine ribonucleoside metabolic process GO:0046128 168 0.013
regulation of nucleotide metabolic process GO:0006140 117 0.013
multi multicellular organism process GO:0044706 138 0.013
response to other organism GO:0051707 220 0.013
response to mechanical stimulus GO:0009612 134 0.013
response to corticosteroid GO:0031960 235 0.013
regulation of cell motility GO:2000145 131 0.013
negative regulation of signal transduction GO:0009968 83 0.013
cellular component morphogenesis GO:0032989 155 0.012
cellular response to oxidative stress GO:0034599 76 0.012
negative regulation of developmental process GO:0051093 125 0.012
response to peptide hormone GO:0043434 278 0.012
lipid storage GO:0019915 1 0.012
neurological system process GO:0050877 219 0.012
positive regulation of signaling GO:0023056 270 0.012
purine containing compound metabolic process GO:0072521 253 0.012
cell cycle GO:0007049 101 0.012
response to oxidative stress GO:0006979 186 0.012
regulation of cellular component organization GO:0051128 368 0.012
neuron projection morphogenesis GO:0048812 122 0.012
positive regulation of neuron differentiation GO:0045666 126 0.012
epithelium development GO:0060429 96 0.012
organ regeneration GO:0031100 101 0.012
circadian rhythm GO:0007623 88 0.012
amide transport GO:0042886 105 0.012
regulation of peptide secretion GO:0002791 82 0.012
positive regulation of protein metabolic process GO:0051247 178 0.012
negative regulation of cellular biosynthetic process GO:0031327 161 0.012
gamete generation GO:0007276 124 0.012
neuron death GO:0070997 127 0.012
nucleoside triphosphate metabolic process GO:0009141 144 0.012
embryonic axis specification GO:0000578 1 0.012
heterocycle catabolic process GO:0046700 167 0.012
ribonucleotide metabolic process GO:0009259 231 0.012
negative regulation of rna biosynthetic process GO:1902679 118 0.012
ribonucleoside metabolic process GO:0009119 174 0.012
aromatic compound catabolic process GO:0019439 168 0.012
response to hydrogen peroxide GO:0042542 89 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.012
regulation of cellular component biogenesis GO:0044087 86 0.012
regulation of anatomical structure size GO:0090066 135 0.012
organic substance catabolic process GO:1901575 316 0.012
positive regulation of signal transduction GO:0009967 175 0.011
growth GO:0040007 165 0.011
Fly
regulation of nucleoside metabolic process GO:0009118 66 0.011
positive regulation of intracellular signal transduction GO:1902533 138 0.011
steroid metabolic process GO:0008202 73 0.011
organic cyclic compound catabolic process GO:1901361 175 0.011
regulation of cellular catabolic process GO:0031329 101 0.011
single organism cellular localization GO:1902580 102 0.011
negative regulation of cell differentiation GO:0045596 99 0.011
protein complex assembly GO:0006461 263 0.011
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.011
urogenital system development GO:0001655 78 0.011
protein oligomerization GO:0051259 191 0.011
peptide transport GO:0015833 97 0.011
regulation of hydrolase activity GO:0051336 143 0.011
organ morphogenesis GO:0009887 75 0.011
protein complex subunit organization GO:0071822 302 0.011
telencephalon development GO:0021537 62 0.011
rhythmic process GO:0048511 156 0.011
cellular response to lipid GO:0071396 201 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
response to ketone GO:1901654 182 0.011
norepinephrine metabolic process GO:0042415 3 0.011
positive regulation of programmed cell death GO:0043068 157 0.011
cellular nitrogen compound catabolic process GO:0044270 163 0.011
positive regulation of kinase activity GO:0033674 77 0.011
negative regulation of cell death GO:0060548 229 0.011
ribose phosphate biosynthetic process GO:0046390 87 0.011
cellular response to growth factor stimulus GO:0071363 162 0.011
regulation of reactive oxygen species metabolic process GO:2000377 26 0.011
regulation of neuron projection development GO:0010975 161 0.011
peptidyl tyrosine modification GO:0018212 72 0.010
protein localization GO:0008104 191 0.010
defense response GO:0006952 194 0.010
response to reactive oxygen species GO:0000302 120 0.010
forebrain development GO:0030900 98 0.010
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.010
protein homooligomerization GO:0051260 91 0.010
nucleobase containing compound catabolic process GO:0034655 152 0.010
ribonucleoside triphosphate catabolic process GO:0009203 122 0.010
dna metabolic process GO:0006259 96 0.010
Human Fly
response to nutrient GO:0007584 248 0.010
regulation of catabolic process GO:0009894 113 0.010
heart morphogenesis GO:0003007 3 0.010
male gamete generation GO:0048232 99 0.010
cardiovascular system development GO:0072358 134 0.010
spermatogenesis GO:0007283 99 0.010

Top3a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.017
nervous system disease DOID:863 0 0.017
central nervous system disease DOID:331 0 0.012
disease of metabolism DOID:0014667 0 0.011