Rattus norvegicus

0 known processes

Ppl

periplakin

Ppl biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of programmed cell death GO:0043067 341 0.102
single organism biosynthetic process GO:0044711 342 0.085
programmed cell death GO:0012501 392 0.085
organic acid metabolic process GO:0006082 292 0.083
apoptotic process GO:0006915 381 0.074
intracellular signal transduction GO:0035556 314 0.066
cellular response to oxygen containing compound GO:1901701 386 0.060
anatomical structure morphogenesis GO:0009653 298 0.060
carboxylic acid metabolic process GO:0019752 289 0.059
oxoacid metabolic process GO:0043436 290 0.058
lipid metabolic process GO:0006629 283 0.057
regulation of apoptotic process GO:0042981 335 0.057
regulation of signal transduction GO:0009966 318 0.052
protein phosphorylation GO:0006468 345 0.047
organelle organization GO:0006996 266 0.047
regulation of phosphorus metabolic process GO:0051174 349 0.046
membrane organization GO:0061024 94 0.046
cellular component assembly GO:0022607 360 0.042
regulation of multicellular organismal development GO:2000026 376 0.042
response to inorganic substance GO:0010035 377 0.041
small molecule biosynthetic process GO:0044283 124 0.041
organophosphate metabolic process GO:0019637 370 0.040
regulation of catalytic activity GO:0050790 304 0.040
single organism reproductive process GO:0044702 297 0.040
cellular response to lipid GO:0071396 201 0.039
central nervous system development GO:0007417 311 0.039
cellular response to organic cyclic compound GO:0071407 202 0.039
lipid biosynthetic process GO:0008610 128 0.039
regulation of molecular function GO:0065009 398 0.038
regulation of cellular component organization GO:0051128 368 0.037
cellular lipid metabolic process GO:0044255 208 0.036
nucleobase containing small molecule metabolic process GO:0055086 316 0.036
locomotion GO:0040011 237 0.036
cellular component morphogenesis GO:0032989 155 0.036
regulation of cell differentiation GO:0045595 320 0.036
positive regulation of transport GO:0051050 245 0.036
positive regulation of multicellular organismal process GO:0051240 387 0.035
brain development GO:0007420 247 0.035
response to metal ion GO:0010038 253 0.034
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.034
homeostatic process GO:0042592 331 0.033
positive regulation of programmed cell death GO:0043068 157 0.033
neuron differentiation GO:0030182 368 0.033
amine metabolic process GO:0009308 38 0.033
nucleotide metabolic process GO:0009117 279 0.032
negative regulation of biosynthetic process GO:0009890 168 0.032
cell projection organization GO:0030030 302 0.032
positive regulation of cell death GO:0010942 184 0.032
regulation of hydrolase activity GO:0051336 143 0.032
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.031
negative regulation of response to stimulus GO:0048585 155 0.031
negative regulation of metabolic process GO:0009892 331 0.031
positive regulation of developmental process GO:0051094 283 0.031
response to extracellular stimulus GO:0009991 380 0.030
regulation of intracellular signal transduction GO:1902531 218 0.030
regulation of membrane potential GO:0042391 110 0.030
gland development GO:0048732 155 0.030
aging GO:0007568 241 0.029
regulation of cellular localization GO:0060341 263 0.029
catabolic process GO:0009056 351 0.029
cellular component movement GO:0006928 248 0.029
macromolecular complex subunit organization GO:0043933 339 0.029
negative regulation of cellular biosynthetic process GO:0031327 161 0.029
negative regulation of apoptotic process GO:0043066 181 0.028
negative regulation of cell death GO:0060548 229 0.028
cell morphogenesis GO:0000902 142 0.028
wound healing GO:0042060 122 0.028
cellular ketone metabolic process GO:0042180 51 0.028
organic anion transport GO:0015711 132 0.027
monocarboxylic acid metabolic process GO:0032787 152 0.027
response to glucocorticoid GO:0051384 223 0.027
head development GO:0060322 247 0.027
positive regulation of response to stimulus GO:0048584 285 0.027
response to estrogen GO:0043627 232 0.027
regulation of phosphorylation GO:0042325 248 0.027
purine containing compound metabolic process GO:0072521 253 0.027
regulation of cellular protein metabolic process GO:0032268 267 0.026
vesicle mediated transport GO:0016192 181 0.026
regulation of cellular ketone metabolic process GO:0010565 27 0.026
biological adhesion GO:0022610 110 0.026
cellular response to endogenous stimulus GO:0071495 377 0.026
carbohydrate derivative metabolic process GO:1901135 346 0.025
cellular response to stress GO:0033554 269 0.025
anion transport GO:0006820 178 0.025
regulation of rna metabolic process GO:0051252 391 0.025
transcription dna templated GO:0006351 377 0.025
cellular amino acid metabolic process GO:0006520 107 0.025
secretion GO:0046903 307 0.025
chemical homeostasis GO:0048878 292 0.025
regulation of rna biosynthetic process GO:2001141 381 0.025
negative regulation of cellular metabolic process GO:0031324 281 0.024
negative regulation of macromolecule metabolic process GO:0010605 260 0.024
regeneration GO:0031099 163 0.024
regulation of protein phosphorylation GO:0001932 183 0.024
single organism membrane organization GO:0044802 74 0.024
reproductive process GO:0022414 372 0.024
neuron projection development GO:0031175 273 0.024
cellular amine metabolic process GO:0044106 38 0.024
positive regulation of cell proliferation GO:0008284 249 0.024
rna biosynthetic process GO:0032774 380 0.023
response to estradiol GO:0032355 164 0.023
ras protein signal transduction GO:0007265 29 0.023
regulation of cellular amine metabolic process GO:0033238 8 0.023
negative regulation of signaling GO:0023057 157 0.023
response to oxidative stress GO:0006979 186 0.023
regulation of neurogenesis GO:0050767 247 0.023
nucleic acid templated transcription GO:0097659 379 0.022
response to acid chemical GO:0001101 222 0.022
regulation of neuron differentiation GO:0045664 208 0.022
regulation of cellular amino acid metabolic process GO:0006521 2 0.022
regulation of nervous system development GO:0051960 264 0.022
organic acid biosynthetic process GO:0016053 83 0.022
positive regulation of biosynthetic process GO:0009891 319 0.022
cellular chemical homeostasis GO:0055082 247 0.022
regulation of secretion by cell GO:1903530 208 0.022
positive regulation of phosphorus metabolic process GO:0010562 262 0.022
establishment of protein localization GO:0045184 141 0.021
response to carbohydrate GO:0009743 183 0.021
cellular homeostasis GO:0019725 252 0.021
macromolecule localization GO:0033036 252 0.021
positive regulation of cellular component organization GO:0051130 200 0.021
protein oligomerization GO:0051259 191 0.021
organ regeneration GO:0031100 101 0.021
regulation of cell projection organization GO:0031344 175 0.021
regulation of cell development GO:0060284 263 0.021
rna metabolic process GO:0016070 406 0.021
purine ribonucleotide catabolic process GO:0009154 136 0.020
negative regulation of gene expression GO:0010629 199 0.020
single organism organelle organization GO:1902589 180 0.020
nucleoside phosphate metabolic process GO:0006753 283 0.020
purine ribonucleotide metabolic process GO:0009150 227 0.020
transmembrane transport GO:0055085 412 0.020
positive regulation of cell development GO:0010720 176 0.020
response to reactive oxygen species GO:0000302 120 0.020
protein complex subunit organization GO:0071822 302 0.020
response to growth factor GO:0070848 189 0.020
cell cell signaling GO:0007267 335 0.020
heart morphogenesis GO:0003007 3 0.020
ribose phosphate metabolic process GO:0019693 235 0.020
response to corticosteroid GO:0031960 235 0.020
positive regulation of cell communication GO:0010647 271 0.020
secretion by cell GO:0032940 248 0.020
regulation of protein modification process GO:0031399 194 0.020
response to monosaccharide GO:0034284 159 0.020
epithelium development GO:0060429 96 0.019
macromolecular complex assembly GO:0065003 273 0.019
positive regulation of cell differentiation GO:0045597 217 0.019
negative regulation of transport GO:0051051 136 0.019
regulation of protein metabolic process GO:0051246 289 0.019
positive regulation of molecular function GO:0044093 230 0.019
positive regulation of phosphate metabolic process GO:0045937 262 0.019
regulation of transcription dna templated GO:0006355 374 0.019
cellular component biogenesis GO:0044085 368 0.019
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.019
purine nucleotide metabolic process GO:0006163 229 0.019
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
proteolysis GO:0006508 175 0.019
negative regulation of cell communication GO:0010648 158 0.019
response to external biotic stimulus GO:0043207 221 0.019
organic hydroxy compound metabolic process GO:1901615 115 0.019
single organism intracellular transport GO:1902582 166 0.019
cell type specific apoptotic process GO:0097285 134 0.019
organophosphate biosynthetic process GO:0090407 143 0.019
positive regulation of cellular biosynthetic process GO:0031328 295 0.018
response to hexose GO:0009746 144 0.018
ribonucleotide metabolic process GO:0009259 231 0.018
cell adhesion GO:0007155 110 0.018
organic substance catabolic process GO:1901575 316 0.018
tissue development GO:0009888 252 0.018
response to wounding GO:0009611 254 0.018
positive regulation of phosphorylation GO:0042327 177 0.018
negative regulation of programmed cell death GO:0043069 183 0.018
multi organism reproductive process GO:0044703 262 0.018
localization of cell GO:0051674 202 0.018
positive regulation of gene expression GO:0010628 244 0.018
glycosyl compound metabolic process GO:1901657 182 0.018
multicellular organism reproduction GO:0032504 233 0.017
nucleoside metabolic process GO:0009116 179 0.017
positive regulation of intracellular signal transduction GO:1902533 138 0.017
purine nucleoside metabolic process GO:0042278 169 0.017
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.017
protein complex biogenesis GO:0070271 263 0.017
regulation of cell proliferation GO:0042127 359 0.017
response to bacterium GO:0009617 200 0.017
purine containing compound catabolic process GO:0072523 138 0.017
actin filament based process GO:0030029 86 0.017
ion homeostasis GO:0050801 212 0.017
organonitrogen compound biosynthetic process GO:1901566 167 0.017
metal ion transport GO:0030001 289 0.017
response to decreased oxygen levels GO:0036293 237 0.017
ribonucleotide catabolic process GO:0009261 136 0.017
cardiac conduction GO:0061337 2 0.017
intracellular transport GO:0046907 185 0.017
cation transport GO:0006812 382 0.016
positive regulation of catalytic activity GO:0043085 184 0.016
nitrogen compound transport GO:0071705 229 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.016
cellular response to hormone stimulus GO:0032870 247 0.016
cellular cation homeostasis GO:0030003 180 0.016
oxidation reduction process GO:0055114 304 0.016
carbohydrate derivative catabolic process GO:1901136 147 0.016
purine ribonucleoside metabolic process GO:0046128 168 0.016
cellular nitrogen compound catabolic process GO:0044270 163 0.016
nucleoside catabolic process GO:0009164 126 0.016
protein complex assembly GO:0006461 263 0.016
response to nutrient levels GO:0031667 370 0.016
response to glucose GO:0009749 136 0.016
small gtpase mediated signal transduction GO:0007264 36 0.016
regulation of hormone levels GO:0010817 187 0.016
cell migration GO:0016477 197 0.016
multicellular organismal reproductive process GO:0048609 233 0.016
positive regulation of signaling GO:0023056 270 0.016
signal transduction by phosphorylation GO:0023014 144 0.016
organic acid transport GO:0015849 116 0.016
regulation of nucleic acid templated transcription GO:1903506 380 0.016
nucleoside triphosphate metabolic process GO:0009141 144 0.016
regulation of catabolic process GO:0009894 113 0.015
response to hydrogen peroxide GO:0042542 89 0.015
single organism catabolic process GO:0044712 283 0.015
nucleobase containing compound catabolic process GO:0034655 152 0.015
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.015
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.015
ribonucleoside catabolic process GO:0042454 126 0.015
positive regulation of protein metabolic process GO:0051247 178 0.015
gastrulation GO:0007369 2 0.015
regulation of system process GO:0044057 208 0.015
response to nutrient GO:0007584 248 0.015
response to hypoxia GO:0001666 231 0.015
regulation of secretion GO:0051046 224 0.015
purine nucleoside triphosphate metabolic process GO:0009144 141 0.015
gliogenesis GO:0042063 93 0.014
divalent metal ion transport GO:0070838 132 0.014
cell projection morphogenesis GO:0048858 123 0.014
response to toxic substance GO:0009636 133 0.014
ribonucleoside metabolic process GO:0009119 174 0.014
carboxylic acid transport GO:0046942 115 0.014
purine nucleotide catabolic process GO:0006195 136 0.014
regulation of response to stress GO:0080134 126 0.014
response to lipopolysaccharide GO:0032496 191 0.014
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.014
purine nucleoside triphosphate catabolic process GO:0009146 122 0.014
g protein coupled receptor signaling pathway GO:0007186 242 0.014
positive regulation of cellular component biogenesis GO:0044089 55 0.014
organophosphate catabolic process GO:0046434 148 0.014
response to oxygen levels GO:0070482 265 0.014
regulation of phosphate metabolic process GO:0019220 349 0.014
cellular catabolic process GO:0044248 295 0.014
positive regulation of hydrolase activity GO:0051345 86 0.014
neuron development GO:0048666 286 0.014
nucleoside triphosphate catabolic process GO:0009143 123 0.014
single organism carbohydrate metabolic process GO:0044723 118 0.014
cellular protein localization GO:0034613 122 0.014
rho protein signal transduction GO:0007266 11 0.014
positive regulation of nervous system development GO:0051962 178 0.014
negative regulation of nucleic acid templated transcription GO:1903507 117 0.014
organonitrogen compound catabolic process GO:1901565 179 0.014
positive regulation of locomotion GO:0040017 102 0.014
cell motility GO:0048870 202 0.014
negative regulation of developmental process GO:0051093 125 0.014
protein transport GO:0015031 132 0.013
response to ketone GO:1901654 182 0.013
response to peptide GO:1901652 292 0.013
negative regulation of multicellular organismal process GO:0051241 203 0.013
regulation of cellular component movement GO:0051270 150 0.013
circulatory system process GO:0003013 183 0.013
alcohol metabolic process GO:0006066 77 0.013
protein localization GO:0008104 191 0.013
positive regulation of protein phosphorylation GO:0001934 135 0.013
rhythmic process GO:0048511 156 0.013
reactive nitrogen species metabolic process GO:2001057 1 0.013
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.013
response to other organism GO:0051707 220 0.013
reproduction GO:0000003 245 0.013
regulation of neuron projection development GO:0010975 161 0.013
cell part morphogenesis GO:0032990 123 0.013
negative regulation of molecular function GO:0044092 133 0.013
sensory perception of pain GO:0019233 73 0.013
cytoskeleton organization GO:0007010 111 0.013
reproductive system development GO:0061458 128 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.013
organic cyclic compound catabolic process GO:1901361 175 0.013
immune system process GO:0002376 204 0.013
multi multicellular organism process GO:0044706 138 0.013
axon development GO:0061564 96 0.013
carboxylic acid biosynthetic process GO:0046394 83 0.013
positive regulation of cellular protein metabolic process GO:0032270 167 0.013
carbohydrate homeostasis GO:0033500 75 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.013
positive regulation of protein modification process GO:0031401 142 0.013
fatty acid metabolic process GO:0006631 99 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.013
heterocycle catabolic process GO:0046700 167 0.012
regulation of cell morphogenesis GO:0022604 77 0.012
blood circulation GO:0008015 183 0.012
regulation of ion transport GO:0043269 245 0.012
regulation of anatomical structure size GO:0090066 135 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.012
glucose homeostasis GO:0042593 75 0.012
cellular response to steroid hormone stimulus GO:0071383 93 0.012
regulation of cell migration GO:0030334 128 0.012
cellular response to metal ion GO:0071248 55 0.012
regulation of anatomical structure morphogenesis GO:0022603 141 0.012
cellular macromolecule localization GO:0070727 122 0.012
regulation of muscle system process GO:0090257 79 0.012
response to calcium ion GO:0051592 59 0.012
response to biotic stimulus GO:0009607 226 0.012
divalent inorganic cation transport GO:0072511 134 0.012
regulation of cell motility GO:2000145 131 0.012
regulation of cellular component biogenesis GO:0044087 86 0.012
regulation of canonical wnt signaling pathway GO:0060828 4 0.012
axis specification GO:0009798 4 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
cellular metal ion homeostasis GO:0006875 172 0.012
ion transmembrane transport GO:0034220 365 0.012
endocrine system development GO:0035270 30 0.012
spermatogenesis GO:0007283 99 0.012
purine nucleoside catabolic process GO:0006152 124 0.012
positive regulation of nucleic acid templated transcription GO:1903508 197 0.012
response to temperature stimulus GO:0009266 94 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
developmental process involved in reproduction GO:0003006 159 0.012
positive regulation of signal transduction GO:0009967 175 0.012
muscle system process GO:0003012 115 0.012
forebrain development GO:0030900 98 0.012
regulation of nucleotide metabolic process GO:0006140 117 0.012
positive regulation of nucleotide metabolic process GO:0045981 91 0.011
ventricular cardiac muscle cell action potential GO:0086005 2 0.011
sexual reproduction GO:0019953 148 0.011
regulation of purine nucleotide metabolic process GO:1900542 115 0.011
cellular response to nitrogen compound GO:1901699 210 0.011
urogenital system development GO:0001655 78 0.011
monocarboxylic acid biosynthetic process GO:0072330 48 0.011
ribonucleoside triphosphate metabolic process GO:0009199 141 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.011
nucleoside phosphate biosynthetic process GO:1901293 102 0.011
male gamete generation GO:0048232 99 0.011
peptidyl amino acid modification GO:0018193 126 0.011
negative regulation of signal transduction GO:0009968 83 0.011
defense response GO:0006952 194 0.011
cellular response to peptide GO:1901653 133 0.011
action potential GO:0001508 54 0.011
divalent inorganic cation homeostasis GO:0072507 165 0.011
amide transport GO:0042886 105 0.011
negative regulation of neuron differentiation GO:0045665 62 0.011
purine ribonucleoside catabolic process GO:0046130 124 0.011
neurological system process GO:0050877 219 0.011
transcription from rna polymerase ii promoter GO:0006366 252 0.011
aromatic compound catabolic process GO:0019439 168 0.011
negative regulation of secretion GO:0051048 82 0.011
negative regulation of rna biosynthetic process GO:1902679 118 0.011
guanosine containing compound catabolic process GO:1901069 71 0.011
response to peptide hormone GO:0043434 278 0.011
cellular response to organonitrogen compound GO:0071417 197 0.011
regulation of response to external stimulus GO:0032101 106 0.011
reactive oxygen species metabolic process GO:0072593 37 0.011
sulfur compound metabolic process GO:0006790 70 0.011
inorganic ion transmembrane transport GO:0098660 229 0.011
cardiac chamber development GO:0003205 1 0.011
metal ion homeostasis GO:0055065 186 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 53 0.011
reproductive structure development GO:0048608 128 0.011
non canonical wnt signaling pathway GO:0035567 3 0.011
cation homeostasis GO:0055080 195 0.011
regulation of mapk cascade GO:0043408 116 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
regulation of cellular catabolic process GO:0031329 101 0.010
nucleotide catabolic process GO:0009166 139 0.010
purine containing compound biosynthetic process GO:0072522 85 0.010
endomembrane system organization GO:0010256 48 0.010
cofactor metabolic process GO:0051186 95 0.010
regulation of stem cell differentiation GO:2000736 2 0.010
inorganic cation transmembrane transport GO:0098662 202 0.010
negative regulation of cell proliferation GO:0008285 119 0.010
epithelial cell differentiation GO:0030855 71 0.010
cellular hormone metabolic process GO:0034754 49 0.010
single organism cellular localization GO:1902580 102 0.010
telencephalon development GO:0021537 62 0.010
response to radiation GO:0009314 137 0.010
unsaturated fatty acid biosynthetic process GO:0006636 21 0.010
dna metabolic process GO:0006259 96 0.010
cell morphogenesis involved in differentiation GO:0000904 119 0.010
positive regulation of neuron differentiation GO:0045666 126 0.010
neuron projection morphogenesis GO:0048812 122 0.010
protein homooligomerization GO:0051260 91 0.010
protein localization to membrane GO:0072657 36 0.010
multicellular organism growth GO:0035264 1 0.010
cellular response to oxidative stress GO:0034599 76 0.010
protein processing GO:0016485 68 0.010
calcium ion transport GO:0006816 131 0.010

Ppl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.021
nervous system disease DOID:863 0 0.021
cardiovascular system disease DOID:1287 0 0.017
musculoskeletal system disease DOID:17 0 0.017
muscular disease DOID:0080000 0 0.013
disease of metabolism DOID:0014667 0 0.012
muscle tissue disease DOID:66 0 0.012
central nervous system disease DOID:331 0 0.011
myopathy DOID:423 0 0.010