Rattus norvegicus

0 known processes

Spag4

sperm associated antigen 4

Spag4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
response to organophosphorus GO:0046683 102 0.169
positive regulation of cell death GO:0010942 184 0.164
intracellular signal transduction GO:0035556 314 0.102
negative regulation of multicellular organismal process GO:0051241 203 0.099
cellular response to oxygen containing compound GO:1901701 386 0.094
response to purine containing compound GO:0014074 126 0.073
programmed cell death GO:0012501 392 0.072
positive regulation of programmed cell death GO:0043068 157 0.066
cellular cation homeostasis GO:0030003 180 0.066
calcium ion import GO:0070509 22 0.055
cellular calcium ion homeostasis GO:0006874 160 0.053
central nervous system development GO:0007417 311 0.052
negative regulation of signaling GO:0023057 157 0.052
regulation of cellular protein metabolic process GO:0032268 267 0.050
organophosphate metabolic process GO:0019637 370 0.050
positive regulation of apoptotic process GO:0043065 154 0.048
metal ion homeostasis GO:0055065 186 0.047
cation transport GO:0006812 382 0.046
secretion GO:0046903 307 0.045
calcium ion transport GO:0006816 131 0.044
negative regulation of gene expression GO:0010629 199 0.043
negative regulation of developmental process GO:0051093 125 0.042
regulation of system process GO:0044057 208 0.042
regulation of blood circulation GO:1903522 110 0.041
regeneration GO:0031099 163 0.041
secretion by cell GO:0032940 248 0.040
positive regulation of multicellular organismal process GO:0051240 387 0.039
negative regulation of cellular metabolic process GO:0031324 281 0.039
regulation of cell proliferation GO:0042127 359 0.039
regulation of programmed cell death GO:0043067 341 0.039
negative regulation of macromolecule metabolic process GO:0010605 260 0.038
transmission of nerve impulse GO:0019226 42 0.038
nucleic acid templated transcription GO:0097659 379 0.037
negative regulation of metabolic process GO:0009892 331 0.037
cellular response to peptide GO:1901653 133 0.037
response to camp GO:0051591 91 0.036
cellular metal ion homeostasis GO:0006875 172 0.036
hormone secretion GO:0046879 115 0.036
regulation of protein metabolic process GO:0051246 289 0.035
cellular chemical homeostasis GO:0055082 247 0.035
catabolic process GO:0009056 351 0.035
cytosolic calcium ion homeostasis GO:0051480 140 0.035
regulation of apoptotic process GO:0042981 335 0.034
cation homeostasis GO:0055080 195 0.033
response to decreased oxygen levels GO:0036293 237 0.032
regulation of metal ion transport GO:0010959 118 0.032
nucleoside phosphate metabolic process GO:0006753 283 0.032
response to hypoxia GO:0001666 231 0.031
biological adhesion GO:0022610 110 0.031
hormone transport GO:0009914 121 0.030
regulation of endocrine process GO:0044060 21 0.029
regulation of phosphorus metabolic process GO:0051174 349 0.029
nucleotide metabolic process GO:0009117 279 0.029
regulation of molecular function GO:0065009 398 0.029
cellular ion homeostasis GO:0006873 184 0.028
proteolysis GO:0006508 175 0.028
circulatory system process GO:0003013 183 0.028
regulation of cellular localization GO:0060341 263 0.028
cellular ketone metabolic process GO:0042180 51 0.028
negative regulation of cell communication GO:0010648 158 0.027
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.027
g protein coupled receptor signaling pathway GO:0007186 242 0.027
cellular response to nitrogen compound GO:1901699 210 0.027
response to oxygen levels GO:0070482 265 0.027
calcium ion homeostasis GO:0055074 162 0.027
divalent inorganic cation transport GO:0072511 134 0.026
apoptotic process GO:0006915 381 0.026
cellular amine metabolic process GO:0044106 38 0.026
organophosphate catabolic process GO:0046434 148 0.026
regulation of cyclic nucleotide biosynthetic process GO:0030802 45 0.025
metal ion transport GO:0030001 289 0.025
positive regulation of phosphorus metabolic process GO:0010562 262 0.025
reproductive process GO:0022414 372 0.025
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.025
single organism biosynthetic process GO:0044711 342 0.025
single organism catabolic process GO:0044712 283 0.024
cell adhesion GO:0007155 110 0.024
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.024
tissue development GO:0009888 252 0.024
negative regulation of biosynthetic process GO:0009890 168 0.024
organic substance catabolic process GO:1901575 316 0.024
negative regulation of transport GO:0051051 136 0.023
motor neuron axon guidance GO:0008045 1 0.023
regulation of ion transmembrane transport GO:0034765 121 0.023
amine metabolic process GO:0009308 38 0.023
action potential GO:0001508 54 0.023
synaptic transmission GO:0007268 235 0.023
reactive oxygen species biosynthetic process GO:1903409 8 0.022
positive regulation of cell proliferation GO:0008284 249 0.022
small gtpase mediated signal transduction GO:0007264 36 0.022
regulation of cellular ketone metabolic process GO:0010565 27 0.022
positive regulation of biosynthetic process GO:0009891 319 0.022
negative regulation of cell differentiation GO:0045596 99 0.022
cyclic nucleotide metabolic process GO:0009187 80 0.022
reactive nitrogen species metabolic process GO:2001057 1 0.022
brain development GO:0007420 247 0.022
carbohydrate derivative biosynthetic process GO:1901137 124 0.021
head development GO:0060322 247 0.021
single organism intracellular transport GO:1902582 166 0.021
response to extracellular stimulus GO:0009991 380 0.021
macromolecule localization GO:0033036 252 0.021
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.021
protein complex subunit organization GO:0071822 302 0.021
regulation of cellular component organization GO:0051128 368 0.021
regulation of calcium ion transport GO:0051924 77 0.021
cellular divalent inorganic cation homeostasis GO:0072503 162 0.020
regulation of secretion by cell GO:1903530 208 0.020
purine ribonucleotide metabolic process GO:0009150 227 0.020
reactive oxygen species metabolic process GO:0072593 37 0.019
positive regulation of cellular component organization GO:0051130 200 0.019
response to peptide hormone GO:0043434 278 0.019
negative regulation of nervous system development GO:0051961 79 0.019
blood circulation GO:0008015 183 0.018
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.018
acid secretion GO:0046717 48 0.018
response to growth factor GO:0070848 189 0.018
ras protein signal transduction GO:0007265 29 0.018
endocrine hormone secretion GO:0060986 21 0.018
cell projection organization GO:0030030 302 0.018
regulation of blood pressure GO:0008217 83 0.018
organelle organization GO:0006996 266 0.018
developmental growth GO:0048589 100 0.018
regulation of transmembrane transport GO:0034762 122 0.018
response to acid chemical GO:0001101 222 0.017
carboxylic acid metabolic process GO:0019752 289 0.017
gamete generation GO:0007276 124 0.017
macromolecular complex subunit organization GO:0043933 339 0.017
regulation of rna metabolic process GO:0051252 391 0.017
neuronal action potential GO:0019228 35 0.017
negative regulation of neurogenesis GO:0050768 78 0.017
negative regulation of nucleic acid templated transcription GO:1903507 117 0.017
protein complex biogenesis GO:0070271 263 0.016
positive regulation of nervous system development GO:0051962 178 0.016
cellular component morphogenesis GO:0032989 155 0.016
neuron development GO:0048666 286 0.016
ribose phosphate metabolic process GO:0019693 235 0.016
signal release GO:0023061 145 0.016
positive regulation of neuron projection development GO:0010976 99 0.016
response to temperature stimulus GO:0009266 94 0.016
nucleoside phosphate biosynthetic process GO:1901293 102 0.016
ventral spinal cord development GO:0021517 3 0.016
cellular response to organonitrogen compound GO:0071417 197 0.016
ion transmembrane transport GO:0034220 365 0.016
endocrine process GO:0050886 32 0.015
glutamate receptor signaling pathway GO:0007215 43 0.015
positive regulation of cell differentiation GO:0045597 217 0.015
regulation of ion transport GO:0043269 245 0.015
intracellular transport GO:0046907 185 0.015
carbohydrate derivative metabolic process GO:1901135 346 0.015
cellular response to growth factor stimulus GO:0071363 162 0.015
epithelium development GO:0060429 96 0.015
immune system process GO:0002376 204 0.015
purine ribonucleotide biosynthetic process GO:0009152 81 0.015
response to inorganic substance GO:0010035 377 0.015
oxoacid metabolic process GO:0043436 290 0.015
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.015
skeletal system development GO:0001501 41 0.015
response to glucocorticoid GO:0051384 223 0.015
growth GO:0040007 165 0.015
negative regulation of cellular protein metabolic process GO:0032269 106 0.015
neuron fate commitment GO:0048663 4 0.015
regulation of protein phosphorylation GO:0001932 183 0.015
regulation of signal transduction GO:0009966 318 0.015
camp biosynthetic process GO:0006171 47 0.015
regulation of cellular amino acid metabolic process GO:0006521 2 0.015
sensory perception of pain GO:0019233 73 0.015
cellular response to endogenous stimulus GO:0071495 377 0.014
regulation of phosphorylation GO:0042325 248 0.014
negative regulation of cellular biosynthetic process GO:0031327 161 0.014
forebrain development GO:0030900 98 0.014
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.014
regulation of nervous system development GO:0051960 264 0.014
cell cell signaling GO:0007267 335 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.014
positive regulation of cellular biosynthetic process GO:0031328 295 0.014
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
regulation of multicellular organismal development GO:2000026 376 0.014
heterocycle catabolic process GO:0046700 167 0.014
ribonucleotide metabolic process GO:0009259 231 0.014
neuron projection development GO:0031175 273 0.014
organic hydroxy compound biosynthetic process GO:1901617 51 0.014
response to nutrient GO:0007584 248 0.014
positive regulation of phosphorylation GO:0042327 177 0.014
carbohydrate metabolic process GO:0005975 130 0.014
regulation of synaptic transmission GO:0050804 141 0.014
regulation of cellular amine metabolic process GO:0033238 8 0.013
regulation of nucleic acid templated transcription GO:1903506 380 0.013
purine containing compound biosynthetic process GO:0072522 85 0.013
positive regulation of nucleotide metabolic process GO:0045981 91 0.013
rna metabolic process GO:0016070 406 0.013
cellular response to stress GO:0033554 269 0.013
cell morphogenesis GO:0000902 142 0.013
limb morphogenesis GO:0035108 4 0.013
gland development GO:0048732 155 0.013
negative regulation of response to stimulus GO:0048585 155 0.013
carbohydrate derivative catabolic process GO:1901136 147 0.013
macromolecular complex assembly GO:0065003 273 0.013
positive regulation of gene expression GO:0010628 244 0.013
regulation of response to external stimulus GO:0032101 106 0.013
response to ethanol GO:0045471 162 0.013
response to nutrient levels GO:0031667 370 0.013
calcium ion transmembrane transport GO:0070588 70 0.013
response to amine GO:0014075 46 0.012
heart contraction GO:0060047 57 0.012
regulation of protein modification process GO:0031399 194 0.012
axonogenesis GO:0007409 71 0.012
response to mechanical stimulus GO:0009612 134 0.012
cellular response to oxygen levels GO:0071453 60 0.012
axon development GO:0061564 96 0.012
purine nucleotide biosynthetic process GO:0006164 83 0.012
detection of stimulus GO:0051606 24 0.012
camp metabolic process GO:0046058 63 0.012
nucleotide biosynthetic process GO:0009165 98 0.012
axis specification GO:0009798 4 0.012
nitrogen compound transport GO:0071705 229 0.012
neuron projection morphogenesis GO:0048812 122 0.012
purine nucleotide metabolic process GO:0006163 229 0.012
signal transduction by phosphorylation GO:0023014 144 0.012
positive regulation of cell communication GO:0010647 271 0.012
protein complex assembly GO:0006461 263 0.012
sex differentiation GO:0007548 113 0.012
positive regulation of neurogenesis GO:0050769 165 0.012
regulation of hydrolase activity GO:0051336 143 0.012
organonitrogen compound catabolic process GO:1901565 179 0.012
organophosphate biosynthetic process GO:0090407 143 0.012
cellular response to cytokine stimulus GO:0071345 127 0.012
cellular amino acid metabolic process GO:0006520 107 0.012
protein phosphorylation GO:0006468 345 0.012
cytoplasmic transport GO:0016482 115 0.012
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.012
multicellular organismal signaling GO:0035637 44 0.012
myeloid leukocyte activation GO:0002274 36 0.011
retinal ganglion cell axon guidance GO:0031290 1 0.011
hematopoietic progenitor cell differentiation GO:0002244 2 0.011
negative regulation of apoptotic process GO:0043066 181 0.011
nucleoside triphosphate catabolic process GO:0009143 123 0.011
eye morphogenesis GO:0048592 4 0.011
cellular nitrogen compound catabolic process GO:0044270 163 0.011
inner ear receptor cell differentiation GO:0060113 2 0.011
response to monosaccharide GO:0034284 159 0.011
regulation of tube size GO:0035150 89 0.011
organonitrogen compound biosynthetic process GO:1901566 167 0.011
nucleobase containing compound catabolic process GO:0034655 152 0.011
positive regulation of developmental process GO:0051094 283 0.011
negative regulation of cell development GO:0010721 82 0.011
response to metal ion GO:0010038 253 0.011
purine containing compound metabolic process GO:0072521 253 0.011
cellular catabolic process GO:0044248 295 0.011
response to atp GO:0033198 13 0.011
positive regulation of signal transduction GO:0009967 175 0.011
regulation of hormone levels GO:0010817 187 0.011
cyclic nucleotide biosynthetic process GO:0009190 63 0.011
single organism carbohydrate metabolic process GO:0044723 118 0.011
vesicle mediated transport GO:0016192 181 0.011
regulation of phosphate metabolic process GO:0019220 349 0.011
cellular carbohydrate metabolic process GO:0044262 72 0.011
embryonic cranial skeleton morphogenesis GO:0048701 2 0.010
regulation of catalytic activity GO:0050790 304 0.010
rna biosynthetic process GO:0032774 380 0.010
second messenger mediated signaling GO:0019932 51 0.010
positive regulation of phosphate metabolic process GO:0045937 262 0.010
ion homeostasis GO:0050801 212 0.010
negative regulation of protein metabolic process GO:0051248 114 0.010
regulation of reactive oxygen species metabolic process GO:2000377 26 0.010
transmembrane transport GO:0055085 412 0.010
positive regulation of secretion GO:0051047 140 0.010
negative regulation of signal transduction GO:0009968 83 0.010
positive regulation of corticosteroid hormone secretion GO:2000848 4 0.010
negative regulation of phosphate metabolic process GO:0045936 80 0.010
morphogenesis of embryonic epithelium GO:0016331 3 0.010
salivary gland morphogenesis GO:0007435 1 0.010
protein maturation GO:0051604 68 0.010
gliogenesis GO:0042063 93 0.010
hair cell differentiation GO:0035315 2 0.010
response to glucose GO:0009749 136 0.010
neurological system process GO:0050877 219 0.010
regulation of blood vessel size GO:0050880 89 0.010

Spag4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.026
nervous system disease DOID:863 0 0.026
bone development disease DOID:0080006 0 0.024
bone disease DOID:0080001 0 0.024
musculoskeletal system disease DOID:17 0 0.024
connective tissue disease DOID:65 0 0.024