Rattus norvegicus

0 known processes

C4-2

complement component 4, gene 2

(Aliases: C4l)

C4-2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
response to wounding GO:0009611 254 0.105
response to metal ion GO:0010038 253 0.093
nucleobase containing small molecule metabolic process GO:0055086 316 0.084
cellular response to organic cyclic compound GO:0071407 202 0.084
oxoacid metabolic process GO:0043436 290 0.082
organic acid metabolic process GO:0006082 292 0.081
single organism catabolic process GO:0044712 283 0.070
single organism biosynthetic process GO:0044711 342 0.068
behavior GO:0007610 205 0.064
response to nutrient levels GO:0031667 370 0.062
programmed cell death GO:0012501 392 0.061
positive regulation of neuron projection development GO:0010976 99 0.060
response to camp GO:0051591 91 0.059
immune system process GO:0002376 204 0.059
response to inorganic substance GO:0010035 377 0.058
cellular amino acid metabolic process GO:0006520 107 0.056
cell motility GO:0048870 202 0.055
cell projection organization GO:0030030 302 0.054
carboxylic acid metabolic process GO:0019752 289 0.052
positive regulation of phosphate metabolic process GO:0045937 262 0.052
positive regulation of cell differentiation GO:0045597 217 0.052
regulation of programmed cell death GO:0043067 341 0.051
negative regulation of apoptotic process GO:0043066 181 0.050
apoptotic process GO:0006915 381 0.050
monocarboxylic acid metabolic process GO:0032787 152 0.050
regulation of cell proliferation GO:0042127 359 0.049
amine metabolic process GO:0009308 38 0.048
neurological system process GO:0050877 219 0.047
negative regulation of macromolecule metabolic process GO:0010605 260 0.046
signal transduction by phosphorylation GO:0023014 144 0.046
regulation of multicellular organismal development GO:2000026 376 0.046
regulation of cell differentiation GO:0045595 320 0.044
neuron projection development GO:0031175 273 0.044
catabolic process GO:0009056 351 0.044
regulation of phosphate metabolic process GO:0019220 349 0.044
response to extracellular stimulus GO:0009991 380 0.044
cellular response to oxygen containing compound GO:1901701 386 0.043
neuron differentiation GO:0030182 368 0.043
regulation of apoptotic process GO:0042981 335 0.042
regulation of cellular amine metabolic process GO:0033238 8 0.042
regulation of phosphorus metabolic process GO:0051174 349 0.042
cellular amine metabolic process GO:0044106 38 0.041
regulation of neurogenesis GO:0050767 247 0.040
cellular response to endogenous stimulus GO:0071495 377 0.040
response to external biotic stimulus GO:0043207 221 0.040
protein phosphorylation GO:0006468 345 0.039
homeostatic process GO:0042592 331 0.039
neuron development GO:0048666 286 0.037
regulation of cellular ketone metabolic process GO:0010565 27 0.037
regulation of phosphorylation GO:0042325 248 0.036
positive regulation of response to stimulus GO:0048584 285 0.036
positive regulation of multicellular organismal process GO:0051240 387 0.036
negative regulation of programmed cell death GO:0043069 183 0.035
regulation of immune system process GO:0002682 123 0.034
cellular ketone metabolic process GO:0042180 51 0.034
intracellular signal transduction GO:0035556 314 0.033
regulation of neuron differentiation GO:0045664 208 0.032
central nervous system development GO:0007417 311 0.032
sensory organ development GO:0007423 74 0.032
negative regulation of multicellular organismal process GO:0051241 203 0.031
regulation of nervous system development GO:0051960 264 0.031
regulation of cell projection organization GO:0031344 175 0.031
cellular catabolic process GO:0044248 295 0.031
positive regulation of developmental process GO:0051094 283 0.031
response to acid chemical GO:0001101 222 0.030
small molecule biosynthetic process GO:0044283 124 0.030
aromatic compound catabolic process GO:0019439 168 0.030
positive regulation of phosphorus metabolic process GO:0010562 262 0.029
cellular response to stress GO:0033554 269 0.029
purine ribonucleotide metabolic process GO:0009150 227 0.029
positive regulation of mapk cascade GO:0043410 92 0.029
negative regulation of cell death GO:0060548 229 0.029
regulation of system process GO:0044057 208 0.029
positive regulation of immune system process GO:0002684 90 0.029
response to nutrient GO:0007584 248 0.029
negative regulation of response to stimulus GO:0048585 155 0.028
carboxylic acid biosynthetic process GO:0046394 83 0.028
cellular response to lipid GO:0071396 201 0.028
negative regulation of cell proliferation GO:0008285 119 0.027
regulation of cellular amino acid metabolic process GO:0006521 2 0.027
organic cyclic compound catabolic process GO:1901361 175 0.027
regulation of cell migration GO:0030334 128 0.027
negative regulation of signaling GO:0023057 157 0.026
positive regulation of signaling GO:0023056 270 0.026
regulation of neuron projection development GO:0010975 161 0.026
chemical homeostasis GO:0048878 292 0.026
regulation of cell activation GO:0050865 50 0.026
organonitrogen compound catabolic process GO:1901565 179 0.026
organic substance catabolic process GO:1901575 316 0.026
purine containing compound metabolic process GO:0072521 253 0.026
positive regulation of cell projection organization GO:0031346 111 0.025
response to retinoic acid GO:0032526 63 0.025
reproductive process GO:0022414 372 0.025
response to bacterium GO:0009617 200 0.025
reactive nitrogen species metabolic process GO:2001057 1 0.025
ion transmembrane transport GO:0034220 365 0.025
ribose phosphate metabolic process GO:0019693 235 0.025
response to glucocorticoid GO:0051384 223 0.025
vasculogenesis GO:0001570 3 0.024
response to molecule of bacterial origin GO:0002237 194 0.024
regulation of protein metabolic process GO:0051246 289 0.024
negative regulation of phosphorus metabolic process GO:0010563 80 0.024
negative regulation of innate immune response GO:0045824 4 0.024
blood coagulation GO:0007596 26 0.024
cellular homeostasis GO:0019725 252 0.024
nitrogen compound transport GO:0071705 229 0.023
response to organophosphorus GO:0046683 102 0.023
cellular response to alcohol GO:0097306 87 0.023
purine nucleotide metabolic process GO:0006163 229 0.023
regulation of hormone levels GO:0010817 187 0.023
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.023
response to ethanol GO:0045471 162 0.023
heart morphogenesis GO:0003007 3 0.023
inorganic cation transmembrane transport GO:0098662 202 0.022
positive regulation of cell communication GO:0010647 271 0.022
positive regulation of cell development GO:0010720 176 0.022
amide transport GO:0042886 105 0.022
negative regulation of developmental process GO:0051093 125 0.022
response to growth factor GO:0070848 189 0.022
tissue development GO:0009888 252 0.022
cellular component biogenesis GO:0044085 368 0.022
heterocycle catabolic process GO:0046700 167 0.022
response to cytokine GO:0034097 215 0.022
reactive oxygen species metabolic process GO:0072593 37 0.022
nucleoside catabolic process GO:0009164 126 0.021
response to axon injury GO:0048678 59 0.021
organophosphate metabolic process GO:0019637 370 0.021
cation transport GO:0006812 382 0.021
carbohydrate derivative metabolic process GO:1901135 346 0.021
positive regulation of nervous system development GO:0051962 178 0.021
positive regulation of neuron differentiation GO:0045666 126 0.021
response to interleukin 1 GO:0070555 55 0.021
regulation of cellular protein metabolic process GO:0032268 267 0.021
localization of cell GO:0051674 202 0.021
regulation of protein phosphorylation GO:0001932 183 0.020
antigen processing and presentation of peptide antigen GO:0048002 2 0.020
sensory perception GO:0007600 101 0.020
regulation of cellular component organization GO:0051128 368 0.020
coagulation GO:0050817 28 0.020
head development GO:0060322 247 0.019
ribonucleotide metabolic process GO:0009259 231 0.019
negative regulation of cell differentiation GO:0045596 99 0.019
regulation of tolerance induction to nonself antigen GO:0002655 1 0.019
response to transition metal nanoparticle GO:1990267 122 0.019
regulation of catalytic activity GO:0050790 304 0.019
locomotion GO:0040011 237 0.019
negative regulation of metabolic process GO:0009892 331 0.019
transmembrane transport GO:0055085 412 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.019
single organism behavior GO:0044708 130 0.018
positive regulation of cellular protein metabolic process GO:0032270 167 0.018
lipid metabolic process GO:0006629 283 0.018
macromolecular complex assembly GO:0065003 273 0.018
regulation of neuron death GO:1901214 115 0.018
lipid biosynthetic process GO:0008610 128 0.018
regulation of molecular function GO:0065009 398 0.018
regulation of locomotion GO:0040012 148 0.018
peptidyl tyrosine phosphorylation GO:0018108 72 0.018
cation homeostasis GO:0055080 195 0.018
organic hydroxy compound metabolic process GO:1901615 115 0.018
response to estradiol GO:0032355 164 0.018
hemostasis GO:0007599 26 0.018
regulation of immune response GO:0050776 55 0.017
small gtpase mediated signal transduction GO:0007264 36 0.017
organic acid biosynthetic process GO:0016053 83 0.017
multi organism reproductive process GO:0044703 262 0.017
brain development GO:0007420 247 0.017
fatty acid metabolic process GO:0006631 99 0.017
cellular response to nitrogen compound GO:1901699 210 0.017
response to hexose GO:0009746 144 0.017
peptide secretion GO:0002790 86 0.017
regulation of homeostatic process GO:0032844 101 0.017
cell type specific apoptotic process GO:0097285 134 0.017
cell activation GO:0001775 97 0.017
defense response GO:0006952 194 0.017
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.017
mapk cascade GO:0000165 140 0.017
positive regulation of catalytic activity GO:0043085 184 0.017
multicellular organismal reproductive process GO:0048609 233 0.017
response to peptide GO:1901652 292 0.017
response to glucose GO:0009749 136 0.017
cellular response to hormone stimulus GO:0032870 247 0.017
response to biotic stimulus GO:0009607 226 0.017
positive regulation of cellular amine metabolic process GO:0033240 3 0.017
response to decreased oxygen levels GO:0036293 237 0.017
response to ketone GO:1901654 182 0.016
positive regulation of t cell mediated cytotoxicity GO:0001916 4 0.016
response to corticosteroid GO:0031960 235 0.016
signal release GO:0023061 145 0.016
response to purine containing compound GO:0014074 126 0.016
cell cell signaling GO:0007267 335 0.016
regulation of tolerance induction dependent upon immune response GO:0002652 1 0.016
nucleotide metabolic process GO:0009117 279 0.016
biological adhesion GO:0022610 110 0.016
multicellular organismal homeostasis GO:0048871 49 0.016
regulation of protein modification process GO:0031399 194 0.016
learning or memory GO:0007611 90 0.016
response to oxygen levels GO:0070482 265 0.016
anatomical structure morphogenesis GO:0009653 298 0.016
regulation of signal transduction GO:0009966 318 0.016
peptidyl tyrosine modification GO:0018212 72 0.016
regulation of response to external stimulus GO:0032101 106 0.016
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.016
nucleoside phosphate metabolic process GO:0006753 283 0.016
negative regulation of secretion GO:0051048 82 0.016
cellular response to external stimulus GO:0071496 118 0.016
cellular lipid metabolic process GO:0044255 208 0.015
cell projection morphogenesis GO:0048858 123 0.015
g protein coupled receptor signaling pathway GO:0007186 242 0.015
multicellular organism reproduction GO:0032504 233 0.015
antigen processing and presentation GO:0019882 2 0.015
purine containing compound biosynthetic process GO:0072522 85 0.015
cellular chemical homeostasis GO:0055082 247 0.015
regulation of mononuclear cell proliferation GO:0032944 26 0.015
acute inflammatory response GO:0002526 58 0.015
regulation of neuron apoptotic process GO:0043523 83 0.015
gland development GO:0048732 155 0.015
positive regulation of cell death GO:0010942 184 0.015
regulation of peptide secretion GO:0002791 82 0.015
response to carbohydrate GO:0009743 183 0.015
membrane organization GO:0061024 94 0.015
regulation of blood circulation GO:1903522 110 0.015
secretion GO:0046903 307 0.015
eye morphogenesis GO:0048592 4 0.014
muscle system process GO:0003012 115 0.014
antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii GO:0002504 1 0.014
lymphocyte homeostasis GO:0002260 2 0.014
ras protein signal transduction GO:0007265 29 0.014
cardiovascular system development GO:0072358 134 0.014
nucleobase containing compound catabolic process GO:0034655 152 0.014
regulation of secretion by cell GO:1903530 208 0.014
cellular nitrogen compound catabolic process GO:0044270 163 0.014
embryonic appendage morphogenesis GO:0035113 4 0.014
vesicle mediated transport GO:0016192 181 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
response to tumor necrosis factor GO:0034612 56 0.014
cellular metal ion homeostasis GO:0006875 172 0.014
positive regulation of biosynthetic process GO:0009891 319 0.014
intracellular transport GO:0046907 185 0.014
positive regulation of protein modification process GO:0031401 142 0.014
response to vitamin GO:0033273 131 0.014
negative regulation of cellular protein metabolic process GO:0032269 106 0.014
regulation of rna metabolic process GO:0051252 391 0.014
cellular response to extracellular stimulus GO:0031668 73 0.014
organophosphate biosynthetic process GO:0090407 143 0.014
cellular component assembly GO:0022607 360 0.014
immune effector process GO:0002252 53 0.014
positive regulation of protein phosphorylation GO:0001934 135 0.014
positive regulation of cellular biosynthetic process GO:0031328 295 0.014
cell part morphogenesis GO:0032990 123 0.014
cognition GO:0050890 92 0.013
positive regulation of cellular component movement GO:0051272 102 0.013
proteolysis GO:0006508 175 0.013
leukocyte migration GO:0050900 38 0.013
regulation of hydrolase activity GO:0051336 143 0.013
blood circulation GO:0008015 183 0.013
alpha amino acid metabolic process GO:1901605 71 0.013
divalent inorganic cation transport GO:0072511 134 0.013
response to lipopolysaccharide GO:0032496 191 0.013
organophosphate catabolic process GO:0046434 148 0.013
negative regulation of phosphate metabolic process GO:0045936 80 0.013
response to monosaccharide GO:0034284 159 0.013
hormone secretion GO:0046879 115 0.013
nucleotide catabolic process GO:0009166 139 0.013
negative regulation of protein metabolic process GO:0051248 114 0.013
negative regulation of immune system process GO:0002683 39 0.013
regulation of response to stress GO:0080134 126 0.013
glycosyl compound metabolic process GO:1901657 182 0.013
cellular response to cytokine stimulus GO:0071345 127 0.013
response to alkaloid GO:0043279 132 0.013
regulation of synaptic transmission GO:0050804 141 0.013
cellular ion homeostasis GO:0006873 184 0.013
regulation of mapk cascade GO:0043408 116 0.013
immune system development GO:0002520 41 0.013
regulation of purine nucleotide metabolic process GO:1900542 115 0.013
steroid metabolic process GO:0008202 73 0.013
protein complex subunit organization GO:0071822 302 0.013
nucleoside triphosphate catabolic process GO:0009143 123 0.013
response to peptide hormone GO:0043434 278 0.013
neuromuscular process GO:0050905 2 0.012
multi multicellular organism process GO:0044706 138 0.012
regulation of cell development GO:0060284 263 0.012
ribonucleoside metabolic process GO:0009119 174 0.012
regulation of nucleic acid templated transcription GO:1903506 380 0.012
response to oxidative stress GO:0006979 186 0.012
positive regulation of phosphorylation GO:0042327 177 0.012
immune response GO:0006955 104 0.012
purine nucleotide biosynthetic process GO:0006164 83 0.012
negative regulation of transport GO:0051051 136 0.012
metal ion transport GO:0030001 289 0.012
cyclic nucleotide biosynthetic process GO:0009190 63 0.012
axis specification GO:0009798 4 0.012
response to starvation GO:0042594 59 0.012
regulation of body fluid levels GO:0050878 90 0.012
response to radiation GO:0009314 137 0.012
inflammatory response GO:0006954 150 0.012
peptide transport GO:0015833 97 0.012
halogenated hydrocarbon metabolic process GO:0042197 4 0.012
calcium ion transport GO:0006816 131 0.012
positive regulation of cell proliferation GO:0008284 249 0.012
single organism reproductive process GO:0044702 297 0.012
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.012
regulation of nucleotide metabolic process GO:0006140 117 0.012
circulatory system development GO:0072359 134 0.012
camp metabolic process GO:0046058 63 0.012
ion homeostasis GO:0050801 212 0.012
positive regulation of reactive oxygen species metabolic process GO:2000379 16 0.012
cellular response to acid chemical GO:0071229 75 0.012
hormone transport GO:0009914 121 0.012
regulation of rna biosynthetic process GO:2001141 381 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
macromolecular complex subunit organization GO:0043933 339 0.012
peptidyl amino acid modification GO:0018193 126 0.012
response to calcium ion GO:0051592 59 0.012
regulation of leukocyte proliferation GO:0070663 26 0.012
divalent metal ion transport GO:0070838 132 0.012
cyclic nucleotide metabolic process GO:0009187 80 0.012
innate immune response GO:0045087 35 0.012
male gonad development GO:0008584 59 0.012
ribonucleotide biosynthetic process GO:0009260 85 0.012
epithelial cell differentiation GO:0030855 71 0.012
endocytosis GO:0006897 84 0.012
purine ribonucleoside metabolic process GO:0046128 168 0.012
aging GO:0007568 241 0.012
wound healing GO:0042060 122 0.012
synaptic transmission GO:0007268 235 0.012
regulation of defense response GO:0031347 68 0.012
activation of cysteine type endopeptidase activity GO:0097202 4 0.011
ribonucleotide catabolic process GO:0009261 136 0.011
monocarboxylic acid biosynthetic process GO:0072330 48 0.011
developmental growth GO:0048589 100 0.011
unsaturated fatty acid metabolic process GO:0033559 39 0.011
nucleoside triphosphate metabolic process GO:0009141 144 0.011
gliogenesis GO:0042063 93 0.011
purine containing compound catabolic process GO:0072523 138 0.011
dicarboxylic acid metabolic process GO:0043648 42 0.011
organonitrogen compound biosynthetic process GO:1901566 167 0.011
negative regulation of signal transduction GO:0009968 83 0.011
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 51 0.011
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 1 0.011
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.011
cellular response to hexose stimulus GO:0071331 65 0.011
cation transmembrane transport GO:0098655 263 0.011
complement activation GO:0006956 11 0.011
positive regulation of leukocyte activation GO:0002696 30 0.011
growth GO:0040007 165 0.011
negative regulation of neuron apoptotic process GO:0043524 45 0.011
response to hypoxia GO:0001666 231 0.011
positive regulation of neurogenesis GO:0050769 165 0.011
morphogenesis of a polarized epithelium GO:0001738 1 0.011
regulation of t cell activation GO:0050863 23 0.011
calcium ion homeostasis GO:0055074 162 0.011
lipid transport GO:0006869 61 0.011
cytoplasmic transport GO:0016482 115 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
sequestering of calcium ion GO:0051208 8 0.011
negative regulation of phosphorylation GO:0042326 57 0.011
positive regulation of blood coagulation GO:0030194 4 0.011
tissue remodeling GO:0048771 40 0.011
cell adhesion GO:0007155 110 0.011
negative regulation of epithelial cell proliferation GO:0050680 16 0.011
sequestering of metal ion GO:0051238 9 0.011
negative regulation of response to external stimulus GO:0032102 37 0.011
olfactory behavior GO:0042048 2 0.011
regulation of lymphocyte proliferation GO:0050670 26 0.011
autophagic cell death GO:0048102 4 0.011
cellular hormone metabolic process GO:0034754 49 0.011
negative regulation of homeostatic process GO:0032845 47 0.011
cytosolic calcium ion homeostasis GO:0051480 140 0.011
lipid storage GO:0019915 1 0.011
regulation of purine nucleotide biosynthetic process GO:1900371 46 0.011
glucose homeostasis GO:0042593 75 0.011
negative regulation of protein maturation GO:1903318 47 0.011
regulation of smooth muscle cell proliferation GO:0048660 75 0.011
regulation of endothelial cell differentiation GO:0045601 4 0.011
regulation of intracellular signal transduction GO:1902531 218 0.011
lipid catabolic process GO:0016042 46 0.011
response to other organism GO:0051707 220 0.011
protein complex assembly GO:0006461 263 0.010
metal ion homeostasis GO:0055065 186 0.010
negative regulation of cellular metabolic process GO:0031324 281 0.010
defense response to gram negative bacterium GO:0050829 3 0.010
regulation of calcium ion transport GO:0051924 77 0.010
cell migration GO:0016477 197 0.010
gtp catabolic process GO:0006184 71 0.010
cellular response to monosaccharide stimulus GO:0071326 67 0.010
cyclic purine nucleotide metabolic process GO:0052652 62 0.010
anterior posterior pattern specification GO:0009952 1 0.010
leukocyte mediated immunity GO:0002443 28 0.010
neuron death GO:0070997 127 0.010
nucleoside metabolic process GO:0009116 179 0.010
regeneration GO:0031099 163 0.010
positive regulation of ion transport GO:0043270 94 0.010
regulation of cell growth GO:0001558 85 0.010
memory GO:0007613 54 0.010
glial cell differentiation GO:0010001 65 0.010
regulation of ion transmembrane transport GO:0034765 121 0.010
cardiac chamber development GO:0003205 1 0.010

C4-2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.031
inherited metabolic disorder DOID:655 0 0.027
disease of anatomical entity DOID:7 0 0.016
cardiovascular system disease DOID:1287 0 0.016
nervous system disease DOID:863 0 0.014
musculoskeletal system disease DOID:17 0 0.012
central nervous system disease DOID:331 0 0.011