Rattus norvegicus

14 known processes

Mme

membrane metallo-endopeptidase

(Aliases: SFE,Nep,CD10,MGC93576)

Mme biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to hypoxia GO:0001666 231 0.105
Rat
organic acid metabolic process GO:0006082 292 0.105
carboxylic acid metabolic process GO:0019752 289 0.090
oxoacid metabolic process GO:0043436 290 0.087
intracellular signal transduction GO:0035556 314 0.065
Rat
response to metal ion GO:0010038 253 0.064
Rat
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.053
Rat
catabolic process GO:0009056 351 0.053
regulation of hormone levels GO:0010817 187 0.052
anatomical structure morphogenesis GO:0009653 298 0.051
carbohydrate derivative metabolic process GO:1901135 346 0.048
Rat
chemical homeostasis GO:0048878 292 0.047
cellular component movement GO:0006928 248 0.047
rna metabolic process GO:0016070 406 0.047
gland development GO:0048732 155 0.047
organelle organization GO:0006996 266 0.046
positive regulation of signal transduction GO:0009967 175 0.046
Rat
cellular homeostasis GO:0019725 252 0.045
cellular component biogenesis GO:0044085 368 0.045
locomotion GO:0040011 237 0.045
cellular response to endogenous stimulus GO:0071495 377 0.044
cell cell signaling GO:0007267 335 0.042
positive regulation of transport GO:0051050 245 0.042
central nervous system development GO:0007417 311 0.041
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.040
response to decreased oxygen levels GO:0036293 237 0.040
Rat
single organism biosynthetic process GO:0044711 342 0.040
Rat
single organism catabolic process GO:0044712 283 0.040
response to growth factor GO:0070848 189 0.039
cellular catabolic process GO:0044248 295 0.039
nucleic acid templated transcription GO:0097659 379 0.039
transcription dna templated GO:0006351 377 0.039
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.038
Rat
regulation of locomotion GO:0040012 148 0.038
cellular amino acid metabolic process GO:0006520 107 0.038
homeostatic process GO:0042592 331 0.038
cellular component assembly GO:0022607 360 0.037
rna biosynthetic process GO:0032774 380 0.036
regulation of nucleic acid templated transcription GO:1903506 380 0.036
nucleobase containing small molecule metabolic process GO:0055086 316 0.036
Rat
positive regulation of nucleic acid templated transcription GO:1903508 197 0.036
cellular ion homeostasis GO:0006873 184 0.035
response to inorganic substance GO:0010035 377 0.035
Rat
response to monosaccharide GO:0034284 159 0.034
positive regulation of biosynthetic process GO:0009891 319 0.034
Rat
regulation of rna metabolic process GO:0051252 391 0.034
ion homeostasis GO:0050801 212 0.034
organic substance catabolic process GO:1901575 316 0.034
cation homeostasis GO:0055080 195 0.034
cellular ketone metabolic process GO:0042180 51 0.033
regulation of cellular component organization GO:0051128 368 0.033
divalent inorganic cation homeostasis GO:0072507 165 0.033
head development GO:0060322 247 0.033
epithelium development GO:0060429 96 0.032
response to nutrient levels GO:0031667 370 0.032
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.031
ion transmembrane transport GO:0034220 365 0.031
secretion GO:0046903 307 0.030
negative regulation of metabolic process GO:0009892 331 0.029
macromolecular complex subunit organization GO:0043933 339 0.029
amine metabolic process GO:0009308 38 0.029
cellular cation homeostasis GO:0030003 180 0.029
transmembrane transport GO:0055085 412 0.028
regulation of transcription dna templated GO:0006355 374 0.028
positive regulation of rna biosynthetic process GO:1902680 197 0.028
regulation of rna biosynthetic process GO:2001141 381 0.028
ribonucleotide metabolic process GO:0009259 231 0.028
Rat
circulatory system process GO:0003013 183 0.027
Rat
cardiovascular system development GO:0072358 134 0.027
purine nucleotide metabolic process GO:0006163 229 0.027
Rat
cation transport GO:0006812 382 0.027
response to extracellular stimulus GO:0009991 380 0.027
regulation of cellular amino acid metabolic process GO:0006521 2 0.027
localization of cell GO:0051674 202 0.026
cellular amine metabolic process GO:0044106 38 0.026
nucleotide metabolic process GO:0009117 279 0.026
Rat
transcription from rna polymerase ii promoter GO:0006366 252 0.026
rhythmic process GO:0048511 156 0.026
heart morphogenesis GO:0003007 3 0.026
blood circulation GO:0008015 183 0.026
Rat
cellular divalent inorganic cation homeostasis GO:0072503 162 0.026
organonitrogen compound catabolic process GO:1901565 179 0.025
small molecule catabolic process GO:0044282 59 0.025
immune system process GO:0002376 204 0.025
positive regulation of rna metabolic process GO:0051254 203 0.025
cellular lipid metabolic process GO:0044255 208 0.025
regulation of cellular protein metabolic process GO:0032268 267 0.024
ribose phosphate metabolic process GO:0019693 235 0.024
Rat
cellular chemical homeostasis GO:0055082 247 0.024
macromolecular complex assembly GO:0065003 273 0.024
regulation of apoptotic process GO:0042981 335 0.024
cell motility GO:0048870 202 0.024
regulation of cellular ketone metabolic process GO:0010565 27 0.023
mesoderm development GO:0007498 2 0.023
cell adhesion GO:0007155 110 0.023
nitrogen compound transport GO:0071705 229 0.023
aging GO:0007568 241 0.023
Human
circulatory system development GO:0072359 134 0.023
regulation of cell proliferation GO:0042127 359 0.023
cation transmembrane transport GO:0098655 263 0.023
protein complex assembly GO:0006461 263 0.022
cell morphogenesis GO:0000902 142 0.022
positive regulation of developmental process GO:0051094 283 0.022
brain development GO:0007420 247 0.022
monocarboxylic acid metabolic process GO:0032787 152 0.022
heterocycle catabolic process GO:0046700 167 0.022
lipid metabolic process GO:0006629 283 0.022
nucleoside phosphate metabolic process GO:0006753 283 0.021
Rat
protein phosphorylation GO:0006468 345 0.021
response to carbohydrate GO:0009743 183 0.021
organic cyclic compound catabolic process GO:1901361 175 0.021
positive regulation of cell communication GO:0010647 271 0.021
Rat
response to glucose GO:0009749 136 0.021
behavior GO:0007610 205 0.021
protein complex subunit organization GO:0071822 302 0.021
positive regulation of phosphorus metabolic process GO:0010562 262 0.020
Rat
regulation of cell differentiation GO:0045595 320 0.020
cell migration GO:0016477 197 0.020
positive regulation of multicellular organismal process GO:0051240 387 0.020
Rat
response to peptide hormone GO:0043434 278 0.020
response to hexose GO:0009746 144 0.020
regulation of secretion by cell GO:1903530 208 0.020
response to glucocorticoid GO:0051384 223 0.020
kidney development GO:0001822 67 0.020
Human
purine containing compound metabolic process GO:0072521 253 0.020
Rat
positive regulation of gene expression GO:0010628 244 0.020
embryonic skeletal system morphogenesis GO:0048704 3 0.020
g protein coupled receptor signaling pathway GO:0007186 242 0.020
Rat
regulation of ion transport GO:0043269 245 0.020
hormone secretion GO:0046879 115 0.020
positive regulation of signaling GO:0023056 270 0.020
Rat
tissue development GO:0009888 252 0.020
regulation of cellular localization GO:0060341 263 0.019
response to alkaloid GO:0043279 132 0.019
cell projection organization GO:0030030 302 0.019
multi organism reproductive process GO:0044703 262 0.019
positive regulation of cell migration GO:0030335 96 0.019
response to transition metal nanoparticle GO:1990267 122 0.019
protein complex biogenesis GO:0070271 263 0.019
eye development GO:0001654 50 0.019
regulation of cellular amine metabolic process GO:0033238 8 0.019
response to ethanol GO:0045471 162 0.019
organophosphate metabolic process GO:0019637 370 0.019
Rat
positive regulation of cellular biosynthetic process GO:0031328 295 0.018
Rat
regulation of signal transduction GO:0009966 318 0.018
Rat
regulation of nervous system development GO:0051960 264 0.018
cellular component morphogenesis GO:0032989 155 0.018
regulation of catalytic activity GO:0050790 304 0.018
calcium ion homeostasis GO:0055074 162 0.018
single organism reproductive process GO:0044702 297 0.018
inorganic ion transmembrane transport GO:0098660 229 0.018
positive regulation of cell proliferation GO:0008284 249 0.018
purine ribonucleoside metabolic process GO:0046128 168 0.018
reproductive process GO:0022414 372 0.018
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.018
negative regulation of gene expression GO:0010629 199 0.018
regulation of cell migration GO:0030334 128 0.018
apoptotic process GO:0006915 381 0.017
Rat
negative regulation of cellular biosynthetic process GO:0031327 161 0.017
positive regulation of cellular amine metabolic process GO:0033240 3 0.017
dephosphorylation GO:0016311 98 0.017
protein oligomerization GO:0051259 191 0.017
aromatic compound catabolic process GO:0019439 168 0.017
positive regulation of secretion GO:0051047 140 0.017
positive regulation of molecular function GO:0044093 230 0.017
hormone transport GO:0009914 121 0.017
positive regulation of phosphate metabolic process GO:0045937 262 0.017
Rat
secretion by cell GO:0032940 248 0.017
sulfur amino acid metabolic process GO:0000096 9 0.017
taxis GO:0042330 67 0.017
small gtpase mediated signal transduction GO:0007264 36 0.017
single organism organelle organization GO:1902589 180 0.017
cardiac chamber development GO:0003205 1 0.017
regulation of phosphorus metabolic process GO:0051174 349 0.016
Rat
positive regulation of transcription dna templated GO:0045893 197 0.016
connective tissue development GO:0061448 33 0.016
nucleoside metabolic process GO:0009116 179 0.016
renal system development GO:0072001 67 0.016
Human
cellular metal ion homeostasis GO:0006875 172 0.016
regulation of cell motility GO:2000145 131 0.016
regulation of nucleotide metabolic process GO:0006140 117 0.016
Rat
response to estrogen GO:0043627 232 0.016
regulation of multicellular organismal development GO:2000026 376 0.016
purine nucleoside metabolic process GO:0042278 169 0.016
embryonic skeletal system development GO:0048706 3 0.016
neuron development GO:0048666 286 0.016
regulation of programmed cell death GO:0043067 341 0.016
positive regulation of cell differentiation GO:0045597 217 0.016
response to nutrient GO:0007584 248 0.016
sensory organ development GO:0007423 74 0.016
ras protein signal transduction GO:0007265 29 0.016
carbohydrate derivative catabolic process GO:1901136 147 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.016
carboxylic acid catabolic process GO:0046395 49 0.016
regulation of cell development GO:0060284 263 0.016
regulation of cell morphogenesis GO:0022604 77 0.015
proteolysis GO:0006508 175 0.015
cellular carbohydrate metabolic process GO:0044262 72 0.015
response to oxygen levels GO:0070482 265 0.015
Rat
regulation of molecular function GO:0065009 398 0.015
response to hydrogen peroxide GO:0042542 89 0.015
organ morphogenesis GO:0009887 75 0.015
organic anion transport GO:0015711 132 0.015
limb morphogenesis GO:0035108 4 0.015
synaptic transmission GO:0007268 235 0.015
response to acid chemical GO:0001101 222 0.015
action potential GO:0001508 54 0.015
regulation of neuron differentiation GO:0045664 208 0.015
cellular response to growth factor stimulus GO:0071363 162 0.015
oxidation reduction process GO:0055114 304 0.015
metal ion transport GO:0030001 289 0.015
cellular response to hormone stimulus GO:0032870 247 0.015
biological adhesion GO:0022610 110 0.015
embryonic appendage morphogenesis GO:0035113 4 0.015
response to oxidative stress GO:0006979 186 0.015
protein localization GO:0008104 191 0.015
purine containing compound catabolic process GO:0072523 138 0.015
mesenchymal cell proliferation GO:0010463 4 0.015
cell part morphogenesis GO:0032990 123 0.014
bmp signaling pathway GO:0030509 4 0.014
nucleobase containing compound catabolic process GO:0034655 152 0.014
regulation of purine nucleotide metabolic process GO:1900542 115 0.014
Rat
regulation of cell projection organization GO:0031344 175 0.014
negative regulation of programmed cell death GO:0043069 183 0.014
cofactor metabolic process GO:0051186 95 0.014
amide transport GO:0042886 105 0.014
cellular calcium ion homeostasis GO:0006874 160 0.014
cellular response to organic cyclic compound GO:0071407 202 0.014
purine nucleoside triphosphate metabolic process GO:0009144 141 0.014
cellular response to nitrogen compound GO:1901699 210 0.014
negative regulation of cell communication GO:0010648 158 0.014
negative regulation of rna metabolic process GO:0051253 123 0.014
eye morphogenesis GO:0048592 4 0.014
positive regulation of cell motility GO:2000147 97 0.014
positive regulation of response to stimulus GO:0048584 285 0.014
Rat
camera type eye development GO:0043010 48 0.014
salivary gland development GO:0007431 3 0.014
multicellular organism reproduction GO:0032504 233 0.014
axis specification GO:0009798 4 0.014
response to ketone GO:1901654 182 0.014
ribonucleoside metabolic process GO:0009119 174 0.014
macromolecule localization GO:0033036 252 0.014
neuron differentiation GO:0030182 368 0.014
peptide secretion GO:0002790 86 0.014
regulation of intracellular signal transduction GO:1902531 218 0.014
Rat
gastrulation GO:0007369 2 0.014
neuron projection development GO:0031175 273 0.014
organophosphate catabolic process GO:0046434 148 0.014
neurological system process GO:0050877 219 0.013
Mouse
alpha amino acid metabolic process GO:1901605 71 0.013
regulation of membrane potential GO:0042391 110 0.013
positive regulation of nucleotide metabolic process GO:0045981 91 0.013
Rat
nucleotide catabolic process GO:0009166 139 0.013
response to reactive oxygen species GO:0000302 120 0.013
reproduction GO:0000003 245 0.013
anterior posterior pattern specification GO:0009952 1 0.013
multi multicellular organism process GO:0044706 138 0.013
glycosyl compound metabolic process GO:1901657 182 0.013
vesicle mediated transport GO:0016192 181 0.013
chromosome segregation GO:0007059 2 0.013
regulation of mapk cascade GO:0043408 116 0.013
Rat
programmed cell death GO:0012501 392 0.013
Rat
multicellular organismal reproductive process GO:0048609 233 0.013
regulation of neurogenesis GO:0050767 247 0.013
metal ion homeostasis GO:0055065 186 0.012
purine nucleotide catabolic process GO:0006195 136 0.012
positive regulation of phosphorylation GO:0042327 177 0.012
chemotaxis GO:0006935 66 0.012
appendage morphogenesis GO:0035107 4 0.012
regulation of cellular component movement GO:0051270 150 0.012
negative regulation of macromolecule metabolic process GO:0010605 260 0.012
regulation of phosphorylation GO:0042325 248 0.012
Rat
sexual reproduction GO:0019953 148 0.012
enzyme linked receptor protein signaling pathway GO:0007167 116 0.012
positive regulation of mapk cascade GO:0043410 92 0.012
hepaticobiliary system development GO:0061008 90 0.012
carbohydrate derivative biosynthetic process GO:1901137 124 0.012
Rat
regulation of cellular catabolic process GO:0031329 101 0.012
skeletal system development GO:0001501 41 0.012
neuromuscular synaptic transmission GO:0007274 2 0.012
ribonucleotide catabolic process GO:0009261 136 0.012
positive regulation of cellular component movement GO:0051272 102 0.012
carbohydrate metabolic process GO:0005975 130 0.012
nucleoside triphosphate catabolic process GO:0009143 123 0.012
regulation of secretion GO:0051046 224 0.012
organic acid catabolic process GO:0016054 49 0.012
negative regulation of nucleic acid templated transcription GO:1903507 117 0.012
regulation of transmembrane transport GO:0034762 122 0.012
purine ribonucleotide metabolic process GO:0009150 227 0.012
Rat
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.012
organophosphate biosynthetic process GO:0090407 143 0.012
Rat
carbohydrate homeostasis GO:0033500 75 0.012
cellular response to organonitrogen compound GO:0071417 197 0.012
negative regulation of signaling GO:0023057 157 0.012
cellular response to steroid hormone stimulus GO:0071383 93 0.012
positive regulation of ion transport GO:0043270 94 0.012
positive regulation of cell development GO:0010720 176 0.012
organ formation GO:0048645 3 0.012
cellular response to oxygen containing compound GO:1901701 386 0.012
negative regulation of rna biosynthetic process GO:1902679 118 0.012
regulation of protein metabolic process GO:0051246 289 0.012
cell projection morphogenesis GO:0048858 123 0.012
regulation of canonical wnt signaling pathway GO:0060828 4 0.012
cellular nitrogen compound catabolic process GO:0044270 163 0.011
regulation of mesenchymal cell proliferation GO:0010464 4 0.011
coenzyme metabolic process GO:0006732 86 0.011
cell morphogenesis involved in differentiation GO:0000904 119 0.011
nucleoside phosphate catabolic process GO:1901292 140 0.011
nucleoside triphosphate metabolic process GO:0009141 144 0.011
gamete generation GO:0007276 124 0.011
single organism carbohydrate metabolic process GO:0044723 118 0.011
blood vessel development GO:0001568 69 0.011
actin filament based process GO:0030029 86 0.011
regulation of smooth muscle cell proliferation GO:0048660 75 0.011
multicellular organismal homeostasis GO:0048871 49 0.011
dna metabolic process GO:0006259 96 0.011
formation of primary germ layer GO:0001704 1 0.011
glucose homeostasis GO:0042593 75 0.011
lipid biosynthetic process GO:0008610 128 0.011
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.011
regulation of catabolic process GO:0009894 113 0.011
peptide transport GO:0015833 97 0.011
regulation of response to external stimulus GO:0032101 106 0.011
cellular modified amino acid metabolic process GO:0006575 61 0.011
positive regulation of protein metabolic process GO:0051247 178 0.011
purine ribonucleotide catabolic process GO:0009154 136 0.011
negative regulation of cellular metabolic process GO:0031324 281 0.011
positive regulation of nervous system development GO:0051962 178 0.011
carboxylic acid transport GO:0046942 115 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.011
inorganic cation transmembrane transport GO:0098662 202 0.011
response to corticosteroid GO:0031960 235 0.011
liver development GO:0001889 90 0.011
positive regulation of secretion by cell GO:1903532 128 0.011
regulation of stem cell differentiation GO:2000736 2 0.011
fatty acid metabolic process GO:0006631 99 0.011
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.011
positive regulation of cellular protein metabolic process GO:0032270 167 0.011
insecticide metabolic process GO:0017143 4 0.011
regulation of system process GO:0044057 208 0.011
Rat
response to peptide GO:1901652 292 0.011
regulation of transferase activity GO:0051338 123 0.010
positive regulation of nucleoside metabolic process GO:0045979 55 0.010
alcohol metabolic process GO:0006066 77 0.010
regulation of protein phosphorylation GO:0001932 183 0.010
cellular response to stress GO:0033554 269 0.010
positive regulation of locomotion GO:0040017 102 0.010
regulation of anatomical structure morphogenesis GO:0022603 141 0.010
organic acid transport GO:0015849 116 0.010
signal release GO:0023061 145 0.010
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.010
small molecule biosynthetic process GO:0044283 124 0.010
positive regulation of catabolic process GO:0009896 78 0.010
cytoskeleton organization GO:0007010 111 0.010
morphogenesis of embryonic epithelium GO:0016331 3 0.010
regulation of metal ion transport GO:0010959 118 0.010
tube development GO:0035295 89 0.010
anion transport GO:0006820 178 0.010
cell cell signaling involved in cell fate commitment GO:0045168 2 0.010
cardiac ventricle development GO:0003231 1 0.010
transmission of nerve impulse GO:0019226 42 0.010
cellular hormone metabolic process GO:0034754 49 0.010
spermatogenesis GO:0007283 99 0.010
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.010
cyclic purine nucleotide metabolic process GO:0052652 62 0.010
Rat
positive regulation of catalytic activity GO:0043085 184 0.010
negative regulation of canonical wnt signaling pathway GO:0090090 4 0.010
negative regulation of catalytic activity GO:0043086 103 0.010

Mme disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.025
disease of cellular proliferation DOID:14566 0 0.025
organ system cancer DOID:0050686 0 0.025
disease of anatomical entity DOID:7 0 0.024
nervous system disease DOID:863 0 0.024
musculoskeletal system disease DOID:17 0 0.019
disease of metabolism DOID:0014667 0 0.013
central nervous system disease DOID:331 0 0.010