Rattus norvegicus

166 known processes

Apoe

apolipoprotein E

(Aliases: APOEA)

Apoe biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryo implantation GO:0007566 15 0.389
regulation of glycoprotein metabolic process GO:1903018 6 0.348
response to nutrient levels GO:0031667 370 0.238
regulation of cell differentiation GO:0045595 320 0.222
sensory organ development GO:0007423 74 0.208
central nervous system development GO:0007417 311 0.199
reproductive process GO:0022414 372 0.199
single organism reproductive process GO:0044702 297 0.190
single organism behavior GO:0044708 130 0.185
response to extracellular stimulus GO:0009991 380 0.178
negative regulation of cell death GO:0060548 229 0.178
response to other organism GO:0051707 220 0.178
tissue development GO:0009888 252 0.174
response to glucocorticoid GO:0051384 223 0.167
response to biotic stimulus GO:0009607 226 0.157
regulation of cell proliferation GO:0042127 359 0.152
response to metal ion GO:0010038 253 0.138
cellular catabolic process GO:0044248 295 0.135
regulation of multicellular organismal development GO:2000026 376 0.126
response to wounding GO:0009611 254 0.117
positive regulation of cell differentiation GO:0045597 217 0.114
brain development GO:0007420 247 0.114
response to chromate GO:0046687 3 0.112
extracellular fibril organization GO:0043206 1 0.110
cell projection organization GO:0030030 302 0.109
response to estradiol GO:0032355 164 0.109
head development GO:0060322 247 0.107
development of primary sexual characteristics GO:0045137 107 0.104
aging GO:0007568 241 0.098
reproductive structure development GO:0048608 128 0.095
positive regulation of developmental process GO:0051094 283 0.094
collagen catabolic process GO:0030574 2 0.093
developmental process involved in reproduction GO:0003006 159 0.091
multi organism reproductive process GO:0044703 262 0.090
multi multicellular organism process GO:0044706 138 0.084
cellular amide metabolic process GO:0043603 44 0.078
reproductive system development GO:0061458 128 0.077
response to external biotic stimulus GO:0043207 221 0.076
regulation of protein metabolic process GO:0051246 289 0.076
rhythmic process GO:0048511 156 0.074
neuron differentiation GO:0030182 368 0.072
behavior GO:0007610 205 0.069
male gonad development GO:0008584 59 0.069
male sex differentiation GO:0046661 64 0.068
epithelium development GO:0060429 96 0.064
salivary gland development GO:0007431 3 0.064
protein maturation GO:0051604 68 0.064
positive regulation of neurogenesis GO:0050769 165 0.064
positive regulation of nervous system development GO:0051962 178 0.063
negative regulation of multicellular organismal metabolic process GO:0044252 4 0.062
negative regulation of cellular protein metabolic process GO:0032269 106 0.062
catabolic process GO:0009056 351 0.060
response to lead ion GO:0010288 33 0.058
proteolysis GO:0006508 175 0.057
neuron development GO:0048666 286 0.054
response to camp GO:0051591 91 0.054
reproduction GO:0000003 245 0.053
positive regulation of cell development GO:0010720 176 0.052
response to organophosphorus GO:0046683 102 0.052
response to inorganic substance GO:0010035 377 0.050
gonad development GO:0008406 104 0.050
positive regulation of neuron projection development GO:0010976 99 0.050
nitrogen compound transport GO:0071705 229 0.050
multicellular organism reproduction GO:0032504 233 0.050
development of primary male sexual characteristics GO:0046546 59 0.050
response to peptide GO:1901652 292 0.049
regulation of ion transport GO:0043269 245 0.048
response to ketone GO:1901654 182 0.048
regulation of establishment of planar polarity GO:0090175 2 0.048
response to corticosteroid GO:0031960 235 0.047
anatomical structure morphogenesis GO:0009653 298 0.046
eye development GO:0001654 50 0.046
neurological system process GO:0050877 219 0.046
regulation of myeloid cell differentiation GO:0045637 12 0.045
circadian sleep wake cycle GO:0042745 23 0.045
female pregnancy GO:0007565 122 0.045
regulation of immune response GO:0050776 55 0.044
regulation of programmed cell death GO:0043067 341 0.044
negative regulation of developmental process GO:0051093 125 0.042
response to purine containing compound GO:0014074 126 0.042
response to acid chemical GO:0001101 222 0.042
multicellular organismal catabolic process GO:0044243 2 0.040
response to estrogen GO:0043627 232 0.040
negative regulation of response to stimulus GO:0048585 155 0.040
negative regulation of cellular metabolic process GO:0031324 281 0.040
circadian sleep wake cycle sleep GO:0050802 21 0.039
circadian rhythm GO:0007623 88 0.039
sexual reproduction GO:0019953 148 0.039
negative regulation of protein metabolic process GO:0051248 114 0.038
response to nutrient GO:0007584 248 0.038
single organism catabolic process GO:0044712 283 0.037
regulation of cellular protein metabolic process GO:0032268 267 0.037
positive regulation of cell proliferation GO:0008284 249 0.035
negative regulation of molecular function GO:0044092 133 0.035
sex differentiation GO:0007548 113 0.035
negative regulation of multicellular organismal process GO:0051241 203 0.034
response to carbohydrate GO:0009743 183 0.033
neuron projection development GO:0031175 273 0.033
cell projection morphogenesis GO:0048858 123 0.033
tissue remodeling GO:0048771 40 0.032
negative regulation of macromolecule metabolic process GO:0010605 260 0.032
regulation of immune system process GO:0002682 123 0.032
negative regulation of metabolic process GO:0009892 331 0.031
protein processing GO:0016485 68 0.031
negative regulation of collagen metabolic process GO:0010713 4 0.031
chemical homeostasis GO:0048878 292 0.031
response to bacterium GO:0009617 200 0.030
negative regulation of innate immune response GO:0045824 4 0.030
neuronal action potential GO:0019228 35 0.030
response to vitamin GO:0033273 131 0.030
positive regulation of response to stimulus GO:0048584 285 0.030
regulation of neurogenesis GO:0050767 247 0.029
response to hydrogen peroxide GO:0042542 89 0.029
rhythmic behavior GO:0007622 24 0.029
positive regulation of multicellular organismal process GO:0051240 387 0.029
complement activation GO:0006956 11 0.029
homeostatic process GO:0042592 331 0.029
regulation of nervous system development GO:0051960 264 0.028
negative regulation of protein processing GO:0010955 47 0.028
regulation of anatomical structure morphogenesis GO:0022603 141 0.028
regulation of neuron projection development GO:0010975 161 0.028
regulation of protein processing GO:0070613 50 0.027
cellular response to stress GO:0033554 269 0.027
response to monosaccharide GO:0034284 159 0.027
heart morphogenesis GO:0003007 3 0.026
positive regulation of cell projection organization GO:0031346 111 0.026
response to molecule of bacterial origin GO:0002237 194 0.026
regulation of neuron differentiation GO:0045664 208 0.026
elastin metabolic process GO:0051541 1 0.026
negative regulation of protein maturation GO:1903318 47 0.025
multicellular organismal reproductive process GO:0048609 233 0.025
response to hypoxia GO:0001666 231 0.025
gamete generation GO:0007276 124 0.025
programmed cell death GO:0012501 392 0.025
localization of cell GO:0051674 202 0.025
carbohydrate derivative metabolic process GO:1901135 346 0.024
negative regulation of apoptotic process GO:0043066 181 0.024
cellular response to oxidative stress GO:0034599 76 0.024
defense response GO:0006952 194 0.024
negative regulation of peptidase activity GO:0010466 38 0.023
negative regulation of programmed cell death GO:0043069 183 0.023
negative regulation of immune system process GO:0002683 39 0.023
regulation of molecular function GO:0065009 398 0.022
positive regulation of neuron differentiation GO:0045666 126 0.022
negative regulation of endopeptidase activity GO:0010951 36 0.022
regulation of catabolic process GO:0009894 113 0.021
cellular response to endogenous stimulus GO:0071495 377 0.021
response to lipopolysaccharide GO:0032496 191 0.021
acute inflammatory response GO:0002526 58 0.021
regulation of fibrinolysis GO:0051917 2 0.021
respiratory system development GO:0060541 45 0.021
regulation of proteolysis GO:0030162 66 0.021
cellular component movement GO:0006928 248 0.020
regulation of cell development GO:0060284 263 0.020
cell killing GO:0001906 13 0.020
cellular chemical homeostasis GO:0055082 247 0.020
regulation of metal ion transport GO:0010959 118 0.020
lipid transport GO:0006869 61 0.020
regulation of protein maturation GO:1903317 50 0.020
kidney development GO:0001822 67 0.020
negative regulation of proteolysis GO:0045861 41 0.020
negative regulation of gene expression GO:0010629 199 0.020
circadian sleep wake cycle process GO:0022410 21 0.020
spermatogenesis GO:0007283 99 0.020
regulation of defense response GO:0031347 68 0.019
regulation of cellular catabolic process GO:0031329 101 0.019
organic substance catabolic process GO:1901575 316 0.019
regulation of cell projection organization GO:0031344 175 0.018
axon development GO:0061564 96 0.018
activation of immune response GO:0002253 26 0.018
hair cycle process GO:0022405 2 0.017
regulation of blood pressure GO:0008217 83 0.017
neuron projection morphogenesis GO:0048812 122 0.017
response to oxygen levels GO:0070482 265 0.017
cell morphogenesis GO:0000902 142 0.017
regulation of cellular component organization GO:0051128 368 0.017
response to decreased oxygen levels GO:0036293 237 0.017
cell motility GO:0048870 202 0.017
response to retinoic acid GO:0032526 63 0.017
response to reactive oxygen species GO:0000302 120 0.017
epithelial cell differentiation GO:0030855 71 0.016
immune system process GO:0002376 204 0.016
regulation of catalytic activity GO:0050790 304 0.016
carbohydrate derivative catabolic process GO:1901136 147 0.016
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.016
hormone metabolic process GO:0042445 69 0.015
dna replication GO:0006260 37 0.015
endocytosis GO:0006897 84 0.015
organic acid metabolic process GO:0006082 292 0.015
apoptotic process GO:0006915 381 0.015
cardiovascular system development GO:0072358 134 0.015
mapk cascade GO:0000165 140 0.015
ossification GO:0001503 70 0.015
multicellular organismal signaling GO:0035637 44 0.014
male gamete generation GO:0048232 99 0.014
regulation of apoptotic process GO:0042981 335 0.014
regulation of peptidase activity GO:0052547 55 0.014
renal system development GO:0072001 67 0.014
sleep GO:0030431 30 0.014
cytosolic calcium ion homeostasis GO:0051480 140 0.014
cellular response to oxygen containing compound GO:1901701 386 0.014
organ morphogenesis GO:0009887 75 0.014
immune effector process GO:0002252 53 0.014
response to potassium ion GO:0035864 9 0.014
macromolecule catabolic process GO:0009057 58 0.014
cellular response to gonadotropin stimulus GO:0071371 17 0.013
circadian behavior GO:0048512 24 0.013
cellular homeostasis GO:0019725 252 0.013
gland development GO:0048732 155 0.013
inflammatory response GO:0006954 150 0.013
cellular calcium ion homeostasis GO:0006874 160 0.013
regulation of proteasomal protein catabolic process GO:0061136 4 0.013
cell type specific apoptotic process GO:0097285 134 0.013
neuromuscular process GO:0050905 2 0.013
response to insulin GO:0032868 133 0.013
rna localization GO:0006403 4 0.013
nucleobase containing small molecule metabolic process GO:0055086 316 0.013
immunoglobulin mediated immune response GO:0016064 4 0.013
regulation of endopeptidase activity GO:0052548 51 0.012
sulfur compound metabolic process GO:0006790 70 0.012
cellular hormone metabolic process GO:0034754 49 0.012
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.012
response to toxic substance GO:0009636 133 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
metal ion transport GO:0030001 289 0.012
response to hexose GO:0009746 144 0.012
cellular response to lipid GO:0071396 201 0.012
cell part morphogenesis GO:0032990 123 0.012
metal ion homeostasis GO:0055065 186 0.012
cell cell signaling involved in cell fate commitment GO:0045168 2 0.012
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.012
innate immune response GO:0045087 35 0.012
cellular response to alcohol GO:0097306 87 0.012
response to oxidative stress GO:0006979 186 0.012
response to amino acid GO:0043200 75 0.011
negative regulation of cell proliferation GO:0008285 119 0.011
cellular amino acid metabolic process GO:0006520 107 0.011
cellular response to hormone stimulus GO:0032870 247 0.011
regulation of tolerance induction to nonself antigen GO:0002655 1 0.011
negative regulation of myeloid cell differentiation GO:0045638 3 0.011
organelle organization GO:0006996 266 0.011
ion homeostasis GO:0050801 212 0.011
purine ribonucleotide metabolic process GO:0009150 227 0.011
organelle inheritance GO:0048308 2 0.011
immune response GO:0006955 104 0.011
ear development GO:0043583 21 0.011
glutamine family amino acid metabolic process GO:0009064 15 0.011
astrocyte development GO:0014002 4 0.011
monovalent inorganic cation transport GO:0015672 172 0.011
cellular response to follicle stimulating hormone stimulus GO:0071372 13 0.011
isoprenoid metabolic process GO:0006720 45 0.010
molting cycle GO:0042303 3 0.010
b cell mediated immunity GO:0019724 4 0.010
cellular response to molecule of bacterial origin GO:0071219 56 0.010
cellular response to nitrogen compound GO:1901699 210 0.010
cation transport GO:0006812 382 0.010
positive regulation of programmed cell death GO:0043068 157 0.010
blood circulation GO:0008015 183 0.010
cellular macromolecule catabolic process GO:0044265 29 0.010
response to antibiotic GO:0046677 39 0.010

Apoe disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.242
nervous system disease DOID:863 0 0.118
sensory system disease DOID:0050155 0 0.118
disease of anatomical entity DOID:7 0 0.118
eye and adnexa disease DOID:1492 0 0.118
eye disease DOID:5614 0 0.079
degeneration of macula and posterior pole DOID:2007 0 0.079
macular degeneration DOID:4448 0 0.079
retinal disease DOID:5679 0 0.079
retinal degeneration DOID:8466 0 0.079
age related macular degeneration DOID:10871 0 0.079
acquired metabolic disease DOID:0060158 0 0.053
inherited metabolic disorder DOID:655 0 0.035
lysosomal storage disease DOID:3211 0 0.012
metal metabolism disorder DOID:896 0 0.011