Rattus norvegicus

144 known processes

Plk2

polo-like kinase 2 (Drosophila)

(Aliases: Snk)

Plk2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nucleic acid templated transcription GO:0097659 379 0.138
transcription dna templated GO:0006351 377 0.100
cellular response to endogenous stimulus GO:0071495 377 0.085
anatomical structure morphogenesis GO:0009653 298 0.084
regulation of transcription dna templated GO:0006355 374 0.084
regulation of molecular function GO:0065009 398 0.079
rna metabolic process GO:0016070 406 0.073
rna biosynthetic process GO:0032774 380 0.070
intracellular signal transduction GO:0035556 314 0.068
regulation of phosphorus metabolic process GO:0051174 349 0.065
regulation of rna metabolic process GO:0051252 391 0.064
cellular response to stress GO:0033554 269 0.064
positive regulation of multicellular organismal process GO:0051240 387 0.063
regulation of rna biosynthetic process GO:2001141 381 0.063
central nervous system development GO:0007417 311 0.061
cellular response to oxygen containing compound GO:1901701 386 0.061
response to oxygen levels GO:0070482 265 0.060
negative regulation of gene expression GO:0010629 199 0.059
positive regulation of cell differentiation GO:0045597 217 0.056
negative regulation of cell death GO:0060548 229 0.056
Mouse
apoptotic process GO:0006915 381 0.056
Mouse
negative regulation of cellular metabolic process GO:0031324 281 0.055
regulation of phosphate metabolic process GO:0019220 349 0.055
positive regulation of cell death GO:0010942 184 0.054
regulation of nucleic acid templated transcription GO:1903506 380 0.054
oxoacid metabolic process GO:0043436 290 0.054
regulation of programmed cell death GO:0043067 341 0.054
Mouse
organic acid metabolic process GO:0006082 292 0.054
positive regulation of signaling GO:0023056 270 0.053
neuron development GO:0048666 286 0.052
cellular component biogenesis GO:0044085 368 0.052
Human Yeast
negative regulation of macromolecule metabolic process GO:0010605 260 0.051
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.051
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.050
regulation of protein metabolic process GO:0051246 289 0.049
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.049
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.047
carboxylic acid metabolic process GO:0019752 289 0.045
negative regulation of rna metabolic process GO:0051253 123 0.045
programmed cell death GO:0012501 392 0.045
Mouse
response to extracellular stimulus GO:0009991 380 0.043
cell projection organization GO:0030030 302 0.043
regulation of multicellular organismal development GO:2000026 376 0.043
regulation of catalytic activity GO:0050790 304 0.042
Yeast
cellular amino acid metabolic process GO:0006520 107 0.042
regulation of signal transduction GO:0009966 318 0.042
Human
single organism behavior GO:0044708 130 0.041
Mouse
regulation of cell differentiation GO:0045595 320 0.041
response to growth factor GO:0070848 189 0.040
regulation of phosphorylation GO:0042325 248 0.040
positive regulation of phosphorus metabolic process GO:0010562 262 0.040
positive regulation of programmed cell death GO:0043068 157 0.039
transcription from rna polymerase ii promoter GO:0006366 252 0.039
regulation of synaptic transmission GO:0050804 141 0.038
negative regulation of metabolic process GO:0009892 331 0.038
cellular response to nitrogen compound GO:1901699 210 0.037
response to hypoxia GO:0001666 231 0.037
regulation of system process GO:0044057 208 0.037
response to oxidative stress GO:0006979 186 0.037
positive regulation of developmental process GO:0051094 283 0.036
regulation of cellular component organization GO:0051128 368 0.036
cellular component assembly GO:0022607 360 0.036
Human Yeast
cellular ketone metabolic process GO:0042180 51 0.035
negative regulation of biosynthetic process GO:0009890 168 0.035
response to nutrient levels GO:0031667 370 0.035
regulation of apoptotic process GO:0042981 335 0.035
Mouse
protein complex assembly GO:0006461 263 0.035
Yeast
response to monosaccharide GO:0034284 159 0.035
amine metabolic process GO:0009308 38 0.034
cellular response to growth factor stimulus GO:0071363 162 0.034
macromolecular complex subunit organization GO:0043933 339 0.034
Human Yeast
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.034
negative regulation of response to stimulus GO:0048585 155 0.033
positive regulation of phosphate metabolic process GO:0045937 262 0.033
signal transduction by phosphorylation GO:0023014 144 0.033
negative regulation of nucleic acid templated transcription GO:1903507 117 0.033
response to hydrogen peroxide GO:0042542 89 0.032
cellular component morphogenesis GO:0032989 155 0.032
response to decreased oxygen levels GO:0036293 237 0.032
positive regulation of rna biosynthetic process GO:1902680 197 0.032
negative regulation of multicellular organismal process GO:0051241 203 0.032
response to peptide hormone GO:0043434 278 0.031
synaptic transmission GO:0007268 235 0.031
negative regulation of rna biosynthetic process GO:1902679 118 0.031
regulation of cellular ketone metabolic process GO:0010565 27 0.031
transmembrane transport GO:0055085 412 0.031
regulation of protein modification process GO:0031399 194 0.031
negative regulation of apoptotic process GO:0043066 181 0.031
Mouse
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.031
regulation of intracellular signal transduction GO:1902531 218 0.030
Human
regulation of cell proliferation GO:0042127 359 0.030
negative regulation of cellular biosynthetic process GO:0031327 161 0.030
positive regulation of gene expression GO:0010628 244 0.030
positive regulation of nucleic acid templated transcription GO:1903508 197 0.030
regulation of cellular amine metabolic process GO:0033238 8 0.030
brain development GO:0007420 247 0.030
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.030
regulation of nervous system development GO:0051960 264 0.029
positive regulation of biosynthetic process GO:0009891 319 0.029
regulation of cell development GO:0060284 263 0.029
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.029
cellular response to organonitrogen compound GO:0071417 197 0.029
response to wounding GO:0009611 254 0.029
regulation of cellular amino acid metabolic process GO:0006521 2 0.029
neuron differentiation GO:0030182 368 0.028
nucleotide metabolic process GO:0009117 279 0.028
cellular catabolic process GO:0044248 295 0.028
positive regulation of cellular protein metabolic process GO:0032270 167 0.028
response to radiation GO:0009314 137 0.028
negative regulation of signaling GO:0023057 157 0.028
regulation of proteasomal protein catabolic process GO:0061136 4 0.028
positive regulation of molecular function GO:0044093 230 0.028
purine containing compound metabolic process GO:0072521 253 0.027
metal ion transport GO:0030001 289 0.027
response to ketone GO:1901654 182 0.027
response to peptide GO:1901652 292 0.026
positive regulation of signal transduction GO:0009967 175 0.026
Human
neuron projection development GO:0031175 273 0.026
response to insulin GO:0032868 133 0.026
positive regulation of cellular biosynthetic process GO:0031328 295 0.026
cell motility GO:0048870 202 0.026
positive regulation of rna metabolic process GO:0051254 203 0.026
catabolic process GO:0009056 351 0.025
response to carbohydrate GO:0009743 183 0.025
organelle organization GO:0006996 266 0.025
Human Yeast Rat
positive regulation of phosphorylation GO:0042327 177 0.025
cellular macromolecule localization GO:0070727 122 0.025
protein complex subunit organization GO:0071822 302 0.025
Human Yeast
response to inorganic substance GO:0010035 377 0.025
response to organophosphorus GO:0046683 102 0.025
nitrogen compound transport GO:0071705 229 0.024
nucleobase containing small molecule metabolic process GO:0055086 316 0.024
negative regulation of cell communication GO:0010648 158 0.024
positive regulation of cell communication GO:0010647 271 0.024
single organism catabolic process GO:0044712 283 0.024
anterior posterior pattern specification GO:0009952 1 0.024
response to purine containing compound GO:0014074 126 0.024
gliogenesis GO:0042063 93 0.024
positive regulation of cellular amine metabolic process GO:0033240 3 0.023
regulation of cell projection organization GO:0031344 175 0.023
response to toxic substance GO:0009636 133 0.023
Rat
carbohydrate derivative metabolic process GO:1901135 346 0.023
mapk cascade GO:0000165 140 0.023
cellular amine metabolic process GO:0044106 38 0.023
negative regulation of transcription dna templated GO:0045892 116 0.023
response to hexose GO:0009746 144 0.023
regulation of neuron projection development GO:0010975 161 0.023
positive regulation of apoptotic process GO:0043065 154 0.023
protein oligomerization GO:0051259 191 0.022
cell morphogenesis GO:0000902 142 0.022
regulation of cellular localization GO:0060341 263 0.022
glial cell differentiation GO:0010001 65 0.022
regulation of neurogenesis GO:0050767 247 0.022
regulation of secretion GO:0051046 224 0.022
response to metal ion GO:0010038 253 0.022
protein heterooligomerization GO:0051291 89 0.022
macromolecule localization GO:0033036 252 0.022
Yeast
anion transport GO:0006820 178 0.022
cognition GO:0050890 92 0.022
Mouse
regulation of protein phosphorylation GO:0001932 183 0.022
reproductive structure development GO:0048608 128 0.022
response to molecule of bacterial origin GO:0002237 194 0.022
purine nucleoside metabolic process GO:0042278 169 0.021
regulation of neuron differentiation GO:0045664 208 0.021
positive regulation of cellular component organization GO:0051130 200 0.021
Yeast
cellular response to abiotic stimulus GO:0071214 85 0.021
organophosphate metabolic process GO:0019637 370 0.021
neuron death GO:0070997 127 0.021
cell cycle GO:0007049 101 0.021
Human Yeast Mouse Rat
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.021
regulation of ion transport GO:0043269 245 0.021
cellular response to peptide GO:1901653 133 0.021
regulation of neuron apoptotic process GO:0043523 83 0.021
glycosyl compound metabolic process GO:1901657 182 0.021
regulation of hydrolase activity GO:0051336 143 0.020
protein phosphorylation GO:0006468 345 0.020
single organism reproductive process GO:0044702 297 0.020
neuron projection morphogenesis GO:0048812 122 0.020
cell cell signaling GO:0007267 335 0.020
bmp signaling pathway GO:0030509 4 0.020
organonitrogen compound catabolic process GO:1901565 179 0.020
cation transport GO:0006812 382 0.020
negative regulation of nervous system development GO:0051961 79 0.020
macromolecular complex assembly GO:0065003 273 0.020
Yeast
proteolysis GO:0006508 175 0.020
positive regulation of cell development GO:0010720 176 0.020
regulation of cellular protein metabolic process GO:0032268 267 0.019
tissue development GO:0009888 252 0.019
gastrulation GO:0007369 2 0.019
cellular nitrogen compound catabolic process GO:0044270 163 0.019
response to acid chemical GO:0001101 222 0.019
purine ribonucleotide catabolic process GO:0009154 136 0.019
purine nucleotide metabolic process GO:0006163 229 0.019
regulation of anatomical structure size GO:0090066 135 0.019
renal system development GO:0072001 67 0.019
behavior GO:0007610 205 0.019
Mouse
synaptic growth at neuromuscular junction GO:0051124 1 0.019
negative regulation of signal transduction GO:0009968 83 0.019
regulation of mapk cascade GO:0043408 116 0.019
homeostatic process GO:0042592 331 0.018
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.018
positive regulation of response to stimulus GO:0048584 285 0.018
Human
head development GO:0060322 247 0.018
negative regulation of protein metabolic process GO:0051248 114 0.018
single organism cellular localization GO:1902580 102 0.018
nucleoside phosphate metabolic process GO:0006753 283 0.018
cellular response to hormone stimulus GO:0032870 247 0.018
negative regulation of molecular function GO:0044092 133 0.018
immune system process GO:0002376 204 0.018
cell projection morphogenesis GO:0048858 123 0.018
regulation of secretion by cell GO:1903530 208 0.018
muscle system process GO:0003012 115 0.018
circulatory system process GO:0003013 183 0.018
ion transmembrane transport GO:0034220 365 0.017
single organism biosynthetic process GO:0044711 342 0.017
protein complex biogenesis GO:0070271 263 0.017
Yeast
purine containing compound catabolic process GO:0072523 138 0.017
circulatory system development GO:0072359 134 0.017
organic substance catabolic process GO:1901575 316 0.017
response to alkaloid GO:0043279 132 0.017
cell migration GO:0016477 197 0.017
ribonucleoside metabolic process GO:0009119 174 0.017
regulation of blood circulation GO:1903522 110 0.017
cellular protein localization GO:0034613 122 0.017
response to glucose GO:0009749 136 0.017
growth GO:0040007 165 0.017
chemical homeostasis GO:0048878 292 0.017
purine ribonucleotide metabolic process GO:0009150 227 0.017
motor neuron axon guidance GO:0008045 1 0.017
carbohydrate derivative catabolic process GO:1901136 147 0.017
axon development GO:0061564 96 0.017
nucleobase containing compound catabolic process GO:0034655 152 0.017
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.017
skeletal muscle cell differentiation GO:0035914 2 0.017
negative regulation of cellular protein metabolic process GO:0032269 106 0.017
response to glucocorticoid GO:0051384 223 0.016
regulation of hormone secretion GO:0046883 106 0.016
coenzyme metabolic process GO:0006732 86 0.016
regulation of muscle system process GO:0090257 79 0.016
ribonucleotide metabolic process GO:0009259 231 0.016
organic cyclic compound catabolic process GO:1901361 175 0.016
negative regulation of programmed cell death GO:0043069 183 0.016
Mouse
locomotion GO:0040011 237 0.015
negative regulation of canonical wnt signaling pathway GO:0090090 4 0.015
secretion GO:0046903 307 0.015
organic anion transport GO:0015711 132 0.015
cell morphogenesis involved in differentiation GO:0000904 119 0.015
blood circulation GO:0008015 183 0.015
positive regulation of neurogenesis GO:0050769 165 0.015
multicellular organism reproduction GO:0032504 233 0.015
response to transition metal nanoparticle GO:1990267 122 0.015
response to nutrient GO:0007584 248 0.015
reproductive process GO:0022414 372 0.015
positive regulation of nervous system development GO:0051962 178 0.015
nucleoside triphosphate metabolic process GO:0009141 144 0.015
cell part morphogenesis GO:0032990 123 0.015
cardiovascular system development GO:0072358 134 0.015
oxidation reduction process GO:0055114 304 0.015
nucleotide catabolic process GO:0009166 139 0.015
peptidyl amino acid modification GO:0018193 126 0.015
regulation of membrane potential GO:0042391 110 0.015
axis specification GO:0009798 4 0.015
positive regulation of transcription dna templated GO:0045893 197 0.015
cellular response to organic cyclic compound GO:0071407 202 0.015
reproduction GO:0000003 245 0.015
Yeast Rat
developmental process involved in reproduction GO:0003006 159 0.015
response to antibiotic GO:0046677 39 0.015
Rat
positive regulation of cell proliferation GO:0008284 249 0.015
regulation of stem cell differentiation GO:2000736 2 0.015
muscle structure development GO:0061061 87 0.015
regulation of response to stress GO:0080134 126 0.015
axonogenesis GO:0007409 71 0.014
response to reactive oxygen species GO:0000302 120 0.014
positive regulation of catalytic activity GO:0043085 184 0.014
Yeast
ribose phosphate metabolic process GO:0019693 235 0.014
heart morphogenesis GO:0003007 3 0.014
dephosphorylation GO:0016311 98 0.014
muscle contraction GO:0006936 88 0.014
monocarboxylic acid metabolic process GO:0032787 152 0.014
positive regulation of ion transport GO:0043270 94 0.014
learning or memory GO:0007611 90 0.014
Mouse
negative regulation of phosphorus metabolic process GO:0010563 80 0.014
response to increased oxygen levels GO:0036296 45 0.014
regulation of hormone levels GO:0010817 187 0.014
nucleoside metabolic process GO:0009116 179 0.014
kidney development GO:0001822 67 0.014
multi organism reproductive process GO:0044703 262 0.014
striated muscle tissue development GO:0014706 58 0.013
response to corticosteroid GO:0031960 235 0.013
embryonic pattern specification GO:0009880 1 0.013
cation transmembrane transport GO:0098655 263 0.013
ribonucleoside triphosphate metabolic process GO:0009199 141 0.013
lipid metabolic process GO:0006629 283 0.013
nucleoside phosphate catabolic process GO:1901292 140 0.013
single organism organelle organization GO:1902589 180 0.013
Human Yeast
intracellular transport GO:0046907 185 0.013
locomotor rhythm GO:0045475 1 0.013
chromosome segregation GO:0007059 2 0.013
Yeast
vesicle mediated transport GO:0016192 181 0.013
hematopoietic or lymphoid organ development GO:0048534 36 0.013
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.013
regulation of kinase activity GO:0043549 117 0.013
positive regulation of protein metabolic process GO:0051247 178 0.013
negative regulation of cell proliferation GO:0008285 119 0.013
cellular homeostasis GO:0019725 252 0.013
regulation of anatomical structure morphogenesis GO:0022603 141 0.013
cytoplasmic transport GO:0016482 115 0.013
positive regulation of protein modification process GO:0031401 142 0.013
myosin filament assembly GO:0031034 1 0.013
regulation of catabolic process GO:0009894 113 0.013
regulation of cellular catabolic process GO:0031329 101 0.013
carboxylic acid transport GO:0046942 115 0.013
actin filament based process GO:0030029 86 0.013
cellular response to peptide hormone stimulus GO:0071375 120 0.013
single organism intracellular transport GO:1902582 166 0.013
regulation of protein localization GO:0032880 81 0.013
response to camp GO:0051591 91 0.012
purine ribonucleoside metabolic process GO:0046128 168 0.012
response to axon injury GO:0048678 59 0.012
cellular component movement GO:0006928 248 0.012
secretion by cell GO:0032940 248 0.012
positive regulation of mapk cascade GO:0043410 92 0.012
cellular response to insulin stimulus GO:0032869 81 0.012
cell adhesion GO:0007155 110 0.012
gamete generation GO:0007276 124 0.012
cellular lipid metabolic process GO:0044255 208 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.012
protein modification by small protein conjugation or removal GO:0070647 35 0.012
peptide transport GO:0015833 97 0.012
urogenital system development GO:0001655 78 0.012
regeneration GO:0031099 163 0.012
calcium ion homeostasis GO:0055074 162 0.012
cellular response to oxygen levels GO:0071453 60 0.012
response to ethanol GO:0045471 162 0.012
positive regulation of cellular catabolic process GO:0031331 71 0.012
regulation of cell morphogenesis GO:0022604 77 0.012
response to bacterium GO:0009617 200 0.012
positive regulation of protein phosphorylation GO:0001934 135 0.012
negative regulation of developmental process GO:0051093 125 0.012
organophosphate catabolic process GO:0046434 148 0.012
hematopoietic progenitor cell differentiation GO:0002244 2 0.012
vascular process in circulatory system GO:0003018 96 0.012
protein localization GO:0008104 191 0.012
Yeast
regulation of peptide transport GO:0090087 87 0.012
multicellular organismal reproductive process GO:0048609 233 0.011
response to estrogen GO:0043627 232 0.011
ras protein signal transduction GO:0007265 29 0.011
circadian rhythm GO:0007623 88 0.011
response to vitamin GO:0033273 131 0.011
nucleoside triphosphate catabolic process GO:0009143 123 0.011
eye morphogenesis GO:0048592 4 0.011
response to cytokine GO:0034097 215 0.011
cellular cation homeostasis GO:0030003 180 0.011
enzyme linked receptor protein signaling pathway GO:0007167 116 0.011
regulation of organelle organization GO:0033043 80 0.011
Human Yeast
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.011
calcium ion transport GO:0006816 131 0.011
positive regulation of cell projection organization GO:0031346 111 0.011
cell cycle checkpoint GO:0000075 2 0.011
Mouse
ribonucleoside triphosphate catabolic process GO:0009203 122 0.011
embryonic skeletal system morphogenesis GO:0048704 3 0.011
cellular response to lipid GO:0071396 201 0.011
response to hyperoxia GO:0055093 45 0.011
cellular macromolecular complex assembly GO:0034622 58 0.011
purine nucleoside catabolic process GO:0006152 124 0.011
regulation of tube size GO:0035150 89 0.011
amide transport GO:0042886 105 0.011
sulfur compound metabolic process GO:0006790 70 0.011
aging GO:0007568 241 0.011
ribonucleoside catabolic process GO:0042454 126 0.011
heart contraction GO:0060047 57 0.011
reactive nitrogen species metabolic process GO:2001057 1 0.011
regulation of cell migration GO:0030334 128 0.011
hormone transport GO:0009914 121 0.011
neurological system process GO:0050877 219 0.010
Mouse
regulation of transferase activity GO:0051338 123 0.010
cellular response to cytokine stimulus GO:0071345 127 0.010
cellular response to external stimulus GO:0071496 118 0.010
regulation of blood vessel size GO:0050880 89 0.010
carboxylic acid biosynthetic process GO:0046394 83 0.010
rho protein signal transduction GO:0007266 11 0.010
cellular metal ion homeostasis GO:0006875 172 0.010
organic acid transport GO:0015849 116 0.010
nuclear transport GO:0051169 49 0.010
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.010
Mouse
regulation of metal ion transport GO:0010959 118 0.010
regulation of response to wounding GO:1903034 69 0.010
heterocycle catabolic process GO:0046700 167 0.010
cellular divalent inorganic cation homeostasis GO:0072503 162 0.010
positive regulation of intracellular signal transduction GO:1902533 138 0.010
Human
gonad development GO:0008406 104 0.010
alternative mrna splicing via spliceosome GO:0000380 4 0.010
heart process GO:0003015 57 0.010

Plk2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.026
nervous system disease DOID:863 0 0.026
sensory system disease DOID:0050155 0 0.017
disease of metabolism DOID:0014667 0 0.011