Rattus norvegicus

30 known processes

Aurkb

aurora kinase B

(Aliases: Stk12,Aim1)

Aurkb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular component biogenesis GO:0044085 368 0.129
Human Fly
negative regulation of metabolic process GO:0009892 331 0.094
Human
cell cycle GO:0007049 101 0.090
negative regulation of macromolecule metabolic process GO:0010605 260 0.082
Human
single organism reproductive process GO:0044702 297 0.080
Fly
regulation of cellular component organization GO:0051128 368 0.079
Human
protein phosphorylation GO:0006468 345 0.076
protein complex biogenesis GO:0070271 263 0.073
Human Fly
chromosome segregation GO:0007059 2 0.071
Fly
protein complex subunit organization GO:0071822 302 0.071
Human Fly
regulation of cell proliferation GO:0042127 359 0.069
meiotic cell cycle process GO:1903046 3 0.067
organic cyclic compound catabolic process GO:1901361 175 0.065
catabolic process GO:0009056 351 0.065
cell cycle checkpoint GO:0000075 2 0.064
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.064
dna packaging GO:0006323 4 0.062
Fly
negative regulation of gene expression GO:0010629 199 0.061
Human
meiosis i GO:0007127 2 0.060
developmental process involved in reproduction GO:0003006 159 0.059
Fly
male meiosis GO:0007140 1 0.059
regulation of rna biosynthetic process GO:2001141 381 0.058
Human
reproductive process GO:0022414 372 0.056
Fly
cellular catabolic process GO:0044248 295 0.055
multicellular organism reproduction GO:0032504 233 0.053
Fly
cellular component movement GO:0006928 248 0.053
anatomical structure morphogenesis GO:0009653 298 0.053
Fly
cellular component assembly GO:0022607 360 0.049
Human Fly
negative regulation of cellular metabolic process GO:0031324 281 0.048
Human
transcription dna templated GO:0006351 377 0.047
Human
apoptotic process GO:0006915 381 0.047
Human
organic substance catabolic process GO:1901575 316 0.047
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.045
rna metabolic process GO:0016070 406 0.045
Human
organophosphate metabolic process GO:0019637 370 0.045
reproduction GO:0000003 245 0.044
Fly
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.044
Human
response to hypoxia GO:0001666 231 0.044
multi organism reproductive process GO:0044703 262 0.042
Fly
regulation of molecular function GO:0065009 398 0.042
Human
reproductive system development GO:0061458 128 0.042
rna biosynthetic process GO:0032774 380 0.041
Human
regulation of cell differentiation GO:0045595 320 0.041
Fly
nucleobase containing small molecule metabolic process GO:0055086 316 0.039
protein complex assembly GO:0006461 263 0.039
Human Fly
regulation of multicellular organismal development GO:2000026 376 0.039
Fly
negative regulation of cellular biosynthetic process GO:0031327 161 0.039
Human
purine ribonucleotide metabolic process GO:0009150 227 0.039
regulation of rna metabolic process GO:0051252 391 0.039
Human
heterocycle catabolic process GO:0046700 167 0.039
cellular nitrogen compound catabolic process GO:0044270 163 0.038
nucleic acid templated transcription GO:0097659 379 0.038
Human
regulation of catalytic activity GO:0050790 304 0.038
negative regulation of cell cycle phase transition GO:1901988 4 0.037
spindle organization GO:0007051 2 0.037
Human Fly
macromolecule catabolic process GO:0009057 58 0.037
carbohydrate derivative metabolic process GO:1901135 346 0.037
lipid metabolic process GO:0006629 283 0.036
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.036
aging GO:0007568 241 0.036
cellular response to oxygen containing compound GO:1901701 386 0.036
rhythmic process GO:0048511 156 0.035
positive regulation of developmental process GO:0051094 283 0.035
protein localization to chromosome centromeric region GO:0071459 1 0.034
Human
organic acid metabolic process GO:0006082 292 0.034
response to ethanol GO:0045471 162 0.034
negative regulation of rna biosynthetic process GO:1902679 118 0.034
Human
negative regulation of transcription dna templated GO:0045892 116 0.034
Human
single organism catabolic process GO:0044712 283 0.034
response to oxygen levels GO:0070482 265 0.033
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.033
Human
positive regulation of biosynthetic process GO:0009891 319 0.033
reproductive structure development GO:0048608 128 0.033
regulation of transcription dna templated GO:0006355 374 0.033
Human
macromolecular complex assembly GO:0065003 273 0.032
Human Fly
negative regulation of cell death GO:0060548 229 0.032
Human
cell projection organization GO:0030030 302 0.032
macromolecular complex subunit organization GO:0043933 339 0.032
Human Mouse Fly
single organism biosynthetic process GO:0044711 342 0.032
regulation of protein metabolic process GO:0051246 289 0.032
macromolecule localization GO:0033036 252 0.032
Human Fly
double strand break repair GO:0006302 1 0.032
nucleotide catabolic process GO:0009166 139 0.032
organophosphate catabolic process GO:0046434 148 0.031
growth GO:0040007 165 0.031
chromosome condensation GO:0030261 3 0.031
Fly
oxoacid metabolic process GO:0043436 290 0.031
programmed cell death GO:0012501 392 0.031
Human
regulation of phosphorus metabolic process GO:0051174 349 0.031
multicellular organismal reproductive process GO:0048609 233 0.031
Fly
regulation of phosphate metabolic process GO:0019220 349 0.031
intracellular transport GO:0046907 185 0.031
nucleobase containing compound catabolic process GO:0034655 152 0.031
regulation of nervous system development GO:0051960 264 0.030
Fly
carboxylic acid metabolic process GO:0019752 289 0.030
neuron differentiation GO:0030182 368 0.030
response to oxidative stress GO:0006979 186 0.030
organonitrogen compound catabolic process GO:1901565 179 0.030
spermatogenesis GO:0007283 99 0.030
response to peptide hormone GO:0043434 278 0.030
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.029
Human
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.029
Human
mitotic spindle organization GO:0007052 2 0.029
Human Fly
positive regulation of multicellular organismal process GO:0051240 387 0.028
cellular response to endogenous stimulus GO:0071495 377 0.028
cellular response to stress GO:0033554 269 0.028
regulation of synapse maturation GO:0090128 2 0.028
metaphase anaphase transition of mitotic cell cycle GO:0007091 1 0.028
cellular amino acid metabolic process GO:0006520 107 0.028
regulation of catabolic process GO:0009894 113 0.027
nucleoside phosphate metabolic process GO:0006753 283 0.027
regulation of apoptotic process GO:0042981 335 0.027
Human
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.027
Human
regulation of phosphorylation GO:0042325 248 0.026
positive regulation of molecular function GO:0044093 230 0.026
regulation of cellular protein metabolic process GO:0032268 267 0.026
negative regulation of chromosome organization GO:2001251 1 0.026
purine containing compound metabolic process GO:0072521 253 0.026
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.026
positive regulation of cell proliferation GO:0008284 249 0.025
response to metal ion GO:0010038 253 0.025
nucleotide metabolic process GO:0009117 279 0.025
positive regulation of cellular biosynthetic process GO:0031328 295 0.025
nucleoside monophosphate metabolic process GO:0009123 93 0.025
mitotic sister chromatid segregation GO:0000070 1 0.025
Fly
positive regulation of cellular component organization GO:0051130 200 0.025
regulation of cell growth GO:0001558 85 0.025
proteolysis GO:0006508 175 0.024
protein localization GO:0008104 191 0.024
Human Fly
regulation of nucleic acid templated transcription GO:1903506 380 0.024
Human
positive regulation of gene expression GO:0010628 244 0.024
response to peptide GO:1901652 292 0.024
tissue development GO:0009888 252 0.024
negative regulation of biosynthetic process GO:0009890 168 0.024
Human
central nervous system development GO:0007417 311 0.024
positive regulation of rna metabolic process GO:0051254 203 0.023
response to external biotic stimulus GO:0043207 221 0.023
ribose phosphate metabolic process GO:0019693 235 0.023
mitotic sister chromatid separation GO:0051306 1 0.023
aromatic compound catabolic process GO:0019439 168 0.023
transcription from rna polymerase ii promoter GO:0006366 252 0.023
Human
positive regulation of nucleic acid templated transcription GO:1903508 197 0.022
purine nucleoside monophosphate catabolic process GO:0009128 55 0.022
cellular amine metabolic process GO:0044106 38 0.022
positive regulation of protein modification process GO:0031401 142 0.022
regulation of cell development GO:0060284 263 0.022
Fly
metaphase anaphase transition of cell cycle GO:0044784 1 0.022
positive regulation of catabolic process GO:0009896 78 0.022
male gamete generation GO:0048232 99 0.022
carbohydrate derivative catabolic process GO:1901136 147 0.022
ribonucleotide metabolic process GO:0009259 231 0.021
cellular response to hormone stimulus GO:0032870 247 0.021
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.021
regulation of growth GO:0040008 105 0.021
sex differentiation GO:0007548 113 0.021
vesicle mediated transport GO:0016192 181 0.021
regulation of signal transduction GO:0009966 318 0.021
negative regulation of programmed cell death GO:0043069 183 0.020
Human
gamete generation GO:0007276 124 0.020
Fly
regeneration GO:0031099 163 0.020
regulation of neurogenesis GO:0050767 247 0.020
Fly
positive regulation of cellular protein metabolic process GO:0032270 167 0.020
purine nucleotide metabolic process GO:0006163 229 0.020
response to estrogen GO:0043627 232 0.020
negative regulation of nucleic acid templated transcription GO:1903507 117 0.020
Human
organelle organization GO:0006996 266 0.020
Human Mouse Fly
response to corticosteroid GO:0031960 235 0.020
positive regulation of triglyceride metabolic process GO:0090208 4 0.020
response to toxic substance GO:0009636 133 0.019
positive regulation of catalytic activity GO:0043085 184 0.019
dna metabolic process GO:0006259 96 0.019
Fly
response to insulin GO:0032868 133 0.019
positive regulation of synapse maturation GO:0090129 2 0.019
protein catabolic process GO:0030163 30 0.019
neuron development GO:0048666 286 0.019
cellular component morphogenesis GO:0032989 155 0.019
response to decreased oxygen levels GO:0036293 237 0.019
cerebellar purkinje cell layer morphogenesis GO:0021692 1 0.019
head development GO:0060322 247 0.019
amine metabolic process GO:0009308 38 0.019
regulation of meiotic cell cycle GO:0051445 3 0.018
single organism organelle organization GO:1902589 180 0.018
Human Mouse Fly
anatomical structure formation involved in morphogenesis GO:0048646 83 0.018
Fly
response to organophosphorus GO:0046683 102 0.018
negative regulation of apoptotic process GO:0043066 181 0.018
Human
development of primary sexual characteristics GO:0045137 107 0.018
negative regulation of cellular protein metabolic process GO:0032269 106 0.018
negative regulation of protein metabolic process GO:0051248 114 0.018
cell growth GO:0016049 104 0.018
cerebellar purkinje cell layer development GO:0021680 2 0.018
regulation of programmed cell death GO:0043067 341 0.017
Human
mitotic cell cycle checkpoint GO:0007093 1 0.017
negative regulation of cell communication GO:0010648 158 0.017
sexual reproduction GO:0019953 148 0.017
Fly
cytokinetic process GO:0032506 1 0.017
ribonucleoside metabolic process GO:0009119 174 0.017
response to wounding GO:0009611 254 0.017
ras protein signal transduction GO:0007265 29 0.017
nucleoside phosphate catabolic process GO:1901292 140 0.017
response to extracellular stimulus GO:0009991 380 0.017
glycosyl compound catabolic process GO:1901658 126 0.016
establishment of protein localization GO:0045184 141 0.016
regulation of cellular catabolic process GO:0031329 101 0.016
positive regulation of growth GO:0045927 55 0.016
negative regulation of nuclear division GO:0051784 1 0.016
response to biotic stimulus GO:0009607 226 0.016
triglyceride metabolic process GO:0006641 21 0.016
cellular response to nitrogen compound GO:1901699 210 0.016
small gtpase mediated signal transduction GO:0007264 36 0.016
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.016
cellular protein localization GO:0034613 122 0.016
Human
cellular macromolecule localization GO:0070727 122 0.016
Human
protein maturation GO:0051604 68 0.016
ribonucleotide catabolic process GO:0009261 136 0.016
positive regulation of transcription dna templated GO:0045893 197 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
gonad development GO:0008406 104 0.015
regulation of chromosome segregation GO:0051983 1 0.015
epithelium development GO:0060429 96 0.015
brain development GO:0007420 247 0.015
protein oligomerization GO:0051259 191 0.015
cell cell signaling GO:0007267 335 0.015
nucleoside triphosphate catabolic process GO:0009143 123 0.015
regulation of mitotic sister chromatid separation GO:0010965 1 0.015
positive regulation of lipid catabolic process GO:0050996 4 0.015
nucleotide biosynthetic process GO:0009165 98 0.015
ribonucleoside catabolic process GO:0042454 126 0.015
regulation of cellular ketone metabolic process GO:0010565 27 0.015
regulation of cellular amino acid metabolic process GO:0006521 2 0.015
negative regulation of rna metabolic process GO:0051253 123 0.015
Human
positive regulation of cellular catabolic process GO:0031331 71 0.015
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.015
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.015
regulation of cellular amine metabolic process GO:0033238 8 0.014
nucleoside triphosphate metabolic process GO:0009141 144 0.014
cell cycle dna replication GO:0044786 1 0.014
purine nucleoside catabolic process GO:0006152 124 0.014
response to nutrient levels GO:0031667 370 0.014
negative regulation of signaling GO:0023057 157 0.014
intracellular signal transduction GO:0035556 314 0.014
carbohydrate derivative biosynthetic process GO:1901137 124 0.014
purine ribonucleoside metabolic process GO:0046128 168 0.014
single organism intracellular transport GO:1902582 166 0.014
glycerolipid metabolic process GO:0046486 67 0.014
positive regulation of phosphorus metabolic process GO:0010562 262 0.014
response to reactive oxygen species GO:0000302 120 0.014
neuron projection development GO:0031175 273 0.014
regulation of cellular localization GO:0060341 263 0.014
nucleoside metabolic process GO:0009116 179 0.014
purine nucleoside metabolic process GO:0042278 169 0.014
centrosome cycle GO:0007098 1 0.014
Fly
synaptic transmission GO:0007268 235 0.014
positive regulation of phosphate metabolic process GO:0045937 262 0.014
glycosyl compound metabolic process GO:1901657 182 0.014
purine ribonucleoside monophosphate catabolic process GO:0009169 55 0.014
cell morphogenesis GO:0000902 142 0.014
circadian rhythm GO:0007623 88 0.013
axis specification GO:0009798 4 0.013
cytoplasmic transport GO:0016482 115 0.013
response to transition metal nanoparticle GO:1990267 122 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
regulation of mitotic sister chromatid segregation GO:0033047 1 0.013
negative regulation of molecular function GO:0044092 133 0.013
Human
chromosome separation GO:0051304 1 0.013
purine containing compound catabolic process GO:0072523 138 0.013
protein processing GO:0016485 68 0.013
peptidyl amino acid modification GO:0018193 126 0.013
Mouse
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 3 0.013
sensory organ development GO:0007423 74 0.013
intracellular protein transport GO:0006886 79 0.013
negative regulation of cell proliferation GO:0008285 119 0.013
cellular ketone metabolic process GO:0042180 51 0.013
positive regulation of cell differentiation GO:0045597 217 0.012
organophosphate biosynthetic process GO:0090407 143 0.012
ribonucleoside triphosphate metabolic process GO:0009199 141 0.012
protein targeting GO:0006605 61 0.012
response to glucocorticoid GO:0051384 223 0.012
purine nucleoside triphosphate catabolic process GO:0009146 122 0.012
regulation of protein modification process GO:0031399 194 0.012
cellular response to insulin stimulus GO:0032869 81 0.012
nucleoside catabolic process GO:0009164 126 0.012
cell part morphogenesis GO:0032990 123 0.012
dna integrity checkpoint GO:0031570 2 0.012
response to cadmium ion GO:0046686 35 0.012
regulation of sister chromatid segregation GO:0033045 1 0.012
purine nucleoside monophosphate metabolic process GO:0009126 84 0.012
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 1 0.012
response to bacterium GO:0009617 200 0.012
cellular response to reactive oxygen species GO:0034614 55 0.012
cilium morphogenesis GO:0060271 2 0.012
homeostatic process GO:0042592 331 0.012
regulation of transferase activity GO:0051338 123 0.012
response to camp GO:0051591 91 0.012
regulation of proteolysis GO:0030162 66 0.012
ribonucleoside triphosphate catabolic process GO:0009203 122 0.012
positive regulation of cardiac muscle cell proliferation GO:0060045 4 0.011
regulation of cell projection organization GO:0031344 175 0.011
positive regulation of transport GO:0051050 245 0.011
chromosome organization GO:0051276 36 0.011
Mouse Fly
positive regulation of synaptic plasticity GO:0031915 3 0.011
atp metabolic process GO:0046034 72 0.011
neurological system process GO:0050877 219 0.011
mitotic cell cycle GO:0000278 49 0.011
Human Fly
cerebellar cortex formation GO:0021697 2 0.011
positive regulation of protein metabolic process GO:0051247 178 0.011
tetrahydrofolate metabolic process GO:0046653 9 0.011
negative regulation of response to stimulus GO:0048585 155 0.011
positive regulation of proteasomal protein catabolic process GO:1901800 3 0.011
actin filament based process GO:0030029 86 0.011
microtubule organizing center organization GO:0031023 1 0.011
Fly
regulation of neuron projection development GO:0010975 161 0.011
nucleoside phosphate biosynthetic process GO:1901293 102 0.011
pyrimidine nucleobase metabolic process GO:0006206 8 0.011
regulation of kinase activity GO:0043549 117 0.011
dephosphorylation GO:0016311 98 0.011
regulation of hydrolase activity GO:0051336 143 0.011
positive regulation of dna metabolic process GO:0051054 39 0.011
cardiovascular system development GO:0072358 134 0.011
epithelial cell differentiation GO:0030855 71 0.010
centrosome organization GO:0051297 1 0.010
Fly
histone serine phosphorylation GO:0035404 1 0.010
Mouse
response to ketone GO:1901654 182 0.010
regulation of membrane potential GO:0042391 110 0.010
muscle cell differentiation GO:0042692 52 0.010
positive regulation of phosphorylation GO:0042327 177 0.010
protein localization to organelle GO:0033365 57 0.010
Human
ribonucleoside monophosphate metabolic process GO:0009161 88 0.010
metaphase plate congression GO:0051310 1 0.010
microtubule anchoring GO:0034453 1 0.010
positive regulation of nervous system development GO:0051962 178 0.010
regulation of organelle organization GO:0033043 80 0.010
Human
response to nutrient GO:0007584 248 0.010
regulation of proteasomal protein catabolic process GO:0061136 4 0.010
protein transport GO:0015031 132 0.010

Aurkb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.010
large intestine cancer DOID:5672 0 0.010
colon cancer DOID:219 0 0.010
gastrointestinal system cancer DOID:3119 0 0.010
intestinal cancer DOID:10155 0 0.010
cancer DOID:162 0 0.010
organ system cancer DOID:0050686 0 0.010
colorectal cancer DOID:9256 0 0.010