Rattus norvegicus

40 known processes

Plk1

polo-like kinase 1 (Drosophila)

(Aliases: Plk)

Plk1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mitotic sister chromatid separation GO:0051306 1 0.255
Human
metaphase anaphase transition of cell cycle GO:0044784 1 0.200
Human
macromolecular complex assembly GO:0065003 273 0.196
Yeast Fly
reproductive process GO:0022414 372 0.186
Worm Fly
organelle organization GO:0006996 266 0.145
chromosome segregation GO:0007059 2 0.126
Human Yeast Worm
regulation of molecular function GO:0065009 398 0.123
Human Yeast Rat
regulation of chromosome segregation GO:0051983 1 0.122
Human
positive regulation of hepatocyte differentiation GO:0070368 2 0.117
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 1 0.115
Human
protein complex assembly GO:0006461 263 0.112
Yeast Fly
neuron differentiation GO:0030182 368 0.105
Rat
single organism organelle organization GO:1902589 180 0.098
Human Yeast Worm Fly
cellular component assembly GO:0022607 360 0.097
Yeast Fly
negative regulation of developmental process GO:0051093 125 0.092
Rat Fly
cellular response to iron iii ion GO:0071283 3 0.088
protein phosphorylation GO:0006468 345 0.088
metaphase plate congression GO:0051310 1 0.086
regulation of cellular protein metabolic process GO:0032268 267 0.083
Human Rat
protein complex subunit organization GO:0071822 302 0.082
Yeast Worm Fly
macromolecular complex subunit organization GO:0043933 339 0.080
Yeast Worm Fly
programmed cell death GO:0012501 392 0.078
Human Worm
cytoskeleton organization GO:0007010 111 0.078
Human Yeast Worm Fly
mitotic cell cycle phase transition GO:0044772 20 0.078
Human
centrosome organization GO:0051297 1 0.077
Human Worm Fly
positive regulation of cellular protein metabolic process GO:0032270 167 0.076
Human Rat
cell cycle GO:0007049 101 0.074
positive regulation of multicellular organismal process GO:0051240 387 0.070
response to extracellular stimulus GO:0009991 380 0.068
positive regulation of nucleic acid templated transcription GO:1903508 197 0.066
regulation of organelle organization GO:0033043 80 0.065
Human Yeast Worm
regulation of cellular component organization GO:0051128 368 0.064
Human Yeast Rat Worm
cellular component biogenesis GO:0044085 368 0.060
Yeast Fly
regulation of protein metabolic process GO:0051246 289 0.059
Human Rat
regulation of phosphorus metabolic process GO:0051174 349 0.059
Human
regulation of catalytic activity GO:0050790 304 0.059
Human Yeast
reproduction GO:0000003 245 0.057
regulation of transferase activity GO:0051338 123 0.056
Human
catabolic process GO:0009056 351 0.056
Human Rat
spindle organization GO:0007051 2 0.054
Yeast Worm Fly
negative regulation of transcription dna templated GO:0045892 116 0.054
Human
positive regulation of developmental process GO:0051094 283 0.053
regulation of cell differentiation GO:0045595 320 0.053
Rat Fly
regulation of cell proliferation GO:0042127 359 0.053
Fly
neuron development GO:0048666 286 0.052
Rat
rna metabolic process GO:0016070 406 0.052
Human
cellular response to stress GO:0033554 269 0.052
Human
proteolysis involved in cellular protein catabolic process GO:0051603 19 0.052
Human Rat
negative regulation of metabolic process GO:0009892 331 0.050
Human
aging GO:0007568 241 0.050
regulation of cell cycle GO:0051726 73 0.050
Human Yeast Worm
proteolysis GO:0006508 175 0.049
Human Rat
positive regulation of synaptic plasticity GO:0031915 3 0.049
positive regulation of synapse maturation GO:0090129 2 0.049
cellular macromolecule catabolic process GO:0044265 29 0.048
Human Rat
response to nutrient levels GO:0031667 370 0.047
meiotic cell cycle process GO:1903046 3 0.046
microtubule polymerization or depolymerization GO:0031109 13 0.045
Fly
microtubule organizing center organization GO:0031023 1 0.044
Human Yeast Worm Fly
single organism reproductive process GO:0044702 297 0.044
Worm Fly
negative regulation of nuclear division GO:0051784 1 0.043
Human
cellular protein localization GO:0034613 122 0.043
Human Fly
mitotic spindle organization GO:0007052 2 0.043
Worm Fly
organelle localization GO:0051640 55 0.043
Fly
regulation of phosphate metabolic process GO:0019220 349 0.042
Human
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.041
Human
cell projection organization GO:0030030 302 0.040
Rat
response to nutrient GO:0007584 248 0.039
regulation of ubiquitin protein transferase activity GO:0051438 1 0.039
Human
metaphase anaphase transition of mitotic cell cycle GO:0007091 1 0.038
Human
multi organism reproductive process GO:0044703 262 0.038
Worm Fly
mitotic cell cycle process GO:1903047 35 0.037
Human Worm Fly
negative regulation of gene expression GO:0010629 199 0.037
Human
organic substance catabolic process GO:1901575 316 0.036
Human Rat
sister chromatid segregation GO:0000819 1 0.035
Human
bmp signaling pathway GO:0030509 4 0.035
positive regulation of rna metabolic process GO:0051254 203 0.035
positive regulation of biosynthetic process GO:0009891 319 0.035
oxoacid metabolic process GO:0043436 290 0.035
negative regulation of rna metabolic process GO:0051253 123 0.035
Human
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.034
Human
negative regulation of cellular component organization GO:0051129 83 0.034
Human Rat
regulation of phosphorylation GO:0042325 248 0.034
Human
positive regulation of cellular component organization GO:0051130 200 0.034
Human Yeast
microtubule anchoring GO:0034453 1 0.033
regulation of protein kinase activity GO:0045859 105 0.033
Human
negative regulation of macromolecule metabolic process GO:0010605 260 0.033
Human
positive regulation of protein modification process GO:0031401 142 0.032
Human
transcription dna templated GO:0006351 377 0.032
Human
cell cycle process GO:0022402 57 0.031
multicellular organism reproduction GO:0032504 233 0.031
Worm Fly
macromolecule catabolic process GO:0009057 58 0.031
Human Rat
regulation of rna biosynthetic process GO:2001141 381 0.031
Human
response to estrogen GO:0043627 232 0.031
organelle assembly GO:0070925 22 0.030
Yeast Fly
negative regulation of microtubule depolymerization GO:0007026 3 0.030
amine metabolic process GO:0009308 38 0.030
ras protein signal transduction GO:0007265 29 0.029
Rat
cellular response to lipid GO:0071396 201 0.029
cellular ketone metabolic process GO:0042180 51 0.029
protein complex biogenesis GO:0070271 263 0.029
Yeast Fly
intracellular signal transduction GO:0035556 314 0.029
Rat
regulation of rna metabolic process GO:0051252 391 0.028
Human
regulation of apoptotic process GO:0042981 335 0.028
Human
response to transition metal nanoparticle GO:1990267 122 0.028
cell cycle phase transition GO:0044770 21 0.028
Human
response to ddt GO:0046680 1 0.028
protein localization GO:0008104 191 0.028
Human Yeast Fly
cell cycle checkpoint GO:0000075 2 0.028
Human
regulation of multicellular organismal development GO:2000026 376 0.027
Rat Fly
regulation of kinase activity GO:0043549 117 0.027
Human
single organism cellular localization GO:1902580 102 0.027
response to glucocorticoid GO:0051384 223 0.027
brain development GO:0007420 247 0.027
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.027
small gtpase mediated signal transduction GO:0007264 36 0.026
Rat
response to corticosteroid GO:0031960 235 0.026
positive regulation of cellular biosynthetic process GO:0031328 295 0.026
negative regulation of cell division GO:0051782 1 0.025
Human
cellular amine metabolic process GO:0044106 38 0.025
regulation of sister chromatid segregation GO:0033045 1 0.025
Human
cellular catabolic process GO:0044248 295 0.025
Human Rat
response to peptide GO:1901652 292 0.025
regulation of microtubule polymerization or depolymerization GO:0031110 12 0.025
regulation of proteasomal protein catabolic process GO:0061136 4 0.025
Human Rat
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.025
Human
double strand break repair GO:0006302 1 0.024
regulation of neuron differentiation GO:0045664 208 0.024
Rat
regulation of nervous system development GO:0051960 264 0.024
Rat Fly
dna packaging GO:0006323 4 0.024
macromolecule localization GO:0033036 252 0.024
Human Yeast Fly
central nervous system development GO:0007417 311 0.024
regulation of synapse maturation GO:0090128 2 0.024
positive regulation of cell proliferation GO:0008284 249 0.023
negative regulation of programmed cell death GO:0043069 183 0.023
Human
negative regulation of molecular function GO:0044092 133 0.023
Human
developmental process involved in reproduction GO:0003006 159 0.023
Worm Fly
positive regulation of catalytic activity GO:0043085 184 0.023
Human Yeast
single organism biosynthetic process GO:0044711 342 0.023
dendrite development GO:0016358 72 0.023
Rat
multicellular organismal reproductive process GO:0048609 233 0.023
Worm Fly
nucleic acid templated transcription GO:0097659 379 0.023
Human
negative regulation of cell death GO:0060548 229 0.023
Human
positive regulation of molecular function GO:0044093 230 0.023
Human Yeast Rat
regulation of cellular ketone metabolic process GO:0010565 27 0.023
potassium ion transport GO:0006813 97 0.023
positive regulation of transport GO:0051050 245 0.022
regulation of cell projection organization GO:0031344 175 0.022
Rat
regulation of programmed cell death GO:0043067 341 0.022
Human
regulation of cellular amine metabolic process GO:0033238 8 0.022
organic acid metabolic process GO:0006082 292 0.022
response to organophosphorus GO:0046683 102 0.022
meiosis i GO:0007127 2 0.022
Yeast Worm
regulation of response to stress GO:0080134 126 0.022
anatomical structure morphogenesis GO:0009653 298 0.021
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 7 0.021
Human Rat
reproductive system development GO:0061458 128 0.021
Worm
nucleosome organization GO:0034728 1 0.021
head development GO:0060322 247 0.021
receptor mediated endocytosis GO:0006898 42 0.020
chromosome separation GO:0051304 1 0.020
Human Yeast
regulation of cellular amino acid metabolic process GO:0006521 2 0.020
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 3 0.020
Human Rat
cellular protein catabolic process GO:0044257 19 0.020
Human Rat
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.020
positive regulation of phosphorylation GO:0042327 177 0.020
Human
protein processing GO:0016485 68 0.019
Human
response to hypoxia GO:0001666 231 0.019
regulation of neurogenesis GO:0050767 247 0.019
Rat Fly
response to cytokine GO:0034097 215 0.019
regulation of cellular catabolic process GO:0031329 101 0.019
Human Rat
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.019
centrosome cycle GO:0007098 1 0.019
Worm
positive regulation of rna biosynthetic process GO:1902680 197 0.019
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.019
negative regulation of transport GO:0051051 136 0.018
regulation of protein modification process GO:0031399 194 0.018
Human
mitotic sister chromatid segregation GO:0000070 1 0.018
Human
negative regulation of cell proliferation GO:0008285 119 0.018
Fly
ubiquitin dependent protein catabolic process GO:0006511 14 0.018
Human Rat
response to ethanol GO:0045471 162 0.018
response to peptide hormone GO:0043434 278 0.017
intracellular transport GO:0046907 185 0.017
cellular macromolecule localization GO:0070727 122 0.017
Human Fly
regulation of transcription dna templated GO:0006355 374 0.017
Human
embryo development GO:0009790 49 0.017
Worm Fly
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.017
positive regulation of gene expression GO:0010628 244 0.017
carboxylic acid metabolic process GO:0019752 289 0.017
dna metabolic process GO:0006259 96 0.017
Yeast
response to oxidative stress GO:0006979 186 0.017
regulation of protein catabolic process GO:0042176 16 0.017
Human Rat
developmental growth GO:0048589 100 0.017
response to oxygen levels GO:0070482 265 0.017
negative regulation of nucleic acid templated transcription GO:1903507 117 0.017
Human
microtubule based process GO:0007017 36 0.017
Human Yeast Worm Fly
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.016
Human
reproductive structure development GO:0048608 128 0.016
Worm
negative regulation of protein processing GO:0010955 47 0.016
Human
regulation of protein phosphorylation GO:0001932 183 0.016
Human
negative regulation of cell differentiation GO:0045596 99 0.015
Rat Fly
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.015
Human
apoptotic process GO:0006915 381 0.015
Human Worm
gastrulation GO:0007369 2 0.015
acetate ester biosynthetic process GO:1900620 2 0.015
response to fatty acid GO:0070542 65 0.015
dephosphorylation GO:0016311 98 0.014
response to decreased oxygen levels GO:0036293 237 0.014
heterocycle catabolic process GO:0046700 167 0.014
regulation of nucleic acid templated transcription GO:1903506 380 0.014
Human
cellular response to oxygen containing compound GO:1901701 386 0.014
mitotic cell cycle GO:0000278 49 0.014
Human Zebrafish Worm Fly
single organism catabolic process GO:0044712 283 0.014
Human
regulation of neuron projection development GO:0010975 161 0.014
Rat
regulation of cellular localization GO:0060341 263 0.014
response to metal ion GO:0010038 253 0.014
negative regulation of protein metabolic process GO:0051248 114 0.014
Human
developmental maturation GO:0021700 25 0.014
response to mechanical stimulus GO:0009612 134 0.014
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
positive regulation of catabolic process GO:0009896 78 0.014
Human Rat
cellular protein complex assembly GO:0043623 44 0.014
Fly
cellular response to hormone stimulus GO:0032870 247 0.014
negative regulation of rna biosynthetic process GO:1902679 118 0.014
Human
positive regulation of protein metabolic process GO:0051247 178 0.014
Human Rat
synaptic transmission GO:0007268 235 0.014
Rat
sexual reproduction GO:0019953 148 0.013
Worm Fly
membrane organization GO:0061024 94 0.013
Worm
chromosome organization GO:0051276 36 0.013
Human Yeast
striated muscle tissue development GO:0014706 58 0.013
response to alkaloid GO:0043279 132 0.013
anterior posterior pattern specification GO:0009952 1 0.013
regulation of protein maturation GO:1903317 50 0.013
Human
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 3 0.013
Human Rat
protein localization to chromosome centromeric region GO:0071459 1 0.013
organic cyclic compound catabolic process GO:1901361 175 0.013
positive regulation of transferase activity GO:0051347 81 0.013
Human
transcription initiation from rna polymerase ii promoter GO:0006367 3 0.013
cellular amino acid metabolic process GO:0006520 107 0.013
synapse maturation GO:0060074 5 0.013
regulation of cytoskeleton organization GO:0051493 49 0.013
Yeast
fatty acid metabolic process GO:0006631 99 0.012
rna biosynthetic process GO:0032774 380 0.012
Human
negative regulation of cell cycle phase transition GO:1901988 4 0.012
Human
positive regulation of protein phosphorylation GO:0001934 135 0.012
Human
positive regulation of cell differentiation GO:0045597 217 0.012
single organism intracellular transport GO:1902582 166 0.012
protein ubiquitination GO:0016567 28 0.012
Human
response to toxic substance GO:0009636 133 0.012
response to estradiol GO:0032355 164 0.012
axis specification GO:0009798 4 0.012
response to camp GO:0051591 91 0.012
nuclear transport GO:0051169 49 0.012
positive regulation of phosphate metabolic process GO:0045937 262 0.012
Human
regulation of mapk cascade GO:0043408 116 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
circulatory system development GO:0072359 134 0.012
Fly
cytoplasmic transport GO:0016482 115 0.012
regulation of cell development GO:0060284 263 0.011
Rat Fly
regulation of meiotic cell cycle GO:0051445 3 0.011
Worm
organelle fission GO:0048285 25 0.011
negative regulation of protein maturation GO:1903318 47 0.011
Human
regulation of cell cycle process GO:0010564 31 0.011
Human Yeast Worm
cell communication involved in cardiac conduction GO:0086065 2 0.011
positive regulation of nervous system development GO:0051962 178 0.011
vesicle mediated transport GO:0016192 181 0.011
Fly
cellular response to extracellular stimulus GO:0031668 73 0.011
establishment of chromosome localization GO:0051303 1 0.011
response to external biotic stimulus GO:0043207 221 0.011
cellular lipid metabolic process GO:0044255 208 0.011
regulation of cell cycle arrest GO:0071156 2 0.011
positive regulation of cellular catabolic process GO:0031331 71 0.011
Human Rat
positive regulation of programmed cell death GO:0043068 157 0.011
regulation of mrna 3 end processing GO:0031440 1 0.011
regulation of catabolic process GO:0009894 113 0.011
Human Rat
gamete generation GO:0007276 124 0.011
Worm Fly
regulation of mitotic sister chromatid separation GO:0010965 1 0.011
Human
negative regulation of cell communication GO:0010648 158 0.011
Rat
transmembrane transport GO:0055085 412 0.011
neuron projection development GO:0031175 273 0.011
Rat
chromatin assembly or disassembly GO:0006333 1 0.011
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.011
Human
gland development GO:0048732 155 0.011
negative regulation of cellular metabolic process GO:0031324 281 0.011
Human
regulation of signal transduction GO:0009966 318 0.010
response to inorganic substance GO:0010035 377 0.010
protein oligomerization GO:0051259 191 0.010
cellular macromolecular complex assembly GO:0034622 58 0.010
Fly
cell cell signaling GO:0007267 335 0.010
Rat
response to radiation GO:0009314 137 0.010
positive regulation of mrna metabolic process GO:1903313 4 0.010
mitotic nuclear division GO:0007067 15 0.010
Human Worm Fly

Plk1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.016
cancer DOID:162 0 0.015
organ system cancer DOID:0050686 0 0.015