Rattus norvegicus

58 known processes

Igfbp1

insulin-like growth factor binding protein 1

(Aliases: IGFBA,IBP1,IGF-BP25)

Igfbp1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oxoacid metabolic process GO:0043436 290 0.339
response to peptide hormone GO:0043434 278 0.304
carboxylic acid metabolic process GO:0019752 289 0.254
response to metal ion GO:0010038 253 0.243
Rat
organic acid metabolic process GO:0006082 292 0.218
organic acid biosynthetic process GO:0016053 83 0.213
response to acid chemical GO:0001101 222 0.210
Rat
carboxylic acid biosynthetic process GO:0046394 83 0.183
response to corticosteroid GO:0031960 235 0.139
Rat
response to organophosphorus GO:0046683 102 0.129
response to peptide GO:1901652 292 0.111
response to camp GO:0051591 91 0.110
response to glucocorticoid GO:0051384 223 0.107
Rat
response to extracellular stimulus GO:0009991 380 0.104
Rat
regulation of serine type peptidase activity GO:1902571 1 0.099
response to nutrient GO:0007584 248 0.095
Rat
cellular response to oxygen containing compound GO:1901701 386 0.089
response to nutrient levels GO:0031667 370 0.088
Rat
cellular amino acid metabolic process GO:0006520 107 0.087
monocarboxylic acid metabolic process GO:0032787 152 0.085
neuron differentiation GO:0030182 368 0.078
cellular response to lipid GO:0071396 201 0.077
cellular response to hormone stimulus GO:0032870 247 0.072
cellular response to organonitrogen compound GO:0071417 197 0.069
positive regulation of transport GO:0051050 245 0.067
alpha amino acid metabolic process GO:1901605 71 0.067
response to retinoic acid GO:0032526 63 0.067
Rat
catabolic process GO:0009056 351 0.065
regulation of body fluid levels GO:0050878 90 0.065
cell migration GO:0016477 197 0.060
fatty acid metabolic process GO:0006631 99 0.059
regulation of cellular component movement GO:0051270 150 0.059
circulatory system process GO:0003013 183 0.059
response to estrogen GO:0043627 232 0.058
Rat
small molecule biosynthetic process GO:0044283 124 0.057
regulation of blood vessel size GO:0050880 89 0.056
chemical homeostasis GO:0048878 292 0.052
positive regulation of programmed cell death GO:0043068 157 0.052
transmembrane transport GO:0055085 412 0.052
response to transition metal nanoparticle GO:1990267 122 0.052
regulation of tube size GO:0035150 89 0.052
cellular response to nitrogen compound GO:1901699 210 0.051
response to interleukin 1 GO:0070555 55 0.051
response to decreased oxygen levels GO:0036293 237 0.051
cellular ketone metabolic process GO:0042180 51 0.050
reproduction GO:0000003 245 0.050
cellular response to endogenous stimulus GO:0071495 377 0.049
cellular response to peptide hormone stimulus GO:0071375 120 0.049
cellular response to cytokine stimulus GO:0071345 127 0.048
response to inorganic substance GO:0010035 377 0.047
Rat
response to carbohydrate GO:0009743 183 0.047
negative regulation of multicellular organismal process GO:0051241 203 0.046
defense response GO:0006952 194 0.046
Rat
regulation of cell development GO:0060284 263 0.044
cellular response to organic cyclic compound GO:0071407 202 0.044
organic substance catabolic process GO:1901575 316 0.044
biological adhesion GO:0022610 110 0.044
regulation of cellular ketone metabolic process GO:0010565 27 0.042
response to ketone GO:1901654 182 0.040
response to bacterium GO:0009617 200 0.039
response to cytokine GO:0034097 215 0.039
cellular response to steroid hormone stimulus GO:0071383 93 0.038
response to hydrogen peroxide GO:0042542 89 0.038
single organism biosynthetic process GO:0044711 342 0.037
multi organism reproductive process GO:0044703 262 0.037
Rat
response to vitamin GO:0033273 131 0.037
cell motility GO:0048870 202 0.037
response to other organism GO:0051707 220 0.037
regulation of apoptotic process GO:0042981 335 0.036
single organism reproductive process GO:0044702 297 0.036
regulation of nucleic acid templated transcription GO:1903506 380 0.035
organic anion transport GO:0015711 132 0.035
carboxylic acid transport GO:0046942 115 0.035
programmed cell death GO:0012501 392 0.034
response to purine containing compound GO:0014074 126 0.034
proteolysis GO:0006508 175 0.033
response to biotic stimulus GO:0009607 226 0.033
renal system process GO:0003014 40 0.033
cellular response to stress GO:0033554 269 0.032
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.032
regulation of programmed cell death GO:0043067 341 0.032
amide biosynthetic process GO:0043604 10 0.032
multi multicellular organism process GO:0044706 138 0.031
Rat
vascular process in circulatory system GO:0003018 96 0.031
aromatic amino acid family metabolic process GO:0009072 9 0.031
cellular modified amino acid metabolic process GO:0006575 61 0.031
cellular amino acid biosynthetic process GO:0008652 32 0.030
renin angiotensin regulation of aldosterone production GO:0002018 3 0.030
response to fatty acid GO:0070542 65 0.030
cation transport GO:0006812 382 0.030
cell adhesion GO:0007155 110 0.029
negative regulation of macromolecule metabolic process GO:0010605 260 0.029
locomotion GO:0040011 237 0.029
apoptotic process GO:0006915 381 0.029
multicellular organism reproduction GO:0032504 233 0.029
organonitrogen compound catabolic process GO:1901565 179 0.027
ion transmembrane transport GO:0034220 365 0.027
regulation of cellular localization GO:0060341 263 0.026
organic acid transport GO:0015849 116 0.026
transmission of nerve impulse GO:0019226 42 0.026
negative regulation of protein metabolic process GO:0051248 114 0.026
regulation of cellular amino acid metabolic process GO:0006521 2 0.026
positive regulation of multicellular organismal process GO:0051240 387 0.026
regulation of locomotion GO:0040012 148 0.026
response to interferon gamma GO:0034341 20 0.026
response to oxygen levels GO:0070482 265 0.026
secretion GO:0046903 307 0.026
cellular amine metabolic process GO:0044106 38 0.026
urea cycle GO:0000050 5 0.026
developmental growth GO:0048589 100 0.025
neuron development GO:0048666 286 0.025
response to amino acid GO:0043200 75 0.025
macromolecular complex assembly GO:0065003 273 0.025
blood circulation GO:0008015 183 0.025
response to external biotic stimulus GO:0043207 221 0.025
small molecule catabolic process GO:0044282 59 0.025
reactive nitrogen species metabolic process GO:2001057 1 0.025
response to hexose GO:0009746 144 0.024
cellular catabolic process GO:0044248 295 0.024
negative regulation of metabolic process GO:0009892 331 0.024
positive regulation of response to stimulus GO:0048584 285 0.024
multicellular organismal reproductive process GO:0048609 233 0.024
cellular response to abiotic stimulus GO:0071214 85 0.023
response to oxidative stress GO:0006979 186 0.023
multicellular organismal signaling GO:0035637 44 0.023
cellular lipid metabolic process GO:0044255 208 0.023
nitrogen compound transport GO:0071705 229 0.023
response to molecule of bacterial origin GO:0002237 194 0.023
regulation of cell motility GO:2000145 131 0.022
protein complex biogenesis GO:0070271 263 0.022
regulation of ion transport GO:0043269 245 0.022
divalent metal ion transport GO:0070838 132 0.022
reproductive process GO:0022414 372 0.022
Rat
cellular component movement GO:0006928 248 0.022
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.022
positive regulation of cell death GO:0010942 184 0.022
cellular response to insulin stimulus GO:0032869 81 0.022
lipid biosynthetic process GO:0008610 128 0.021
aromatic amino acid family catabolic process GO:0009074 7 0.021
positive regulation of apoptotic process GO:0043065 154 0.021
vesicle mediated transport GO:0016192 181 0.021
regulation of phosphate metabolic process GO:0019220 349 0.021
pyruvate metabolic process GO:0006090 27 0.021
cellular sodium ion homeostasis GO:0006883 4 0.021
amide transport GO:0042886 105 0.021
vasoconstriction GO:0042310 54 0.021
positive regulation of cell proliferation GO:0008284 249 0.021
protein homooligomerization GO:0051260 91 0.021
amine metabolic process GO:0009308 38 0.021
response to mineralocorticoid GO:0051385 49 0.020
regulation of serine type endopeptidase activity GO:1900003 1 0.020
negative regulation of nucleic acid templated transcription GO:1903507 117 0.020
positive regulation of blood coagulation GO:0030194 4 0.020
response to hypoxia GO:0001666 231 0.020
regulation of cellular amine metabolic process GO:0033238 8 0.020
response to insulin GO:0032868 133 0.020
regulation of nervous system development GO:0051960 264 0.020
reactive oxygen species biosynthetic process GO:1903409 8 0.020
secretion by cell GO:0032940 248 0.020
cellular response to interleukin 1 GO:0071347 37 0.019
alpha amino acid biosynthetic process GO:1901607 23 0.019
response to chromate GO:0046687 3 0.019
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.019
response to zinc ion GO:0010043 39 0.019
response to toxic substance GO:0009636 133 0.019
developmental process involved in reproduction GO:0003006 159 0.018
positive regulation of extracellular matrix constituent secretion GO:0003331 2 0.018
lipid metabolic process GO:0006629 283 0.018
unsaturated fatty acid metabolic process GO:0033559 39 0.018
regulation of hydrolase activity GO:0051336 143 0.018
linoleic acid metabolic process GO:0043651 4 0.018
regulation of anatomical structure size GO:0090066 135 0.017
regulation of cell migration GO:0030334 128 0.017
cellular response to glucocorticoid stimulus GO:0071385 68 0.017
regulation of rna biosynthetic process GO:2001141 381 0.017
positive regulation of signaling GO:0023056 270 0.017
response to muscle activity involved in regulation of muscle adaptation GO:0014873 2 0.017
negative regulation of response to stimulus GO:0048585 155 0.017
negative regulation of catalytic activity GO:0043086 103 0.017
cellular response to external stimulus GO:0071496 118 0.017
gamete generation GO:0007276 124 0.017
response to monosaccharide GO:0034284 159 0.017
cellular component assembly GO:0022607 360 0.017
cellular response to alcohol GO:0097306 87 0.017
inflammatory response GO:0006954 150 0.017
Rat
cellular cation homeostasis GO:0030003 180 0.016
positive regulation of protein modification process GO:0031401 142 0.016
regulation of cellular protein metabolic process GO:0032268 267 0.016
cellular response to peptide GO:1901653 133 0.016
negative regulation of cell communication GO:0010648 158 0.016
response to lead ion GO:0010288 33 0.016
positive regulation of molecular function GO:0044093 230 0.016
protein complex assembly GO:0006461 263 0.016
regulation of catalytic activity GO:0050790 304 0.016
response to reactive oxygen species GO:0000302 120 0.016
anion transport GO:0006820 178 0.016
cellular amide metabolic process GO:0043603 44 0.016
tonic smooth muscle contraction GO:0014820 4 0.016
icosanoid biosynthetic process GO:0046456 18 0.016
response to lipopolysaccharide GO:0032496 191 0.016
regulation of reactive oxygen species metabolic process GO:2000377 26 0.015
coenzyme metabolic process GO:0006732 86 0.015
reactive oxygen species metabolic process GO:0072593 37 0.015
positive regulation of rna biosynthetic process GO:1902680 197 0.015
negative regulation of cellular protein metabolic process GO:0032269 106 0.015
cellular response to biotic stimulus GO:0071216 59 0.015
regeneration GO:0031099 163 0.015
protein maturation GO:0051604 68 0.015
negative regulation of nervous system development GO:0051961 79 0.015
response to dexamethasone GO:0071548 49 0.015
response to activity GO:0014823 73 0.015
artery smooth muscle contraction GO:0014824 4 0.015
cellular chemical homeostasis GO:0055082 247 0.014
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.014
metal ion transport GO:0030001 289 0.014
cell projection organization GO:0030030 302 0.014
reproductive system development GO:0061458 128 0.014
cellular response to interferon gamma GO:0071346 14 0.014
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.014
sulfur compound metabolic process GO:0006790 70 0.014
cellular homeostasis GO:0019725 252 0.014
negative regulation of signaling GO:0023057 157 0.014
tissue remodeling GO:0048771 40 0.014
positive regulation of hemostasis GO:1900048 4 0.014
macromolecular complex subunit organization GO:0043933 339 0.014
peptide transport GO:0015833 97 0.014
nitrogen cycle metabolic process GO:0071941 5 0.014
regulation of protein maturation GO:1903317 50 0.014
exogenous drug catabolic process GO:0042738 1 0.014
regulation of blood circulation GO:1903522 110 0.014
regulation of response to stress GO:0080134 126 0.014
response to estradiol GO:0032355 164 0.013
Rat
response to glucose GO:0009749 136 0.013
positive regulation of humoral immune response GO:0002922 2 0.013
cofactor metabolic process GO:0051186 95 0.013
syncytium formation by plasma membrane fusion GO:0000768 3 0.013
g protein coupled receptor signaling pathway GO:0007186 242 0.013
regulation of molecular function GO:0065009 398 0.013
positive regulation of biosynthetic process GO:0009891 319 0.013
protein complex subunit organization GO:0071822 302 0.013
positive regulation of catalytic activity GO:0043085 184 0.013
regulation of proteolysis GO:0030162 66 0.013
dephosphorylation GO:0016311 98 0.013
divalent inorganic cation transport GO:0072511 134 0.013
endocytosis GO:0006897 84 0.013
regulation of cellular component organization GO:0051128 368 0.012
central nervous system development GO:0007417 311 0.012
liver development GO:0001889 90 0.012
cellular response to corticosteroid stimulus GO:0071384 69 0.012
female pregnancy GO:0007565 122 0.012
Rat
epithelium development GO:0060429 96 0.012
negative regulation of innate immune response GO:0045824 4 0.012
regulation of rna metabolic process GO:0051252 391 0.012
monocarboxylic acid biosynthetic process GO:0072330 48 0.012
regulation of neurogenesis GO:0050767 247 0.012
regulation of response to external stimulus GO:0032101 106 0.012
catenin import into nucleus GO:0035411 1 0.012
regulation of extracellular matrix constituent secretion GO:0003330 2 0.012
limb morphogenesis GO:0035108 4 0.012
plasminogen activation GO:0031639 2 0.012
negative regulation of peptidase activity GO:0010466 38 0.012
negative regulation of gene expression GO:0010629 199 0.012
macromolecule catabolic process GO:0009057 58 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.012
brain development GO:0007420 247 0.012
positive regulation of cellular component movement GO:0051272 102 0.012
positive regulation of cellular component organization GO:0051130 200 0.012
regulation of system process GO:0044057 208 0.012
regulation of cell projection organization GO:0031344 175 0.011
spermatogenesis GO:0007283 99 0.011
organonitrogen compound biosynthetic process GO:1901566 167 0.011
regulation of cell proliferation GO:0042127 359 0.011
sexual reproduction GO:0019953 148 0.011
negative regulation of fibrinolysis GO:0051918 2 0.011
response to mercury ion GO:0046689 15 0.011
neuron projection morphogenesis GO:0048812 122 0.011
male gamete generation GO:0048232 99 0.011
retina morphogenesis in camera type eye GO:0060042 1 0.011
regulation of protein metabolic process GO:0051246 289 0.011
neuron projection development GO:0031175 273 0.011
positive regulation of cell projection organization GO:0031346 111 0.011
positive regulation of vasodilation GO:0045909 29 0.011
positive regulation of extracellular matrix organization GO:1903055 4 0.011
mapk cascade GO:0000165 140 0.011
cellular response to low density lipoprotein particle stimulus GO:0071404 3 0.011
positive regulation of transcription dna templated GO:0045893 197 0.011
carbohydrate derivative metabolic process GO:1901135 346 0.011
positive regulation of cellular amine metabolic process GO:0033240 3 0.011
negative regulation of serine type peptidase activity GO:1902572 1 0.011
regulation of phosphorylation GO:0042325 248 0.011
negative regulation of organ growth GO:0046621 3 0.011
regulation of signal transduction GO:0009966 318 0.011
regulation of neurological system process GO:0031644 43 0.011
cellular nitrogen compound catabolic process GO:0044270 163 0.011
alpha amino acid catabolic process GO:1901606 20 0.011
response to corticosterone GO:0051412 40 0.010
negative regulation of developmental process GO:0051093 125 0.010
glycerol transport GO:0015793 2 0.010
regulation of neuron differentiation GO:0045664 208 0.010
positive regulation of secretion GO:0051047 140 0.010
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.010
insecticide metabolic process GO:0017143 4 0.010
protein phosphorylation GO:0006468 345 0.010
cell cell signaling GO:0007267 335 0.010
growth GO:0040007 165 0.010
positive regulation of cellular biosynthetic process GO:0031328 295 0.010
regulation of vasodilation GO:0042312 36 0.010
positive regulation of phosphorus metabolic process GO:0010562 262 0.010
sodium ion transport GO:0006814 82 0.010
benzene containing compound metabolic process GO:0042537 22 0.010

Igfbp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.027
disease of anatomical entity DOID:7 0 0.024
nervous system disease DOID:863 0 0.024
sensory system disease DOID:0050155 0 0.019
immune system disease DOID:2914 0 0.015
blood coagulation disease DOID:1247 0 0.015
inherited blood coagulation disease DOID:2214 0 0.015
hematopoietic system disease DOID:74 0 0.015
acquired metabolic disease DOID:0060158 0 0.010