Rattus norvegicus

0 known processes

Dyrk2

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

Dyrk2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
nucleic acid templated transcription GO:0097659 379 0.128
positive regulation of response to stimulus GO:0048584 285 0.107
positive regulation of cell communication GO:0010647 271 0.107
rna metabolic process GO:0016070 406 0.099
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.092
transcription dna templated GO:0006351 377 0.086
positive regulation of gene expression GO:0010628 244 0.081
regulation of rna biosynthetic process GO:2001141 381 0.078
regulation of signal transduction GO:0009966 318 0.077
regulation of phosphate metabolic process GO:0019220 349 0.075
regulation of nucleic acid templated transcription GO:1903506 380 0.074
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.073
positive regulation of signaling GO:0023056 270 0.073
positive regulation of cellular biosynthetic process GO:0031328 295 0.072
cellular response to oxygen containing compound GO:1901701 386 0.070
regulation of rna metabolic process GO:0051252 391 0.069
rna biosynthetic process GO:0032774 380 0.067
regulation of cellular protein metabolic process GO:0032268 267 0.066
protein phosphorylation GO:0006468 345 0.065
cellular response to endogenous stimulus GO:0071495 377 0.065
positive regulation of biosynthetic process GO:0009891 319 0.064
programmed cell death GO:0012501 392 0.064
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.062
organic acid metabolic process GO:0006082 292 0.060
regulation of transcription dna templated GO:0006355 374 0.060
positive regulation of rna biosynthetic process GO:1902680 197 0.058
cellular response to hormone stimulus GO:0032870 247 0.057
apoptotic process GO:0006915 381 0.056
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.054
regulation of cellular component organization GO:0051128 368 0.054
regulation of phosphorus metabolic process GO:0051174 349 0.053
regulation of protein metabolic process GO:0051246 289 0.052
brain development GO:0007420 247 0.052
cellular ketone metabolic process GO:0042180 51 0.051
positive regulation of transcription dna templated GO:0045893 197 0.050
cellular component movement GO:0006928 248 0.049
regulation of cellular ketone metabolic process GO:0010565 27 0.049
positive regulation of nucleic acid templated transcription GO:1903508 197 0.048
positive regulation of rna metabolic process GO:0051254 203 0.048
neuron differentiation GO:0030182 368 0.048
regulation of molecular function GO:0065009 398 0.046
transcription from rna polymerase ii promoter GO:0006366 252 0.046
positive regulation of transport GO:0051050 245 0.045
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.045
neuron projection development GO:0031175 273 0.044
cellular component biogenesis GO:0044085 368 0.044
central nervous system development GO:0007417 311 0.044
regulation of programmed cell death GO:0043067 341 0.044
regulation of catalytic activity GO:0050790 304 0.043
catabolic process GO:0009056 351 0.043
cellular component assembly GO:0022607 360 0.043
regulation of cell proliferation GO:0042127 359 0.042
reproductive process GO:0022414 372 0.042
response to extracellular stimulus GO:0009991 380 0.042
positive regulation of signal transduction GO:0009967 175 0.042
cellular amino acid metabolic process GO:0006520 107 0.040
cation transport GO:0006812 382 0.040
tissue development GO:0009888 252 0.039
cellular macromolecule localization GO:0070727 122 0.039
locomotion GO:0040011 237 0.038
response to wounding GO:0009611 254 0.038
response to peptide GO:1901652 292 0.037
negative regulation of biosynthetic process GO:0009890 168 0.037
positive regulation of multicellular organismal process GO:0051240 387 0.037
regulation of protein modification process GO:0031399 194 0.037
regulation of apoptotic process GO:0042981 335 0.036
macromolecule localization GO:0033036 252 0.035
intracellular signal transduction GO:0035556 314 0.034
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.034
single organism reproductive process GO:0044702 297 0.034
neuron development GO:0048666 286 0.034
negative regulation of cellular metabolic process GO:0031324 281 0.034
secretion GO:0046903 307 0.034
carboxylic acid metabolic process GO:0019752 289 0.034
head development GO:0060322 247 0.033
regulation of intracellular signal transduction GO:1902531 218 0.033
negative regulation of macromolecule metabolic process GO:0010605 260 0.033
amine metabolic process GO:0009308 38 0.033
cell projection organization GO:0030030 302 0.033
cellular response to organonitrogen compound GO:0071417 197 0.032
regulation of phosphorylation GO:0042325 248 0.032
negative regulation of signaling GO:0023057 157 0.032
cellular catabolic process GO:0044248 295 0.031
positive regulation of molecular function GO:0044093 230 0.031
macromolecular complex assembly GO:0065003 273 0.031
cellular response to growth factor stimulus GO:0071363 162 0.031
positive regulation of phosphate metabolic process GO:0045937 262 0.031
metal ion transport GO:0030001 289 0.030
cell cell signaling GO:0007267 335 0.030
positive regulation of cell proliferation GO:0008284 249 0.030
regulation of multicellular organismal development GO:2000026 376 0.029
negative regulation of cell death GO:0060548 229 0.029
anatomical structure morphogenesis GO:0009653 298 0.029
cellular amine metabolic process GO:0044106 38 0.029
chemical homeostasis GO:0048878 292 0.029
cellular response to steroid hormone stimulus GO:0071383 93 0.028
cellular response to organic cyclic compound GO:0071407 202 0.028
response to corticosteroid GO:0031960 235 0.028
regulation of cellular amine metabolic process GO:0033238 8 0.027
oxoacid metabolic process GO:0043436 290 0.027
regulation of cell differentiation GO:0045595 320 0.027
mapk cascade GO:0000165 140 0.027
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.027
enzyme linked receptor protein signaling pathway GO:0007167 116 0.027
positive regulation of programmed cell death GO:0043068 157 0.027
lipid biosynthetic process GO:0008610 128 0.027
organophosphate metabolic process GO:0019637 370 0.027
response to nutrient levels GO:0031667 370 0.026
protein complex biogenesis GO:0070271 263 0.026
reproduction GO:0000003 245 0.026
response to decreased oxygen levels GO:0036293 237 0.026
regulation of system process GO:0044057 208 0.026
cellular response to lipid GO:0071396 201 0.026
regulation of cellular amino acid metabolic process GO:0006521 2 0.026
regulation of cell projection organization GO:0031344 175 0.026
homeostatic process GO:0042592 331 0.026
negative regulation of protein metabolic process GO:0051248 114 0.026
response to estrogen GO:0043627 232 0.025
nucleoside phosphate metabolic process GO:0006753 283 0.025
regulation of cell development GO:0060284 263 0.025
cellular protein localization GO:0034613 122 0.025
organic substance catabolic process GO:1901575 316 0.025
negative regulation of apoptotic process GO:0043066 181 0.025
cellular chemical homeostasis GO:0055082 247 0.025
regulation of secretion by cell GO:1903530 208 0.025
response to growth factor GO:0070848 189 0.025
positive regulation of secretion by cell GO:1903532 128 0.025
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.025
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.024
response to peptide hormone GO:0043434 278 0.024
negative regulation of response to stimulus GO:0048585 155 0.024
regulation of cell cycle GO:0051726 73 0.024
cell part morphogenesis GO:0032990 123 0.024
regulation of protein phosphorylation GO:0001932 183 0.024
organelle organization GO:0006996 266 0.023
regulation of hormone levels GO:0010817 187 0.023
regulation of protein kinase activity GO:0045859 105 0.023
negative regulation of cell communication GO:0010648 158 0.023
protein complex subunit organization GO:0071822 302 0.023
growth GO:0040007 165 0.023
lipid metabolic process GO:0006629 283 0.023
positive regulation of phosphorylation GO:0042327 177 0.022
ion homeostasis GO:0050801 212 0.022
regulation of cellular localization GO:0060341 263 0.022
intracellular transport GO:0046907 185 0.022
positive regulation of catalytic activity GO:0043085 184 0.022
positive regulation of cellular component organization GO:0051130 200 0.022
cell migration GO:0016477 197 0.022
negative regulation of programmed cell death GO:0043069 183 0.022
aromatic compound catabolic process GO:0019439 168 0.022
gland development GO:0048732 155 0.022
synaptic growth at neuromuscular junction GO:0051124 1 0.021
negative regulation of cellular biosynthetic process GO:0031327 161 0.021
protein localization GO:0008104 191 0.021
macromolecular complex subunit organization GO:0043933 339 0.021
neuron death GO:0070997 127 0.021
dendrite development GO:0016358 72 0.021
positive regulation of cell death GO:0010942 184 0.021
cell type specific apoptotic process GO:0097285 134 0.021
muscle system process GO:0003012 115 0.021
regulation of nervous system development GO:0051960 264 0.021
regulation of neurogenesis GO:0050767 247 0.021
single organism organelle organization GO:1902589 180 0.021
cellular response to stress GO:0033554 269 0.021
multi organism reproductive process GO:0044703 262 0.021
negative regulation of transcription dna templated GO:0045892 116 0.020
secretion by cell GO:0032940 248 0.020
protein heterooligomerization GO:0051291 89 0.020
regulation of g0 to g1 transition GO:0070316 3 0.020
cellular response to peptide GO:1901653 133 0.020
response to hypoxia GO:0001666 231 0.020
response to ketone GO:1901654 182 0.020
single organism biosynthetic process GO:0044711 342 0.020
response to oxygen levels GO:0070482 265 0.020
localization of cell GO:0051674 202 0.020
behavior GO:0007610 205 0.019
ribose phosphate metabolic process GO:0019693 235 0.019
regulation of neuron differentiation GO:0045664 208 0.019
dephosphorylation GO:0016311 98 0.019
negative regulation of gene expression GO:0010629 199 0.019
reproductive system development GO:0061458 128 0.019
development of primary sexual characteristics GO:0045137 107 0.019
ras protein signal transduction GO:0007265 29 0.019
positive regulation of cell projection organization GO:0031346 111 0.019
positive regulation of developmental process GO:0051094 283 0.019
developmental process involved in reproduction GO:0003006 159 0.019
purine nucleoside triphosphate catabolic process GO:0009146 122 0.019
regulation of protein localization GO:0032880 81 0.019
regulation of neuron death GO:1901214 115 0.019
single organism catabolic process GO:0044712 283 0.019
positive regulation of cellular amine metabolic process GO:0033240 3 0.018
negative regulation of cellular protein metabolic process GO:0032269 106 0.018
response to glucose GO:0009749 136 0.018
positive regulation of intracellular signal transduction GO:1902533 138 0.018
cellular homeostasis GO:0019725 252 0.018
vesicle mediated transport GO:0016192 181 0.018
cell morphogenesis involved in differentiation GO:0000904 119 0.018
establishment of protein localization GO:0045184 141 0.018
negative regulation of nucleic acid templated transcription GO:1903507 117 0.018
synaptic transmission GO:0007268 235 0.018
single organism cellular localization GO:1902580 102 0.018
negative regulation of signal transduction GO:0009968 83 0.017
multicellular organismal reproductive process GO:0048609 233 0.017
positive regulation of nervous system development GO:0051962 178 0.017
positive regulation of cell development GO:0010720 176 0.017
anterior posterior pattern specification GO:0009952 1 0.017
metal ion homeostasis GO:0055065 186 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
response to carbohydrate GO:0009743 183 0.017
cell cycle GO:0007049 101 0.017
regulation of neuron projection development GO:0010975 161 0.017
negative regulation of rna biosynthetic process GO:1902679 118 0.017
rhythmic process GO:0048511 156 0.017
positive regulation of cellular protein metabolic process GO:0032270 167 0.017
positive regulation of protein metabolic process GO:0051247 178 0.017
cellular response to insulin stimulus GO:0032869 81 0.017
proteolysis GO:0006508 175 0.017
small gtpase mediated signal transduction GO:0007264 36 0.017
response to glucocorticoid GO:0051384 223 0.016
cellular response to nitrogen compound GO:1901699 210 0.016
response to acid chemical GO:0001101 222 0.016
transmembrane transport GO:0055085 412 0.016
positive regulation of neurogenesis GO:0050769 165 0.016
purine containing compound metabolic process GO:0072521 253 0.016
nitrogen compound transport GO:0071705 229 0.016
cellular nitrogen compound catabolic process GO:0044270 163 0.016
calcium ion transport GO:0006816 131 0.016
nucleobase containing small molecule metabolic process GO:0055086 316 0.016
purine nucleoside triphosphate metabolic process GO:0009144 141 0.016
regulation of canonical wnt signaling pathway GO:0060828 4 0.016
wound healing GO:0042060 122 0.016
cellular ion homeostasis GO:0006873 184 0.016
aging GO:0007568 241 0.016
carbohydrate derivative metabolic process GO:1901135 346 0.016
peptidyl amino acid modification GO:0018193 126 0.016
cardiovascular system development GO:0072358 134 0.016
developmental growth GO:0048589 100 0.016
gastrulation GO:0007369 2 0.016
response to insulin GO:0032868 133 0.016
immune system process GO:0002376 204 0.016
negative regulation of multicellular organismal process GO:0051241 203 0.016
cell growth GO:0016049 104 0.016
nucleotide metabolic process GO:0009117 279 0.016
motor neuron axon guidance GO:0008045 1 0.016
cellular response to corticosteroid stimulus GO:0071384 69 0.016
ion transmembrane transport GO:0034220 365 0.016
reproductive structure development GO:0048608 128 0.016
heterocycle catabolic process GO:0046700 167 0.016
response to hexose GO:0009746 144 0.015
regulation of catabolic process GO:0009894 113 0.015
regulation of secretion GO:0051046 224 0.015
cell motility GO:0048870 202 0.015
protein transport GO:0015031 132 0.015
single organism intracellular transport GO:1902582 166 0.015
gamete generation GO:0007276 124 0.015
positive regulation of phosphorus metabolic process GO:0010562 262 0.015
gonad development GO:0008406 104 0.015
protein complex assembly GO:0006461 263 0.015
cell adhesion GO:0007155 110 0.014
response to transforming growth factor beta GO:0071559 46 0.014
cellular response to glucocorticoid stimulus GO:0071385 68 0.014
sex differentiation GO:0007548 113 0.014
muscle structure development GO:0061061 87 0.014
positive regulation of neuron differentiation GO:0045666 126 0.014
salivary gland development GO:0007431 3 0.014
multicellular organism reproduction GO:0032504 233 0.014
sexual reproduction GO:0019953 148 0.014
hormone transport GO:0009914 121 0.014
ribonucleoside triphosphate metabolic process GO:0009199 141 0.014
female pregnancy GO:0007565 122 0.014
cytoplasmic transport GO:0016482 115 0.014
response to estradiol GO:0032355 164 0.014
transforming growth factor beta receptor signaling pathway GO:0007179 18 0.014
nucleobase containing compound catabolic process GO:0034655 152 0.014
urogenital system development GO:0001655 78 0.014
axis specification GO:0009798 4 0.014
negative regulation of cellular component organization GO:0051129 83 0.014
negative regulation of metabolic process GO:0009892 331 0.014
cell morphogenesis GO:0000902 142 0.014
nucleotide catabolic process GO:0009166 139 0.013
positive regulation of cell differentiation GO:0045597 217 0.013
cell projection morphogenesis GO:0048858 123 0.013
ribonucleotide catabolic process GO:0009261 136 0.013
purine nucleotide metabolic process GO:0006163 229 0.013
glycosyl compound metabolic process GO:1901657 182 0.013
regulation of homeostatic process GO:0032844 101 0.013
negative regulation of rna metabolic process GO:0051253 123 0.013
multicellular organism growth GO:0035264 1 0.013
chromosome segregation GO:0007059 2 0.013
negative regulation of cell proliferation GO:0008285 119 0.013
eye morphogenesis GO:0048592 4 0.013
cation homeostasis GO:0055080 195 0.013
organic cyclic compound catabolic process GO:1901361 175 0.013
neuron apoptotic process GO:0051402 88 0.013
regulation of cellular component biogenesis GO:0044087 86 0.013
cellular component morphogenesis GO:0032989 155 0.013
positive regulation of protein phosphorylation GO:0001934 135 0.013
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.013
response to metal ion GO:0010038 253 0.013
purine ribonucleotide metabolic process GO:0009150 227 0.013
renal system development GO:0072001 67 0.013
response to radiation GO:0009314 137 0.013
salivary gland morphogenesis GO:0007435 1 0.013
cellular response to peptide hormone stimulus GO:0071375 120 0.013
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.013
maintenance of location GO:0051235 17 0.013
regulation of kinase activity GO:0043549 117 0.013
ribonucleoside triphosphate catabolic process GO:0009203 122 0.013
divalent inorganic cation transport GO:0072511 134 0.013
regulation of lipid metabolic process GO:0019216 68 0.013
forebrain development GO:0030900 98 0.013
glycosyl compound catabolic process GO:1901658 126 0.012
regulation of muscle system process GO:0090257 79 0.012
neurological system process GO:0050877 219 0.012
taxis GO:0042330 67 0.012
lipid storage GO:0019915 1 0.012
cell cycle process GO:0022402 57 0.012
carbohydrate derivative catabolic process GO:1901136 147 0.012
regulation of ion transport GO:0043269 245 0.012
inorganic ion transmembrane transport GO:0098660 229 0.012
cellular response to ketone GO:1901655 51 0.012
cellular response to alcohol GO:0097306 87 0.012
cell cycle checkpoint GO:0000075 2 0.012
signal transduction by phosphorylation GO:0023014 144 0.012
multi multicellular organism process GO:0044706 138 0.012
neurotrophin trk receptor signaling pathway GO:0048011 10 0.012
embryonic pattern specification GO:0009880 1 0.012
regulation of transferase activity GO:0051338 123 0.012
purine nucleoside metabolic process GO:0042278 169 0.012
response to ethanol GO:0045471 162 0.012
cell junction organization GO:0034330 21 0.012
regulation of response to stress GO:0080134 126 0.012
striated muscle tissue development GO:0014706 58 0.012
cellular divalent inorganic cation homeostasis GO:0072503 162 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.012
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.012
lipid localization GO:0010876 62 0.012
regulation of anatomical structure morphogenesis GO:0022603 141 0.012
positive regulation of secretion GO:0051047 140 0.012
response to oxidative stress GO:0006979 186 0.011
divalent inorganic cation homeostasis GO:0072507 165 0.011
nucleoside phosphate catabolic process GO:1901292 140 0.011
regulation of establishment of protein localization GO:0070201 69 0.011
protein maturation GO:0051604 68 0.011
establishment of tissue polarity GO:0007164 2 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.011
tube development GO:0035295 89 0.011
response to vitamin GO:0033273 131 0.011
negative regulation of molecular function GO:0044092 133 0.011
regulation of synaptic transmission GO:0050804 141 0.011
ribonucleotide metabolic process GO:0009259 231 0.011
nucleoside triphosphate catabolic process GO:0009143 123 0.011
amide transport GO:0042886 105 0.011
purine ribonucleoside catabolic process GO:0046130 124 0.011
purine nucleotide catabolic process GO:0006195 136 0.011
positive regulation of transferase activity GO:0051347 81 0.011
formation of primary germ layer GO:0001704 1 0.011
calcium ion homeostasis GO:0055074 162 0.011
negative regulation of transport GO:0051051 136 0.011
response to molecule of bacterial origin GO:0002237 194 0.011
positive regulation of apoptotic process GO:0043065 154 0.011
response to other organism GO:0051707 220 0.011
purine ribonucleotide catabolic process GO:0009154 136 0.011
hormone secretion GO:0046879 115 0.011
positive regulation of neuron projection development GO:0010976 99 0.011
regulation of cell morphogenesis GO:0022604 77 0.011
defense response GO:0006952 194 0.011
response to monosaccharide GO:0034284 159 0.011
embryonic skeletal system development GO:0048706 3 0.011
biological adhesion GO:0022610 110 0.011
response to temperature stimulus GO:0009266 94 0.011
signal release GO:0023061 145 0.011
protein oligomerization GO:0051259 191 0.011
response to bacterium GO:0009617 200 0.011
regulation of proteasomal protein catabolic process GO:0061136 4 0.011
macromolecule catabolic process GO:0009057 58 0.011
cellular response to oxidative stress GO:0034599 76 0.011
regulation of growth GO:0040008 105 0.011
cellular response to external stimulus GO:0071496 118 0.011
organophosphate biosynthetic process GO:0090407 143 0.011
regulation of hydrolase activity GO:0051336 143 0.011
organonitrogen compound catabolic process GO:1901565 179 0.011
anion transport GO:0006820 178 0.011
nucleoside triphosphate metabolic process GO:0009141 144 0.011
regulation of cell growth GO:0001558 85 0.011
dna metabolic process GO:0006259 96 0.011
negative regulation of cell cycle phase transition GO:1901988 4 0.011
regulation of hormone secretion GO:0046883 106 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.010
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.010
neuron projection morphogenesis GO:0048812 122 0.010
intracellular protein transport GO:0006886 79 0.010
regulation of stem cell differentiation GO:2000736 2 0.010
regulation of intracellular transport GO:0032386 65 0.010
axonogenesis GO:0007409 71 0.010
cellular lipid metabolic process GO:0044255 208 0.010
regulation of cell migration GO:0030334 128 0.010
endocytosis GO:0006897 84 0.010
muscle tissue development GO:0060537 58 0.010
carbohydrate homeostasis GO:0033500 75 0.010
divalent metal ion transport GO:0070838 132 0.010
epithelium development GO:0060429 96 0.010
organophosphate catabolic process GO:0046434 148 0.010
negative regulation of secretion GO:0051048 82 0.010
response to inorganic substance GO:0010035 377 0.010

Dyrk2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
disease of anatomical entity DOID:7 0 0.011
nervous system disease DOID:863 0 0.011
musculoskeletal system disease DOID:17 0 0.010