Rattus norvegicus

19 known processes

Clcnkb

chloride channel Kb

(Aliases: Clcnk1l,Clck2,ClC-K2L)

Clcnkb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cation transmembrane transport GO:0098655 263 0.508
anion transport GO:0006820 178 0.365
regulation of ion transport GO:0043269 245 0.284
Rat
regulation of system process GO:0044057 208 0.253
metal ion transport GO:0030001 289 0.243
cellular response to nitrogen compound GO:1901699 210 0.235
homeostatic process GO:0042592 331 0.223
organophosphate metabolic process GO:0019637 370 0.220
ion homeostasis GO:0050801 212 0.205
ion transmembrane transport GO:0034220 365 0.188
sodium ion transport GO:0006814 82 0.175
blood circulation GO:0008015 183 0.172
chemical homeostasis GO:0048878 292 0.164
vascular process in circulatory system GO:0003018 96 0.163
sodium ion transmembrane transport GO:0035725 67 0.154
aging GO:0007568 241 0.145
response to purine containing compound GO:0014074 126 0.145
inorganic ion transmembrane transport GO:0098660 229 0.141
cation homeostasis GO:0055080 195 0.140
organonitrogen compound biosynthetic process GO:1901566 167 0.137
monovalent inorganic cation transport GO:0015672 172 0.135
cellular homeostasis GO:0019725 252 0.132
tissue morphogenesis GO:0048729 22 0.132
cellular cation homeostasis GO:0030003 180 0.127
metal ion homeostasis GO:0055065 186 0.122
circulatory system process GO:0003013 183 0.121
cellular response to abiotic stimulus GO:0071214 85 0.120
growth GO:0040007 165 0.117
cation transport GO:0006812 382 0.115
regulation of cellular component organization GO:0051128 368 0.110
cellular component biogenesis GO:0044085 368 0.110
cellular response to oxygen containing compound GO:1901701 386 0.099
response to camp GO:0051591 91 0.098
response to organophosphorus GO:0046683 102 0.096
apoptotic process GO:0006915 381 0.095
cellular chemical homeostasis GO:0055082 247 0.093
response to acid chemical GO:0001101 222 0.087
Rat
heart process GO:0003015 57 0.083
regulation of cell proliferation GO:0042127 359 0.080
cellular response to organonitrogen compound GO:0071417 197 0.080
cellular metal ion homeostasis GO:0006875 172 0.079
inorganic cation transmembrane transport GO:0098662 202 0.078
transmembrane transport GO:0055085 412 0.077
cardiac muscle contraction GO:0060048 27 0.075
central nervous system development GO:0007417 311 0.073
regulation of homeostatic process GO:0032844 101 0.073
response to inorganic substance GO:0010035 377 0.073
Rat
brain development GO:0007420 247 0.072
cellular response to organic cyclic compound GO:0071407 202 0.072
single organism biosynthetic process GO:0044711 342 0.068
cellular calcium ion homeostasis GO:0006874 160 0.067
carboxylic acid metabolic process GO:0019752 289 0.067
negative regulation of cell proliferation GO:0008285 119 0.067
cellular divalent inorganic cation homeostasis GO:0072503 162 0.067
neurological system process GO:0050877 219 0.066
action potential GO:0001508 54 0.066
response to mechanical stimulus GO:0009612 134 0.065
rhythmic process GO:0048511 156 0.064
regulation of phosphate metabolic process GO:0019220 349 0.064
single organism reproductive process GO:0044702 297 0.063
cellular response to endogenous stimulus GO:0071495 377 0.063
cell growth GO:0016049 104 0.063
heart contraction GO:0060047 57 0.061
urogenital system development GO:0001655 78 0.061
Rat
reproductive process GO:0022414 372 0.060
ovulation cycle process GO:0022602 50 0.059
carboxylic acid transport GO:0046942 115 0.058
regulation of phosphorus metabolic process GO:0051174 349 0.058
organic acid biosynthetic process GO:0016053 83 0.057
regulation of immune system process GO:0002682 123 0.057
muscle contraction GO:0006936 88 0.055
intracellular signal transduction GO:0035556 314 0.055
regulation of multicellular organismal development GO:2000026 376 0.055
organic anion transport GO:0015711 132 0.053
immune system process GO:0002376 204 0.053
sensory perception GO:0007600 101 0.052
calcium ion transport GO:0006816 131 0.052
organophosphate biosynthetic process GO:0090407 143 0.050
regulation of heart contraction GO:0008016 48 0.048
head development GO:0060322 247 0.046
tissue development GO:0009888 252 0.046
multi organism reproductive process GO:0044703 262 0.046
regulation of metal ion transport GO:0010959 118 0.045
regulation of anatomical structure size GO:0090066 135 0.045
response to nutrient levels GO:0031667 370 0.043
divalent inorganic cation homeostasis GO:0072507 165 0.043
small molecule biosynthetic process GO:0044283 124 0.042
negative regulation of cell differentiation GO:0045596 99 0.042
carboxylic acid biosynthetic process GO:0046394 83 0.042
regulation of endocytosis GO:0030100 42 0.042
acid secretion GO:0046717 48 0.042
organic acid metabolic process GO:0006082 292 0.042
anatomical structure morphogenesis GO:0009653 298 0.041
response to metal ion GO:0010038 253 0.040
Rat
regulation of blood vessel size GO:0050880 89 0.040
response to molecule of bacterial origin GO:0002237 194 0.040
response to extracellular stimulus GO:0009991 380 0.040
response to estrogen GO:0043627 232 0.039
negative regulation of cell development GO:0010721 82 0.039
cognition GO:0050890 92 0.039
regulation of blood circulation GO:1903522 110 0.038
defense response GO:0006952 194 0.038
macromolecular complex assembly GO:0065003 273 0.038
protein complex biogenesis GO:0070271 263 0.038
behavior GO:0007610 205 0.038
cellular response to hormone stimulus GO:0032870 247 0.038
regulation of programmed cell death GO:0043067 341 0.037
calcium ion transport into cytosol GO:0060402 38 0.037
amine metabolic process GO:0009308 38 0.037
renal system development GO:0072001 67 0.037
Rat
multicellular organismal signaling GO:0035637 44 0.037
multicellular organism reproduction GO:0032504 233 0.037
regulation of membrane potential GO:0042391 110 0.036
purine ribonucleotide metabolic process GO:0009150 227 0.036
cytosolic calcium ion homeostasis GO:0051480 140 0.035
response to carbohydrate GO:0009743 183 0.035
nucleoside phosphate metabolic process GO:0006753 283 0.034
nitrogen compound transport GO:0071705 229 0.034
response to vitamin GO:0033273 131 0.033
cellular ion homeostasis GO:0006873 184 0.033
response to external biotic stimulus GO:0043207 221 0.033
organic acid transport GO:0015849 116 0.033
ribose phosphate metabolic process GO:0019693 235 0.033
regulation of molecular function GO:0065009 398 0.033
response to oxygen levels GO:0070482 265 0.033
fatty acid metabolic process GO:0006631 99 0.032
cellular response to camp GO:0071320 26 0.032
regulation of organic acid transport GO:0032890 35 0.031
response to hyperoxia GO:0055093 45 0.031
regulation of smooth muscle cell proliferation GO:0048660 75 0.031
organ formation GO:0048645 3 0.031
regulation of phagocytosis GO:0050764 13 0.031
regulation of fat cell proliferation GO:0070344 1 0.031
cellular response to mechanical stimulus GO:0071260 48 0.031
regulation of muscle system process GO:0090257 79 0.030
gonad development GO:0008406 104 0.030
regulation of organelle organization GO:0033043 80 0.030
oxoacid metabolic process GO:0043436 290 0.030
transmission of nerve impulse GO:0019226 42 0.030
programmed cell death GO:0012501 392 0.030
cell communication involved in cardiac conduction GO:0086065 2 0.030
single organism catabolic process GO:0044712 283 0.029
muscle cell proliferation GO:0033002 84 0.029
response to growth factor GO:0070848 189 0.029
cellular response to external stimulus GO:0071496 118 0.029
nucleotide metabolic process GO:0009117 279 0.029
reproduction GO:0000003 245 0.028
regulation of blood pressure GO:0008217 83 0.028
positive regulation of biosynthetic process GO:0009891 319 0.028
cellular component assembly GO:0022607 360 0.027
fatty acid biosynthetic process GO:0006633 33 0.027
response to oxidative stress GO:0006979 186 0.027
response to lipopolysaccharide GO:0032496 191 0.027
developmental process involved in reproduction GO:0003006 159 0.027
positive regulation of synaptic transmission gabaergic GO:0032230 9 0.026
muscle system process GO:0003012 115 0.026
purine nucleotide metabolic process GO:0006163 229 0.026
positive regulation of cell death GO:0010942 184 0.026
small gtpase mediated signal transduction GO:0007264 36 0.026
maintenance of location GO:0051235 17 0.026
peptide transport GO:0015833 97 0.026
divalent inorganic cation transport GO:0072511 134 0.026
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.026
response to insulin GO:0032868 133 0.026
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.025
sequestering of calcium ion GO:0051208 8 0.025
regulation of tube size GO:0035150 89 0.025
kidney development GO:0001822 67 0.025
Rat
multicellular organismal reproductive process GO:0048609 233 0.025
endocytosis GO:0006897 84 0.024
cellular amine metabolic process GO:0044106 38 0.024
protein complex subunit organization GO:0071822 302 0.024
regulation of neuron differentiation GO:0045664 208 0.024
regulation of organ formation GO:0003156 2 0.024
macromolecular complex subunit organization GO:0043933 339 0.024
response to monosaccharide GO:0034284 159 0.024
specification of organ identity GO:0010092 2 0.024
regulation of ion homeostasis GO:2000021 63 0.024
eye development GO:0001654 50 0.023
muscle structure development GO:0061061 87 0.023
protein oligomerization GO:0051259 191 0.023
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.023
ureteric bud development GO:0001657 14 0.023
positive regulation of cellular component organization GO:0051130 200 0.023
epithelium development GO:0060429 96 0.023
cardiac conduction GO:0061337 2 0.022
single organism intracellular transport GO:1902582 166 0.022
regulation of transcription dna templated GO:0006355 374 0.022
regulation of cytoskeleton organization GO:0051493 49 0.022
positive regulation of muscle contraction GO:0045933 22 0.022
sequestering of metal ion GO:0051238 9 0.022
regulation of signal transduction GO:0009966 318 0.022
neuron projection development GO:0031175 273 0.022
organic hydroxy compound metabolic process GO:1901615 115 0.021
locomotion GO:0040011 237 0.021
response to tumor necrosis factor GO:0034612 56 0.021
intracellular transport GO:0046907 185 0.021
leukotriene biosynthetic process GO:0019370 3 0.021
regulation of ion transmembrane transport GO:0034765 121 0.020
Rat
sodium ion homeostasis GO:0055078 23 0.020
response to other organism GO:0051707 220 0.020
response to calcium ion GO:0051592 59 0.020
Rat
localization of cell GO:0051674 202 0.020
response to decreased oxygen levels GO:0036293 237 0.020
divalent metal ion transport GO:0070838 132 0.020
positive regulation of apoptotic process GO:0043065 154 0.020
cellular component movement GO:0006928 248 0.020
response to osmotic stress GO:0006970 42 0.020
nucleobase containing small molecule metabolic process GO:0055086 316 0.020
camera type eye development GO:0043010 48 0.019
response to ketone GO:1901654 182 0.019
regulation of cellular amino acid metabolic process GO:0006521 2 0.019
lens development in camera type eye GO:0002088 13 0.019
g protein coupled receptor signaling pathway GO:0007186 242 0.019
positive regulation of developmental process GO:0051094 283 0.019
development of primary sexual characteristics GO:0045137 107 0.019
positive regulation of biomineral tissue development GO:0070169 4 0.019
regulation of apoptotic process GO:0042981 335 0.019
positive regulation of phosphorus metabolic process GO:0010562 262 0.019
negative regulation of kidney development GO:0090185 2 0.019
positive regulation of signaling GO:0023056 270 0.019
protein complex assembly GO:0006461 263 0.018
cell migration GO:0016477 197 0.018
regulation of cellular protein metabolic process GO:0032268 267 0.018
positive regulation of fat cell proliferation GO:0070346 1 0.018
steroid hormone mediated signaling pathway GO:0043401 8 0.018
lipid biosynthetic process GO:0008610 128 0.018
organonitrogen compound catabolic process GO:1901565 179 0.018
transcription from rna polymerase ii promoter GO:0006366 252 0.018
micturition GO:0060073 4 0.018
negative regulation of nervous system development GO:0051961 79 0.018
positive regulation of multicellular organismal process GO:0051240 387 0.018
single organismal cell cell adhesion GO:0016337 42 0.018
regulation of rna biosynthetic process GO:2001141 381 0.018
striated muscle contraction GO:0006941 44 0.018
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.018
negative regulation of secretion GO:0051048 82 0.018
positive regulation of molecular function GO:0044093 230 0.017
regulation of nervous system development GO:0051960 264 0.017
regulation of sodium ion transport GO:0002028 21 0.017
response to cytokine GO:0034097 215 0.017
reproductive structure development GO:0048608 128 0.017
ribonucleoside metabolic process GO:0009119 174 0.017
chemosensory behavior GO:0007635 2 0.016
cytosolic calcium ion transport GO:0060401 39 0.016
negative regulation of transporter activity GO:0032410 13 0.016
organic hydroxy compound biosynthetic process GO:1901617 51 0.016
regulation of cellular component biogenesis GO:0044087 86 0.016
tube development GO:0035295 89 0.016
Rat
response to nutrient GO:0007584 248 0.016
regulation of heart rate GO:0002027 16 0.016
smooth muscle cell proliferation GO:0048659 77 0.016
renal system process GO:0003014 40 0.016
behavioral response to nicotine GO:0035095 2 0.016
regulation of cardiac muscle contraction GO:0055117 17 0.016
embryo development GO:0009790 49 0.016
reproductive system development GO:0061458 128 0.016
negative regulation of signal transduction GO:0009968 83 0.016
retina morphogenesis in camera type eye GO:0060042 1 0.016
ovulation cycle GO:0042698 67 0.016
mesenchymal to epithelial transition GO:0060231 3 0.016
regulation of excretion GO:0044062 21 0.016
purine containing compound metabolic process GO:0072521 253 0.016
response to hypoxia GO:0001666 231 0.016
protein localization GO:0008104 191 0.016
cytoplasmic transport GO:0016482 115 0.016
learning or memory GO:0007611 90 0.015
positive regulation of gene expression GO:0010628 244 0.015
monovalent inorganic cation homeostasis GO:0055067 36 0.015
hair cycle process GO:0022405 2 0.015
phospholipid biosynthetic process GO:0008654 29 0.015
hormone transport GO:0009914 121 0.015
single organism cell adhesion GO:0098602 46 0.015
nephron tubule development GO:0072080 12 0.015
carbohydrate derivative catabolic process GO:1901136 147 0.015
positive regulation of blood circulation GO:1903524 65 0.015
axis specification GO:0009798 4 0.015
rna biosynthetic process GO:0032774 380 0.015
neuronal action potential GO:0019228 35 0.015
negative regulation of transport GO:0051051 136 0.015
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.015
actin filament based movement GO:0030048 16 0.015
organ morphogenesis GO:0009887 75 0.015
response to electrical stimulus GO:0051602 56 0.015
positive regulation of endocytosis GO:0045807 28 0.015
regulation of phosphorylation GO:0042325 248 0.015
circadian rhythm GO:0007623 88 0.015
tissue remodeling GO:0048771 40 0.015
ribonucleotide biosynthetic process GO:0009260 85 0.014
myeloid leukocyte differentiation GO:0002573 20 0.014
phospholipid metabolic process GO:0006644 61 0.014
response to glucose GO:0009749 136 0.014
organ growth GO:0035265 24 0.014
multi multicellular organism process GO:0044706 138 0.014
lipid metabolic process GO:0006629 283 0.014
negative regulation of cell communication GO:0010648 158 0.014
proteolysis GO:0006508 175 0.014
regulation of amino acid transport GO:0051955 25 0.014
biological adhesion GO:0022610 110 0.014
response to estradiol GO:0032355 164 0.014
single organism behavior GO:0044708 130 0.014
membrane organization GO:0061024 94 0.014
regulation of cell differentiation GO:0045595 320 0.014
cellular response to gonadotropin stimulus GO:0071371 17 0.014
cellular ketone metabolic process GO:0042180 51 0.014
actin filament based process GO:0030029 86 0.014
actin mediated cell contraction GO:0070252 12 0.014
regulation of calcium ion transmembrane transport GO:1903169 18 0.014
negative regulation of metanephros development GO:0072217 2 0.014
negative regulation of hormone secretion GO:0046888 46 0.014
cardiac muscle cell contraction GO:0086003 10 0.013
ribonucleotide metabolic process GO:0009259 231 0.013
alpha amino acid metabolic process GO:1901605 71 0.013
response to hexose GO:0009746 144 0.013
brown fat cell proliferation GO:0070342 2 0.013
positive regulation of cell proliferation GO:0008284 249 0.013
regulation of inflammatory response GO:0050727 48 0.013
potassium ion transmembrane transport GO:0071805 71 0.013
odontogenesis GO:0042476 32 0.013
cell activation GO:0001775 97 0.013
positive regulation of epithelial cell proliferation GO:0050679 32 0.013
cellular response to drug GO:0035690 30 0.013
dna metabolic process GO:0006259 96 0.013
mesonephric tubule development GO:0072164 14 0.013
regulation of cell projection organization GO:0031344 175 0.013
positive regulation of programmed cell death GO:0043068 157 0.013
regulation of reactive oxygen species metabolic process GO:2000377 26 0.013
ras protein signal transduction GO:0007265 29 0.013
male mating behavior GO:0060179 3 0.013
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 3 0.012
response to increased oxygen levels GO:0036296 45 0.012
kidney epithelium development GO:0072073 19 0.012
morphogenesis of an epithelium GO:0002009 20 0.012
vasoconstriction GO:0042310 54 0.012
regulation of cellular amine metabolic process GO:0033238 8 0.012
camp metabolic process GO:0046058 63 0.012
nucleotide biosynthetic process GO:0009165 98 0.012
protein tetramerization GO:0051262 38 0.012
cellular modified amino acid metabolic process GO:0006575 61 0.012
negative regulation of intracellular signal transduction GO:1902532 38 0.012
nucleoside phosphate catabolic process GO:1901292 140 0.012
glycerophospholipid metabolic process GO:0006650 47 0.012
regulation of membrane repolarization GO:0060306 1 0.012
regulation of secretion GO:0051046 224 0.012
leukocyte differentiation GO:0002521 30 0.012
sensory perception of pain GO:0019233 73 0.012
regulation of peptide hormone secretion GO:0090276 80 0.012
cellular response to lipid GO:0071396 201 0.012
mesonephros development GO:0001823 14 0.012
multicellular organismal homeostasis GO:0048871 49 0.012
molting cycle GO:0042303 3 0.012
organ induction GO:0001759 1 0.012
cell adhesion GO:0007155 110 0.012
regulation of nucleotide metabolic process GO:0006140 117 0.012
response to anoxia GO:0034059 4 0.012
cellular response to acid chemical GO:0071229 75 0.012
neuron development GO:0048666 286 0.012
negative regulation of calcium ion transport into cytosol GO:0010523 4 0.012
cellular amino acid metabolic process GO:0006520 107 0.012
amino acid transport GO:0006865 70 0.011
cellular amide metabolic process GO:0043603 44 0.011
response to peptide hormone GO:0043434 278 0.011
nucleic acid templated transcription GO:0097659 379 0.011
regulation of actin filament based process GO:0032970 42 0.011
cellular modified amino acid biosynthetic process GO:0042398 18 0.011
cellular response to growth factor stimulus GO:0071363 162 0.011
cell differentiation involved in kidney development GO:0061005 4 0.011
positive regulation of ion transport GO:0043270 94 0.011
regulation of cell development GO:0060284 263 0.011
thyroid gland development GO:0030878 1 0.011
regulation of defense response GO:0031347 68 0.011
regulation of protein metabolic process GO:0051246 289 0.011
regulation of cellular ketone metabolic process GO:0010565 27 0.011
response to gonadotropin GO:0034698 34 0.011
leukocyte cell cell adhesion GO:0007159 4 0.011
calcium ion homeostasis GO:0055074 162 0.011
lipid transport GO:0006869 61 0.011
response to activity GO:0014823 73 0.011
carbohydrate derivative metabolic process GO:1901135 346 0.011
regulation of anion transport GO:0044070 43 0.011
Rat
negative regulation of multicellular organismal process GO:0051241 203 0.011
negative regulation of neuron differentiation GO:0045665 62 0.011
regulation of vesicle mediated transport GO:0060627 81 0.011
regulation of body fluid levels GO:0050878 90 0.011
Rat
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016339 3 0.011
protein phosphorylation GO:0006468 345 0.011
cardiovascular system development GO:0072358 134 0.011
positive regulation of cellular amine metabolic process GO:0033240 3 0.011
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.011
gastrulation GO:0007369 2 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.011
rna metabolic process GO:0016070 406 0.011
phagocytosis GO:0006909 17 0.011
negative regulation of ion transport GO:0043271 51 0.011
positive regulation of cellular component biogenesis GO:0044089 55 0.011
embryonic pattern specification GO:0009880 1 0.011
cellular nitrogen compound catabolic process GO:0044270 163 0.011
cellular response to stress GO:0033554 269 0.011
positive regulation of rna metabolic process GO:0051254 203 0.011
negative regulation of response to stimulus GO:0048585 155 0.011
negative regulation of homeostatic process GO:0032845 47 0.011
positive regulation of peptide hormone secretion GO:0090277 50 0.011
calcium ion transport from endoplasmic reticulum to cytosol GO:1903514 4 0.011
cellular response to insulin stimulus GO:0032869 81 0.011
negative regulation of organic acid transport GO:0032891 14 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.010
regulation of behavior GO:0050795 61 0.010
reactive oxygen species metabolic process GO:0072593 37 0.010
positive regulation of phosphorylation GO:0042327 177 0.010
developmental growth GO:0048589 100 0.010
positive regulation of smooth muscle contraction GO:0045987 18 0.010
metanephric epithelium development GO:0072207 4 0.010
coronary vasculature morphogenesis GO:0060977 3 0.010
regulation of locomotion GO:0040012 148 0.010
organic substance catabolic process GO:1901575 316 0.010
rho protein signal transduction GO:0007266 11 0.010
nucleobase containing compound catabolic process GO:0034655 152 0.010
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.010
grooming behavior GO:0007625 4 0.010

Clcnkb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.515
Human
urinary system disease DOID:18 0 0.515
Human
kidney disease DOID:557 0 0.497
Human
renal tubular transport disease DOID:447 0 0.388
Human
sensory system disease DOID:0050155 0 0.097
nervous system disease DOID:863 0 0.097
retinal disease DOID:5679 0 0.048
eye and adnexa disease DOID:1492 0 0.048
eye disease DOID:5614 0 0.048
retinal degeneration DOID:8466 0 0.031
endocrine system disease DOID:28 0 0.023
musculoskeletal system disease DOID:17 0 0.010
retinitis pigmentosa DOID:10584 0 0.010