Rattus norvegicus

0 known processes

Top3b

topoisomerase (DNA) III beta

Top3b biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
rna metabolic process GO:0016070 406 0.065
rna biosynthetic process GO:0032774 380 0.056
catabolic process GO:0009056 351 0.049
Fly
nucleic acid templated transcription GO:0097659 379 0.041
negative regulation of cellular metabolic process GO:0031324 281 0.040
regulation of transcription dna templated GO:0006355 374 0.040
regulation of rna biosynthetic process GO:2001141 381 0.038
programmed cell death GO:0012501 392 0.038
organic cyclic compound catabolic process GO:1901361 175 0.036
Fly
purine nucleotide metabolic process GO:0006163 229 0.036
cellular component biogenesis GO:0044085 368 0.036
Fly
macromolecular complex subunit organization GO:0043933 339 0.035
organophosphate metabolic process GO:0019637 370 0.035
organelle organization GO:0006996 266 0.034
oxoacid metabolic process GO:0043436 290 0.034
regulation of nucleic acid templated transcription GO:1903506 380 0.034
negative regulation of macromolecule metabolic process GO:0010605 260 0.034
regulation of rna metabolic process GO:0051252 391 0.033
nucleotide metabolic process GO:0009117 279 0.031
heterocycle catabolic process GO:0046700 167 0.030
Fly
carboxylic acid metabolic process GO:0019752 289 0.030
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.030
macromolecular complex assembly GO:0065003 273 0.030
secretion GO:0046903 307 0.029
cellular catabolic process GO:0044248 295 0.029
Fly
protein complex subunit organization GO:0071822 302 0.029
single organism catabolic process GO:0044712 283 0.029
transcription dna templated GO:0006351 377 0.028
protein localization GO:0008104 191 0.028
regulation of protein metabolic process GO:0051246 289 0.028
nucleobase containing small molecule metabolic process GO:0055086 316 0.027
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.027
negative regulation of metabolic process GO:0009892 331 0.027
protein complex biogenesis GO:0070271 263 0.027
organic substance catabolic process GO:1901575 316 0.027
Fly
regulation of molecular function GO:0065009 398 0.026
nucleoside phosphate metabolic process GO:0006753 283 0.026
ribonucleotide metabolic process GO:0009259 231 0.026
protein complex assembly GO:0006461 263 0.025
macromolecule localization GO:0033036 252 0.025
regulation of phosphate metabolic process GO:0019220 349 0.024
secretion by cell GO:0032940 248 0.024
organonitrogen compound catabolic process GO:1901565 179 0.024
ribose phosphate metabolic process GO:0019693 235 0.024
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.024
carbohydrate derivative metabolic process GO:1901135 346 0.023
cellular amino acid metabolic process GO:0006520 107 0.023
regulation of phosphorus metabolic process GO:0051174 349 0.023
purine nucleoside metabolic process GO:0042278 169 0.023
organic acid metabolic process GO:0006082 292 0.023
nucleoside triphosphate catabolic process GO:0009143 123 0.023
intracellular signal transduction GO:0035556 314 0.023
reproductive process GO:0022414 372 0.023
positive regulation of cellular biosynthetic process GO:0031328 295 0.022
nucleoside catabolic process GO:0009164 126 0.022
neuron differentiation GO:0030182 368 0.022
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.022
ion transmembrane transport GO:0034220 365 0.022
anatomical structure morphogenesis GO:0009653 298 0.022
ribonucleoside triphosphate metabolic process GO:0009199 141 0.022
cation transport GO:0006812 382 0.022
aromatic compound catabolic process GO:0019439 168 0.022
Fly
single organism reproductive process GO:0044702 297 0.022
nucleoside triphosphate metabolic process GO:0009141 144 0.021
negative regulation of cell death GO:0060548 229 0.021
purine containing compound metabolic process GO:0072521 253 0.021
regulation of programmed cell death GO:0043067 341 0.021
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.021
purine ribonucleotide metabolic process GO:0009150 227 0.020
central nervous system development GO:0007417 311 0.020
transcription from rna polymerase ii promoter GO:0006366 252 0.020
carbohydrate derivative catabolic process GO:1901136 147 0.020
purine ribonucleoside metabolic process GO:0046128 168 0.020
positive regulation of cellular component organization GO:0051130 200 0.020
Fly
cellular response to stress GO:0033554 269 0.020
positive regulation of biosynthetic process GO:0009891 319 0.020
negative regulation of cellular biosynthetic process GO:0031327 161 0.020
regulation of protein modification process GO:0031399 194 0.019
protein oligomerization GO:0051259 191 0.019
positive regulation of developmental process GO:0051094 283 0.019
Fly
purine nucleoside catabolic process GO:0006152 124 0.019
cellular response to oxygen containing compound GO:1901701 386 0.019
amine metabolic process GO:0009308 38 0.019
ribonucleoside catabolic process GO:0042454 126 0.019
regulation of apoptotic process GO:0042981 335 0.019
neuron development GO:0048666 286 0.019
protein phosphorylation GO:0006468 345 0.018
nucleotide catabolic process GO:0009166 139 0.018
cellular nitrogen compound catabolic process GO:0044270 163 0.018
Fly
regulation of multicellular organismal development GO:2000026 376 0.018
Fly
regulation of signal transduction GO:0009966 318 0.018
single organism organelle organization GO:1902589 180 0.018
ribonucleotide catabolic process GO:0009261 136 0.018
cellular amine metabolic process GO:0044106 38 0.018
negative regulation of nucleic acid templated transcription GO:1903507 117 0.018
response to oxygen levels GO:0070482 265 0.018
peptidyl amino acid modification GO:0018193 126 0.018
regulation of cellular amino acid metabolic process GO:0006521 2 0.017
regulation of cellular component organization GO:0051128 368 0.017
Fly
ribonucleoside metabolic process GO:0009119 174 0.017
nucleoside metabolic process GO:0009116 179 0.017
ras protein signal transduction GO:0007265 29 0.017
positive regulation of multicellular organismal process GO:0051240 387 0.017
Fly
positive regulation of gene expression GO:0010628 244 0.017
cellular component assembly GO:0022607 360 0.017
Fly
cell projection organization GO:0030030 302 0.017
positive regulation of phosphorus metabolic process GO:0010562 262 0.017
neuron projection development GO:0031175 273 0.017
glycosyl compound catabolic process GO:1901658 126 0.017
transmembrane transport GO:0055085 412 0.017
regulation of phosphorylation GO:0042325 248 0.017
ribonucleoside triphosphate catabolic process GO:0009203 122 0.017
oxidation reduction process GO:0055114 304 0.017
cellular component movement GO:0006928 248 0.016
response to extracellular stimulus GO:0009991 380 0.016
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.016
glycosyl compound metabolic process GO:1901657 182 0.016
positive regulation of protein metabolic process GO:0051247 178 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.016
regulation of catalytic activity GO:0050790 304 0.016
positive regulation of cell differentiation GO:0045597 217 0.016
intracellular transport GO:0046907 185 0.016
purine ribonucleotide catabolic process GO:0009154 136 0.016
apoptotic process GO:0006915 381 0.016
homeostatic process GO:0042592 331 0.016
cellular homeostasis GO:0019725 252 0.016
purine nucleoside triphosphate metabolic process GO:0009144 141 0.016
cellular chemical homeostasis GO:0055082 247 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.015
regulation of cell differentiation GO:0045595 320 0.015
positive regulation of phosphate metabolic process GO:0045937 262 0.015
regulation of cellular amine metabolic process GO:0033238 8 0.015
nucleoside phosphate catabolic process GO:1901292 140 0.015
purine ribonucleoside catabolic process GO:0046130 124 0.015
nucleobase containing compound catabolic process GO:0034655 152 0.015
Fly
amino acid transport GO:0006865 70 0.015
positive regulation of molecular function GO:0044093 230 0.015
response to inorganic substance GO:0010035 377 0.015
small gtpase mediated signal transduction GO:0007264 36 0.015
regulation of cellular protein metabolic process GO:0032268 267 0.015
cellular macromolecule localization GO:0070727 122 0.015
negative regulation of rna metabolic process GO:0051253 123 0.015
purine containing compound catabolic process GO:0072523 138 0.015
cellular ketone metabolic process GO:0042180 51 0.015
purine nucleotide catabolic process GO:0006195 136 0.014
negative regulation of signaling GO:0023057 157 0.014
carboxylic acid transport GO:0046942 115 0.014
cellular protein localization GO:0034613 122 0.014
growth GO:0040007 165 0.014
positive regulation of cellular protein metabolic process GO:0032270 167 0.014
response to peptide hormone GO:0043434 278 0.014
regulation of hydrolase activity GO:0051336 143 0.014
response to radiation GO:0009314 137 0.014
multicellular organism reproduction GO:0032504 233 0.014
multi organism reproductive process GO:0044703 262 0.014
multicellular organismal reproductive process GO:0048609 233 0.014
aging GO:0007568 241 0.014
regulation of nucleotide metabolic process GO:0006140 117 0.014
negative regulation of biosynthetic process GO:0009890 168 0.014
regulation of cellular localization GO:0060341 263 0.014
negative regulation of rna biosynthetic process GO:1902679 118 0.014
positive regulation of phosphorylation GO:0042327 177 0.014
positive regulation of nervous system development GO:0051962 178 0.014
Fly
nitrogen compound transport GO:0071705 229 0.014
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.013
regulation of cellular ketone metabolic process GO:0010565 27 0.013
response to ethanol GO:0045471 162 0.013
organophosphate catabolic process GO:0046434 148 0.013
negative regulation of apoptotic process GO:0043066 181 0.013
negative regulation of cell communication GO:0010648 158 0.013
positive regulation of rna metabolic process GO:0051254 203 0.013
single organism biosynthetic process GO:0044711 342 0.013
organic anion transport GO:0015711 132 0.013
proteolysis GO:0006508 175 0.013
cation transmembrane transport GO:0098655 263 0.013
dna metabolic process GO:0006259 96 0.012
Fly
positive regulation of transcription dna templated GO:0045893 197 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.012
regulation of catabolic process GO:0009894 113 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.012
organic acid transport GO:0015849 116 0.012
negative regulation of response to stimulus GO:0048585 155 0.012
anion transport GO:0006820 178 0.012
regulation of system process GO:0044057 208 0.012
cellular component morphogenesis GO:0032989 155 0.012
negative regulation of molecular function GO:0044092 133 0.012
positive regulation of neurogenesis GO:0050769 165 0.012
reproduction GO:0000003 245 0.012
regulation of protein kinase activity GO:0045859 105 0.012
cellular response to hormone stimulus GO:0032870 247 0.012
regulation of secretion GO:0051046 224 0.012
cellular response to endogenous stimulus GO:0071495 377 0.012
negative regulation of gene expression GO:0010629 199 0.012
regulation of neuron differentiation GO:0045664 208 0.012
actin filament based process GO:0030029 86 0.012
positive regulation of rna biosynthetic process GO:1902680 197 0.012
regulation of nervous system development GO:0051960 264 0.012
Fly
positive regulation of catalytic activity GO:0043085 184 0.012
cellular response to cytokine stimulus GO:0071345 127 0.012
response to estradiol GO:0032355 164 0.012
regulation of protein phosphorylation GO:0001932 183 0.012
cytoplasmic transport GO:0016482 115 0.012
response to external biotic stimulus GO:0043207 221 0.012
regulation of nucleotide catabolic process GO:0030811 65 0.011
regulation of gtpase activity GO:0043087 57 0.011
synaptic growth at neuromuscular junction GO:0051124 1 0.011
positive regulation of protein modification process GO:0031401 142 0.011
response to decreased oxygen levels GO:0036293 237 0.011
mapk cascade GO:0000165 140 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.011
regulation of purine nucleotide metabolic process GO:1900542 115 0.011
response to hexose GO:0009746 144 0.011
regulation of intracellular signal transduction GO:1902531 218 0.011
regulation of cell proliferation GO:0042127 359 0.011
response to glucocorticoid GO:0051384 223 0.011
locomotion GO:0040011 237 0.011
regulation of membrane potential GO:0042391 110 0.011
regulation of neuron projection development GO:0010975 161 0.011
guanosine containing compound metabolic process GO:1901068 74 0.011
regulation of secretion by cell GO:1903530 208 0.011
response to peptide GO:1901652 292 0.011
multicellular organism growth GO:0035264 1 0.011
oligopeptide transport GO:0006857 4 0.011
gamete generation GO:0007276 124 0.011
response to oxidative stress GO:0006979 186 0.011
regulation of transferase activity GO:0051338 123 0.011
negative regulation of programmed cell death GO:0043069 183 0.011
signal release GO:0023061 145 0.010
response to acid chemical GO:0001101 222 0.010
purine nucleoside triphosphate catabolic process GO:0009146 122 0.010
gtp metabolic process GO:0046039 72 0.010
signal transduction by phosphorylation GO:0023014 144 0.010
cellular response to nitrogen compound GO:1901699 210 0.010
cellular macromolecular complex assembly GO:0034622 58 0.010
regulation of cell projection organization GO:0031344 175 0.010
cell growth GO:0016049 104 0.010
chemical homeostasis GO:0048878 292 0.010
cell cell signaling GO:0007267 335 0.010
Fly
regulation of cell development GO:0060284 263 0.010
inorganic cation transmembrane transport GO:0098662 202 0.010
negative regulation of catalytic activity GO:0043086 103 0.010
regulation of growth GO:0040008 105 0.010
negative regulation of protein metabolic process GO:0051248 114 0.010

Top3b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.033
nervous system disease DOID:863 0 0.033
sensory system disease DOID:0050155 0 0.023
eye and adnexa disease DOID:1492 0 0.016
eye disease DOID:5614 0 0.016
retinal disease DOID:5679 0 0.013
retinal degeneration DOID:8466 0 0.013
retinitis pigmentosa DOID:10584 0 0.013
central nervous system disease DOID:331 0 0.011
musculoskeletal system disease DOID:17 0 0.011