Rattus norvegicus

15 known processes

Lyz2

lysozyme 2

(Aliases: Lysz,Lyz1,Lyz)

Lyz2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
immune system process GO:0002376 204 0.840
Fly
cell activation GO:0001775 97 0.635
t cell activation GO:0042110 29 0.518
defense response GO:0006952 194 0.506
negative regulation of response to stimulus GO:0048585 155 0.428
Fly
macromolecular complex subunit organization GO:0043933 339 0.417
locomotion GO:0040011 237 0.380
negative regulation of immune system process GO:0002683 39 0.369
Fly
programmed cell death GO:0012501 392 0.289
Fly
macromolecular complex assembly GO:0065003 273 0.268
cellular component biogenesis GO:0044085 368 0.237
protein complex subunit organization GO:0071822 302 0.236
cellular component assembly GO:0022607 360 0.221
homeostatic process GO:0042592 331 0.217
regulation of mononuclear cell proliferation GO:0032944 26 0.210
positive regulation of multicellular organismal process GO:0051240 387 0.205
negative regulation of metabolic process GO:0009892 331 0.205
regulation of phosphorus metabolic process GO:0051174 349 0.203
protein complex biogenesis GO:0070271 263 0.201
organic acid biosynthetic process GO:0016053 83 0.201
regulation of cell activation GO:0050865 50 0.197
regulation of immune system process GO:0002682 123 0.184
Fly
negative regulation of cell death GO:0060548 229 0.169
protein complex assembly GO:0006461 263 0.164
regulation of cell proliferation GO:0042127 359 0.163
unsaturated fatty acid biosynthetic process GO:0006636 21 0.153
carboxylic acid metabolic process GO:0019752 289 0.143
protein phosphorylation GO:0006468 345 0.136
cell migration GO:0016477 197 0.130
regulation of response to external stimulus GO:0032101 106 0.124
oxoacid metabolic process GO:0043436 290 0.123
regulation of apoptotic process GO:0042981 335 0.121
organic acid metabolic process GO:0006082 292 0.119
cell projection organization GO:0030030 302 0.116
regulation of cellular component movement GO:0051270 150 0.115
cellular response to endogenous stimulus GO:0071495 377 0.115
regulation of leukocyte activation GO:0002694 45 0.113
catabolic process GO:0009056 351 0.113
cell motility GO:0048870 202 0.112
immunoglobulin mediated immune response GO:0016064 4 0.111
apoptotic process GO:0006915 381 0.108
cellular response to stress GO:0033554 269 0.106
regulation of phosphorylation GO:0042325 248 0.106
regulation of locomotion GO:0040012 148 0.103
regulation of cell motility GO:2000145 131 0.101
regulation of programmed cell death GO:0043067 341 0.096
vesicle mediated transport GO:0016192 181 0.096
regulation of phosphate metabolic process GO:0019220 349 0.092
cellular component movement GO:0006928 248 0.091
single organism catabolic process GO:0044712 283 0.091
regulation of cellular ketone metabolic process GO:0010565 27 0.089
response to glucocorticoid GO:0051384 223 0.088
regulation of protein modification process GO:0031399 194 0.088
negative regulation of neutrophil apoptotic process GO:0033030 3 0.088
negative regulation of cellular metabolic process GO:0031324 281 0.087
lymphocyte activation GO:0046649 43 0.087
leukocyte homeostasis GO:0001776 7 0.086
anatomical structure morphogenesis GO:0009653 298 0.086
Fly
tube development GO:0035295 89 0.086
positive regulation of response to stimulus GO:0048584 285 0.085
regulation of cellular component organization GO:0051128 368 0.083
rna metabolic process GO:0016070 406 0.082
neurological system process GO:0050877 219 0.081
organic substance catabolic process GO:1901575 316 0.079
biological adhesion GO:0022610 110 0.078
response to inorganic substance GO:0010035 377 0.078
regulation of multicellular organismal development GO:2000026 376 0.078
regulation of cellular protein metabolic process GO:0032268 267 0.077
regulation of response to stress GO:0080134 126 0.076
Fly
regulation of leukocyte chemotaxis GO:0002688 12 0.076
respiratory tube development GO:0030323 43 0.076
negative regulation of macromolecule metabolic process GO:0010605 260 0.076
cellular amino acid metabolic process GO:0006520 107 0.074
hematopoietic or lymphoid organ development GO:0048534 36 0.073
cellular lipid metabolic process GO:0044255 208 0.073
monocarboxylic acid metabolic process GO:0032787 152 0.072
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.072
icosanoid biosynthetic process GO:0046456 18 0.072
response to oxygen levels GO:0070482 265 0.071
response to cytokine GO:0034097 215 0.070
negative regulation of cell differentiation GO:0045596 99 0.069
reactive oxygen species metabolic process GO:0072593 37 0.068
localization of cell GO:0051674 202 0.067
regulation of cellular amine metabolic process GO:0033238 8 0.066
cellular catabolic process GO:0044248 295 0.066
single organism biosynthetic process GO:0044711 342 0.066
antigen processing and presentation of peptide antigen GO:0048002 2 0.065
response to peptide hormone GO:0043434 278 0.065
immune response GO:0006955 104 0.064
Fly
leukocyte activation GO:0045321 76 0.063
positive regulation of molecular function GO:0044093 230 0.063
carboxylic acid biosynthetic process GO:0046394 83 0.062
negative regulation of apoptotic process GO:0043066 181 0.062
response to wounding GO:0009611 254 0.061
hemopoiesis GO:0030097 34 0.061
positive regulation of cell differentiation GO:0045597 217 0.061
cellular response to organic cyclic compound GO:0071407 202 0.059
intracellular transport GO:0046907 185 0.059
response to vitamin GO:0033273 131 0.059
regulation of cell differentiation GO:0045595 320 0.057
lung development GO:0030324 43 0.057
positive regulation of phosphorus metabolic process GO:0010562 262 0.057
response to reactive oxygen species GO:0000302 120 0.057
negative regulation of cellular biosynthetic process GO:0031327 161 0.057
transcription from rna polymerase ii promoter GO:0006366 252 0.057
small molecule biosynthetic process GO:0044283 124 0.056
regulation of t cell activation GO:0050863 23 0.056
regulation of protein metabolic process GO:0051246 289 0.055
negative regulation of biosynthetic process GO:0009890 168 0.054
positive regulation of phosphorylation GO:0042327 177 0.054
transcription dna templated GO:0006351 377 0.054
cellular ketone metabolic process GO:0042180 51 0.053
regulation of catalytic activity GO:0050790 304 0.053
positive regulation of developmental process GO:0051094 283 0.052
positive regulation of apoptotic process GO:0043065 154 0.049
developmental process involved in reproduction GO:0003006 159 0.047
response to axon injury GO:0048678 59 0.047
leukocyte migration GO:0050900 38 0.047
regulation of rna metabolic process GO:0051252 391 0.045
response to external biotic stimulus GO:0043207 221 0.045
regulation of cellular amino acid metabolic process GO:0006521 2 0.044
cellular response to external stimulus GO:0071496 118 0.044
regulation of lymphocyte proliferation GO:0050670 26 0.044
reproductive structure development GO:0048608 128 0.044
positive regulation of cell motility GO:2000147 97 0.044
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.042
regulation of behavior GO:0050795 61 0.042
response to hexose GO:0009746 144 0.041
regulation of neutrophil migration GO:1902622 6 0.041
regulation of molecular function GO:0065009 398 0.040
blood coagulation GO:0007596 26 0.040
protein oligomerization GO:0051259 191 0.040
negative regulation of phosphorus metabolic process GO:0010563 80 0.040
positive regulation of response to external stimulus GO:0032103 51 0.039
rna biosynthetic process GO:0032774 380 0.039
response to fibroblast growth factor GO:0071774 29 0.039
hematopoietic progenitor cell differentiation GO:0002244 2 0.039
organonitrogen compound catabolic process GO:1901565 179 0.039
positive regulation of cell death GO:0010942 184 0.038
positive regulation of phosphate metabolic process GO:0045937 262 0.038
anterior posterior pattern specification GO:0009952 1 0.038
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.038
cellular amine metabolic process GO:0044106 38 0.038
response to metal ion GO:0010038 253 0.037
cellular response to fibroblast growth factor stimulus GO:0044344 24 0.037
positive regulation of cellular protein metabolic process GO:0032270 167 0.037
homeostasis of number of cells GO:0048872 10 0.037
leukocyte mediated immunity GO:0002443 28 0.036
cellular response to growth factor stimulus GO:0071363 162 0.036
lipid biosynthetic process GO:0008610 128 0.036
positive regulation of cellular component organization GO:0051130 200 0.036
aromatic compound catabolic process GO:0019439 168 0.036
negative regulation of developmental process GO:0051093 125 0.036
negative regulation of programmed cell death GO:0043069 183 0.036
icosanoid metabolic process GO:0006690 38 0.036
negative regulation of multicellular organismal process GO:0051241 203 0.036
regulation of transcription dna templated GO:0006355 374 0.036
positive regulation of protein metabolic process GO:0051247 178 0.035
positive regulation of hydrolase activity GO:0051345 86 0.035
calcium ion transport GO:0006816 131 0.035
fatty acid metabolic process GO:0006631 99 0.035
ribonucleoside triphosphate catabolic process GO:0009203 122 0.035
response to nutrient levels GO:0031667 370 0.035
protein transport GO:0015031 132 0.035
cellular response to cytokine stimulus GO:0071345 127 0.034
positive regulation of cell activation GO:0050867 34 0.034
cellular homeostasis GO:0019725 252 0.034
negative regulation of lymphocyte activation GO:0051250 10 0.034
response to estrogen GO:0043627 232 0.034
positive regulation of catalytic activity GO:0043085 184 0.034
nucleic acid templated transcription GO:0097659 379 0.033
wound healing GO:0042060 122 0.033
cellular response to hormone stimulus GO:0032870 247 0.033
fatty acid biosynthetic process GO:0006633 33 0.032
behavior GO:0007610 205 0.032
immune system development GO:0002520 41 0.032
peptidyl amino acid modification GO:0018193 126 0.031
reproductive process GO:0022414 372 0.031
signal transduction by phosphorylation GO:0023014 144 0.031
negative regulation of phosphate metabolic process GO:0045936 80 0.031
positive regulation of biosynthetic process GO:0009891 319 0.031
muscle structure development GO:0061061 87 0.030
response to estradiol GO:0032355 164 0.030
response to monosaccharide GO:0034284 159 0.030
organelle organization GO:0006996 266 0.030
regulation of protein phosphorylation GO:0001932 183 0.029
positive regulation of cellular component biogenesis GO:0044089 55 0.029
regulation of ion transmembrane transport GO:0034765 121 0.029
lipid metabolic process GO:0006629 283 0.029
antigen processing and presentation of exogenous peptide antigen via mhc class ii GO:0019886 1 0.029
regulation of homeostatic process GO:0032844 101 0.028
protein localization GO:0008104 191 0.028
protein homooligomerization GO:0051260 91 0.028
intracellular protein transport GO:0006886 79 0.028
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.028
positive regulation of cell proliferation GO:0008284 249 0.028
negative regulation of rna metabolic process GO:0051253 123 0.027
metal ion transport GO:0030001 289 0.027
carbohydrate derivative catabolic process GO:1901136 147 0.027
regulation of body fluid levels GO:0050878 90 0.027
leukotriene biosynthetic process GO:0019370 3 0.027
intracellular signal transduction GO:0035556 314 0.027
response to ketone GO:1901654 182 0.027
regulation of cell morphogenesis GO:0022604 77 0.027
regulation of anatomical structure morphogenesis GO:0022603 141 0.027
cellular response to oxygen containing compound GO:1901701 386 0.027
response to glucose GO:0009749 136 0.027
cellular response to alcohol GO:0097306 87 0.027
regulation of cell development GO:0060284 263 0.026
positive regulation of response to wounding GO:1903036 34 0.026
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.026
antigen processing and presentation GO:0019882 2 0.026
axonogenesis GO:0007409 71 0.026
response to growth factor GO:0070848 189 0.026
cellular component morphogenesis GO:0032989 155 0.026
response to biotic stimulus GO:0009607 226 0.026
unsaturated fatty acid metabolic process GO:0033559 39 0.026
negative regulation of humoral immune response GO:0002921 4 0.026
response to peptide GO:1901652 292 0.025
positive regulation of protein phosphorylation GO:0001934 135 0.025
cardiovascular system development GO:0072358 134 0.025
tissue development GO:0009888 252 0.025
Fly
neuron projection development GO:0031175 273 0.025
negative regulation of gene expression GO:0010629 199 0.025
cellular response to nitrogen compound GO:1901699 210 0.025
cell cell signaling GO:0007267 335 0.025
reactive nitrogen species metabolic process GO:2001057 1 0.025
regulation of immunoglobulin mediated immune response GO:0002889 2 0.025
immune effector process GO:0002252 53 0.025
carbohydrate derivative metabolic process GO:1901135 346 0.025
negative regulation of homeostatic process GO:0032845 47 0.025
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.025
regulation of immune effector process GO:0002697 32 0.025
regulation of immunoglobulin production GO:0002637 4 0.024
nucleoside catabolic process GO:0009164 126 0.024
purine nucleoside metabolic process GO:0042278 169 0.024
response to other organism GO:0051707 220 0.024
inflammatory response GO:0006954 150 0.024
fatty acid derivative metabolic process GO:1901568 38 0.024
chemical homeostasis GO:0048878 292 0.024
monocarboxylic acid biosynthetic process GO:0072330 48 0.023
cellular protein complex assembly GO:0043623 44 0.023
circulatory system development GO:0072359 134 0.023
cellular response to lipid GO:0071396 201 0.023
cellular chemical homeostasis GO:0055082 247 0.023
positive regulation of transport GO:0051050 245 0.022
negative regulation of leukocyte activation GO:0002695 14 0.022
negative regulation of protein modification process GO:0031400 52 0.022
lymphocyte mediated immunity GO:0002449 14 0.022
regulation of cellular response to stress GO:0080135 49 0.022
positive regulation of cell migration GO:0030335 96 0.022
negative regulation of cell proliferation GO:0008285 119 0.022
central nervous system development GO:0007417 311 0.021
cytoskeleton organization GO:0007010 111 0.021
negative regulation of signal transduction GO:0009968 83 0.021
response to oxidative stress GO:0006979 186 0.021
reproduction GO:0000003 245 0.021
leukocyte proliferation GO:0070661 29 0.020
endocytosis GO:0006897 84 0.020
positive regulation of nervous system development GO:0051962 178 0.020
single organism organelle organization GO:1902589 180 0.020
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.020
enzyme linked receptor protein signaling pathway GO:0007167 116 0.020
positive regulation of signaling GO:0023056 270 0.020
positive regulation of programmed cell death GO:0043068 157 0.019
response to acid chemical GO:0001101 222 0.019
purine ribonucleoside catabolic process GO:0046130 124 0.019
regulation of adaptive immune response GO:0002819 8 0.019
nucleobase containing small molecule metabolic process GO:0055086 316 0.019
positive regulation of hemostasis GO:1900048 4 0.019
multicellular organismal reproductive process GO:0048609 233 0.019
anatomical structure homeostasis GO:0060249 29 0.019
regulation of neurogenesis GO:0050767 247 0.019
tissue remodeling GO:0048771 40 0.019
regulation of rna biosynthetic process GO:2001141 381 0.019
lymphocyte differentiation GO:0030098 10 0.019
nucleoside phosphate catabolic process GO:1901292 140 0.018
glycosyl compound metabolic process GO:1901657 182 0.018
regulation of t cell proliferation GO:0042129 17 0.018
multicellular organismal homeostasis GO:0048871 49 0.018
ribonucleoside catabolic process GO:0042454 126 0.018
regulation of neuron death GO:1901214 115 0.018
cellular response to nutrient levels GO:0031669 60 0.018
regulation of signal transduction GO:0009966 318 0.018
cellular protein localization GO:0034613 122 0.017
establishment of protein localization GO:0045184 141 0.017
antigen processing and presentation of peptide antigen via mhc class ii GO:0002495 1 0.017
neuron death GO:0070997 127 0.017
gamete generation GO:0007276 124 0.017
cellular response to oxidative stress GO:0034599 76 0.017
regulation of p38mapk cascade GO:1900744 1 0.017
lymphocyte homeostasis GO:0002260 2 0.017
multi organism reproductive process GO:0044703 262 0.017
positive regulation of cellular biosynthetic process GO:0031328 295 0.017
cellular macromolecule localization GO:0070727 122 0.017
embryonic pattern specification GO:0009880 1 0.017
nucleoside triphosphate catabolic process GO:0009143 123 0.017
cellular response to nutrient GO:0031670 30 0.017
response to hydrogen peroxide GO:0042542 89 0.017
regulation of catabolic process GO:0009894 113 0.016
t cell differentiation GO:0030217 9 0.016
negative regulation of immune response GO:0050777 15 0.016
Fly
amine metabolic process GO:0009308 38 0.016
positive regulation of cellular component movement GO:0051272 102 0.016
alcohol metabolic process GO:0006066 77 0.016
negative regulation of lymphocyte proliferation GO:0050672 6 0.016
cation transport GO:0006812 382 0.016
regulation of reactive oxygen species metabolic process GO:2000377 26 0.016
neuron differentiation GO:0030182 368 0.016
positive regulation of reactive oxygen species metabolic process GO:2000379 16 0.016
negative regulation of cell activation GO:0050866 15 0.016
triglyceride homeostasis GO:0070328 2 0.016
nucleobase containing compound catabolic process GO:0034655 152 0.016
cellular response to extracellular stimulus GO:0031668 73 0.016
antigen processing and presentation of exogenous antigen GO:0019884 1 0.016
secretion GO:0046903 307 0.016
cellular nitrogen compound catabolic process GO:0044270 163 0.016
positive regulation of cell development GO:0010720 176 0.016
sexual reproduction GO:0019953 148 0.015
negative regulation of cellular amine metabolic process GO:0033239 3 0.015
protein homotrimerization GO:0070207 15 0.015
cell morphogenesis GO:0000902 142 0.015
multicellular organism reproduction GO:0032504 233 0.015
negative regulation of rna biosynthetic process GO:1902679 118 0.015
ribonucleoside metabolic process GO:0009119 174 0.015
divalent inorganic cation transport GO:0072511 134 0.015
membrane organization GO:0061024 94 0.015
leukocyte chemotaxis GO:0030595 22 0.015
positive regulation of immune system process GO:0002684 90 0.015
axis specification GO:0009798 4 0.015
regulation of b cell mediated immunity GO:0002712 2 0.015
cellular metal ion homeostasis GO:0006875 172 0.015
cellular response to peptide hormone stimulus GO:0071375 120 0.014
response to ethanol GO:0045471 162 0.014
negative regulation of phosphorylation GO:0042326 57 0.014
protein maturation GO:0051604 68 0.014
ribonucleoside triphosphate metabolic process GO:0009199 141 0.014
single organism cell adhesion GO:0098602 46 0.014
glycosyl compound catabolic process GO:1901658 126 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.014
negative regulation of lymphocyte mediated immunity GO:0002707 5 0.014
proteolysis GO:0006508 175 0.014
positive regulation of non canonical wnt signaling pathway GO:2000052 1 0.014
regulation of cell killing GO:0031341 12 0.014
heterocycle catabolic process GO:0046700 167 0.014
cellular macromolecular complex assembly GO:0034622 58 0.014
ras protein signal transduction GO:0007265 29 0.013
single organism intracellular transport GO:1902582 166 0.013
nucleoside metabolic process GO:0009116 179 0.013
actin filament bundle assembly GO:0051017 19 0.013
cellular response to organonitrogen compound GO:0071417 197 0.013
head development GO:0060322 247 0.013
actin filament based process GO:0030029 86 0.013
cellular response to vitamin GO:0071295 21 0.013
response to decreased oxygen levels GO:0036293 237 0.013
t cell selection GO:0045058 1 0.013
macromolecule catabolic process GO:0009057 58 0.013
bone remodeling GO:0046849 23 0.013
divalent metal ion transport GO:0070838 132 0.013
chemotaxis GO:0006935 66 0.013
negative regulation of collateral sprouting GO:0048671 2 0.013
reproductive system development GO:0061458 128 0.013
b cell mediated immunity GO:0019724 4 0.013
small gtpase mediated signal transduction GO:0007264 36 0.012
ossification GO:0001503 70 0.012
fatty acid derivative biosynthetic process GO:1901570 18 0.012
purine containing compound metabolic process GO:0072521 253 0.012
positive regulation of neuron projection development GO:0010976 99 0.012
regulation of heart morphogenesis GO:2000826 2 0.012
response to vitamin d GO:0033280 34 0.012
response to camp GO:0051591 91 0.012
regulation of kinase activity GO:0043549 117 0.012
regulation of neutrophil apoptotic process GO:0033029 4 0.012
leukocyte differentiation GO:0002521 30 0.012
cellular response to abiotic stimulus GO:0071214 85 0.012
lymphocyte proliferation GO:0046651 29 0.012
brain development GO:0007420 247 0.012
positive regulation of proteasomal protein catabolic process GO:1901800 3 0.012
respiratory system development GO:0060541 45 0.012
regulation of cell migration GO:0030334 128 0.012
purine nucleotide metabolic process GO:0006163 229 0.012
response to carbohydrate GO:0009743 183 0.012
regulation of neuron projection development GO:0010975 161 0.012
mitotic spindle organization GO:0007052 2 0.012
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.012
regulation of leukocyte proliferation GO:0070663 26 0.012
negative regulation of protein phosphorylation GO:0001933 44 0.011
amide transport GO:0042886 105 0.011
tissue homeostasis GO:0001894 28 0.011
regeneration GO:0031099 163 0.011
positive regulation of signal transduction GO:0009967 175 0.011
positive regulation of chemotaxis GO:0050921 23 0.011
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.011
cell adhesion GO:0007155 110 0.011
positive regulation of intracellular signal transduction GO:1902533 138 0.011
chronic inflammatory response GO:0002544 16 0.011
antigen processing and presentation of exogenous peptide antigen GO:0002478 1 0.011
purine nucleoside catabolic process GO:0006152 124 0.011
neuron projection morphogenesis GO:0048812 122 0.011
response to corticosteroid GO:0031960 235 0.011
response to organophosphorus GO:0046683 102 0.011
regulation of lymphocyte activation GO:0051249 34 0.011
spindle organization GO:0007051 2 0.011
negative regulation of transport GO:0051051 136 0.011
response to symbiont GO:0009608 1 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
divalent inorganic cation homeostasis GO:0072507 165 0.011
positive regulation of protein modification process GO:0031401 142 0.011
mononuclear cell proliferation GO:0032943 29 0.011
nucleotide catabolic process GO:0009166 139 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
regulation of neuron differentiation GO:0045664 208 0.011
regulation of ion transport GO:0043269 245 0.011
regulation of cellular component biogenesis GO:0044087 86 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.011
actin filament bundle organization GO:0061572 19 0.011
response to hypoxia GO:0001666 231 0.010
positive regulation of neurogenesis GO:0050769 165 0.010
guanosine containing compound metabolic process GO:1901068 74 0.010
osteoblast differentiation GO:0001649 26 0.010
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.010
response to testosterone GO:0033574 55 0.010
cation homeostasis GO:0055080 195 0.010
positive regulation of neuron differentiation GO:0045666 126 0.010
regulation of response to wounding GO:1903034 69 0.010
regulation of wound healing GO:0061041 14 0.010
protein localization to cell surface GO:0034394 1 0.010
rho protein signal transduction GO:0007266 11 0.010

Lyz2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.016
musculoskeletal system disease DOID:17 0 0.016
connective tissue disease DOID:65 0 0.016