Rattus norvegicus

0 known processes

Hhip

Hedgehog-interacting protein

(Aliases: RGD1564108)

Hhip biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to endogenous stimulus GO:0071495 377 0.211
cellular response to oxygen containing compound GO:1901701 386 0.162
cellular response to organonitrogen compound GO:0071417 197 0.154
response to estradiol GO:0032355 164 0.151
regulation of signal transduction GO:0009966 318 0.130
Human
response to nutrient levels GO:0031667 370 0.117
response to inorganic substance GO:0010035 377 0.113
cell projection organization GO:0030030 302 0.103
transmembrane transport GO:0055085 412 0.099
response to glucocorticoid GO:0051384 223 0.097
regulation of cellular component organization GO:0051128 368 0.097
neuron projection development GO:0031175 273 0.095
response to external biotic stimulus GO:0043207 221 0.083
response to extracellular stimulus GO:0009991 380 0.083
cellular response to lipid GO:0071396 201 0.083
epithelium development GO:0060429 96 0.077
regulation of system process GO:0044057 208 0.075
negative regulation of response to stimulus GO:0048585 155 0.074
Human
cellular response to organic cyclic compound GO:0071407 202 0.074
central nervous system development GO:0007417 311 0.070
negative regulation of signaling GO:0023057 157 0.070
Human
positive regulation of apoptotic process GO:0043065 154 0.070
positive regulation of gene expression GO:0010628 244 0.067
lipid metabolic process GO:0006629 283 0.067
hormone transport GO:0009914 121 0.064
chemical homeostasis GO:0048878 292 0.064
neuron death GO:0070997 127 0.063
apoptotic process GO:0006915 381 0.063
positive regulation of transcription dna templated GO:0045893 197 0.062
neuron development GO:0048666 286 0.062
nitrogen compound transport GO:0071705 229 0.062
rna metabolic process GO:0016070 406 0.061
positive regulation of cellular biosynthetic process GO:0031328 295 0.059
response to peptide hormone GO:0043434 278 0.058
head development GO:0060322 247 0.058
cellular response to hormone stimulus GO:0032870 247 0.058
negative regulation of gene expression GO:0010629 199 0.057
response to estrogen GO:0043627 232 0.057
signal release GO:0023061 145 0.056
positive regulation of cell communication GO:0010647 271 0.055
positive regulation of signal transduction GO:0009967 175 0.053
negative regulation of metabolic process GO:0009892 331 0.053
mesoderm development GO:0007498 2 0.053
positive regulation of signaling GO:0023056 270 0.051
cell projection morphogenesis GO:0048858 123 0.051
regulation of hormone secretion GO:0046883 106 0.050
single organism reproductive process GO:0044702 297 0.050
organic anion transport GO:0015711 132 0.049
sensory perception GO:0007600 101 0.048
amide transport GO:0042886 105 0.048
intracellular signal transduction GO:0035556 314 0.048
cation transport GO:0006812 382 0.047
ion transmembrane transport GO:0034220 365 0.047
regulation of neuron projection development GO:0010975 161 0.047
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.045
carboxylic acid transport GO:0046942 115 0.045
response to nutrient GO:0007584 248 0.045
neuron differentiation GO:0030182 368 0.045
nucleic acid templated transcription GO:0097659 379 0.045
positive regulation of nucleic acid templated transcription GO:1903508 197 0.045
response to glucose GO:0009749 136 0.045
negative regulation of macromolecule metabolic process GO:0010605 260 0.044
regulation of nervous system development GO:0051960 264 0.044
cellular component biogenesis GO:0044085 368 0.044
transcription from rna polymerase ii promoter GO:0006366 252 0.044
regulation of neurogenesis GO:0050767 247 0.044
negative regulation of luteinizing hormone secretion GO:0033685 4 0.044
cell part morphogenesis GO:0032990 123 0.043
macromolecular complex assembly GO:0065003 273 0.042
response to hexose GO:0009746 144 0.041
cellular response to alcohol GO:0097306 87 0.041
response to biotic stimulus GO:0009607 226 0.041
circulatory system process GO:0003013 183 0.040
regulation of multicellular organismal development GO:2000026 376 0.039
positive regulation of molecular function GO:0044093 230 0.039
regulation of secretion GO:0051046 224 0.038
protein complex subunit organization GO:0071822 302 0.038
cellular response to nitrogen compound GO:1901699 210 0.038
reproductive process GO:0022414 372 0.038
organic acid transport GO:0015849 116 0.037
brain development GO:0007420 247 0.036
positive regulation of rna biosynthetic process GO:1902680 197 0.036
negative regulation of multicellular organismal process GO:0051241 203 0.036
regulation of peptide secretion GO:0002791 82 0.036
reproduction GO:0000003 245 0.036
salivary gland development GO:0007431 3 0.035
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.035
regulation of intracellular signal transduction GO:1902531 218 0.035
positive regulation of cell proliferation GO:0008284 249 0.035
positive regulation of multicellular organismal process GO:0051240 387 0.035
reproductive system development GO:0061458 128 0.035
response to peptide GO:1901652 292 0.035
muscle system process GO:0003012 115 0.034
cell morphogenesis GO:0000902 142 0.034
macromolecular complex subunit organization GO:0043933 339 0.034
negative regulation of peptide hormone secretion GO:0090278 30 0.033
response to oxygen levels GO:0070482 265 0.033
response to hypoxia GO:0001666 231 0.033
negative regulation of cellular metabolic process GO:0031324 281 0.032
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.032
blood circulation GO:0008015 183 0.032
development of primary sexual characteristics GO:0045137 107 0.032
regulation of cell differentiation GO:0045595 320 0.032
neurological system process GO:0050877 219 0.032
regulation of synaptic transmission GO:0050804 141 0.031
single organism intracellular transport GO:1902582 166 0.031
regulation of peptide transport GO:0090087 87 0.031
regulation of cell projection organization GO:0031344 175 0.031
regulation of apoptotic process GO:0042981 335 0.030
regulation of programmed cell death GO:0043067 341 0.030
peptide secretion GO:0002790 86 0.030
cellular response to stress GO:0033554 269 0.030
negative regulation of programmed cell death GO:0043069 183 0.030
neuron projection morphogenesis GO:0048812 122 0.030
regulation of cellular ketone metabolic process GO:0010565 27 0.029
response to purine containing compound GO:0014074 126 0.029
peptide hormone secretion GO:0030072 84 0.029
cellular component morphogenesis GO:0032989 155 0.029
cellular component movement GO:0006928 248 0.029
organic acid metabolic process GO:0006082 292 0.029
regulation of cell development GO:0060284 263 0.029
positive regulation of rna metabolic process GO:0051254 203 0.028
negative regulation of cell development GO:0010721 82 0.028
positive regulation of neurogenesis GO:0050769 165 0.028
hormone secretion GO:0046879 115 0.028
regulation of cell proliferation GO:0042127 359 0.028
positive regulation of cell differentiation GO:0045597 217 0.028
forebrain development GO:0030900 98 0.028
vesicle mediated transport GO:0016192 181 0.028
cellular response to glucocorticoid stimulus GO:0071385 68 0.027
response to acid chemical GO:0001101 222 0.027
carbohydrate homeostasis GO:0033500 75 0.027
positive regulation of transport GO:0051050 245 0.027
cellular ketone metabolic process GO:0042180 51 0.027
epithelial cell differentiation GO:0030855 71 0.026
negative regulation of cell differentiation GO:0045596 99 0.026
cellular response to peptide hormone stimulus GO:0071375 120 0.026
endocrine hormone secretion GO:0060986 21 0.026
regulation of smooth muscle cell migration GO:0014910 36 0.026
sensory perception of pain GO:0019233 73 0.026
catabolic process GO:0009056 351 0.025
positive regulation of cellular component organization GO:0051130 200 0.025
organelle organization GO:0006996 266 0.025
drug transmembrane transport GO:0006855 13 0.025
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.025
muscle cell proliferation GO:0033002 84 0.025
anion transport GO:0006820 178 0.025
single organism biosynthetic process GO:0044711 342 0.024
regulation of phosphorylation GO:0042325 248 0.024
rna biosynthetic process GO:0032774 380 0.024
protein complex biogenesis GO:0070271 263 0.024
positive regulation of secretion GO:0051047 140 0.024
reproductive structure development GO:0048608 128 0.024
regulation of neuron death GO:1901214 115 0.024
carboxylic acid metabolic process GO:0019752 289 0.024
sex differentiation GO:0007548 113 0.024
regulation of hormone levels GO:0010817 187 0.024
positive regulation of programmed cell death GO:0043068 157 0.024
protein complex assembly GO:0006461 263 0.024
peptide transport GO:0015833 97 0.024
negative regulation of cell death GO:0060548 229 0.024
protein oligomerization GO:0051259 191 0.023
negative regulation of cell communication GO:0010648 158 0.023
Human
tube development GO:0035295 89 0.023
cation transmembrane transport GO:0098655 263 0.023
regulation of cell motility GO:2000145 131 0.023
response to monosaccharide GO:0034284 159 0.023
oxoacid metabolic process GO:0043436 290 0.023
secretion GO:0046903 307 0.023
regulation of ion transport GO:0043269 245 0.023
cerebral cortex tangential migration GO:0021800 1 0.023
cellular component assembly GO:0022607 360 0.023
negative regulation of neurogenesis GO:0050768 78 0.023
transcription dna templated GO:0006351 377 0.023
hormone mediated signaling pathway GO:0009755 23 0.023
cellular chemical homeostasis GO:0055082 247 0.023
cellular response to steroid hormone stimulus GO:0071383 93 0.022
regulation of neuron apoptotic process GO:0043523 83 0.022
inner ear morphogenesis GO:0042472 1 0.022
regulation of cell growth GO:0001558 85 0.022
regulation of feeding behavior GO:0060259 14 0.022
positive regulation of catalytic activity GO:0043085 184 0.022
regulation of neuron differentiation GO:0045664 208 0.022
action potential GO:0001508 54 0.022
cell type specific apoptotic process GO:0097285 134 0.022
female pregnancy GO:0007565 122 0.022
gland development GO:0048732 155 0.022
cellular response to corticosteroid stimulus GO:0071384 69 0.022
positive regulation of ion transport GO:0043270 94 0.022
negative regulation of hormone secretion GO:0046888 46 0.022
positive regulation of serotonin secretion GO:0014064 1 0.021
regulation of smooth muscle cell proliferation GO:0048660 75 0.021
developmental process involved in reproduction GO:0003006 159 0.021
multicellular organism growth GO:0035264 1 0.021
lipid catabolic process GO:0016042 46 0.021
oxidation reduction process GO:0055114 304 0.021
glucose homeostasis GO:0042593 75 0.021
regulation of catalytic activity GO:0050790 304 0.021
inorganic cation transmembrane transport GO:0098662 202 0.020
regulation of insulin secretion GO:0050796 65 0.020
regulation of secretion by cell GO:1903530 208 0.020
regulation of cellular response to stress GO:0080135 49 0.020
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.020
insulin secretion GO:0030073 69 0.020
olfactory bulb interneuron differentiation GO:0021889 1 0.020
defense response GO:0006952 194 0.020
steroid metabolic process GO:0008202 73 0.020
positive regulation of biosynthetic process GO:0009891 319 0.019
l glutamate import GO:0051938 2 0.019
negative regulation of cell proliferation GO:0008285 119 0.019
response to other organism GO:0051707 220 0.019
regulation of reactive oxygen species metabolic process GO:2000377 26 0.019
negative regulation of nervous system development GO:0051961 79 0.019
cell migration GO:0016477 197 0.019
positive regulation of nervous system development GO:0051962 178 0.019
cellular lipid metabolic process GO:0044255 208 0.019
glutathione transport GO:0034635 2 0.019
male sex differentiation GO:0046661 64 0.019
positive regulation of cell projection organization GO:0031346 111 0.019
regulation of molecular function GO:0065009 398 0.019
locomotion GO:0040011 237 0.018
lipid transport GO:0006869 61 0.018
regulation of muscle system process GO:0090257 79 0.018
localization of cell GO:0051674 202 0.018
regulation of rna biosynthetic process GO:2001141 381 0.018
growth GO:0040007 165 0.018
multicellular organismal reproductive process GO:0048609 233 0.018
cellular amino acid metabolic process GO:0006520 107 0.018
monosaccharide metabolic process GO:0005996 61 0.018
positive regulation of neuron death GO:1901216 43 0.018
actin cytoskeleton organization GO:0030036 73 0.018
positive regulation of cellular amine metabolic process GO:0033240 3 0.018
organ morphogenesis GO:0009887 75 0.018
axon development GO:0061564 96 0.018
regulation of rna metabolic process GO:0051252 391 0.018
regulation of cellular amino acid metabolic process GO:0006521 2 0.017
tissue development GO:0009888 252 0.017
regulation of lipid metabolic process GO:0019216 68 0.017
positive regulation of intracellular signal transduction GO:1902533 138 0.017
neuromuscular process GO:0050905 2 0.017
positive regulation of developmental process GO:0051094 283 0.017
response to metal ion GO:0010038 253 0.017
negative regulation of secretion by cell GO:1903531 72 0.017
regulation of cellular amine metabolic process GO:0033238 8 0.017
positive regulation of stress activated mapk cascade GO:0032874 17 0.017
positive regulation of cell migration GO:0030335 96 0.017
transmission of nerve impulse GO:0019226 42 0.017
response to decreased oxygen levels GO:0036293 237 0.017
muscle structure development GO:0061061 87 0.017
anterior posterior pattern specification GO:0009952 1 0.017
regulation of peptide hormone secretion GO:0090276 80 0.017
negative regulation of developmental process GO:0051093 125 0.016
regulation of blood circulation GO:1903522 110 0.016
locomotory exploration behavior GO:0035641 1 0.016
inorganic ion transmembrane transport GO:0098660 229 0.016
regulation of protein modification process GO:0031399 194 0.016
regulation of hydrolase activity GO:0051336 143 0.016
lipid modification GO:0030258 52 0.016
secretion by cell GO:0032940 248 0.016
positive regulation of mapk cascade GO:0043410 92 0.016
positive regulation of secretion by cell GO:1903532 128 0.016
regulation of cellular protein metabolic process GO:0032268 267 0.016
inner ear development GO:0048839 21 0.016
reactive oxygen species biosynthetic process GO:1903409 8 0.016
purine containing compound catabolic process GO:0072523 138 0.016
interleukin 6 production GO:0032635 12 0.016
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.016
positive regulation of phosphorylation GO:0042327 177 0.015
amino acid transport GO:0006865 70 0.015
cellular response to hexose stimulus GO:0071331 65 0.015
negative regulation of neuron differentiation GO:0045665 62 0.015
postnatal olfactory bulb interneuron migration GO:0021827 1 0.015
response to carbohydrate GO:0009743 183 0.015
anatomical structure morphogenesis GO:0009653 298 0.015
positive regulation of hydrolase activity GO:0051345 86 0.015
multicellular organismal signaling GO:0035637 44 0.015
ion homeostasis GO:0050801 212 0.015
regulation of response to stress GO:0080134 126 0.015
regulation of transcription dna templated GO:0006355 374 0.015
defecation GO:0030421 1 0.015
single organism catabolic process GO:0044712 283 0.015
sexual reproduction GO:0019953 148 0.015
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.015
heart process GO:0003015 57 0.015
response to insulin GO:0032868 133 0.015
cellular homeostasis GO:0019725 252 0.015
programmed cell death GO:0012501 392 0.014
nucleoside metabolic process GO:0009116 179 0.014
regulation of protein serine threonine kinase activity GO:0071900 64 0.014
sensory organ development GO:0007423 74 0.014
cellular carbohydrate metabolic process GO:0044262 72 0.014
single organism organelle organization GO:1902589 180 0.014
multi multicellular organism process GO:0044706 138 0.014
neuron apoptotic process GO:0051402 88 0.014
positive regulation of exocytosis GO:0045921 19 0.014
multi organism reproductive process GO:0044703 262 0.014
single organism behavior GO:0044708 130 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.014
regulation of protein metabolic process GO:0051246 289 0.014
defense response to gram negative bacterium GO:0050829 3 0.014
mammary gland epithelium development GO:0061180 1 0.014
cellular response to glucose stimulus GO:0071333 65 0.014
embryonic pattern specification GO:0009880 1 0.014
axon guidance GO:0007411 24 0.014
substrate dependent cerebral cortex tangential migration GO:0021825 1 0.013
insulin like growth factor receptor signaling pathway GO:0048009 3 0.013
positive regulation of phosphate metabolic process GO:0045937 262 0.013
negative regulation of biosynthetic process GO:0009890 168 0.013
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.013
g protein coupled receptor signaling pathway GO:0007186 242 0.013
homeostatic process GO:0042592 331 0.013
positive regulation of transferase activity GO:0051347 81 0.013
regulation of nucleic acid templated transcription GO:1903506 380 0.013
regulation of locomotion GO:0040012 148 0.013
hematopoietic progenitor cell differentiation GO:0002244 2 0.013
positive regulation of neuron apoptotic process GO:0043525 33 0.013
positive regulation of kinase activity GO:0033674 77 0.013
bmp signaling pathway GO:0030509 4 0.013
axis specification GO:0009798 4 0.013
regulation of vesicle mediated transport GO:0060627 81 0.013
cellular response to cytokine stimulus GO:0071345 127 0.013
regulation of anatomical structure size GO:0090066 135 0.013
regulation of translation GO:0006417 27 0.013
translation GO:0006412 35 0.013
response to electrical stimulus GO:0051602 56 0.013
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.013
tangential migration from the subventricular zone to the olfactory bulb GO:0022028 1 0.013
stress activated mapk cascade GO:0051403 35 0.013
neuronal action potential GO:0019228 35 0.013
lipid oxidation GO:0034440 30 0.013
cell morphogenesis involved in differentiation GO:0000904 119 0.013
actin filament organization GO:0007015 42 0.012
synaptic transmission GO:0007268 235 0.012
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.012
antibiotic transport GO:0042891 2 0.012
cellular response to peptide GO:1901653 133 0.012
regulation of kinase activity GO:0043549 117 0.012
divalent inorganic cation transport GO:0072511 134 0.012
saliva secretion GO:0046541 3 0.012
forebrain neuron development GO:0021884 3 0.012
positive regulation of protein modification process GO:0031401 142 0.012
dicarboxylic acid transport GO:0006835 34 0.012
cation homeostasis GO:0055080 195 0.012
regulation of cell migration GO:0030334 128 0.012
response to alkaloid GO:0043279 132 0.012
protein maturation GO:0051604 68 0.012
cellular ion homeostasis GO:0006873 184 0.012
organelle localization GO:0051640 55 0.012
response to radiation GO:0009314 137 0.012
chemotaxis GO:0006935 66 0.012
oligopeptide transport GO:0006857 4 0.012
cellular calcium ion homeostasis GO:0006874 160 0.012
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.012
negative regulation of signal transduction GO:0009968 83 0.012
Human
positive regulation of phagocytosis engulfment GO:0060100 4 0.012
response to bacterium GO:0009617 200 0.012
cerebral cortex cell migration GO:0021795 4 0.012
response to growth factor GO:0070848 189 0.012
positive regulation of locomotion GO:0040017 102 0.011
gamete generation GO:0007276 124 0.011
multicellular organism reproduction GO:0032504 233 0.011
regulation of canonical wnt signaling pathway GO:0060828 4 0.011
response to mercury ion GO:0046689 15 0.011
regulation of cellular localization GO:0060341 263 0.011
positive regulation of cell development GO:0010720 176 0.011
ear development GO:0043583 21 0.011
embryonic skeletal system development GO:0048706 3 0.011
divalent metal ion transport GO:0070838 132 0.011
response to oxidative stress GO:0006979 186 0.011
cellular response to carbohydrate stimulus GO:0071322 72 0.011
negative regulation of neuron projection development GO:0010977 46 0.011
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.011
cellular catabolic process GO:0044248 295 0.011
reactive nitrogen species metabolic process GO:2001057 1 0.011
posttranscriptional regulation of gene expression GO:0010608 37 0.011
gonad development GO:0008406 104 0.011
positive regulation of protein phosphorylation GO:0001934 135 0.011
limb morphogenesis GO:0035108 4 0.011
positive regulation of neuron projection development GO:0010976 99 0.011
gastrulation GO:0007369 2 0.011
motor neuron axon guidance GO:0008045 1 0.011
diencephalon development GO:0021536 21 0.011
regulation of dendrite development GO:0050773 59 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
negative regulation of apoptotic process GO:0043066 181 0.011
negative regulation of cellular component organization GO:0051129 83 0.011
positive regulation of immune response GO:0050778 42 0.011
mechanoreceptor differentiation GO:0042490 2 0.011
ribose phosphate metabolic process GO:0019693 235 0.011
response to corticosteroid GO:0031960 235 0.011
organic hydroxy compound transport GO:0015850 77 0.011
neuron neuron synaptic transmission GO:0007270 60 0.011
negative regulation of cell projection organization GO:0031345 50 0.011
epinephrine transport GO:0048241 7 0.011
positive regulation of leukocyte degranulation GO:0043302 4 0.010
endocytosis GO:0006897 84 0.010
cell cell signaling GO:0007267 335 0.010
cerebral cortex tangential migration using cell cell interactions GO:0021823 1 0.010
exploration behavior GO:0035640 1 0.010
tripeptide transport GO:0042939 2 0.010
drug transport GO:0015893 18 0.010
ossification GO:0001503 70 0.010
glutamate receptor signaling pathway GO:0007215 43 0.010
embryonic cranial skeleton morphogenesis GO:0048701 2 0.010
multicellular organismal homeostasis GO:0048871 49 0.010
cellular amine metabolic process GO:0044106 38 0.010
neuron projection guidance GO:0097485 24 0.010
organic cyclic compound catabolic process GO:1901361 175 0.010
positive regulation of transmembrane transport GO:0034764 25 0.010
fatty acid metabolic process GO:0006631 99 0.010
positive regulation of response to stimulus GO:0048584 285 0.010
dephosphorylation GO:0016311 98 0.010
lipid localization GO:0010876 62 0.010

Hhip disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.032
disease of anatomical entity DOID:7 0 0.025
nervous system disease DOID:863 0 0.025
cancer DOID:162 0 0.022
organ system cancer DOID:0050686 0 0.022
hypertension DOID:10763 0 0.020
artery disease DOID:0050828 0 0.020
vascular disease DOID:178 0 0.020
cardiovascular system disease DOID:1287 0 0.020
musculoskeletal system disease DOID:17 0 0.019
connective tissue disease DOID:65 0 0.014
central nervous system disease DOID:331 0 0.012
sensory system disease DOID:0050155 0 0.011