Rattus norvegicus

0 known processes

Tob1

transducer of ErbB-2.1

Tob1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
carboxylic acid metabolic process GO:0019752 289 0.097
catabolic process GO:0009056 351 0.080
cation transport GO:0006812 382 0.077
negative regulation of cell death GO:0060548 229 0.075
intracellular signal transduction GO:0035556 314 0.071
lipid metabolic process GO:0006629 283 0.065
regulation of apoptotic process GO:0042981 335 0.057
positive regulation of molecular function GO:0044093 230 0.056
regulation of molecular function GO:0065009 398 0.056
organophosphate metabolic process GO:0019637 370 0.056
nucleic acid templated transcription GO:0097659 379 0.052
cellular ketone metabolic process GO:0042180 51 0.050
anion transmembrane transport GO:0098656 77 0.049
oxoacid metabolic process GO:0043436 290 0.047
regulation of programmed cell death GO:0043067 341 0.047
carbohydrate derivative metabolic process GO:1901135 346 0.047
entrainment of circadian clock GO:0009649 3 0.044
regulation of multicellular organismal development GO:2000026 376 0.043
cellular catabolic process GO:0044248 295 0.042
ion transmembrane transport GO:0034220 365 0.040
cell projection organization GO:0030030 302 0.040
regulation of cell differentiation GO:0045595 320 0.040
regulation of signal transduction GO:0009966 318 0.039
response to inorganic substance GO:0010035 377 0.039
regulation of phosphorylation GO:0042325 248 0.039
regulation of intracellular signal transduction GO:1902531 218 0.038
programmed cell death GO:0012501 392 0.037
regulation of nucleic acid templated transcription GO:1903506 380 0.037
protein phosphorylation GO:0006468 345 0.036
rna metabolic process GO:0016070 406 0.035
cellular amino acid metabolic process GO:0006520 107 0.035
regulation of transferase activity GO:0051338 123 0.034
organic acid metabolic process GO:0006082 292 0.034
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.033
regulation of catalytic activity GO:0050790 304 0.032
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.032
regulation of rna biosynthetic process GO:2001141 381 0.031
transcription dna templated GO:0006351 377 0.030
regulation of phosphate metabolic process GO:0019220 349 0.029
positive regulation of transcription dna templated GO:0045893 197 0.029
transmembrane transport GO:0055085 412 0.029
single organism catabolic process GO:0044712 283 0.029
positive regulation of multicellular organismal process GO:0051240 387 0.029
negative regulation of apoptotic process GO:0043066 181 0.028
dna integrity checkpoint GO:0031570 2 0.028
amino acid transport GO:0006865 70 0.028
regulation of system process GO:0044057 208 0.028
single organism biosynthetic process GO:0044711 342 0.028
apoptotic process GO:0006915 381 0.027
mapk cascade GO:0000165 140 0.027
cellular response to endogenous stimulus GO:0071495 377 0.027
negative regulation of programmed cell death GO:0043069 183 0.027
cellular lipid metabolic process GO:0044255 208 0.027
negative regulation of cell cycle phase transition GO:1901988 4 0.027
positive regulation of nucleic acid templated transcription GO:1903508 197 0.026
regulation of protein metabolic process GO:0051246 289 0.026
negative regulation of macromolecule metabolic process GO:0010605 260 0.026
regulation of phosphorus metabolic process GO:0051174 349 0.025
cell cycle checkpoint GO:0000075 2 0.025
cell cell signaling GO:0007267 335 0.025
nucleoside metabolic process GO:0009116 179 0.024
glycosyl compound metabolic process GO:1901657 182 0.024
regulation of neurogenesis GO:0050767 247 0.024
neuron development GO:0048666 286 0.024
circadian rhythm GO:0007623 88 0.024
cellular response to stress GO:0033554 269 0.024
rhythmic process GO:0048511 156 0.024
organic substance catabolic process GO:1901575 316 0.024
negative regulation of cell communication GO:0010648 158 0.024
nucleotide metabolic process GO:0009117 279 0.024
transcription from rna polymerase ii promoter GO:0006366 252 0.023
negative regulation of developmental process GO:0051093 125 0.023
regulation of cellular localization GO:0060341 263 0.023
anion transport GO:0006820 178 0.023
regulation of protein phosphorylation GO:0001932 183 0.023
regulation of rna metabolic process GO:0051252 391 0.022
gastrulation GO:0007369 2 0.022
cellular amine metabolic process GO:0044106 38 0.022
positive regulation of gene expression GO:0010628 244 0.022
regulation of cell development GO:0060284 263 0.022
central nervous system development GO:0007417 311 0.022
regulation of transcription dna templated GO:0006355 374 0.022
regulation of dna metabolic process GO:0051052 60 0.022
carboxylic acid transport GO:0046942 115 0.022
rna biosynthetic process GO:0032774 380 0.022
tissue development GO:0009888 252 0.022
regulation of cellular ketone metabolic process GO:0010565 27 0.021
positive regulation of cellular component organization GO:0051130 200 0.021
neuron projection development GO:0031175 273 0.021
negative regulation of response to stimulus GO:0048585 155 0.021
regulation of protein modification process GO:0031399 194 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.021
dephosphorylation GO:0016311 98 0.021
response to acid chemical GO:0001101 222 0.021
negative regulation of metabolic process GO:0009892 331 0.021
regulation of cell projection organization GO:0031344 175 0.021
regulation of nervous system development GO:0051960 264 0.021
protein localization GO:0008104 191 0.021
negative regulation of biosynthetic process GO:0009890 168 0.021
positive regulation of cell proliferation GO:0008284 249 0.021
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.020
ion homeostasis GO:0050801 212 0.020
neuron differentiation GO:0030182 368 0.020
signal transduction by phosphorylation GO:0023014 144 0.020
positive regulation of rna metabolic process GO:0051254 203 0.020
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.020
amine metabolic process GO:0009308 38 0.020
nucleobase containing small molecule metabolic process GO:0055086 316 0.020
positive regulation of catalytic activity GO:0043085 184 0.020
negative regulation of gene expression GO:0010629 199 0.020
homeostatic process GO:0042592 331 0.019
cell cycle GO:0007049 101 0.019
positive regulation of transport GO:0051050 245 0.019
blood circulation GO:0008015 183 0.019
negative regulation of cellular metabolic process GO:0031324 281 0.019
regulation of cellular amino acid metabolic process GO:0006521 2 0.019
chemical homeostasis GO:0048878 292 0.019
positive regulation of biosynthetic process GO:0009891 319 0.019
mitotic cell cycle phase transition GO:0044772 20 0.019
regulation of kinase activity GO:0043549 117 0.019
negative regulation of multicellular organismal process GO:0051241 203 0.018
nucleoside phosphate metabolic process GO:0006753 283 0.018
response to growth factor GO:0070848 189 0.018
establishment of protein localization GO:0045184 141 0.018
purine ribonucleoside metabolic process GO:0046128 168 0.018
response to peptide GO:1901652 292 0.018
secretion GO:0046903 307 0.018
response to nutrient levels GO:0031667 370 0.017
circulatory system development GO:0072359 134 0.017
regulation of cellular amine metabolic process GO:0033238 8 0.017
regulation of catabolic process GO:0009894 113 0.017
anatomical structure morphogenesis GO:0009653 298 0.017
single organism carbohydrate metabolic process GO:0044723 118 0.017
positive regulation of cellular biosynthetic process GO:0031328 295 0.017
ribose phosphate metabolic process GO:0019693 235 0.017
positive regulation of cell differentiation GO:0045597 217 0.017
regulation of homeostatic process GO:0032844 101 0.017
protein complex subunit organization GO:0071822 302 0.017
response to hypoxia GO:0001666 231 0.017
muscle system process GO:0003012 115 0.016
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.016
brain development GO:0007420 247 0.016
mitotic cell cycle checkpoint GO:0007093 1 0.016
inorganic ion transmembrane transport GO:0098660 229 0.016
regulation of cellular catabolic process GO:0031329 101 0.016
purine containing compound metabolic process GO:0072521 253 0.016
response to extracellular stimulus GO:0009991 380 0.016
response to radiation GO:0009314 137 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.016
growth GO:0040007 165 0.016
negative regulation of signaling GO:0023057 157 0.016
negative regulation of cellular biosynthetic process GO:0031327 161 0.016
er associated ubiquitin dependent protein catabolic process GO:0030433 1 0.016
action potential GO:0001508 54 0.016
protein complex assembly GO:0006461 263 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.016
cardiovascular system development GO:0072358 134 0.016
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
cellular component biogenesis GO:0044085 368 0.015
cellular response to oxygen containing compound GO:1901701 386 0.015
purine ribonucleoside catabolic process GO:0046130 124 0.015
positive regulation of protein modification process GO:0031401 142 0.015
protein complex biogenesis GO:0070271 263 0.015
ribonucleoside metabolic process GO:0009119 174 0.015
dna metabolic process GO:0006259 96 0.015
carbohydrate metabolic process GO:0005975 130 0.015
cellular macromolecule localization GO:0070727 122 0.015
embryonic pattern specification GO:0009880 1 0.015
regulation of cell proliferation GO:0042127 359 0.015
serine transport GO:0032329 4 0.015
proteolysis GO:0006508 175 0.015
ribonucleoside triphosphate metabolic process GO:0009199 141 0.015
multicellular organismal signaling GO:0035637 44 0.015
heart morphogenesis GO:0003007 3 0.015
nucleoside phosphate catabolic process GO:1901292 140 0.015
negative regulation of cell differentiation GO:0045596 99 0.015
regulation of secretion by cell GO:1903530 208 0.015
cellular nitrogen compound catabolic process GO:0044270 163 0.015
response to ketone GO:1901654 182 0.015
axis specification GO:0009798 4 0.015
organic cyclic compound catabolic process GO:1901361 175 0.015
nitrogen compound transport GO:0071705 229 0.015
negative regulation of rna biosynthetic process GO:1902679 118 0.015
g protein coupled receptor signaling pathway GO:0007186 242 0.015
positive regulation of cell death GO:0010942 184 0.014
cellular glucan metabolic process GO:0006073 23 0.014
cell part morphogenesis GO:0032990 123 0.014
single organism intracellular transport GO:1902582 166 0.014
phospholipid metabolic process GO:0006644 61 0.014
organic acid transport GO:0015849 116 0.014
regulation of cell cycle GO:0051726 73 0.014
cellular response to growth factor stimulus GO:0071363 162 0.014
multi organism reproductive process GO:0044703 262 0.014
purine ribonucleotide metabolic process GO:0009150 227 0.014
head development GO:0060322 247 0.014
organic anion transport GO:0015711 132 0.014
purine nucleoside metabolic process GO:0042278 169 0.014
response to metal ion GO:0010038 253 0.014
negative regulation of phosphorus metabolic process GO:0010563 80 0.014
reproductive process GO:0022414 372 0.014
cellular response to hormone stimulus GO:0032870 247 0.014
small gtpase mediated signal transduction GO:0007264 36 0.014
anterior posterior pattern specification GO:0009952 1 0.014
positive regulation of developmental process GO:0051094 283 0.014
positive regulation of apoptotic process GO:0043065 154 0.014
regulation of protein kinase activity GO:0045859 105 0.014
positive regulation of phosphorus metabolic process GO:0010562 262 0.014
metal ion transport GO:0030001 289 0.014
macromolecule catabolic process GO:0009057 58 0.014
response to camp GO:0051591 91 0.014
glycosyl compound catabolic process GO:1901658 126 0.014
cellular response to organonitrogen compound GO:0071417 197 0.014
negative regulation of rna metabolic process GO:0051253 123 0.014
organonitrogen compound catabolic process GO:1901565 179 0.014
regulation of secretion GO:0051046 224 0.014
positive regulation of rna biosynthetic process GO:1902680 197 0.013
heterocycle catabolic process GO:0046700 167 0.013
response to nutrient GO:0007584 248 0.013
somatic stem cell maintenance GO:0035019 2 0.013
macromolecule localization GO:0033036 252 0.013
multicellular organism reproduction GO:0032504 233 0.013
cation homeostasis GO:0055080 195 0.013
cellular component assembly GO:0022607 360 0.013
aromatic compound catabolic process GO:0019439 168 0.013
positive regulation of transferase activity GO:0051347 81 0.013
cellular response to fluid shear stress GO:0071498 4 0.013
regulation of mapk cascade GO:0043408 116 0.013
response to insulin GO:0032868 133 0.013
cellular macromolecule catabolic process GO:0044265 29 0.013
positive regulation of cell development GO:0010720 176 0.013
immune system process GO:0002376 204 0.013
positive regulation of cellular protein metabolic process GO:0032270 167 0.013
monosaccharide metabolic process GO:0005996 61 0.013
positive regulation of protein metabolic process GO:0051247 178 0.013
negative regulation of transcription dna templated GO:0045892 116 0.013
positive regulation of nervous system development GO:0051962 178 0.013
regulation of cellular protein metabolic process GO:0032268 267 0.013
negative regulation of stress activated protein kinase signaling cascade GO:0070303 4 0.013
ribonucleotide metabolic process GO:0009259 231 0.013
positive regulation of phosphate metabolic process GO:0045937 262 0.013
intracellular transport GO:0046907 185 0.012
neurological system process GO:0050877 219 0.012
developmental process involved in reproduction GO:0003006 159 0.012
cellular divalent inorganic cation homeostasis GO:0072503 162 0.012
single organism cellular localization GO:1902580 102 0.012
regulation of cellular component organization GO:0051128 368 0.012
localization of cell GO:0051674 202 0.012
positive regulation of phosphorylation GO:0042327 177 0.012
organelle organization GO:0006996 266 0.012
mitotic dna damage checkpoint GO:0044773 1 0.012
response to organophosphorus GO:0046683 102 0.012
cellular chemical homeostasis GO:0055082 247 0.012
cellular protein localization GO:0034613 122 0.012
positive regulation of neuron differentiation GO:0045666 126 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.012
coenzyme metabolic process GO:0006732 86 0.012
positive regulation of protein phosphorylation GO:0001934 135 0.012
nucleoside triphosphate metabolic process GO:0009141 144 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
response to estradiol GO:0032355 164 0.012
regulation of proteasomal protein catabolic process GO:0061136 4 0.012
ras protein signal transduction GO:0007265 29 0.012
multicellular organismal reproductive process GO:0048609 233 0.011
myelination GO:0042552 39 0.011
positive regulation of neurogenesis GO:0050769 165 0.011
response to estrogen GO:0043627 232 0.011
oligopeptide transport GO:0006857 4 0.011
cation transmembrane transport GO:0098655 263 0.011
macromolecular complex subunit organization GO:0043933 339 0.011
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.011
response to transition metal nanoparticle GO:1990267 122 0.011
purine nucleotide metabolic process GO:0006163 229 0.011
nucleobase containing compound catabolic process GO:0034655 152 0.011
cellular cation homeostasis GO:0030003 180 0.011
glycogen biosynthetic process GO:0005978 15 0.011
reproduction GO:0000003 245 0.011
cytoplasmic transport GO:0016482 115 0.011
synaptic transmission GO:0007268 235 0.011
regulation of neuron differentiation GO:0045664 208 0.011
amide transport GO:0042886 105 0.011
response to ethanol GO:0045471 162 0.010
salivary gland development GO:0007431 3 0.010
cellular ion homeostasis GO:0006873 184 0.010
positive regulation of cell projection organization GO:0031346 111 0.010
single organism organelle organization GO:1902589 180 0.010
cell adhesion GO:0007155 110 0.010
glucose metabolic process GO:0006006 52 0.010
response to other organism GO:0051707 220 0.010
response to oxygen levels GO:0070482 265 0.010
organophosphate biosynthetic process GO:0090407 143 0.010
defense response to gram negative bacterium GO:0050829 3 0.010
response to decreased oxygen levels GO:0036293 237 0.010
negative regulation of cell development GO:0010721 82 0.010
glycerolipid metabolic process GO:0046486 67 0.010
negative regulation of catalytic activity GO:0043086 103 0.010
positive regulation of secretion GO:0051047 140 0.010
carbohydrate derivative catabolic process GO:1901136 147 0.010
circadian regulation of gene expression GO:0032922 3 0.010
oxidation reduction process GO:0055114 304 0.010

Tob1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.038
nervous system disease DOID:863 0 0.038
disease of metabolism DOID:0014667 0 0.023
inherited metabolic disorder DOID:655 0 0.023
amino acid metabolic disorder DOID:9252 0 0.021
organic acidemia DOID:0060159 0 0.021
sensory system disease DOID:0050155 0 0.020
eye and adnexa disease DOID:1492 0 0.011
eye disease DOID:5614 0 0.011