Rattus norvegicus

0 known processes

Fbxl8

F-box and leucine-rich repeat protein 8

(Aliases: RGD1566420)

Fbxl8 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
rna metabolic process GO:0016070 406 0.063
carboxylic acid metabolic process GO:0019752 289 0.061
regulation of molecular function GO:0065009 398 0.052
regulation of rna biosynthetic process GO:2001141 381 0.049
transcription dna templated GO:0006351 377 0.047
programmed cell death GO:0012501 392 0.047
rna biosynthetic process GO:0032774 380 0.045
organophosphate metabolic process GO:0019637 370 0.045
positive regulation of cell proliferation GO:0008284 249 0.045
oxoacid metabolic process GO:0043436 290 0.044
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.043
macromolecular complex subunit organization GO:0043933 339 0.043
transcription from rna polymerase ii promoter GO:0006366 252 0.043
regulation of nucleic acid templated transcription GO:1903506 380 0.043
nucleobase containing small molecule metabolic process GO:0055086 316 0.042
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.042
carbohydrate derivative metabolic process GO:1901135 346 0.041
regulation of programmed cell death GO:0043067 341 0.041
organic acid metabolic process GO:0006082 292 0.041
cellular amino acid metabolic process GO:0006520 107 0.041
nucleic acid templated transcription GO:0097659 379 0.040
single organism catabolic process GO:0044712 283 0.040
positive regulation of biosynthetic process GO:0009891 319 0.038
regulation of rna metabolic process GO:0051252 391 0.038
regulation of catalytic activity GO:0050790 304 0.038
ribonucleoside metabolic process GO:0009119 174 0.038
catabolic process GO:0009056 351 0.038
macromolecular complex assembly GO:0065003 273 0.037
protein complex biogenesis GO:0070271 263 0.037
organic substance catabolic process GO:1901575 316 0.037
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.036
intracellular signal transduction GO:0035556 314 0.036
regulation of signal transduction GO:0009966 318 0.036
regulation of transcription dna templated GO:0006355 374 0.036
cellular amine metabolic process GO:0044106 38 0.036
regulation of apoptotic process GO:0042981 335 0.036
tissue development GO:0009888 252 0.035
regulation of cell proliferation GO:0042127 359 0.034
negative regulation of metabolic process GO:0009892 331 0.034
positive regulation of rna metabolic process GO:0051254 203 0.034
nucleoside phosphate metabolic process GO:0006753 283 0.033
protein oligomerization GO:0051259 191 0.033
cellular catabolic process GO:0044248 295 0.032
regulation of cell differentiation GO:0045595 320 0.032
negative regulation of macromolecule metabolic process GO:0010605 260 0.032
nucleotide metabolic process GO:0009117 279 0.031
cellular response to oxygen containing compound GO:1901701 386 0.031
positive regulation of cellular biosynthetic process GO:0031328 295 0.031
protein phosphorylation GO:0006468 345 0.031
response to inorganic substance GO:0010035 377 0.031
cellular ketone metabolic process GO:0042180 51 0.031
amine metabolic process GO:0009308 38 0.031
protein complex assembly GO:0006461 263 0.031
response to cytokine GO:0034097 215 0.031
regulation of protein metabolic process GO:0051246 289 0.030
negative regulation of biosynthetic process GO:0009890 168 0.030
homeostatic process GO:0042592 331 0.030
regulation of phosphorus metabolic process GO:0051174 349 0.029
cellular response to endogenous stimulus GO:0071495 377 0.028
regulation of cellular amino acid metabolic process GO:0006521 2 0.028
ribose phosphate metabolic process GO:0019693 235 0.028
negative regulation of cellular metabolic process GO:0031324 281 0.027
response to nutrient levels GO:0031667 370 0.027
response to peptide hormone GO:0043434 278 0.027
anatomical structure morphogenesis GO:0009653 298 0.027
regulation of cellular protein metabolic process GO:0032268 267 0.027
organic cyclic compound catabolic process GO:1901361 175 0.026
purine nucleoside triphosphate catabolic process GO:0009146 122 0.026
negative regulation of gene expression GO:0010629 199 0.026
heterocycle catabolic process GO:0046700 167 0.026
regulation of intracellular signal transduction GO:1902531 218 0.026
lipid biosynthetic process GO:0008610 128 0.026
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.026
cell cell signaling GO:0007267 335 0.026
neuron differentiation GO:0030182 368 0.026
neuron development GO:0048666 286 0.026
secretion GO:0046903 307 0.026
positive regulation of catalytic activity GO:0043085 184 0.025
positive regulation of phosphate metabolic process GO:0045937 262 0.025
regulation of multicellular organismal development GO:2000026 376 0.025
positive regulation of gene expression GO:0010628 244 0.025
secretion by cell GO:0032940 248 0.025
central nervous system development GO:0007417 311 0.025
purine ribonucleotide metabolic process GO:0009150 227 0.025
chemical homeostasis GO:0048878 292 0.024
single organism biosynthetic process GO:0044711 342 0.024
response to peptide GO:1901652 292 0.024
organic acid biosynthetic process GO:0016053 83 0.024
ribonucleotide metabolic process GO:0009259 231 0.024
purine containing compound metabolic process GO:0072521 253 0.024
guanosine containing compound metabolic process GO:1901068 74 0.024
positive regulation of molecular function GO:0044093 230 0.024
lipid metabolic process GO:0006629 283 0.024
nucleoside metabolic process GO:0009116 179 0.023
cellular component biogenesis GO:0044085 368 0.023
aging GO:0007568 241 0.023
cellular response to stress GO:0033554 269 0.023
apoptotic process GO:0006915 381 0.023
response to oxidative stress GO:0006979 186 0.023
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.023
cellular response to hormone stimulus GO:0032870 247 0.022
regulation of cellular amine metabolic process GO:0033238 8 0.022
cellular component assembly GO:0022607 360 0.022
organonitrogen compound catabolic process GO:1901565 179 0.022
macromolecule localization GO:0033036 252 0.022
positive regulation of programmed cell death GO:0043068 157 0.022
protein complex subunit organization GO:0071822 302 0.022
purine ribonucleotide catabolic process GO:0009154 136 0.022
purine nucleotide metabolic process GO:0006163 229 0.022
regulation of phosphate metabolic process GO:0019220 349 0.022
single organism reproductive process GO:0044702 297 0.022
carbohydrate derivative catabolic process GO:1901136 147 0.022
positive regulation of nucleic acid templated transcription GO:1903508 197 0.021
cellular component movement GO:0006928 248 0.021
organophosphate biosynthetic process GO:0090407 143 0.021
regulation of cellular ketone metabolic process GO:0010565 27 0.021
positive regulation of response to stimulus GO:0048584 285 0.021
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.021
gtp catabolic process GO:0006184 71 0.021
purine ribonucleoside metabolic process GO:0046128 168 0.021
protein localization GO:0008104 191 0.020
organophosphate catabolic process GO:0046434 148 0.020
regulation of cellular localization GO:0060341 263 0.020
negative regulation of signaling GO:0023057 157 0.020
cellular nitrogen compound catabolic process GO:0044270 163 0.020
cellular response to lipid GO:0071396 201 0.020
nucleoside phosphate catabolic process GO:1901292 140 0.020
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.020
vesicle mediated transport GO:0016192 181 0.020
regulation of hydrolase activity GO:0051336 143 0.020
regulation of cell development GO:0060284 263 0.020
reproductive process GO:0022414 372 0.020
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.019
response to molecule of bacterial origin GO:0002237 194 0.019
cellular homeostasis GO:0019725 252 0.019
regulation of cellular component organization GO:0051128 368 0.019
response to oxygen levels GO:0070482 265 0.019
axis specification GO:0009798 4 0.019
regulation of anatomical structure morphogenesis GO:0022603 141 0.019
cellular lipid metabolic process GO:0044255 208 0.019
nucleotide catabolic process GO:0009166 139 0.018
positive regulation of protein metabolic process GO:0051247 178 0.018
response to extracellular stimulus GO:0009991 380 0.018
positive regulation of cellular protein metabolic process GO:0032270 167 0.018
nucleoside catabolic process GO:0009164 126 0.018
positive regulation of rna biosynthetic process GO:1902680 197 0.018
cellular response to nitrogen compound GO:1901699 210 0.018
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.018
cellular chemical homeostasis GO:0055082 247 0.018
single organism intracellular transport GO:1902582 166 0.018
purine containing compound catabolic process GO:0072523 138 0.018
protein transport GO:0015031 132 0.018
regulation of membrane potential GO:0042391 110 0.018
positive regulation of transcription dna templated GO:0045893 197 0.018
response to ketone GO:1901654 182 0.017
nucleobase containing compound catabolic process GO:0034655 152 0.017
aromatic compound catabolic process GO:0019439 168 0.017
cellular response to cytokine stimulus GO:0071345 127 0.017
regulation of catabolic process GO:0009894 113 0.017
organonitrogen compound biosynthetic process GO:1901566 167 0.017
regulation of neurogenesis GO:0050767 247 0.017
multicellular organism growth GO:0035264 1 0.017
response to toxic substance GO:0009636 133 0.017
response to metal ion GO:0010038 253 0.017
ribonucleoside triphosphate metabolic process GO:0009199 141 0.017
establishment of protein localization GO:0045184 141 0.017
response to carbohydrate GO:0009743 183 0.017
protein heterooligomerization GO:0051291 89 0.017
response to decreased oxygen levels GO:0036293 237 0.017
proteolysis GO:0006508 175 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
regulation of protein phosphorylation GO:0001932 183 0.017
negative regulation of apoptotic process GO:0043066 181 0.017
reproduction GO:0000003 245 0.016
response to acid chemical GO:0001101 222 0.016
regulation of locomotion GO:0040012 148 0.016
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
regulation of secretion by cell GO:1903530 208 0.016
transmembrane transport GO:0055085 412 0.016
ribonucleotide catabolic process GO:0009261 136 0.016
small molecule biosynthetic process GO:0044283 124 0.016
negative regulation of rna metabolic process GO:0051253 123 0.016
regulation of neuron apoptotic process GO:0043523 83 0.016
eye morphogenesis GO:0048592 4 0.016
gtp metabolic process GO:0046039 72 0.016
purine nucleoside metabolic process GO:0042278 169 0.016
ras protein signal transduction GO:0007265 29 0.016
positive regulation of secretion GO:0051047 140 0.016
regulation of secretion GO:0051046 224 0.016
regulation of protein modification process GO:0031399 194 0.016
neurological system process GO:0050877 219 0.016
purine nucleoside catabolic process GO:0006152 124 0.016
sensory organ development GO:0007423 74 0.015
response to tumor necrosis factor GO:0034612 56 0.015
organelle organization GO:0006996 266 0.015
positive regulation of apoptotic process GO:0043065 154 0.015
glycosyl compound catabolic process GO:1901658 126 0.015
response to glucocorticoid GO:0051384 223 0.015
regulation of purine nucleotide catabolic process GO:0033121 65 0.015
fertilization GO:0009566 3 0.015
positive regulation of cell differentiation GO:0045597 217 0.015
cellular response to growth factor stimulus GO:0071363 162 0.015
positive regulation of protein modification process GO:0031401 142 0.015
positive regulation of multicellular organismal process GO:0051240 387 0.015
negative regulation of programmed cell death GO:0043069 183 0.015
brain development GO:0007420 247 0.015
g protein coupled receptor signaling pathway GO:0007186 242 0.015
intracellular transport GO:0046907 185 0.015
response to nutrient GO:0007584 248 0.015
nucleoside triphosphate catabolic process GO:0009143 123 0.015
positive regulation of cell death GO:0010942 184 0.015
positive regulation of signaling GO:0023056 270 0.015
regulation of purine nucleotide metabolic process GO:1900542 115 0.015
regulation of phosphorylation GO:0042325 248 0.015
defense response GO:0006952 194 0.015
female pregnancy GO:0007565 122 0.015
regulation of nervous system development GO:0051960 264 0.015
ribonucleoside catabolic process GO:0042454 126 0.015
cellular cation homeostasis GO:0030003 180 0.015
neuron projection development GO:0031175 273 0.015
guanosine containing compound catabolic process GO:1901069 71 0.015
regulation of cellular catabolic process GO:0031329 101 0.014
ribonucleoside triphosphate catabolic process GO:0009203 122 0.014
response to other organism GO:0051707 220 0.014
cellular protein localization GO:0034613 122 0.014
oxidation reduction process GO:0055114 304 0.014
ion homeostasis GO:0050801 212 0.014
gland development GO:0048732 155 0.014
positive regulation of secretion by cell GO:1903532 128 0.014
response to hypoxia GO:0001666 231 0.014
negative regulation of cell communication GO:0010648 158 0.014
positive regulation of phosphorus metabolic process GO:0010562 262 0.014
glycosyl compound metabolic process GO:1901657 182 0.014
peptidyl amino acid modification GO:0018193 126 0.014
regulation of cell motility GO:2000145 131 0.014
cellular response to peptide GO:1901653 133 0.014
negative regulation of cell death GO:0060548 229 0.014
purine nucleoside triphosphate metabolic process GO:0009144 141 0.014
intracellular protein transport GO:0006886 79 0.014
anterior posterior pattern specification GO:0009952 1 0.014
developmental process involved in reproduction GO:0003006 159 0.014
small gtpase mediated signal transduction GO:0007264 36 0.014
regulation of establishment of protein localization GO:0070201 69 0.013
embryonic pattern specification GO:0009880 1 0.013
negative regulation of transport GO:0051051 136 0.013
purine nucleotide catabolic process GO:0006195 136 0.013
positive regulation of catabolic process GO:0009896 78 0.013
cellular response to organonitrogen compound GO:0071417 197 0.013
metal ion homeostasis GO:0055065 186 0.013
negative regulation of rna biosynthetic process GO:1902679 118 0.013
cellular macromolecule localization GO:0070727 122 0.013
positive regulation of signal transduction GO:0009967 175 0.013
nucleoside triphosphate metabolic process GO:0009141 144 0.013
negative regulation of cellular biosynthetic process GO:0031327 161 0.013
cytoplasmic transport GO:0016482 115 0.013
cation transport GO:0006812 382 0.013
response to estrogen GO:0043627 232 0.013
multicellular organismal reproductive process GO:0048609 233 0.013
regulation of cell migration GO:0030334 128 0.013
rhythmic process GO:0048511 156 0.013
regulation of kinase activity GO:0043549 117 0.013
response to corticosteroid GO:0031960 235 0.013
single organism organelle organization GO:1902589 180 0.013
response to transition metal nanoparticle GO:1990267 122 0.013
regeneration GO:0031099 163 0.013
carboxylic acid biosynthetic process GO:0046394 83 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.013
signal release GO:0023061 145 0.012
cell projection organization GO:0030030 302 0.012
positive regulation of phosphorylation GO:0042327 177 0.012
response to wounding GO:0009611 254 0.012
multicellular organism reproduction GO:0032504 233 0.012
negative regulation of nucleic acid templated transcription GO:1903507 117 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.012
locomotion GO:0040011 237 0.012
regulation of protein localization GO:0032880 81 0.012
cellular metal ion homeostasis GO:0006875 172 0.012
synaptic transmission GO:0007268 235 0.012
protein targeting GO:0006605 61 0.012
cellular ion homeostasis GO:0006873 184 0.012
coenzyme metabolic process GO:0006732 86 0.012
positive regulation of cell development GO:0010720 176 0.012
response to ethanol GO:0045471 162 0.012
response to external biotic stimulus GO:0043207 221 0.012
gastrulation GO:0007369 2 0.012
reactive nitrogen species metabolic process GO:2001057 1 0.012
response to glucose GO:0009749 136 0.011
negative regulation of innate immune response GO:0045824 4 0.011
cell morphogenesis GO:0000902 142 0.011
response to insulin GO:0032868 133 0.011
metal ion transport GO:0030001 289 0.011
multi organism reproductive process GO:0044703 262 0.011
response to hexose GO:0009746 144 0.011
cation homeostasis GO:0055080 195 0.011
response to lipopolysaccharide GO:0032496 191 0.011
positive regulation of nucleotide metabolic process GO:0045981 91 0.011
positive regulation of mapk cascade GO:0043410 92 0.011
negative regulation of signal transduction GO:0009968 83 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
cellular calcium ion homeostasis GO:0006874 160 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.011
negative regulation of multicellular organismal process GO:0051241 203 0.011
positive regulation of hydrolase activity GO:0051345 86 0.011
response to biotic stimulus GO:0009607 226 0.011
carbohydrate derivative biosynthetic process GO:1901137 124 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
hepaticobiliary system development GO:0061008 90 0.011
negative regulation of protein metabolic process GO:0051248 114 0.011
cardiac chamber development GO:0003205 1 0.011
multi multicellular organism process GO:0044706 138 0.011
divalent inorganic cation homeostasis GO:0072507 165 0.011
regulation of gtp catabolic process GO:0033124 58 0.011
head development GO:0060322 247 0.011
regulation of hormone levels GO:0010817 187 0.011
negative regulation of phosphate metabolic process GO:0045936 80 0.011
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.011
response to amino acid GO:0043200 75 0.011
response to bacterium GO:0009617 200 0.011
regulation of neuron differentiation GO:0045664 208 0.010
response to radiation GO:0009314 137 0.010
response to mechanical stimulus GO:0009612 134 0.010
nitrogen compound transport GO:0071705 229 0.010
mapk cascade GO:0000165 140 0.010
hormone transport GO:0009914 121 0.010
single fertilization GO:0007338 3 0.010
regulation of nucleoside metabolic process GO:0009118 66 0.010
localization of cell GO:0051674 202 0.010
immune system process GO:0002376 204 0.010
regulation of nucleotide metabolic process GO:0006140 117 0.010
glycerolipid metabolic process GO:0046486 67 0.010
nucleotide biosynthetic process GO:0009165 98 0.010
lipid storage GO:0019915 1 0.010
axon development GO:0061564 96 0.010
cell morphogenesis involved in differentiation GO:0000904 119 0.010
cell type specific apoptotic process GO:0097285 134 0.010

Fbxl8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.022
nervous system disease DOID:863 0 0.022
sensory system disease DOID:0050155 0 0.017
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
organ system cancer DOID:0050686 0 0.011
central nervous system disease DOID:331 0 0.010
eye and adnexa disease DOID:1492 0 0.010