Rattus norvegicus

0 known processes

Kcnk12

potassium channel, subfamily K, member 12

(Aliases: THIK-2)

Kcnk12 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of multicellular organismal process GO:0051240 387 0.202
regulation of rna metabolic process GO:0051252 391 0.186
cellular component assembly GO:0022607 360 0.165
regulation of phosphorus metabolic process GO:0051174 349 0.136
transcription from rna polymerase ii promoter GO:0006366 252 0.135
cellular component biogenesis GO:0044085 368 0.131
positive regulation of cellular biosynthetic process GO:0031328 295 0.129
regulation of phosphate metabolic process GO:0019220 349 0.120
regulation of anatomical structure morphogenesis GO:0022603 141 0.110
head development GO:0060322 247 0.107
Rat
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.104
regulation of cellular component organization GO:0051128 368 0.102
tissue development GO:0009888 252 0.101
regulation of cell proliferation GO:0042127 359 0.098
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.092
protein phosphorylation GO:0006468 345 0.092
regulation of cell development GO:0060284 263 0.087
regulation of neurogenesis GO:0050767 247 0.083
regulation of nucleic acid templated transcription GO:1903506 380 0.080
cellular response to endogenous stimulus GO:0071495 377 0.078
negative regulation of macromolecule metabolic process GO:0010605 260 0.075
brain development GO:0007420 247 0.073
Rat
central nervous system development GO:0007417 311 0.073
Rat
mapk cascade GO:0000165 140 0.072
cell projection organization GO:0030030 302 0.069
regulation of transcription dna templated GO:0006355 374 0.068
positive regulation of phosphate metabolic process GO:0045937 262 0.068
positive regulation of developmental process GO:0051094 283 0.067
cell morphogenesis GO:0000902 142 0.067
single organism reproductive process GO:0044702 297 0.066
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.065
positive regulation of cell differentiation GO:0045597 217 0.060
regulation of protein metabolic process GO:0051246 289 0.060
regulation of molecular function GO:0065009 398 0.058
positive regulation of phosphorus metabolic process GO:0010562 262 0.057
regulation of hormone levels GO:0010817 187 0.056
regulation of multicellular organismal development GO:2000026 376 0.055
cellular component morphogenesis GO:0032989 155 0.053
regulation of camp metabolic process GO:0030814 43 0.053
positive regulation of cell proliferation GO:0008284 249 0.053
monovalent inorganic cation transport GO:0015672 172 0.052
Rat
organophosphate metabolic process GO:0019637 370 0.051
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.051
neuron differentiation GO:0030182 368 0.051
reproductive process GO:0022414 372 0.051
regulation of phosphorylation GO:0042325 248 0.050
anatomical structure morphogenesis GO:0009653 298 0.050
negative regulation of gene expression GO:0010629 199 0.048
sodium ion transport GO:0006814 82 0.048
nucleoside phosphate metabolic process GO:0006753 283 0.048
regulation of membrane potential GO:0042391 110 0.048
positive regulation of nervous system development GO:0051962 178 0.046
positive regulation of neurogenesis GO:0050769 165 0.045
cation transport GO:0006812 382 0.044
Rat
positive regulation of rna metabolic process GO:0051254 203 0.044
regulation of nervous system development GO:0051960 264 0.043
protein complex biogenesis GO:0070271 263 0.043
negative regulation of nucleic acid templated transcription GO:1903507 117 0.043
nucleic acid templated transcription GO:0097659 379 0.043
rna biosynthetic process GO:0032774 380 0.043
nucleobase containing small molecule metabolic process GO:0055086 316 0.042
regulation of secretion by cell GO:1903530 208 0.042
positive regulation of response to stimulus GO:0048584 285 0.042
regulation of signal transduction GO:0009966 318 0.041
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.040
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.040
negative regulation of cellular metabolic process GO:0031324 281 0.038
positive regulation of biosynthetic process GO:0009891 319 0.038
negative regulation of rna metabolic process GO:0051253 123 0.038
transcription dna templated GO:0006351 377 0.038
cellular metal ion homeostasis GO:0006875 172 0.038
Rat
neuron development GO:0048666 286 0.038
synaptic transmission GO:0007268 235 0.037
rna metabolic process GO:0016070 406 0.037
neuron projection development GO:0031175 273 0.037
protein localization GO:0008104 191 0.037
regulation of protein phosphorylation GO:0001932 183 0.037
regulation of apoptotic process GO:0042981 335 0.037
transmembrane transport GO:0055085 412 0.037
Rat
positive regulation of cell development GO:0010720 176 0.036
macromolecular complex subunit organization GO:0043933 339 0.036
cellular ketone metabolic process GO:0042180 51 0.036
intracellular signal transduction GO:0035556 314 0.036
single organism organelle organization GO:1902589 180 0.035
positive regulation of rna biosynthetic process GO:1902680 197 0.034
positive regulation of phosphorylation GO:0042327 177 0.034
positive regulation of nucleic acid templated transcription GO:1903508 197 0.034
regulation of cell morphogenesis GO:0022604 77 0.034
signal transduction by phosphorylation GO:0023014 144 0.034
forebrain development GO:0030900 98 0.034
cell morphogenesis involved in differentiation GO:0000904 119 0.033
protein complex subunit organization GO:0071822 302 0.033
positive regulation of protein modification process GO:0031401 142 0.033
carbohydrate derivative metabolic process GO:1901135 346 0.033
response to hypoxia GO:0001666 231 0.033
Rat
positive regulation of cellular component organization GO:0051130 200 0.033
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.033
multi multicellular organism process GO:0044706 138 0.032
purine ribonucleotide metabolic process GO:0009150 227 0.032
cell cell signaling GO:0007267 335 0.032
organelle organization GO:0006996 266 0.031
regulation of rna biosynthetic process GO:2001141 381 0.031
regulation of cell growth GO:0001558 85 0.031
programmed cell death GO:0012501 392 0.030
macromolecule localization GO:0033036 252 0.030
epithelium development GO:0060429 96 0.030
response to nutrient levels GO:0031667 370 0.030
positive regulation of transcription dna templated GO:0045893 197 0.030
cellular divalent inorganic cation homeostasis GO:0072503 162 0.030
Rat
regulation of catalytic activity GO:0050790 304 0.030
negative regulation of cellular biosynthetic process GO:0031327 161 0.029
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.029
reproduction GO:0000003 245 0.029
protein complex assembly GO:0006461 263 0.029
positive regulation of signal transduction GO:0009967 175 0.029
purine nucleotide metabolic process GO:0006163 229 0.029
anatomical structure formation involved in morphogenesis GO:0048646 83 0.029
cellular protein complex assembly GO:0043623 44 0.029
response to inorganic substance GO:0010035 377 0.029
Rat
cellular amine metabolic process GO:0044106 38 0.028
developmental process involved in reproduction GO:0003006 159 0.028
regulation of protein modification process GO:0031399 194 0.027
ribose phosphate biosynthetic process GO:0046390 87 0.027
regulation of protein kinase activity GO:0045859 105 0.027
negative regulation of metabolic process GO:0009892 331 0.027
ribose phosphate metabolic process GO:0019693 235 0.027
catabolic process GO:0009056 351 0.027
purine containing compound metabolic process GO:0072521 253 0.027
multicellular organism reproduction GO:0032504 233 0.026
regulation of camp biosynthetic process GO:0030817 38 0.026
calcium ion homeostasis GO:0055074 162 0.026
Rat
regulation of neuron differentiation GO:0045664 208 0.026
positive regulation of protein phosphorylation GO:0001934 135 0.026
regulation of cellular amino acid metabolic process GO:0006521 2 0.025
cellular amino acid metabolic process GO:0006520 107 0.025
negative regulation of transcription dna templated GO:0045892 116 0.025
positive regulation of cell projection organization GO:0031346 111 0.025
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.025
anterior posterior pattern specification GO:0009952 1 0.025
intracellular transport GO:0046907 185 0.025
nucleotide biosynthetic process GO:0009165 98 0.025
cytosolic calcium ion homeostasis GO:0051480 140 0.024
Rat
negative regulation of secretion by cell GO:1903531 72 0.024
regulation of nucleotide metabolic process GO:0006140 117 0.024
camera type eye development GO:0043010 48 0.024
response to wounding GO:0009611 254 0.024
secretion GO:0046903 307 0.024
amine metabolic process GO:0009308 38 0.024
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.024
multi organism reproductive process GO:0044703 262 0.024
nucleotide metabolic process GO:0009117 279 0.024
oxoacid metabolic process GO:0043436 290 0.024
macromolecular complex assembly GO:0065003 273 0.023
cellular macromolecule localization GO:0070727 122 0.023
purine ribonucleotide biosynthetic process GO:0009152 81 0.023
multicellular organismal reproductive process GO:0048609 233 0.023
negative regulation of neurogenesis GO:0050768 78 0.023
carboxylic acid metabolic process GO:0019752 289 0.023
regulation of cell projection organization GO:0031344 175 0.023
growth GO:0040007 165 0.023
regulation of intracellular signal transduction GO:1902531 218 0.022
regulation of neuron projection development GO:0010975 161 0.022
response to peptide GO:1901652 292 0.022
negative regulation of rna biosynthetic process GO:1902679 118 0.022
regulation of cellular amine metabolic process GO:0033238 8 0.022
response to growth factor GO:0070848 189 0.022
cyclic nucleotide biosynthetic process GO:0009190 63 0.022
establishment of protein localization GO:0045184 141 0.022
negative regulation of vesicle fusion GO:0031339 2 0.021
axon development GO:0061564 96 0.021
negative regulation of biosynthetic process GO:0009890 168 0.021
ribonucleotide biosynthetic process GO:0009260 85 0.021
regulation of transferase activity GO:0051338 123 0.021
ion transmembrane transport GO:0034220 365 0.021
Rat
cell part morphogenesis GO:0032990 123 0.021
regulation of programmed cell death GO:0043067 341 0.021
apoptotic process GO:0006915 381 0.021
cellular protein localization GO:0034613 122 0.021
regulation of cellular protein metabolic process GO:0032268 267 0.020
regulation of mapk cascade GO:0043408 116 0.020
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.020
cardiovascular system development GO:0072358 134 0.020
ion homeostasis GO:0050801 212 0.020
Rat
positive regulation of neuron projection development GO:0010976 99 0.020
negative regulation of protein metabolic process GO:0051248 114 0.020
sex differentiation GO:0007548 113 0.020
neuromuscular process GO:0050905 2 0.020
positive regulation of cell death GO:0010942 184 0.020
regulation of cellular ketone metabolic process GO:0010565 27 0.020
positive regulation of cellular amine metabolic process GO:0033240 3 0.020
cellular response to stress GO:0033554 269 0.020
Rat
positive regulation of protein kinase activity GO:0045860 73 0.019
negative regulation of secretion GO:0051048 82 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.019
regulation of purine nucleotide biosynthetic process GO:1900371 46 0.019
inorganic ion transmembrane transport GO:0098660 229 0.019
Rat
nucleoside phosphate biosynthetic process GO:1901293 102 0.019
organic hydroxy compound metabolic process GO:1901615 115 0.019
purine containing compound biosynthetic process GO:0072522 85 0.019
organic substance catabolic process GO:1901575 316 0.019
telencephalon development GO:0021537 62 0.018
neurotransmitter transport GO:0006836 42 0.018
tube development GO:0035295 89 0.018
blood circulation GO:0008015 183 0.018
negative regulation of cellular protein metabolic process GO:0032269 106 0.018
response to oxygen levels GO:0070482 265 0.018
Rat
retinal ganglion cell axon guidance GO:0031290 1 0.018
organic acid metabolic process GO:0006082 292 0.018
negative regulation of programmed cell death GO:0043069 183 0.017
axis specification GO:0009798 4 0.017
eye morphogenesis GO:0048592 4 0.017
positive regulation of kinase activity GO:0033674 77 0.017
regulation of cellular localization GO:0060341 263 0.017
cyclic nucleotide metabolic process GO:0009187 80 0.017
hormone transport GO:0009914 121 0.017
negative regulation of multicellular organismal process GO:0051241 203 0.017
regulation of dendrite development GO:0050773 59 0.017
embryonic pattern specification GO:0009880 1 0.017
gliogenesis GO:0042063 93 0.017
phosphatidylinositol dephosphorylation GO:0046856 4 0.017
cellular response to growth factor stimulus GO:0071363 162 0.017
axon extension involved in axon guidance GO:0048846 6 0.017
response to ketone GO:1901654 182 0.016
single organism cellular localization GO:1902580 102 0.016
cellular catabolic process GO:0044248 295 0.016
urogenital system development GO:0001655 78 0.016
positive regulation of epithelial cell proliferation GO:0050679 32 0.016
negative regulation of cell development GO:0010721 82 0.016
cellular component movement GO:0006928 248 0.016
embryo development GO:0009790 49 0.016
sensory organ development GO:0007423 74 0.016
Rat
carbohydrate derivative biosynthetic process GO:1901137 124 0.016
response to estrogen GO:0043627 232 0.016
protein heterooligomerization GO:0051291 89 0.016
ossification GO:0001503 70 0.016
circulatory system development GO:0072359 134 0.016
reproductive system development GO:0061458 128 0.016
regulation of hormone secretion GO:0046883 106 0.016
neuron projection morphogenesis GO:0048812 122 0.016
response to decreased oxygen levels GO:0036293 237 0.016
Rat
behavior GO:0007610 205 0.016
regulation of cell differentiation GO:0045595 320 0.016
reproductive structure development GO:0048608 128 0.016
membrane organization GO:0061024 94 0.016
mechanoreceptor differentiation GO:0042490 2 0.016
positive regulation of transferase activity GO:0051347 81 0.016
negative regulation of molecular function GO:0044092 133 0.015
action potential GO:0001508 54 0.015
positive regulation of catalytic activity GO:0043085 184 0.015
negative regulation of cell death GO:0060548 229 0.015
signal release GO:0023061 145 0.015
establishment of planar polarity GO:0001736 1 0.015
regulation of cardiac muscle tissue development GO:0055024 12 0.015
single organism catabolic process GO:0044712 283 0.015
regulation of kinase activity GO:0043549 117 0.015
grooming behavior GO:0007625 4 0.015
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.015
response to glucocorticoid GO:0051384 223 0.015
cation homeostasis GO:0055080 195 0.015
Rat
phasic smooth muscle contraction GO:0014821 3 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
regulation of cellular component biogenesis GO:0044087 86 0.014
secretion by cell GO:0032940 248 0.014
positive regulation of cellular protein metabolic process GO:0032270 167 0.014
eye development GO:0001654 50 0.014
saliva secretion GO:0046541 3 0.014
protein oligomerization GO:0051259 191 0.014
ras protein signal transduction GO:0007265 29 0.014
regulation of ossification GO:0030278 32 0.014
response to insulin GO:0032868 133 0.014
regulation of growth GO:0040008 105 0.014
cellular response to oxygen containing compound GO:1901701 386 0.013
negative regulation of developmental process GO:0051093 125 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.013
carbohydrate derivative catabolic process GO:1901136 147 0.013
synaptic vesicle exocytosis GO:0016079 15 0.013
dephosphorylation GO:0016311 98 0.013
regulation of peptide secretion GO:0002791 82 0.013
peptide hormone secretion GO:0030072 84 0.013
positive regulation of neuron differentiation GO:0045666 126 0.013
regulation of dendrite morphogenesis GO:0048814 33 0.013
adult locomotory behavior GO:0008344 4 0.013
limbic system development GO:0021761 38 0.013
neurotransmitter secretion GO:0007269 33 0.013
mammary gland epithelium development GO:0061180 1 0.013
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.013
single organism membrane organization GO:0044802 74 0.013
dendrite development GO:0016358 72 0.013
negative regulation of response to stimulus GO:0048585 155 0.013
embryonic axis specification GO:0000578 1 0.013
positive regulation of nucleotide biosynthetic process GO:0030810 36 0.012
response to toxic substance GO:0009636 133 0.012
negative regulation of cell proliferation GO:0008285 119 0.012
bmp signaling pathway GO:0030509 4 0.012
cell projection morphogenesis GO:0048858 123 0.012
regulation of peptide transport GO:0090087 87 0.012
cellular chemical homeostasis GO:0055082 247 0.012
Rat
male sex differentiation GO:0046661 64 0.012
macromolecule catabolic process GO:0009057 58 0.012
regulation of response to stress GO:0080134 126 0.012
lung development GO:0030324 43 0.012
cell growth GO:0016049 104 0.012
divalent inorganic cation homeostasis GO:0072507 165 0.012
Rat
aging GO:0007568 241 0.012
positive regulation of response to food GO:0032097 3 0.012
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 34 0.012
positive regulation of molecular function GO:0044093 230 0.012
sodium ion transmembrane transport GO:0035725 67 0.012
motor neuron axon guidance GO:0008045 1 0.012
regulation of peptide hormone secretion GO:0090276 80 0.012
cellular response to hormone stimulus GO:0032870 247 0.012
positive regulation of mapk cascade GO:0043410 92 0.011
negative regulation of cell communication GO:0010648 158 0.011
transmission of nerve impulse GO:0019226 42 0.011
positive regulation of organelle organization GO:0010638 48 0.011
developmental induction GO:0031128 2 0.011
endoplasmic reticulum organization GO:0007029 1 0.011
small gtpase mediated signal transduction GO:0007264 36 0.011
cellular homeostasis GO:0019725 252 0.011
Rat
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.011
camp metabolic process GO:0046058 63 0.011
positive regulation of nucleotide metabolic process GO:0045981 91 0.011
negative regulation of neuron differentiation GO:0045665 62 0.011
gonad development GO:0008406 104 0.011
response to ethanol GO:0045471 162 0.011
positive regulation of ossification GO:0045778 17 0.011
cell cycle GO:0007049 101 0.011
response to corticosteroid GO:0031960 235 0.011
regulation of anatomical structure size GO:0090066 135 0.011
regulation of developmental growth GO:0048638 45 0.011
nucleoside metabolic process GO:0009116 179 0.011
regulation of neurotransmitter levels GO:0001505 42 0.011
developmental growth GO:0048589 100 0.011
retina morphogenesis in camera type eye GO:0060042 1 0.010
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.010
single organism intracellular transport GO:1902582 166 0.010
wound healing GO:0042060 122 0.010
regulation of organelle organization GO:0033043 80 0.010
purine nucleotide biosynthetic process GO:0006164 83 0.010
molting cycle GO:0042303 3 0.010
positive regulation of intracellular signal transduction GO:1902533 138 0.010
synaptic growth at neuromuscular junction GO:0051124 1 0.010
negative regulation of nervous system development GO:0051961 79 0.010
glycosyl compound metabolic process GO:1901657 182 0.010
epithelial cell differentiation GO:0030855 71 0.010
regulation of axonogenesis GO:0050770 37 0.010
endoplasmic reticulum membrane organization GO:0090158 1 0.010
positive regulation of protein serine threonine kinase activity GO:0071902 52 0.010

Kcnk12 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.016
nervous system disease DOID:863 0 0.016