Rattus norvegicus

0 known processes

Mdc1

mediator of DNA damage checkpoint 1

(Aliases: KIAA0170)

Mdc1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
rna biosynthetic process GO:0032774 380 0.080
rna metabolic process GO:0016070 406 0.076
regulation of rna biosynthetic process GO:2001141 381 0.076
nucleic acid templated transcription GO:0097659 379 0.075
negative regulation of gene expression GO:0010629 199 0.074
transcription from rna polymerase ii promoter GO:0006366 252 0.067
oxoacid metabolic process GO:0043436 290 0.065
regulation of nucleic acid templated transcription GO:1903506 380 0.064
carboxylic acid metabolic process GO:0019752 289 0.059
regulation of rna metabolic process GO:0051252 391 0.057
regulation of transcription dna templated GO:0006355 374 0.054
transcription dna templated GO:0006351 377 0.053
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.049
negative regulation of cellular biosynthetic process GO:0031327 161 0.045
negative regulation of biosynthetic process GO:0009890 168 0.045
organic substance catabolic process GO:1901575 316 0.045
negative regulation of metabolic process GO:0009892 331 0.042
organic acid metabolic process GO:0006082 292 0.041
regulation of cellular component organization GO:0051128 368 0.041
positive regulation of gene expression GO:0010628 244 0.041
negative regulation of rna metabolic process GO:0051253 123 0.041
positive regulation of biosynthetic process GO:0009891 319 0.041
organelle organization GO:0006996 266 0.040
negative regulation of cellular metabolic process GO:0031324 281 0.040
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.038
head development GO:0060322 247 0.037
carbohydrate derivative metabolic process GO:1901135 346 0.036
central nervous system development GO:0007417 311 0.036
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.035
organophosphate metabolic process GO:0019637 370 0.035
cellular amino acid metabolic process GO:0006520 107 0.034
nucleobase containing small molecule metabolic process GO:0055086 316 0.034
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.034
regulation of cell development GO:0060284 263 0.033
macromolecular complex subunit organization GO:0043933 339 0.033
negative regulation of macromolecule metabolic process GO:0010605 260 0.032
regulation of nervous system development GO:0051960 264 0.031
response to acid chemical GO:0001101 222 0.031
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.030
positive regulation of developmental process GO:0051094 283 0.030
intracellular signal transduction GO:0035556 314 0.030
nucleotide metabolic process GO:0009117 279 0.030
dna metabolic process GO:0006259 96 0.030
positive regulation of nucleic acid templated transcription GO:1903508 197 0.029
cellular response to oxygen containing compound GO:1901701 386 0.029
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.029
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.029
reproduction GO:0000003 245 0.029
neuron differentiation GO:0030182 368 0.028
cell projection organization GO:0030030 302 0.028
positive regulation of rna metabolic process GO:0051254 203 0.028
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.028
regulation of cellular amine metabolic process GO:0033238 8 0.027
nucleoside phosphate metabolic process GO:0006753 283 0.027
mechanoreceptor differentiation GO:0042490 2 0.027
single organism catabolic process GO:0044712 283 0.027
macromolecular complex assembly GO:0065003 273 0.026
cellular response to stress GO:0033554 269 0.026
regulation of cell differentiation GO:0045595 320 0.025
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.025
positive regulation of transcription dna templated GO:0045893 197 0.025
positive regulation of nervous system development GO:0051962 178 0.025
positive regulation of cellular biosynthetic process GO:0031328 295 0.025
positive regulation of cell differentiation GO:0045597 217 0.025
protein complex biogenesis GO:0070271 263 0.025
regulation of cellular ketone metabolic process GO:0010565 27 0.024
negative regulation of rna biosynthetic process GO:1902679 118 0.024
regulation of molecular function GO:0065009 398 0.024
positive regulation of rna biosynthetic process GO:1902680 197 0.024
chromosome segregation GO:0007059 2 0.024
response to estrogen GO:0043627 232 0.024
catabolic process GO:0009056 351 0.023
cellular catabolic process GO:0044248 295 0.023
brain development GO:0007420 247 0.023
positive regulation of multicellular organismal process GO:0051240 387 0.023
cofactor metabolic process GO:0051186 95 0.023
single organism intracellular transport GO:1902582 166 0.023
regulation of proteasomal protein catabolic process GO:0061136 4 0.022
response to molecule of bacterial origin GO:0002237 194 0.022
purine containing compound metabolic process GO:0072521 253 0.022
nucleoside metabolic process GO:0009116 179 0.022
anatomical structure morphogenesis GO:0009653 298 0.022
macromolecule localization GO:0033036 252 0.022
negative regulation of nucleic acid templated transcription GO:1903507 117 0.021
negative regulation of transcription dna templated GO:0045892 116 0.021
purine nucleotide metabolic process GO:0006163 229 0.021
single organism organelle organization GO:1902589 180 0.021
regulation of multicellular organismal development GO:2000026 376 0.021
positive regulation of cellular component organization GO:0051130 200 0.021
response to peptide hormone GO:0043434 278 0.021
reproductive process GO:0022414 372 0.020
cellular component biogenesis GO:0044085 368 0.020
response to extracellular stimulus GO:0009991 380 0.020
regulation of cellular amino acid metabolic process GO:0006521 2 0.020
cellular response to endogenous stimulus GO:0071495 377 0.020
multicellular organism reproduction GO:0032504 233 0.020
cellular modified amino acid metabolic process GO:0006575 61 0.020
cellular response to hormone stimulus GO:0032870 247 0.020
intracellular transport GO:0046907 185 0.020
neuron projection development GO:0031175 273 0.020
purine nucleoside metabolic process GO:0042278 169 0.020
cellular amine metabolic process GO:0044106 38 0.020
ribose phosphate metabolic process GO:0019693 235 0.019
response to nutrient levels GO:0031667 370 0.019
ribonucleotide metabolic process GO:0009259 231 0.019
purine ribonucleotide metabolic process GO:0009150 227 0.019
double strand break repair GO:0006302 1 0.019
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.019
aging GO:0007568 241 0.019
neuron development GO:0048666 286 0.019
response to biotic stimulus GO:0009607 226 0.019
cellular ketone metabolic process GO:0042180 51 0.019
regulation of apoptotic process GO:0042981 335 0.019
positive regulation of cell development GO:0010720 176 0.019
cellular nitrogen compound catabolic process GO:0044270 163 0.019
regulation of protein metabolic process GO:0051246 289 0.019
regulation of phosphorus metabolic process GO:0051174 349 0.018
locomotion GO:0040011 237 0.018
protein complex assembly GO:0006461 263 0.018
amine metabolic process GO:0009308 38 0.018
single organism reproductive process GO:0044702 297 0.018
response to nutrient GO:0007584 248 0.018
regulation of neurogenesis GO:0050767 247 0.018
chemical homeostasis GO:0048878 292 0.018
small gtpase mediated signal transduction GO:0007264 36 0.018
cellular component movement GO:0006928 248 0.018
protein complex subunit organization GO:0071822 302 0.018
regulation of programmed cell death GO:0043067 341 0.017
spindle organization GO:0007051 2 0.017
programmed cell death GO:0012501 392 0.017
response to other organism GO:0051707 220 0.017
organic cyclic compound catabolic process GO:1901361 175 0.017
regulation of neuron differentiation GO:0045664 208 0.017
regulation of catalytic activity GO:0050790 304 0.017
taxis GO:0042330 67 0.017
coenzyme metabolic process GO:0006732 86 0.017
cellular macromolecule localization GO:0070727 122 0.017
nucleobase containing compound catabolic process GO:0034655 152 0.017
multicellular organismal reproductive process GO:0048609 233 0.017
anterior posterior pattern specification GO:0009952 1 0.016
regulation of signal transduction GO:0009966 318 0.016
cellular component assembly GO:0022607 360 0.016
chromosome organization GO:0051276 36 0.016
response to lipopolysaccharide GO:0032496 191 0.016
apoptotic process GO:0006915 381 0.016
alpha amino acid metabolic process GO:1901605 71 0.016
ribonucleoside metabolic process GO:0009119 174 0.016
response to bacterium GO:0009617 200 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.016
response to inorganic substance GO:0010035 377 0.016
positive regulation of neurogenesis GO:0050769 165 0.016
response to vitamin GO:0033273 131 0.016
heterocycle catabolic process GO:0046700 167 0.016
gastrulation GO:0007369 2 0.016
inner ear receptor cell differentiation GO:0060113 2 0.015
positive regulation of molecular function GO:0044093 230 0.015
glycosyl compound metabolic process GO:1901657 182 0.015
organonitrogen compound catabolic process GO:1901565 179 0.015
tissue development GO:0009888 252 0.015
multi organism reproductive process GO:0044703 262 0.015
cell motility GO:0048870 202 0.015
nucleoside triphosphate catabolic process GO:0009143 123 0.015
nitrogen compound transport GO:0071705 229 0.015
protein localization GO:0008104 191 0.015
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.015
positive regulation of cell proliferation GO:0008284 249 0.015
response to external biotic stimulus GO:0043207 221 0.014
regulation of cell projection organization GO:0031344 175 0.014
microtubule organizing center organization GO:0031023 1 0.014
secretion GO:0046903 307 0.014
carbohydrate derivative catabolic process GO:1901136 147 0.014
cell cell signaling GO:0007267 335 0.014
tube development GO:0035295 89 0.014
response to metal ion GO:0010038 253 0.014
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
sulfur compound metabolic process GO:0006790 70 0.014
protein oligomerization GO:0051259 191 0.014
regulation of neuron projection development GO:0010975 161 0.014
response to ketone GO:1901654 182 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
positive regulation of neuron differentiation GO:0045666 126 0.014
protein phosphorylation GO:0006468 345 0.014
glycosyl compound catabolic process GO:1901658 126 0.014
peptidyl amino acid modification GO:0018193 126 0.014
epithelium development GO:0060429 96 0.013
regulation of anatomical structure morphogenesis GO:0022603 141 0.013
establishment of protein localization GO:0045184 141 0.013
cellular homeostasis GO:0019725 252 0.013
single organism biosynthetic process GO:0044711 342 0.013
axis specification GO:0009798 4 0.013
purine ribonucleoside catabolic process GO:0046130 124 0.013
negative regulation of multicellular organismal process GO:0051241 203 0.013
ras protein signal transduction GO:0007265 29 0.013
proteolysis GO:0006508 175 0.013
single organism cellular localization GO:1902580 102 0.013
positive regulation of response to stimulus GO:0048584 285 0.013
carbohydrate derivative biosynthetic process GO:1901137 124 0.013
tube formation GO:0035148 3 0.013
gland development GO:0048732 155 0.013
regulation of cellular protein metabolic process GO:0032268 267 0.013
nucleoside triphosphate metabolic process GO:0009141 144 0.013
positive regulation of protein modification process GO:0031401 142 0.013
response to corticosteroid GO:0031960 235 0.013
negative regulation of cell communication GO:0010648 158 0.013
cellular response to nitrogen compound GO:1901699 210 0.013
positive regulation of signaling GO:0023056 270 0.013
regulation of phosphate metabolic process GO:0019220 349 0.013
vesicle mediated transport GO:0016192 181 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.013
reactive oxygen species metabolic process GO:0072593 37 0.013
ribonucleoside catabolic process GO:0042454 126 0.013
cytoplasmic transport GO:0016482 115 0.012
nuclear transport GO:0051169 49 0.012
cell cycle GO:0007049 101 0.012
meiotic cell cycle process GO:1903046 3 0.012
negative regulation of cellular component organization GO:0051129 83 0.012
regulation of cellular localization GO:0060341 263 0.012
mitotic spindle organization GO:0007052 2 0.012
positive regulation of neuron projection development GO:0010976 99 0.012
regulation of cell cycle GO:0051726 73 0.012
negative regulation of transport GO:0051051 136 0.012
protein transport GO:0015031 132 0.012
aromatic compound catabolic process GO:0019439 168 0.012
urogenital system development GO:0001655 78 0.012
gamete generation GO:0007276 124 0.012
oligopeptide transport GO:0006857 4 0.012
negative regulation of programmed cell death GO:0043069 183 0.012
regulation of phosphorylation GO:0042325 248 0.012
positive regulation of catalytic activity GO:0043085 184 0.012
morphogenesis of embryonic epithelium GO:0016331 3 0.012
cell morphogenesis involved in differentiation GO:0000904 119 0.012
ribonucleoside triphosphate catabolic process GO:0009203 122 0.011
nucleoside monophosphate metabolic process GO:0009123 93 0.011
negative regulation of developmental process GO:0051093 125 0.011
small molecule biosynthetic process GO:0044283 124 0.011
response to peptide GO:1901652 292 0.011
embryonic pattern specification GO:0009880 1 0.011
regulation of cell proliferation GO:0042127 359 0.011
cell cycle checkpoint GO:0000075 2 0.011
eye morphogenesis GO:0048592 4 0.011
heart morphogenesis GO:0003007 3 0.011
negative regulation of signaling GO:0023057 157 0.011
endocytosis GO:0006897 84 0.011
sexual reproduction GO:0019953 148 0.011
organophosphate catabolic process GO:0046434 148 0.011
nucleoside catabolic process GO:0009164 126 0.011
limb morphogenesis GO:0035108 4 0.011
homeostatic process GO:0042592 331 0.011
purine nucleoside triphosphate metabolic process GO:0009144 141 0.011
purine ribonucleoside metabolic process GO:0046128 168 0.011
metal ion transport GO:0030001 289 0.011
purine nucleoside catabolic process GO:0006152 124 0.011
positive regulation of cellular protein metabolic process GO:0032270 167 0.011
response to ethanol GO:0045471 162 0.011
regulation of intracellular signal transduction GO:1902531 218 0.011
regulation of reactive oxygen species metabolic process GO:2000377 26 0.011
circulatory system development GO:0072359 134 0.011
developmental process involved in reproduction GO:0003006 159 0.010
response to cytokine GO:0034097 215 0.010
purine nucleotide catabolic process GO:0006195 136 0.010
histone h3 k9 methylation GO:0051567 1 0.010
cation transport GO:0006812 382 0.010
carboxylic acid transport GO:0046942 115 0.010
response to oxidative stress GO:0006979 186 0.010
cellular chemical homeostasis GO:0055082 247 0.010
chromatin assembly or disassembly GO:0006333 1 0.010
inner ear morphogenesis GO:0042472 1 0.010
organic acid transport GO:0015849 116 0.010
positive regulation of phosphate metabolic process GO:0045937 262 0.010
multicellular organism growth GO:0035264 1 0.010

Mdc1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.019
disease of cellular proliferation DOID:14566 0 0.019
organ system cancer DOID:0050686 0 0.015
disease of anatomical entity DOID:7 0 0.014
nervous system disease DOID:863 0 0.014
gastrointestinal system cancer DOID:3119 0 0.014
intestinal cancer DOID:10155 0 0.014
sensory system disease DOID:0050155 0 0.011