Rattus norvegicus

54 known processes

Polb

polymerase (DNA directed), beta

Polb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of apoptotic process GO:0042981 335 0.169
macromolecular complex subunit organization GO:0043933 339 0.156
macromolecular complex assembly GO:0065003 273 0.147
programmed cell death GO:0012501 392 0.133
apoptotic process GO:0006915 381 0.132
cellular component biogenesis GO:0044085 368 0.124
regulation of programmed cell death GO:0043067 341 0.112
organelle organization GO:0006996 266 0.109
cellular component assembly GO:0022607 360 0.106
protein complex subunit organization GO:0071822 302 0.104
protein complex assembly GO:0006461 263 0.097
negative regulation of cellular metabolic process GO:0031324 281 0.095
protein complex biogenesis GO:0070271 263 0.088
negative regulation of apoptotic process GO:0043066 181 0.087
intracellular signal transduction GO:0035556 314 0.087
macromolecule localization GO:0033036 252 0.083
rna metabolic process GO:0016070 406 0.082
negative regulation of gene expression GO:0010629 199 0.074
positive regulation of transport GO:0051050 245 0.073
response to oxygen levels GO:0070482 265 0.073
regulation of protein metabolic process GO:0051246 289 0.071
negative regulation of programmed cell death GO:0043069 183 0.071
negative regulation of biosynthetic process GO:0009890 168 0.070
negative regulation of cellular biosynthetic process GO:0031327 161 0.070
rna biosynthetic process GO:0032774 380 0.068
regulation of cellular localization GO:0060341 263 0.064
regulation of rna biosynthetic process GO:2001141 381 0.063
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.062
negative regulation of cell death GO:0060548 229 0.061
negative regulation of metabolic process GO:0009892 331 0.057
neurological system process GO:0050877 219 0.055
regulation of cellular protein metabolic process GO:0032268 267 0.054
single organism organelle organization GO:1902589 180 0.054
transcription from rna polymerase ii promoter GO:0006366 252 0.054
regulation of multicellular organismal development GO:2000026 376 0.054
protein phosphorylation GO:0006468 345 0.053
establishment of protein localization GO:0045184 141 0.053
nucleic acid templated transcription GO:0097659 379 0.053
oxoacid metabolic process GO:0043436 290 0.051
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.051
regulation of signal transduction GO:0009966 318 0.050
response to decreased oxygen levels GO:0036293 237 0.050
regulation of cell proliferation GO:0042127 359 0.050
cellular response to oxygen containing compound GO:1901701 386 0.049
central nervous system development GO:0007417 311 0.049
regulation of molecular function GO:0065009 398 0.049
cellular amino acid metabolic process GO:0006520 107 0.048
negative regulation of signaling GO:0023057 157 0.048
localization of cell GO:0051674 202 0.046
single organism reproductive process GO:0044702 297 0.046
organophosphate metabolic process GO:0019637 370 0.046
negative regulation of macromolecule metabolic process GO:0010605 260 0.046
transcription dna templated GO:0006351 377 0.045
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.044
negative regulation of transcription dna templated GO:0045892 116 0.044
reproduction GO:0000003 245 0.044
secretion GO:0046903 307 0.043
negative regulation of nucleic acid templated transcription GO:1903507 117 0.042
multicellular organism reproduction GO:0032504 233 0.042
neuron differentiation GO:0030182 368 0.042
purine containing compound metabolic process GO:0072521 253 0.042
regulation of phosphate metabolic process GO:0019220 349 0.041
response to inorganic substance GO:0010035 377 0.041
nucleobase containing small molecule metabolic process GO:0055086 316 0.041
regulation of nucleic acid templated transcription GO:1903506 380 0.040
circulatory system development GO:0072359 134 0.040
cell type specific apoptotic process GO:0097285 134 0.039
multicellular organismal reproductive process GO:0048609 233 0.039
response to nutrient levels GO:0031667 370 0.039
positive regulation of biosynthetic process GO:0009891 319 0.038
regulation of transcription dna templated GO:0006355 374 0.038
regulation of protein localization GO:0032880 81 0.038
cellular component movement GO:0006928 248 0.038
positive regulation of cell proliferation GO:0008284 249 0.037
intracellular transport GO:0046907 185 0.037
negative regulation of rna metabolic process GO:0051253 123 0.036
secretion by cell GO:0032940 248 0.036
regulation of cellular ketone metabolic process GO:0010565 27 0.036
catabolic process GO:0009056 351 0.036
positive regulation of programmed cell death GO:0043068 157 0.036
protein oligomerization GO:0051259 191 0.035
nucleoside phosphate metabolic process GO:0006753 283 0.035
regulation of cellular component organization GO:0051128 368 0.035
regulation of cellular amino acid metabolic process GO:0006521 2 0.035
positive regulation of developmental process GO:0051094 283 0.035
organic substance catabolic process GO:1901575 316 0.035
positive regulation of cell death GO:0010942 184 0.035
aging GO:0007568 241 0.034
response to bacterium GO:0009617 200 0.034
developmental process involved in reproduction GO:0003006 159 0.034
carboxylic acid metabolic process GO:0019752 289 0.034
positive regulation of cellular protein metabolic process GO:0032270 167 0.034
cardiovascular system development GO:0072358 134 0.033
cell migration GO:0016477 197 0.033
positive regulation of multicellular organismal process GO:0051240 387 0.033
cellular response to endogenous stimulus GO:0071495 377 0.033
response to estrogen GO:0043627 232 0.033
response to peptide GO:1901652 292 0.033
amine metabolic process GO:0009308 38 0.033
reproductive process GO:0022414 372 0.033
cellular catabolic process GO:0044248 295 0.033
axis specification GO:0009798 4 0.032
response to lipopolysaccharide GO:0032496 191 0.032
positive regulation of apoptotic process GO:0043065 154 0.032
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.032
regulation of phosphorylation GO:0042325 248 0.032
positive regulation of cellular component organization GO:0051130 200 0.032
cellular protein localization GO:0034613 122 0.032
chromosome segregation GO:0007059 2 0.031
response to wounding GO:0009611 254 0.031
homeostatic process GO:0042592 331 0.031
sexual reproduction GO:0019953 148 0.031
response to temperature stimulus GO:0009266 94 0.031
negative regulation of rna biosynthetic process GO:1902679 118 0.031
cellular macromolecule localization GO:0070727 122 0.030
cellular response to organic cyclic compound GO:0071407 202 0.030
behavior GO:0007610 205 0.030
brain development GO:0007420 247 0.030
locomotion GO:0040011 237 0.029
regulation of protein transport GO:0051223 68 0.029
cellular lipid metabolic process GO:0044255 208 0.029
positive regulation of cell communication GO:0010647 271 0.029
protein transport GO:0015031 132 0.029
cellular response to stress GO:0033554 269 0.029
response to hypoxia GO:0001666 231 0.029
positive regulation of gene expression GO:0010628 244 0.029
regulation of intracellular signal transduction GO:1902531 218 0.029
response to cytokine GO:0034097 215 0.029
organic acid metabolic process GO:0006082 292 0.028
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.028
neuron projection development GO:0031175 273 0.028
growth GO:0040007 165 0.028
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.028
anterior posterior pattern specification GO:0009952 1 0.028
regulation of rna metabolic process GO:0051252 391 0.028
response to glucocorticoid GO:0051384 223 0.028
carbohydrate derivative metabolic process GO:1901135 346 0.028
cell cycle GO:0007049 101 0.027
regulation of secretion GO:0051046 224 0.027
response to insulin GO:0032868 133 0.027
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.027
anatomical structure morphogenesis GO:0009653 298 0.027
response to ethanol GO:0045471 162 0.027
purine ribonucleotide metabolic process GO:0009150 227 0.027
cellular amine metabolic process GO:0044106 38 0.027
regulation of cell cycle GO:0051726 73 0.027
response to toxic substance GO:0009636 133 0.027
ribonucleotide metabolic process GO:0009259 231 0.027
response to peptide hormone GO:0043434 278 0.027
single organism catabolic process GO:0044712 283 0.027
regulation of catalytic activity GO:0050790 304 0.027
regulation of cell migration GO:0030334 128 0.027
positive regulation of protein metabolic process GO:0051247 178 0.027
response to biotic stimulus GO:0009607 226 0.027
regulation of phosphorus metabolic process GO:0051174 349 0.026
response to extracellular stimulus GO:0009991 380 0.026
cell motility GO:0048870 202 0.026
cytoskeleton organization GO:0007010 111 0.026
positive regulation of molecular function GO:0044093 230 0.026
regulation of neuron apoptotic process GO:0043523 83 0.026
neuron apoptotic process GO:0051402 88 0.026
response to glucose GO:0009749 136 0.025
rhythmic process GO:0048511 156 0.025
positive regulation of response to stimulus GO:0048584 285 0.025
learning or memory GO:0007611 90 0.025
positive regulation of cellular biosynthetic process GO:0031328 295 0.025
regulation of protein modification process GO:0031399 194 0.025
response to radiation GO:0009314 137 0.025
cellular response to hormone stimulus GO:0032870 247 0.025
purine ribonucleotide biosynthetic process GO:0009152 81 0.024
ribonucleoside metabolic process GO:0009119 174 0.024
neuron development GO:0048666 286 0.024
response to nutrient GO:0007584 248 0.024
regulation of cell differentiation GO:0045595 320 0.024
purine nucleotide metabolic process GO:0006163 229 0.024
cellular ketone metabolic process GO:0042180 51 0.024
response to metal ion GO:0010038 253 0.023
response to growth factor GO:0070848 189 0.023
synaptic transmission GO:0007268 235 0.023
regulation of neuron death GO:1901214 115 0.023
ribose phosphate metabolic process GO:0019693 235 0.023
response to hydrogen peroxide GO:0042542 89 0.023
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.023
cell growth GO:0016049 104 0.023
negative regulation of signal transduction GO:0009968 83 0.023
regulation of cellular amine metabolic process GO:0033238 8 0.023
cell cell signaling GO:0007267 335 0.022
peptidyl amino acid modification GO:0018193 126 0.022
tissue development GO:0009888 252 0.022
nucleoside monophosphate metabolic process GO:0009123 93 0.022
head development GO:0060322 247 0.021
lipid metabolic process GO:0006629 283 0.021
single organism biosynthetic process GO:0044711 342 0.021
heterocycle catabolic process GO:0046700 167 0.021
response to other organism GO:0051707 220 0.021
dephosphorylation GO:0016311 98 0.021
spindle organization GO:0007051 2 0.021
single organism intracellular transport GO:1902582 166 0.021
negative regulation of response to stimulus GO:0048585 155 0.020
axon development GO:0061564 96 0.020
positive regulation of phosphorus metabolic process GO:0010562 262 0.020
nucleotide metabolic process GO:0009117 279 0.020
positive regulation of locomotion GO:0040017 102 0.020
negative regulation of cell communication GO:0010648 158 0.020
cytoplasmic transport GO:0016482 115 0.020
regulation of secretion by cell GO:1903530 208 0.020
cell cycle checkpoint GO:0000075 2 0.020
response to external biotic stimulus GO:0043207 221 0.020
response to reactive oxygen species GO:0000302 120 0.020
gamete generation GO:0007276 124 0.020
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.020
nucleoside catabolic process GO:0009164 126 0.020
regulation of anatomical structure size GO:0090066 135 0.019
multi organism reproductive process GO:0044703 262 0.019
response to heat GO:0009408 60 0.019
regulation of lipid metabolic process GO:0019216 68 0.019
response to molecule of bacterial origin GO:0002237 194 0.019
positive regulation of signaling GO:0023056 270 0.019
proteolysis GO:0006508 175 0.019
glycosyl compound metabolic process GO:1901657 182 0.019
establishment of organelle localization GO:0051656 37 0.019
purine nucleoside triphosphate metabolic process GO:0009144 141 0.019
actin filament based process GO:0030029 86 0.019
embryonic pattern specification GO:0009880 1 0.019
response to estradiol GO:0032355 164 0.019
muscle system process GO:0003012 115 0.019
spermatogenesis GO:0007283 99 0.018
cellular nitrogen compound catabolic process GO:0044270 163 0.018
negative regulation of molecular function GO:0044092 133 0.018
regulation of protein phosphorylation GO:0001932 183 0.018
apoptotic signaling pathway GO:0097190 27 0.018
regulation of establishment of protein localization GO:0070201 69 0.018
multicellular organism growth GO:0035264 1 0.018
positive regulation of cellular component movement GO:0051272 102 0.018
regulation of cellular component movement GO:0051270 150 0.018
response to acid chemical GO:0001101 222 0.018
protein localization GO:0008104 191 0.018
regulation of cell development GO:0060284 263 0.018
cellular response to abiotic stimulus GO:0071214 85 0.018
defense response GO:0006952 194 0.018
single organism cellular localization GO:1902580 102 0.017
negative regulation of cellular protein metabolic process GO:0032269 106 0.017
negative regulation of cell cycle phase transition GO:1901988 4 0.017
anatomical structure formation involved in morphogenesis GO:0048646 83 0.017
small gtpase mediated signal transduction GO:0007264 36 0.017
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.017
neuron death GO:0070997 127 0.017
regulation of neurogenesis GO:0050767 247 0.017
synaptic growth at neuromuscular junction GO:0051124 1 0.017
negative regulation of cell proliferation GO:0008285 119 0.017
reproductive structure development GO:0048608 128 0.017
ribose phosphate biosynthetic process GO:0046390 87 0.017
embryonic skeletal system development GO:0048706 3 0.017
regulation of locomotion GO:0040012 148 0.017
cellular response to lipid GO:0071396 201 0.017
regulation of membrane potential GO:0042391 110 0.017
positive regulation of phosphorylation GO:0042327 177 0.017
immune system process GO:0002376 204 0.017
muscle structure development GO:0061061 87 0.017
purine nucleoside metabolic process GO:0042278 169 0.017
cognition GO:0050890 92 0.017
regulation of anatomical structure morphogenesis GO:0022603 141 0.016
regulation of system process GO:0044057 208 0.016
nuclear transport GO:0051169 49 0.016
ras protein signal transduction GO:0007265 29 0.016
single organism behavior GO:0044708 130 0.016
response to corticosteroid GO:0031960 235 0.016
g protein coupled receptor signaling pathway GO:0007186 242 0.016
negative regulation of transport GO:0051051 136 0.016
negative regulation of multicellular organismal process GO:0051241 203 0.016
endocytosis GO:0006897 84 0.016
organic cyclic compound catabolic process GO:1901361 175 0.016
positive regulation of secretion by cell GO:1903532 128 0.016
cellular response to growth factor stimulus GO:0071363 162 0.016
nucleotide biosynthetic process GO:0009165 98 0.016
cellular response to organonitrogen compound GO:0071417 197 0.016
cell projection organization GO:0030030 302 0.016
nucleoside phosphate biosynthetic process GO:1901293 102 0.016
cell part morphogenesis GO:0032990 123 0.015
vesicle mediated transport GO:0016192 181 0.015
positive regulation of protein modification process GO:0031401 142 0.015
regulation of hydrolase activity GO:0051336 143 0.015
cellular response to external stimulus GO:0071496 118 0.015
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.015
purine ribonucleoside metabolic process GO:0046128 168 0.015
membrane organization GO:0061024 94 0.015
sex differentiation GO:0007548 113 0.015
regulation of proteolysis GO:0030162 66 0.015
positive regulation of cell migration GO:0030335 96 0.015
embryonic axis specification GO:0000578 1 0.015
development of primary sexual characteristics GO:0045137 107 0.015
nucleoside triphosphate metabolic process GO:0009141 144 0.015
positive regulation of secretion GO:0051047 140 0.015
response to alkaloid GO:0043279 132 0.014
response to oxidative stress GO:0006979 186 0.014
nucleotide catabolic process GO:0009166 139 0.014
cellular response to insulin stimulus GO:0032869 81 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.014
nucleobase containing compound catabolic process GO:0034655 152 0.014
positive regulation of cell projection organization GO:0031346 111 0.014
reproductive system development GO:0061458 128 0.014
negative regulation of protein metabolic process GO:0051248 114 0.014
circulatory system process GO:0003013 183 0.014
positive regulation of cell motility GO:2000147 97 0.014
monocarboxylic acid metabolic process GO:0032787 152 0.014
nucleoside metabolic process GO:0009116 179 0.014
regulation of cellular component biogenesis GO:0044087 86 0.014
protein maturation GO:0051604 68 0.014
regulation of response to external stimulus GO:0032101 106 0.014
cell projection morphogenesis GO:0048858 123 0.014
negative regulation of neuron apoptotic process GO:0043524 45 0.014
carbohydrate derivative biosynthetic process GO:1901137 124 0.014
regulation of mapk cascade GO:0043408 116 0.013
cation transport GO:0006812 382 0.013
cytoskeleton dependent cytokinesis GO:0061640 2 0.013
tube development GO:0035295 89 0.013
regulation of cell motility GO:2000145 131 0.013
ribonucleoside triphosphate metabolic process GO:0009199 141 0.013
dna metabolic process GO:0006259 96 0.013
positive regulation of cellular amine metabolic process GO:0033240 3 0.013
inflammatory response GO:0006954 150 0.013
muscle contraction GO:0006936 88 0.013
peptide secretion GO:0002790 86 0.013
protein heterooligomerization GO:0051291 89 0.013
response to transition metal nanoparticle GO:1990267 122 0.013
blood circulation GO:0008015 183 0.013
eye morphogenesis GO:0048592 4 0.013
positive regulation of signal transduction GO:0009967 175 0.013
intracellular protein transport GO:0006886 79 0.013
purine nucleoside monophosphate metabolic process GO:0009126 84 0.013
regulation of cell projection organization GO:0031344 175 0.013
oxidation reduction process GO:0055114 304 0.013
response to monosaccharide GO:0034284 159 0.013
actin cytoskeleton organization GO:0030036 73 0.013
single organism carbohydrate metabolic process GO:0044723 118 0.012
gastrulation GO:0007369 2 0.012
mitotic cell cycle checkpoint GO:0007093 1 0.012
positive regulation of protein transport GO:0051222 41 0.012
purine nucleotide catabolic process GO:0006195 136 0.012
regulation of hormone levels GO:0010817 187 0.012
positive regulation of rna metabolic process GO:0051254 203 0.012
positive regulation of cell differentiation GO:0045597 217 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
male gamete generation GO:0048232 99 0.012
aromatic compound catabolic process GO:0019439 168 0.012
ovulation cycle GO:0042698 67 0.012
signal release GO:0023061 145 0.012
response to antibiotic GO:0046677 39 0.012
regulation of vesicle mediated transport GO:0060627 81 0.012
response to carbohydrate GO:0009743 183 0.012
protein processing GO:0016485 68 0.012
nitrogen compound transport GO:0071705 229 0.012
cellular response to peptide hormone stimulus GO:0071375 120 0.012
positive regulation of nucleic acid templated transcription GO:1903508 197 0.012
positive regulation of catalytic activity GO:0043085 184 0.012
regulation of actin filament based process GO:0032970 42 0.012
purine ribonucleotide catabolic process GO:0009154 136 0.011
organonitrogen compound biosynthetic process GO:1901566 167 0.011
organophosphate biosynthetic process GO:0090407 143 0.011
dna integrity checkpoint GO:0031570 2 0.011
maintenance of location GO:0051235 17 0.011
cell morphogenesis GO:0000902 142 0.011
regulation of protein processing GO:0070613 50 0.011
enzyme linked receptor protein signaling pathway GO:0007167 116 0.011
chemical homeostasis GO:0048878 292 0.011
negative regulation of developmental process GO:0051093 125 0.011
purine containing compound biosynthetic process GO:0072522 85 0.011
metal ion transport GO:0030001 289 0.011
mitotic cell cycle GO:0000278 49 0.011
ribonucleotide biosynthetic process GO:0009260 85 0.011
negative regulation of neuron death GO:1901215 69 0.011
positive regulation of phosphate metabolic process GO:0045937 262 0.011
reactive oxygen species metabolic process GO:0072593 37 0.011
ion transmembrane transport GO:0034220 365 0.011
mitotic spindle organization GO:0007052 2 0.011
regulation of cellular component size GO:0032535 51 0.011
cellular carbohydrate metabolic process GO:0044262 72 0.011
regulation of nervous system development GO:0051960 264 0.011
positive regulation of organelle organization GO:0010638 48 0.011
regulation of catabolic process GO:0009894 113 0.011
cell morphogenesis involved in differentiation GO:0000904 119 0.011
positive regulation of nervous system development GO:0051962 178 0.011
striated muscle contraction GO:0006941 44 0.011
regulation of cytokine biosynthetic process GO:0042035 3 0.011
nucleocytoplasmic transport GO:0006913 48 0.011
lipid biosynthetic process GO:0008610 128 0.011
response to light stimulus GO:0009416 52 0.011
organelle localization GO:0051640 55 0.011
positive regulation of protein phosphorylation GO:0001934 135 0.011
regulation of cell growth GO:0001558 85 0.011
regulation of epithelial cell proliferation GO:0050678 49 0.011
single organism membrane organization GO:0044802 74 0.010
organophosphate catabolic process GO:0046434 148 0.010
eye development GO:0001654 50 0.010
response to vitamin GO:0033273 131 0.010
glycosyl compound catabolic process GO:1901658 126 0.010
regulation of ion transport GO:0043269 245 0.010
striated muscle tissue development GO:0014706 58 0.010
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.010
response to amino acid GO:0043200 75 0.010
regulation of smooth muscle cell proliferation GO:0048660 75 0.010

Polb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.020
nervous system disease DOID:863 0 0.020
disease of cellular proliferation DOID:14566 0 0.015
cancer DOID:162 0 0.012
organ system cancer DOID:0050686 0 0.012
sensory system disease DOID:0050155 0 0.012