Rattus norvegicus

38 known processes

Smpd2

sphingomyelin phosphodiesterase 2, neutral membrane

(Aliases: nSMase)

Smpd2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
rna metabolic process GO:0016070 406 0.089
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.070
regulation of rna biosynthetic process GO:2001141 381 0.065
catabolic process GO:0009056 351 0.063
organophosphate metabolic process GO:0019637 370 0.063
organic substance catabolic process GO:1901575 316 0.062
regulation of molecular function GO:0065009 398 0.062
organelle organization GO:0006996 266 0.062
purine containing compound metabolic process GO:0072521 253 0.060
intracellular signal transduction GO:0035556 314 0.059
single organism biosynthetic process GO:0044711 342 0.058
apoptotic process GO:0006915 381 0.055
regulation of phosphate metabolic process GO:0019220 349 0.053
nucleic acid templated transcription GO:0097659 379 0.052
positive regulation of cellular biosynthetic process GO:0031328 295 0.052
regulation of phosphorus metabolic process GO:0051174 349 0.051
regulation of rna metabolic process GO:0051252 391 0.051
organic acid metabolic process GO:0006082 292 0.051
regulation of transcription dna templated GO:0006355 374 0.050
neuron development GO:0048666 286 0.050
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.049
programmed cell death GO:0012501 392 0.047
nucleoside phosphate metabolic process GO:0006753 283 0.046
cellular response to stress GO:0033554 269 0.046
anatomical structure morphogenesis GO:0009653 298 0.046
ribonucleotide metabolic process GO:0009259 231 0.046
rna biosynthetic process GO:0032774 380 0.044
carbohydrate derivative metabolic process GO:1901135 346 0.044
purine nucleotide metabolic process GO:0006163 229 0.043
nucleotide metabolic process GO:0009117 279 0.042
neuron differentiation GO:0030182 368 0.042
positive regulation of cell communication GO:0010647 271 0.042
intracellular transport GO:0046907 185 0.041
purine ribonucleoside metabolic process GO:0046128 168 0.041
positive regulation of molecular function GO:0044093 230 0.040
nucleoside metabolic process GO:0009116 179 0.040
cellular response to oxygen containing compound GO:1901701 386 0.040
positive regulation of transport GO:0051050 245 0.039
nucleobase containing small molecule metabolic process GO:0055086 316 0.039
cation transport GO:0006812 382 0.039
protein phosphorylation GO:0006468 345 0.039
single organism organelle organization GO:1902589 180 0.039
organic cyclic compound catabolic process GO:1901361 175 0.038
positive regulation of gene expression GO:0010628 244 0.037
cellular amino acid metabolic process GO:0006520 107 0.037
glycosyl compound metabolic process GO:1901657 182 0.037
regulation of protein modification process GO:0031399 194 0.036
aromatic compound catabolic process GO:0019439 168 0.036
regulation of cellular protein metabolic process GO:0032268 267 0.036
transmembrane transport GO:0055085 412 0.036
positive regulation of biosynthetic process GO:0009891 319 0.036
reproductive process GO:0022414 372 0.036
purine ribonucleotide metabolic process GO:0009150 227 0.036
positive regulation of catalytic activity GO:0043085 184 0.036
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.035
positive regulation of signaling GO:0023056 270 0.035
regulation of catalytic activity GO:0050790 304 0.035
ribonucleotide catabolic process GO:0009261 136 0.035
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.035
regulation of protein metabolic process GO:0051246 289 0.034
transcription dna templated GO:0006351 377 0.034
regulation of cellular amino acid metabolic process GO:0006521 2 0.034
regulation of nucleic acid templated transcription GO:1903506 380 0.034
chemical homeostasis GO:0048878 292 0.034
regulation of phosphorylation GO:0042325 248 0.034
cellular ketone metabolic process GO:0042180 51 0.033
heterocycle catabolic process GO:0046700 167 0.033
positive regulation of response to stimulus GO:0048584 285 0.033
single organism catabolic process GO:0044712 283 0.033
cellular catabolic process GO:0044248 295 0.033
ribonucleoside triphosphate metabolic process GO:0009199 141 0.033
neuron projection development GO:0031175 273 0.033
regulation of cell proliferation GO:0042127 359 0.032
purine ribonucleotide catabolic process GO:0009154 136 0.032
purine nucleoside metabolic process GO:0042278 169 0.032
amine metabolic process GO:0009308 38 0.032
cellular component biogenesis GO:0044085 368 0.032
response to peptide GO:1901652 292 0.032
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.031
actin filament based process GO:0030029 86 0.031
organonitrogen compound catabolic process GO:1901565 179 0.031
negative regulation of macromolecule metabolic process GO:0010605 260 0.031
cell projection organization GO:0030030 302 0.031
regulation of cellular component organization GO:0051128 368 0.030
negative regulation of cellular metabolic process GO:0031324 281 0.030
regulation of intracellular signal transduction GO:1902531 218 0.030
homeostatic process GO:0042592 331 0.029
regulation of apoptotic process GO:0042981 335 0.029
cellular amine metabolic process GO:0044106 38 0.029
cellular component movement GO:0006928 248 0.029
regulation of cellular amine metabolic process GO:0033238 8 0.029
transcription from rna polymerase ii promoter GO:0006366 252 0.029
regulation of cellular ketone metabolic process GO:0010565 27 0.029
purine containing compound catabolic process GO:0072523 138 0.028
ribose phosphate metabolic process GO:0019693 235 0.028
purine ribonucleoside catabolic process GO:0046130 124 0.028
cellular nitrogen compound catabolic process GO:0044270 163 0.028
negative regulation of metabolic process GO:0009892 331 0.028
purine nucleoside triphosphate metabolic process GO:0009144 141 0.028
regulation of signal transduction GO:0009966 318 0.027
ribonucleoside metabolic process GO:0009119 174 0.027
nucleoside triphosphate metabolic process GO:0009141 144 0.027
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.027
oxoacid metabolic process GO:0043436 290 0.027
response to nutrient levels GO:0031667 370 0.027
positive regulation of cellular protein metabolic process GO:0032270 167 0.027
regulation of multicellular organismal development GO:2000026 376 0.027
response to extracellular stimulus GO:0009991 380 0.026
macromolecular complex assembly GO:0065003 273 0.026
store operated calcium entry GO:0002115 2 0.026
regulation of kinase activity GO:0043549 117 0.025
nucleoside phosphate catabolic process GO:1901292 140 0.025
secretion GO:0046903 307 0.025
macromolecular complex subunit organization GO:0043933 339 0.025
cellular component assembly GO:0022607 360 0.025
nucleobase containing compound catabolic process GO:0034655 152 0.024
carbohydrate derivative catabolic process GO:1901136 147 0.024
reproduction GO:0000003 245 0.024
protein complex subunit organization GO:0071822 302 0.024
cellular response to hormone stimulus GO:0032870 247 0.024
positive regulation of phosphorus metabolic process GO:0010562 262 0.024
negative regulation of nucleic acid templated transcription GO:1903507 117 0.024
positive regulation of phosphate metabolic process GO:0045937 262 0.024
metal ion transport GO:0030001 289 0.023
protein localization GO:0008104 191 0.023
positive regulation of multicellular organismal process GO:0051240 387 0.023
aging GO:0007568 241 0.023
positive regulation of rna metabolic process GO:0051254 203 0.023
single organism reproductive process GO:0044702 297 0.023
central nervous system development GO:0007417 311 0.023
regulation of cell differentiation GO:0045595 320 0.023
response to ketone GO:1901654 182 0.023
multicellular organism reproduction GO:0032504 233 0.023
response to biotic stimulus GO:0009607 226 0.023
negative regulation of cellular biosynthetic process GO:0031327 161 0.022
negative regulation of gene expression GO:0010629 199 0.022
negative regulation of molecular function GO:0044092 133 0.022
regulation of membrane potential GO:0042391 110 0.022
multicellular organismal reproductive process GO:0048609 233 0.022
glycosyl compound catabolic process GO:1901658 126 0.022
macromolecule localization GO:0033036 252 0.022
response to other organism GO:0051707 220 0.022
ribonucleoside catabolic process GO:0042454 126 0.021
ribonucleoside triphosphate catabolic process GO:0009203 122 0.021
regulation of protein kinase activity GO:0045859 105 0.021
positive regulation of cellular amine metabolic process GO:0033240 3 0.021
purine nucleotide catabolic process GO:0006195 136 0.021
protein complex assembly GO:0006461 263 0.021
multi organism reproductive process GO:0044703 262 0.021
regulation of transferase activity GO:0051338 123 0.021
purine nucleoside catabolic process GO:0006152 124 0.021
ion transmembrane transport GO:0034220 365 0.021
regulation of programmed cell death GO:0043067 341 0.020
negative regulation of rna biosynthetic process GO:1902679 118 0.020
positive regulation of transcription dna templated GO:0045893 197 0.020
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.020
response to cytokine GO:0034097 215 0.020
positive regulation of signal transduction GO:0009967 175 0.020
cellular homeostasis GO:0019725 252 0.020
response to inorganic substance GO:0010035 377 0.020
cytoskeleton organization GO:0007010 111 0.020
protein complex biogenesis GO:0070271 263 0.020
carboxylic acid metabolic process GO:0019752 289 0.020
single organism intracellular transport GO:1902582 166 0.020
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.020
negative regulation of cell communication GO:0010648 158 0.019
cell cell signaling GO:0007267 335 0.019
brain development GO:0007420 247 0.019
defense response GO:0006952 194 0.019
organophosphate biosynthetic process GO:0090407 143 0.019
positive regulation of nucleic acid templated transcription GO:1903508 197 0.019
nucleotide catabolic process GO:0009166 139 0.019
nucleoside catabolic process GO:0009164 126 0.019
organophosphate catabolic process GO:0046434 148 0.019
developmental process involved in reproduction GO:0003006 159 0.019
response to external biotic stimulus GO:0043207 221 0.019
response to oxidative stress GO:0006979 186 0.018
positive regulation of phosphorylation GO:0042327 177 0.018
cell migration GO:0016477 197 0.018
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.018
regulation of cell development GO:0060284 263 0.018
negative regulation of cell death GO:0060548 229 0.018
negative regulation of apoptotic process GO:0043066 181 0.018
neurological system process GO:0050877 219 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
lipid metabolic process GO:0006629 283 0.017
embryonic pattern specification GO:0009880 1 0.017
cellular response to cytokine stimulus GO:0071345 127 0.017
negative regulation of transcription dna templated GO:0045892 116 0.017
negative regulation of rna metabolic process GO:0051253 123 0.017
chromosome segregation GO:0007059 2 0.017
response to nutrient GO:0007584 248 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.017
regulation of cellular localization GO:0060341 263 0.017
negative regulation of protein metabolic process GO:0051248 114 0.017
regulation of neurogenesis GO:0050767 247 0.017
positive regulation of protein metabolic process GO:0051247 178 0.017
establishment of protein localization GO:0045184 141 0.017
response to wounding GO:0009611 254 0.017
tissue development GO:0009888 252 0.017
gamete generation GO:0007276 124 0.017
cell morphogenesis GO:0000902 142 0.017
response to hypoxia GO:0001666 231 0.017
response to peptide hormone GO:0043434 278 0.017
response to purine containing compound GO:0014074 126 0.017
negative regulation of signaling GO:0023057 157 0.016
purine nucleoside monophosphate metabolic process GO:0009126 84 0.016
positive regulation of rna biosynthetic process GO:1902680 197 0.016
locomotion GO:0040011 237 0.016
response to decreased oxygen levels GO:0036293 237 0.016
regulation of protein phosphorylation GO:0001932 183 0.016
small gtpase mediated signal transduction GO:0007264 36 0.016
regulation of response to stress GO:0080134 126 0.016
negative regulation of response to stimulus GO:0048585 155 0.015
response to estrogen GO:0043627 232 0.015
response to ethanol GO:0045471 162 0.015
single organism carbohydrate metabolic process GO:0044723 118 0.015
response to insulin GO:0032868 133 0.015
single organism cellular localization GO:1902580 102 0.015
response to oxygen levels GO:0070482 265 0.015
nucleoside triphosphate catabolic process GO:0009143 123 0.015
cellular component morphogenesis GO:0032989 155 0.015
response to bacterium GO:0009617 200 0.015
positive regulation of protein modification process GO:0031401 142 0.015
cellular chemical homeostasis GO:0055082 247 0.015
cellular response to nitrogen compound GO:1901699 210 0.015
metal ion homeostasis GO:0055065 186 0.015
positive regulation of catabolic process GO:0009896 78 0.015
cell projection morphogenesis GO:0048858 123 0.015
positive regulation of neurogenesis GO:0050769 165 0.014
axis specification GO:0009798 4 0.014
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.014
membrane organization GO:0061024 94 0.014
cellular response to endogenous stimulus GO:0071495 377 0.014
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.014
regulation of catabolic process GO:0009894 113 0.014
response to acid chemical GO:0001101 222 0.014
negative regulation of programmed cell death GO:0043069 183 0.014
carbohydrate metabolic process GO:0005975 130 0.014
negative regulation of cellular protein metabolic process GO:0032269 106 0.014
response to vitamin GO:0033273 131 0.014
regulation of response to external stimulus GO:0032101 106 0.014
cell cycle GO:0007049 101 0.014
regulation of cell projection organization GO:0031344 175 0.014
positive regulation of cell proliferation GO:0008284 249 0.014
regulation of system process GO:0044057 208 0.014
positive regulation of cellular component organization GO:0051130 200 0.014
regulation of nucleotide metabolic process GO:0006140 117 0.014
organonitrogen compound biosynthetic process GO:1901566 167 0.014
response to organophosphorus GO:0046683 102 0.014
response to growth factor GO:0070848 189 0.014
positive regulation of developmental process GO:0051094 283 0.014
positive regulation of hydrolase activity GO:0051345 86 0.014
divalent inorganic cation homeostasis GO:0072507 165 0.013
regulation of fat cell differentiation GO:0045598 3 0.013
positive regulation of protein phosphorylation GO:0001934 135 0.013
proteolysis GO:0006508 175 0.013
monovalent inorganic cation transport GO:0015672 172 0.013
cellular response to growth factor stimulus GO:0071363 162 0.013
secretion by cell GO:0032940 248 0.013
regulation of hydrolase activity GO:0051336 143 0.013
response to transition metal nanoparticle GO:1990267 122 0.013
regulation of defense response GO:0031347 68 0.013
positive regulation of nucleoside metabolic process GO:0045979 55 0.013
sexual reproduction GO:0019953 148 0.013
regulation of neuron death GO:1901214 115 0.013
regulation of cellular component movement GO:0051270 150 0.013
response to lipopolysaccharide GO:0032496 191 0.013
single organism membrane organization GO:0044802 74 0.013
negative regulation of catalytic activity GO:0043086 103 0.013
axon development GO:0061564 96 0.013
ion homeostasis GO:0050801 212 0.013
anterior posterior pattern specification GO:0009952 1 0.013
regulation of ion transport GO:0043269 245 0.012
heart morphogenesis GO:0003007 3 0.012
cellular macromolecule localization GO:0070727 122 0.012
action potential GO:0001508 54 0.012
cell motility GO:0048870 202 0.012
positive regulation of intracellular signal transduction GO:1902533 138 0.012
regulation of anatomical structure size GO:0090066 135 0.012
gastrulation GO:0007369 2 0.012
regulation of purine nucleotide metabolic process GO:1900542 115 0.012
positive regulation of cell development GO:0010720 176 0.012
regulation of nervous system development GO:0051960 264 0.012
nucleoside monophosphate metabolic process GO:0009123 93 0.012
localization of cell GO:0051674 202 0.012
gland development GO:0048732 155 0.012
cellular carbohydrate metabolic process GO:0044262 72 0.012
cation homeostasis GO:0055080 195 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
chemosensory behavior GO:0007635 2 0.012
actin cytoskeleton organization GO:0030036 73 0.012
head development GO:0060322 247 0.012
regulation of cell migration GO:0030334 128 0.012
vesicle mediated transport GO:0016192 181 0.012
ribonucleoside monophosphate metabolic process GO:0009161 88 0.012
cell adhesion GO:0007155 110 0.012
oxidation reduction process GO:0055114 304 0.012
response to carbohydrate GO:0009743 183 0.012
positive regulation of secretion by cell GO:1903532 128 0.012
cellular response to lipid GO:0071396 201 0.012
positive regulation of cell death GO:0010942 184 0.012
response to metal ion GO:0010038 253 0.011
immune effector process GO:0002252 53 0.011
regulation of neuron projection development GO:0010975 161 0.011
divalent inorganic cation transport GO:0072511 134 0.011
nitrogen compound transport GO:0071705 229 0.011
cellular response to external stimulus GO:0071496 118 0.011
response to reactive oxygen species GO:0000302 120 0.011
cell cycle checkpoint GO:0000075 2 0.011
regulation of metal ion transport GO:0010959 118 0.011
cytosolic calcium ion homeostasis GO:0051480 140 0.011
carbohydrate derivative biosynthetic process GO:1901137 124 0.011
dephosphorylation GO:0016311 98 0.011
regulation of neuron differentiation GO:0045664 208 0.011
regulation of immune system process GO:0002682 123 0.011
immune system process GO:0002376 204 0.011
g protein coupled receptor signaling pathway GO:0007186 242 0.011
intracellular protein transport GO:0006886 79 0.011
ras protein signal transduction GO:0007265 29 0.011
cellular protein localization GO:0034613 122 0.011
purine nucleoside triphosphate catabolic process GO:0009146 122 0.011
gtp metabolic process GO:0046039 72 0.011
cellular response to organic cyclic compound GO:0071407 202 0.011
cell part morphogenesis GO:0032990 123 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.011
negative regulation of innate immune response GO:0045824 4 0.011
cellular metal ion homeostasis GO:0006875 172 0.011
behavior GO:0007610 205 0.011
positive regulation of cellular catabolic process GO:0031331 71 0.011
negative regulation of phosphate metabolic process GO:0045936 80 0.011
muscle system process GO:0003012 115 0.011
divalent metal ion transport GO:0070838 132 0.011
calcium ion transport GO:0006816 131 0.010
protein transport GO:0015031 132 0.010
reactive oxygen species biosynthetic process GO:1903409 8 0.010
positive regulation of programmed cell death GO:0043068 157 0.010
response to hydrogen peroxide GO:0042542 89 0.010
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.010
positive regulation of neuron differentiation GO:0045666 126 0.010
male gamete generation GO:0048232 99 0.010
anion transport GO:0006820 178 0.010
positive regulation of nervous system development GO:0051962 178 0.010
cellular response to organonitrogen compound GO:0071417 197 0.010
lipid storage GO:0019915 1 0.010
defense response to gram negative bacterium GO:0050829 3 0.010
negative regulation of multicellular organismal process GO:0051241 203 0.010
muscle contraction GO:0006936 88 0.010

Smpd2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.022
nervous system disease DOID:863 0 0.022
sensory system disease DOID:0050155 0 0.016
musculoskeletal system disease DOID:17 0 0.014
central nervous system disease DOID:331 0 0.011