Rattus norvegicus

33 known processes

Pdha2

pyruvate dehydrogenase (lipoamide) alpha 2

(Aliases: Pdhal)

Pdha2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
single organism reproductive process GO:0044702 297 0.205
response to nutrient levels GO:0031667 370 0.194
response to extracellular stimulus GO:0009991 380 0.194
cellular response to endogenous stimulus GO:0071495 377 0.187
oxoacid metabolic process GO:0043436 290 0.171
carboxylic acid metabolic process GO:0019752 289 0.153
cellular response to organonitrogen compound GO:0071417 197 0.142
organic acid metabolic process GO:0006082 292 0.135
response to camp GO:0051591 91 0.108
organic substance catabolic process GO:1901575 316 0.104
catabolic process GO:0009056 351 0.098
single organism biosynthetic process GO:0044711 342 0.098
single organism catabolic process GO:0044712 283 0.096
multicellular organism reproduction GO:0032504 233 0.093
regulation of programmed cell death GO:0043067 341 0.093
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.093
regulation of multicellular organismal development GO:2000026 376 0.090
metanephric comma shaped body morphogenesis GO:0072278 2 0.088
cellular response to growth factor stimulus GO:0071363 162 0.085
nucleobase containing small molecule metabolic process GO:0055086 316 0.085
purine containing compound metabolic process GO:0072521 253 0.082
cellular response to stress GO:0033554 269 0.082
programmed cell death GO:0012501 392 0.082
reproductive process GO:0022414 372 0.079
cellular response to nitrogen compound GO:1901699 210 0.078
response to ketone GO:1901654 182 0.072
response to biotic stimulus GO:0009607 226 0.070
positive regulation of apoptotic process GO:0043065 154 0.069
response to organophosphorus GO:0046683 102 0.068
cardiac ventricle development GO:0003231 1 0.066
response to nutrient GO:0007584 248 0.063
organonitrogen compound biosynthetic process GO:1901566 167 0.063
regulation of membrane repolarization GO:0060306 1 0.063
response to external biotic stimulus GO:0043207 221 0.060
nucleoside metabolic process GO:0009116 179 0.059
brain development GO:0007420 247 0.059
transmission of nerve impulse GO:0019226 42 0.059
cellular response to peptide hormone stimulus GO:0071375 120 0.058
cellular response to hormone stimulus GO:0032870 247 0.058
developmental process involved in reproduction GO:0003006 159 0.057
cellular response to insulin stimulus GO:0032869 81 0.057
defense response GO:0006952 194 0.057
cellular response to cytokine stimulus GO:0071345 127 0.056
gonad development GO:0008406 104 0.056
response to glucocorticoid GO:0051384 223 0.055
lipid biosynthetic process GO:0008610 128 0.054
cellular catabolic process GO:0044248 295 0.053
response to other organism GO:0051707 220 0.052
response to chromate GO:0046687 3 0.049
positive regulation of cell proliferation GO:0008284 249 0.049
positive regulation of signaling GO:0023056 270 0.049
reproductive structure development GO:0048608 128 0.048
response to amine GO:0014075 46 0.048
renin angiotensin regulation of aldosterone production GO:0002018 3 0.048
antral ovarian follicle growth GO:0001547 3 0.048
epithelium development GO:0060429 96 0.046
reproductive system development GO:0061458 128 0.045
tissue development GO:0009888 252 0.045
multicellular organismal reproductive process GO:0048609 233 0.045
central nervous system development GO:0007417 311 0.045
chemical homeostasis GO:0048878 292 0.045
response to cytokine GO:0034097 215 0.045
nucleoside phosphate metabolic process GO:0006753 283 0.044
rna metabolic process GO:0016070 406 0.044
cellular response to oxygen containing compound GO:1901701 386 0.042
response to ethanol GO:0045471 162 0.042
response to oxygen levels GO:0070482 265 0.041
neural crest cell migration GO:0001755 1 0.041
g protein coupled receptor signaling pathway GO:0007186 242 0.041
neural crest cell differentiation GO:0014033 2 0.040
negative regulation of macromolecule metabolic process GO:0010605 260 0.040
lipid metabolic process GO:0006629 283 0.040
cellular component biogenesis GO:0044085 368 0.039
secretion GO:0046903 307 0.039
response to peptide hormone GO:0043434 278 0.039
neural crest cell development GO:0014032 2 0.038
cell cell signaling GO:0007267 335 0.038
stress activated protein kinase signaling cascade GO:0031098 37 0.038
protein transport GO:0015031 132 0.038
organophosphate biosynthetic process GO:0090407 143 0.038
rna biosynthetic process GO:0032774 380 0.037
rhythmic process GO:0048511 156 0.037
purine nucleotide metabolic process GO:0006163 229 0.036
response to lipopolysaccharide GO:0032496 191 0.036
heart morphogenesis GO:0003007 3 0.036
membrane repolarization GO:0086009 1 0.035
neurological system process GO:0050877 219 0.035
macromolecular complex assembly GO:0065003 273 0.035
protein localization GO:0008104 191 0.035
negative regulation of metabolic process GO:0009892 331 0.035
cation homeostasis GO:0055080 195 0.034
anatomical structure morphogenesis GO:0009653 298 0.034
artery smooth muscle contraction GO:0014824 4 0.034
developmental growth GO:0048589 100 0.034
cellular response to peptide GO:1901653 133 0.034
regulation of rna metabolic process GO:0051252 391 0.034
head development GO:0060322 247 0.033
growth GO:0040007 165 0.033
response to purine containing compound GO:0014074 126 0.033
organonitrogen compound catabolic process GO:1901565 179 0.033
development of primary sexual characteristics GO:0045137 107 0.033
macromolecular complex subunit organization GO:0043933 339 0.033
organic acid biosynthetic process GO:0016053 83 0.032
cellular amino acid metabolic process GO:0006520 107 0.032
negative regulation of rna metabolic process GO:0051253 123 0.032
cellular divalent inorganic cation homeostasis GO:0072503 162 0.032
regulation of cell proliferation GO:0042127 359 0.032
ion homeostasis GO:0050801 212 0.032
regulation of secretion GO:0051046 224 0.032
protein targeting GO:0006605 61 0.031
protein complex assembly GO:0006461 263 0.031
monocarboxylic acid metabolic process GO:0032787 152 0.031
negative regulation of cellular biosynthetic process GO:0031327 161 0.031
cellular response to organic cyclic compound GO:0071407 202 0.030
regulation of rna biosynthetic process GO:2001141 381 0.030
positive regulation of cell death GO:0010942 184 0.030
regulation of nucleic acid templated transcription GO:1903506 380 0.030
amine metabolic process GO:0009308 38 0.030
regulation of molecular function GO:0065009 398 0.029
cellular response to camp GO:0071320 26 0.029
nucleotide biosynthetic process GO:0009165 98 0.029
aromatic compound catabolic process GO:0019439 168 0.029
intracellular signal transduction GO:0035556 314 0.029
positive regulation of programmed cell death GO:0043068 157 0.029
gamete generation GO:0007276 124 0.029
feeding behavior GO:0007631 53 0.028
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.028
circulatory system development GO:0072359 134 0.028
organophosphate catabolic process GO:0046434 148 0.028
intracellular protein transport GO:0006886 79 0.028
regulation of apoptotic process GO:0042981 335 0.027
purine nucleotide biosynthetic process GO:0006164 83 0.027
establishment of protein localization to organelle GO:0072594 44 0.027
homeostatic process GO:0042592 331 0.027
nucleotide metabolic process GO:0009117 279 0.026
response to decreased oxygen levels GO:0036293 237 0.026
heterocycle catabolic process GO:0046700 167 0.026
positive regulation of developmental process GO:0051094 283 0.026
negative regulation of gene expression GO:0010629 199 0.026
muscle structure development GO:0061061 87 0.025
regulation of catalytic activity GO:0050790 304 0.025
response to activity GO:0014823 73 0.025
carbohydrate derivative catabolic process GO:1901136 147 0.025
monocarboxylic acid biosynthetic process GO:0072330 48 0.025
apoptotic process GO:0006915 381 0.025
multi organism reproductive process GO:0044703 262 0.025
intracellular transport GO:0046907 185 0.025
negative regulation of transcription dna templated GO:0045892 116 0.025
response to estrogen GO:0043627 232 0.024
cardiovascular system development GO:0072358 134 0.024
response to inorganic substance GO:0010035 377 0.024
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.024
immune system process GO:0002376 204 0.024
positive regulation of biosynthetic process GO:0009891 319 0.024
proteolysis GO:0006508 175 0.024
axis specification GO:0009798 4 0.024
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.023
protein complex subunit organization GO:0071822 302 0.023
response to testosterone GO:0033574 55 0.023
response to mineralocorticoid GO:0051385 49 0.023
regulation of phosphate metabolic process GO:0019220 349 0.023
cellular lipid metabolic process GO:0044255 208 0.022
regulation of phosphorus metabolic process GO:0051174 349 0.022
nucleoside phosphate biosynthetic process GO:1901293 102 0.022
inflammatory response GO:0006954 150 0.022
response to amino acid GO:0043200 75 0.022
regulation of transcription dna templated GO:0006355 374 0.022
response to cocaine GO:0042220 39 0.022
negative regulation of rna biosynthetic process GO:1902679 118 0.022
sexual reproduction GO:0019953 148 0.022
response to toxic substance GO:0009636 133 0.021
muscle cell differentiation GO:0042692 52 0.021
protein localization to organelle GO:0033365 57 0.021
cellular amine metabolic process GO:0044106 38 0.021
regulation of system process GO:0044057 208 0.021
female gonad development GO:0008585 53 0.021
cellular hormone metabolic process GO:0034754 49 0.021
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.021
fatty acid metabolic process GO:0006631 99 0.021
response to corticosterone GO:0051412 40 0.021
development of primary female sexual characteristics GO:0046545 56 0.021
organic cyclic compound catabolic process GO:1901361 175 0.021
nuclear transport GO:0051169 49 0.020
hormone metabolic process GO:0042445 69 0.020
metanephric s shaped body morphogenesis GO:0072284 2 0.020
cell growth GO:0016049 104 0.020
regulation of protein metabolic process GO:0051246 289 0.020
small molecule biosynthetic process GO:0044283 124 0.020
negative regulation of cellular metabolic process GO:0031324 281 0.020
response to growth factor GO:0070848 189 0.020
cardiac muscle tissue development GO:0048738 26 0.020
cellular protein localization GO:0034613 122 0.020
circadian rhythm GO:0007623 88 0.020
localization of cell GO:0051674 202 0.020
metanephric part of ureteric bud development GO:0035502 1 0.020
negative regulation of apoptotic process GO:0043066 181 0.020
cardiac muscle cell development GO:0055013 16 0.020
regulation of blood vessel size GO:0050880 89 0.019
purine containing compound catabolic process GO:0072523 138 0.019
response to amphetamine GO:0001975 25 0.019
response to transition metal nanoparticle GO:1990267 122 0.019
cellular response to lipid GO:0071396 201 0.019
peptide biosynthetic process GO:0043043 3 0.019
regeneration GO:0031099 163 0.019
nitrogen compound transport GO:0071705 229 0.019
mitotic sister chromatid separation GO:0051306 1 0.019
response to peptide GO:1901652 292 0.019
ribonucleotide biosynthetic process GO:0009260 85 0.019
reproduction GO:0000003 245 0.019
cellular chemical homeostasis GO:0055082 247 0.019
vascular process in circulatory system GO:0003018 96 0.019
sex differentiation GO:0007548 113 0.019
organ growth GO:0035265 24 0.018
positive regulation of cell differentiation GO:0045597 217 0.018
regulation of catabolic process GO:0009894 113 0.018
regulation of blood volume by renal aldosterone GO:0002017 1 0.018
ribose phosphate metabolic process GO:0019693 235 0.018
protein oligomerization GO:0051259 191 0.018
regulation of ion transport GO:0043269 245 0.018
response to vitamin GO:0033273 131 0.018
epithelial cell proliferation GO:0050673 54 0.018
salivary gland development GO:0007431 3 0.018
oxidation reduction process GO:0055114 304 0.018
response to corticosteroid GO:0031960 235 0.017
cellular metal ion homeostasis GO:0006875 172 0.017
cellular nitrogen compound catabolic process GO:0044270 163 0.017
heart growth GO:0060419 20 0.017
spermatogenesis GO:0007283 99 0.017
negative regulation of molecular function GO:0044092 133 0.017
positive regulation of phosphatidylinositol 3 kinase activity GO:0043552 2 0.017
protein complex biogenesis GO:0070271 263 0.017
secretion by cell GO:0032940 248 0.017
cellular macromolecule localization GO:0070727 122 0.017
ribose phosphate biosynthetic process GO:0046390 87 0.017
comma shaped body morphogenesis GO:0072049 2 0.017
purine ribonucleotide biosynthetic process GO:0009152 81 0.017
negative regulation of programmed cell death GO:0043069 183 0.017
regulation of ion homeostasis GO:2000021 63 0.017
carboxylic acid biosynthetic process GO:0046394 83 0.017
purine ribonucleoside catabolic process GO:0046130 124 0.017
cardiac cell development GO:0055006 16 0.017
carbohydrate derivative metabolic process GO:1901135 346 0.017
response to metal ion GO:0010038 253 0.016
muscle tissue development GO:0060537 58 0.016
striated muscle tissue development GO:0014706 58 0.016
positive regulation of multicellular organismal process GO:0051240 387 0.016
purine containing compound biosynthetic process GO:0072522 85 0.016
organic anion transport GO:0015711 132 0.016
eye development GO:0001654 50 0.016
cellular response to external stimulus GO:0071496 118 0.016
fatty acid biosynthetic process GO:0006633 33 0.016
behavior GO:0007610 205 0.016
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.016
multi multicellular organism process GO:0044706 138 0.016
cognition GO:0050890 92 0.016
negative regulation of protein metabolic process GO:0051248 114 0.016
cellular component assembly GO:0022607 360 0.015
response to herbicide GO:0009635 16 0.015
negative regulation of biosynthetic process GO:0009890 168 0.015
circulatory system process GO:0003013 183 0.015
multicellular organismal signaling GO:0035637 44 0.015
negative regulation of cell communication GO:0010648 158 0.015
purine ribonucleoside metabolic process GO:0046128 168 0.015
response to carbohydrate GO:0009743 183 0.015
response to hypoxia GO:0001666 231 0.015
single organism cell adhesion GO:0098602 46 0.015
establishment of protein localization GO:0045184 141 0.015
response to molecule of bacterial origin GO:0002237 194 0.015
muscle organ development GO:0007517 50 0.015
regulation of cellular ketone metabolic process GO:0010565 27 0.015
regulation of intracellular signal transduction GO:1902531 218 0.015
positive regulation of cell communication GO:0010647 271 0.015
transcription dna templated GO:0006351 377 0.015
epithelial cell differentiation GO:0030855 71 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
synaptic transmission GO:0007268 235 0.014
regulation of cellular catabolic process GO:0031329 101 0.014
cellular response to glucocorticoid stimulus GO:0071385 68 0.014
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.014
response to insulin GO:0032868 133 0.014
neuronal action potential GO:0019228 35 0.014
anterior posterior pattern specification GO:0009952 1 0.014
regulation of serine type peptidase activity GO:1902571 1 0.014
muscle tissue morphogenesis GO:0060415 1 0.014
chylomicron remodeling GO:0034371 1 0.014
liver development GO:0001889 90 0.014
cell differentiation involved in kidney development GO:0061005 4 0.014
regulation of cellular component organization GO:0051128 368 0.014
nephric duct development GO:0072176 1 0.014
cellular sodium ion homeostasis GO:0006883 4 0.014
gastrulation GO:0007369 2 0.014
regulation of nervous system development GO:0051960 264 0.014
cardiac conduction GO:0061337 2 0.014
s shaped body morphogenesis GO:0072050 2 0.014
adrenal gland development GO:0030325 11 0.014
telencephalon development GO:0021537 62 0.014
choline transport GO:0015871 4 0.014
regulation of purine nucleotide metabolic process GO:1900542 115 0.014
cellular response to corticosteroid stimulus GO:0071384 69 0.014
protein import GO:0017038 37 0.014
ribonucleotide catabolic process GO:0009261 136 0.014
drinking behavior GO:0042756 11 0.014
biological adhesion GO:0022610 110 0.014
nuclear import GO:0051170 35 0.014
chromosome segregation GO:0007059 2 0.014
ribonucleotide metabolic process GO:0009259 231 0.013
regulation of kinase activity GO:0043549 117 0.013
response to dexamethasone GO:0071548 49 0.013
positive regulation of catalytic activity GO:0043085 184 0.013
response to follicle stimulating hormone GO:0032354 18 0.013
regulation of epithelial cell proliferation GO:0050678 49 0.013
negative regulation of multicellular organismal process GO:0051241 203 0.013
response to bacterium GO:0009617 200 0.013
single organismal cell cell adhesion GO:0016337 42 0.013
regulation of cellular protein metabolic process GO:0032268 267 0.013
negative regulation of cell cycle phase transition GO:1901988 4 0.013
response to acid chemical GO:0001101 222 0.013
organophosphate metabolic process GO:0019637 370 0.013
purine nucleoside biosynthetic process GO:0042451 21 0.013
positive regulation of cell development GO:0010720 176 0.013
cell adhesion GO:0007155 110 0.013
embryonic pattern specification GO:0009880 1 0.013
mapk cascade GO:0000165 140 0.013
positive regulation of growth GO:0045927 55 0.013
negative regulation of nucleic acid templated transcription GO:1903507 117 0.013
regulation of transferase activity GO:0051338 123 0.013
muscle organ morphogenesis GO:0048644 1 0.013
anion transport GO:0006820 178 0.013
response to gonadotropin GO:0034698 34 0.013
cellular ketone metabolic process GO:0042180 51 0.012
regulation of long term neuronal synaptic plasticity GO:0048169 15 0.012
regulation of cellular amino acid metabolic process GO:0006521 2 0.012
regulation of blood circulation GO:1903522 110 0.012
regulation of homeostatic process GO:0032844 101 0.012
regulation of protein kinase activity GO:0045859 105 0.012
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.012
response to methanol GO:0033986 1 0.012
positive regulation of response to stimulus GO:0048584 285 0.012
positive regulation of molecular function GO:0044093 230 0.012
positive regulation of cell growth GO:0030307 44 0.012
cyclic nucleotide metabolic process GO:0009187 80 0.012
nucleobase containing compound catabolic process GO:0034655 152 0.012
single organism cellular localization GO:1902580 102 0.012
hepaticobiliary system development GO:0061008 90 0.012
cardiac muscle tissue growth GO:0055017 20 0.012
phthalate metabolic process GO:0018963 8 0.012
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.012
negative regulation of cell proliferation GO:0008285 119 0.012
response to fatty acid GO:0070542 65 0.012
chemokine metabolic process GO:0050755 3 0.012
negative regulation of peptidase activity GO:0010466 38 0.012
positive regulation of signal transduction GO:0009967 175 0.012
fertilization GO:0009566 3 0.012
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.012
cell communication involved in cardiac conduction GO:0086065 2 0.011
cellular response to extracellular stimulus GO:0031668 73 0.011
negative regulation of developmental process GO:0051093 125 0.011
regulation of neurogenesis GO:0050767 247 0.011
purine ribonucleotide metabolic process GO:0009150 227 0.011
regulation of map kinase activity GO:0043405 53 0.011
cellular homeostasis GO:0019725 252 0.011
positive regulation of transport GO:0051050 245 0.011
transmembrane transport GO:0055085 412 0.011
organelle organization GO:0006996 266 0.011
cytokine production GO:0001816 61 0.011
positive regulation of transferase activity GO:0051347 81 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
amine transport GO:0015837 57 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.011
positive regulation of reactive oxygen species metabolic process GO:2000379 16 0.011
negative regulation of growth GO:0045926 37 0.011
calcium ion homeostasis GO:0055074 162 0.011
cellular lipid catabolic process GO:0044242 37 0.011
regulation of protein serine threonine kinase activity GO:0071900 64 0.011
immune response GO:0006955 104 0.011
positive regulation of intracellular signal transduction GO:1902533 138 0.011
reactive nitrogen species metabolic process GO:2001057 1 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
cell cycle checkpoint GO:0000075 2 0.011
cardiac chamber development GO:0003205 1 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.011
fractalkine metabolic process GO:0050756 3 0.011
cytoplasmic transport GO:0016482 115 0.011
nucleoside phosphate catabolic process GO:1901292 140 0.011
regulation of secretion by cell GO:1903530 208 0.011
renal system process involved in regulation of systemic arterial blood pressure GO:0003071 14 0.011
adult locomotory behavior GO:0008344 4 0.011
response to fungicide GO:0060992 20 0.011
regulation of proteolysis GO:0030162 66 0.011
tissue remodeling GO:0048771 40 0.010
protein homooligomerization GO:0051260 91 0.010
heart development GO:0007507 72 0.010
response to cadmium ion GO:0046686 35 0.010
regulation of signal transduction GO:0009966 318 0.010
positive regulation of transcription dna templated GO:0045893 197 0.010
lipid localization GO:0010876 62 0.010
cellular component morphogenesis GO:0032989 155 0.010
very low density lipoprotein particle remodeling GO:0034372 1 0.010
ribonucleoside triphosphate metabolic process GO:0009199 141 0.010
ionotropic glutamate receptor signaling pathway GO:0035235 34 0.010
cgmp catabolic process GO:0046069 6 0.010
negative regulation of neuron differentiation GO:0045665 62 0.010
response to zinc ion GO:0010043 39 0.010
nucleocytoplasmic transport GO:0006913 48 0.010
positive regulation of protein serine threonine kinase activity GO:0071902 52 0.010
epithelial cell differentiation involved in kidney development GO:0035850 3 0.010

Pdha2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.024
inherited metabolic disorder DOID:655 0 0.024
congenital adrenal hyperplasia DOID:0050811 0 0.023
lipid metabolism disorder DOID:3146 0 0.023
steroid inherited metabolic disorder DOID:1701 0 0.023
disease of cellular proliferation DOID:14566 0 0.016
disease of anatomical entity DOID:7 0 0.016
urinary system disease DOID:18 0 0.016
nervous system disease DOID:863 0 0.014