Rattus norvegicus

98 known processes

Pde5a

phosphodiesterase 5A, cGMP-specific

(Aliases: PDE5A2)

Pde5a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neuron death GO:0070997 127 0.415
cardiac muscle contraction GO:0060048 27 0.394
Mouse
tissue development GO:0009888 252 0.389
Rat
cation transport GO:0006812 382 0.379
neuron differentiation GO:0030182 368 0.344
circulatory system process GO:0003013 183 0.330
neuron development GO:0048666 286 0.322
negative regulation of multicellular organismal process GO:0051241 203 0.268
Mouse
regulation of cell proliferation GO:0042127 359 0.250
Mouse
response to insulin GO:0032868 133 0.250
regulation of system process GO:0044057 208 0.249
divalent inorganic cation transport GO:0072511 134 0.241
response to other organism GO:0051707 220 0.236
anatomical structure morphogenesis GO:0009653 298 0.232
metal ion transport GO:0030001 289 0.229
regulation of signal transduction GO:0009966 318 0.196
Mouse
positive regulation of catalytic activity GO:0043085 184 0.190
Mouse
regulation of ion transport GO:0043269 245 0.188
response to hypoxia GO:0001666 231 0.187
cell projection organization GO:0030030 302 0.181
regulation of multicellular organismal development GO:2000026 376 0.176
striated muscle contraction GO:0006941 44 0.173
Mouse
regulation of phosphate metabolic process GO:0019220 349 0.165
Mouse Rat
response to peptide GO:1901652 292 0.164
positive regulation of developmental process GO:0051094 283 0.162
Mouse
epithelium development GO:0060429 96 0.160
Rat
brain development GO:0007420 247 0.154
protein phosphorylation GO:0006468 345 0.152
Mouse
cellular ion homeostasis GO:0006873 184 0.151
response to external biotic stimulus GO:0043207 221 0.148
regulation of protein metabolic process GO:0051246 289 0.136
Mouse
behavior GO:0007610 205 0.135
negative regulation of apoptotic process GO:0043066 181 0.133
circulatory system development GO:0072359 134 0.132
positive regulation of phosphorus metabolic process GO:0010562 262 0.131
Mouse
cellular response to endogenous stimulus GO:0071495 377 0.130
regulation of metal ion transport GO:0010959 118 0.130
neuron projection development GO:0031175 273 0.128
cellular chemical homeostasis GO:0055082 247 0.126
response to decreased oxygen levels GO:0036293 237 0.125
regulation of cellular protein metabolic process GO:0032268 267 0.123
Mouse
cellular catabolic process GO:0044248 295 0.121
Human Mouse Rat
regulation of phosphorus metabolic process GO:0051174 349 0.119
Mouse Rat
cellular response to hormone stimulus GO:0032870 247 0.117
epithelial cell differentiation GO:0030855 71 0.113
Rat
biological adhesion GO:0022610 110 0.113
immune system process GO:0002376 204 0.112
Mouse
cellular component morphogenesis GO:0032989 155 0.111
negative regulation of rna metabolic process GO:0051253 123 0.110
regulation of mapk cascade GO:0043408 116 0.108
Mouse
regulation of nervous system development GO:0051960 264 0.107
negative regulation of cellular metabolic process GO:0031324 281 0.107
Rat
action potential GO:0001508 54 0.105
transcription dna templated GO:0006351 377 0.104
regulation of cellular component organization GO:0051128 368 0.102
ion homeostasis GO:0050801 212 0.102
synaptic transmission GO:0007268 235 0.101
rna biosynthetic process GO:0032774 380 0.098
cell part morphogenesis GO:0032990 123 0.098
positive regulation of phosphorylation GO:0042327 177 0.097
Mouse
cell morphogenesis GO:0000902 142 0.097
regulation of neurogenesis GO:0050767 247 0.097
single organism behavior GO:0044708 130 0.097
regulation of cell differentiation GO:0045595 320 0.097
Mouse
negative regulation of cellular biosynthetic process GO:0031327 161 0.097
Rat
head development GO:0060322 247 0.096
positive regulation of molecular function GO:0044093 230 0.093
Mouse
chemical homeostasis GO:0048878 292 0.093
response to corticosteroid GO:0031960 235 0.093
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.092
response to purine containing compound GO:0014074 126 0.091
regulation of cellular component movement GO:0051270 150 0.091
response to oxidative stress GO:0006979 186 0.090
divalent metal ion transport GO:0070838 132 0.090
response to estrogen GO:0043627 232 0.089
cation homeostasis GO:0055080 195 0.089
central nervous system development GO:0007417 311 0.088
cellular response to stress GO:0033554 269 0.088
negative regulation of cell death GO:0060548 229 0.086
cell chemotaxis GO:0060326 31 0.086
regulation of catalytic activity GO:0050790 304 0.086
Mouse
single organism biosynthetic process GO:0044711 342 0.085
Rat
positive regulation of protein serine threonine kinase activity GO:0071902 52 0.085
Mouse
response to glucocorticoid GO:0051384 223 0.083
positive regulation of protein kinase activity GO:0045860 73 0.082
Mouse
positive regulation of biosynthetic process GO:0009891 319 0.082
cellular response to corticosteroid stimulus GO:0071384 69 0.082
taxis GO:0042330 67 0.082
apoptotic process GO:0006915 381 0.081
positive regulation of cellular protein metabolic process GO:0032270 167 0.079
Mouse
cell projection morphogenesis GO:0048858 123 0.079
reactive oxygen species metabolic process GO:0072593 37 0.078
negative regulation of programmed cell death GO:0043069 183 0.077
regulation of transcription dna templated GO:0006355 374 0.077
anterior posterior pattern specification GO:0009952 1 0.076
regulation of membrane potential GO:0042391 110 0.076
regulation of behavior GO:0050795 61 0.076
positive regulation of protein metabolic process GO:0051247 178 0.075
Mouse
secretion GO:0046903 307 0.075
positive regulation of mapk cascade GO:0043410 92 0.074
Mouse
locomotion GO:0040011 237 0.074
cellular component biogenesis GO:0044085 368 0.073
regulation of nucleic acid templated transcription GO:1903506 380 0.073
regulation of protein phosphorylation GO:0001932 183 0.073
Mouse
negative regulation of gene expression GO:0010629 199 0.073
transcription from rna polymerase ii promoter GO:0006366 252 0.072
positive regulation of multicellular organismal process GO:0051240 387 0.072
response to peptide hormone GO:0043434 278 0.072
metal ion homeostasis GO:0055065 186 0.072
regulation of cell development GO:0060284 263 0.071
Mouse
single organism reproductive process GO:0044702 297 0.070
Mouse
regulation of calcium ion transport GO:0051924 77 0.070
negative regulation of metabolic process GO:0009892 331 0.069
Rat
calcium ion transport GO:0006816 131 0.069
programmed cell death GO:0012501 392 0.069
intracellular transport GO:0046907 185 0.069
Rat
negative regulation of developmental process GO:0051093 125 0.069
regulation of apoptotic process GO:0042981 335 0.068
reproduction GO:0000003 245 0.068
Mouse
response to inorganic substance GO:0010035 377 0.068
cellular metal ion homeostasis GO:0006875 172 0.068
heart morphogenesis GO:0003007 3 0.068
cellular component movement GO:0006928 248 0.068
heart process GO:0003015 57 0.067
positive regulation of signal transduction GO:0009967 175 0.067
Mouse
positive regulation of cell proliferation GO:0008284 249 0.067
positive regulation of phosphate metabolic process GO:0045937 262 0.067
Mouse
positive regulation of nervous system development GO:0051962 178 0.067
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.066
Rat
regulation of kinase activity GO:0043549 117 0.066
Mouse
response to lipopolysaccharide GO:0032496 191 0.066
regulation of programmed cell death GO:0043067 341 0.065
regulation of anatomical structure morphogenesis GO:0022603 141 0.065
immune response GO:0006955 104 0.064
cation transmembrane transport GO:0098655 263 0.064
monovalent inorganic cation transport GO:0015672 172 0.063
cardiovascular system development GO:0072358 134 0.063
rna metabolic process GO:0016070 406 0.063
nucleic acid templated transcription GO:0097659 379 0.062
muscle contraction GO:0006936 88 0.061
Mouse
regulation of muscle cell apoptotic process GO:0010660 26 0.061
positive regulation of protein phosphorylation GO:0001934 135 0.061
Mouse
single organism catabolic process GO:0044712 283 0.060
Human Mouse Rat
regulation of body fluid levels GO:0050878 90 0.060
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.060
intracellular signal transduction GO:0035556 314 0.060
Mouse Rat
renal system process GO:0003014 40 0.059
carbohydrate derivative metabolic process GO:1901135 346 0.059
Human Mouse Rat Fly
mast cell migration GO:0097531 4 0.059
heart contraction GO:0060047 57 0.059
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.058
steroid metabolic process GO:0008202 73 0.058
calcium ion homeostasis GO:0055074 162 0.058
cellular cation homeostasis GO:0030003 180 0.058
regulation of rna metabolic process GO:0051252 391 0.057
homeostatic process GO:0042592 331 0.057
hepaticobiliary system development GO:0061008 90 0.056
cell cell signaling GO:0007267 335 0.055
Fly
response to transforming growth factor beta GO:0071559 46 0.055
regulation of cell migration GO:0030334 128 0.055
cell motility GO:0048870 202 0.054
sensory perception GO:0007600 101 0.053
protein localization GO:0008104 191 0.053
Rat
skeletal system development GO:0001501 41 0.053
neuromuscular process GO:0050905 2 0.053
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.052
neuron projection morphogenesis GO:0048812 122 0.052
cell adhesion GO:0007155 110 0.052
protein complex subunit organization GO:0071822 302 0.052
aging GO:0007568 241 0.051
positive regulation of transport GO:0051050 245 0.051
cell type specific apoptotic process GO:0097285 134 0.051
positive regulation of signaling GO:0023056 270 0.051
Mouse
negative regulation of cell differentiation GO:0045596 99 0.051
response to molecule of bacterial origin GO:0002237 194 0.050
response to estradiol GO:0032355 164 0.050
positive regulation of neurogenesis GO:0050769 165 0.049
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.049
response to growth factor GO:0070848 189 0.049
cellular amine metabolic process GO:0044106 38 0.048
positive regulation of cellular biosynthetic process GO:0031328 295 0.048
transmembrane transport GO:0055085 412 0.048
negative regulation of neuron differentiation GO:0045665 62 0.048
organ morphogenesis GO:0009887 75 0.048
oxoacid metabolic process GO:0043436 290 0.048
calcium ion transmembrane transport GO:0070588 70 0.047
negative regulation of cell development GO:0010721 82 0.047
regulation of cellular localization GO:0060341 263 0.047
positive regulation of nucleic acid templated transcription GO:1903508 197 0.047
regulation of cardiac muscle contraction GO:0055117 17 0.047
Mouse
positive regulation of intracellular signal transduction GO:1902533 138 0.047
Mouse
regulation of cell motility GO:2000145 131 0.046
regulation of transferase activity GO:0051338 123 0.046
Mouse
regulation of reactive oxygen species metabolic process GO:2000377 26 0.045
cellular lipid metabolic process GO:0044255 208 0.045
negative regulation of nervous system development GO:0051961 79 0.045
leukocyte activation GO:0045321 76 0.045
Mouse
regulation of molecular function GO:0065009 398 0.045
Mouse
neural crest cell differentiation GO:0014033 2 0.044
positive regulation of kinase activity GO:0033674 77 0.044
Mouse
regulation of immune system process GO:0002682 123 0.044
Mouse
cellular amino acid metabolic process GO:0006520 107 0.044
chemotaxis GO:0006935 66 0.044
cellular response to growth factor stimulus GO:0071363 162 0.043
positive regulation of protein modification process GO:0031401 142 0.043
Mouse
regulation of phosphorylation GO:0042325 248 0.043
Mouse
rhythmic process GO:0048511 156 0.043
muscle system process GO:0003012 115 0.043
Mouse
lymphocyte chemotaxis GO:0048247 3 0.043
regulation of sodium ion transport GO:0002028 21 0.042
positive regulation of transcription dna templated GO:0045893 197 0.041
regulation of synaptic transmission GO:0050804 141 0.041
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.041
regulation of response to stress GO:0080134 126 0.040
carbohydrate derivative biosynthetic process GO:1901137 124 0.040
Rat
cellular modified amino acid metabolic process GO:0006575 61 0.040
regulation of protein kinase activity GO:0045859 105 0.039
Mouse
single organism intracellular transport GO:1902582 166 0.039
Rat
localization of cell GO:0051674 202 0.038
regulation of rna biosynthetic process GO:2001141 381 0.038
carboxylic acid metabolic process GO:0019752 289 0.038
positive regulation of secretion GO:0051047 140 0.038
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.038
inorganic cation transmembrane transport GO:0098662 202 0.037
cell activation GO:0001775 97 0.037
Mouse
protein complex assembly GO:0006461 263 0.037
melanocyte differentiation GO:0030318 2 0.037
response to nutrient GO:0007584 248 0.037
glycerolipid metabolic process GO:0046486 67 0.037
cellular homeostasis GO:0019725 252 0.036
heart development GO:0007507 72 0.036
striated muscle tissue development GO:0014706 58 0.036
regulation of locomotion GO:0040012 148 0.036
blood vessel development GO:0001568 69 0.036
cellular component assembly GO:0022607 360 0.035
actin mediated cell contraction GO:0070252 12 0.035
negative regulation of macromolecule metabolic process GO:0010605 260 0.035
endoplasmic reticulum to cytosol transport GO:1903513 4 0.035
reproductive process GO:0022414 372 0.035
Mouse
inorganic ion transmembrane transport GO:0098660 229 0.035
eye development GO:0001654 50 0.035
negative regulation of transport GO:0051051 136 0.035
proteolysis GO:0006508 175 0.035
negative regulation of cellular component organization GO:0051129 83 0.035
regulation of cell projection organization GO:0031344 175 0.035
response to ketone GO:1901654 182 0.035
macromolecular complex subunit organization GO:0043933 339 0.035
regulation of neuron differentiation GO:0045664 208 0.034
regulation of protein modification process GO:0031399 194 0.034
Mouse
positive regulation of cell communication GO:0010647 271 0.034
Mouse
negative regulation of rna biosynthetic process GO:1902679 118 0.034
cytoskeleton organization GO:0007010 111 0.034
establishment of protein localization GO:0045184 141 0.034
Rat
potassium ion transport GO:0006813 97 0.034
divalent inorganic cation homeostasis GO:0072507 165 0.034
mast cell chemotaxis GO:0002551 4 0.034
positive regulation of response to stimulus GO:0048584 285 0.034
regulation of heart contraction GO:0008016 48 0.033
multicellular organismal signaling GO:0035637 44 0.033
blood circulation GO:0008015 183 0.033
regulation of neuron projection development GO:0010975 161 0.033
regulation of muscle system process GO:0090257 79 0.033
Mouse
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.033
cell migration GO:0016477 197 0.032
negative regulation of phosphate metabolic process GO:0045936 80 0.032
Rat
response to biotic stimulus GO:0009607 226 0.032
circadian rhythm GO:0007623 88 0.032
positive regulation of cytokine production GO:0001819 42 0.032
cytoplasmic transport GO:0016482 115 0.032
Rat
response to oxygen levels GO:0070482 265 0.032
regulation of monooxygenase activity GO:0032768 8 0.031
cellular divalent inorganic cation homeostasis GO:0072503 162 0.031
single organism organelle organization GO:1902589 180 0.031
cellular response to glucocorticoid stimulus GO:0071385 68 0.031
cytosolic calcium ion homeostasis GO:0051480 140 0.031
amine metabolic process GO:0009308 38 0.031
organic acid metabolic process GO:0006082 292 0.030
positive regulation of rna biosynthetic process GO:1902680 197 0.029
cell cycle GO:0007049 101 0.029
anion transport GO:0006820 178 0.029
neural crest cell development GO:0014032 2 0.029
negative regulation of neurogenesis GO:0050768 78 0.029
axon development GO:0061564 96 0.028
organic substance catabolic process GO:1901575 316 0.028
Human Mouse Rat
activation of protein kinase activity GO:0032147 47 0.028
cellular response to nitrogen compound GO:1901699 210 0.028
liver development GO:0001889 90 0.028
catabolic process GO:0009056 351 0.028
Human Mouse Rat
response to metal ion GO:0010038 253 0.027
cellular calcium ion homeostasis GO:0006874 160 0.027
regulation of exocytosis GO:0017157 37 0.027
actin filament based process GO:0030029 86 0.027
cellular response to organonitrogen compound GO:0071417 197 0.027
negative regulation of neuron apoptotic process GO:0043524 45 0.027
myeloid leukocyte activation GO:0002274 36 0.027
organelle organization GO:0006996 266 0.027
Rat
negative regulation of response to stimulus GO:0048585 155 0.026
signal release GO:0023061 145 0.026
response to cytokine GO:0034097 215 0.026
multi organism reproductive process GO:0044703 262 0.026
Mouse
regulation of neuron death GO:1901214 115 0.026
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.026
neurological system process GO:0050877 219 0.026
negative regulation of molecular function GO:0044092 133 0.025
forebrain development GO:0030900 98 0.025
positive regulation of cell development GO:0010720 176 0.025
Mouse
response to organophosphorus GO:0046683 102 0.025
organ regeneration GO:0031100 101 0.025
sequestering of metal ion GO:0051238 9 0.025
negative regulation of transcription dna templated GO:0045892 116 0.025
regulation of tube size GO:0035150 89 0.024
positive regulation of cell differentiation GO:0045597 217 0.024
Mouse
amide transport GO:0042886 105 0.024
regulation of cellular response to stress GO:0080135 49 0.024
negative regulation of muscle cell apoptotic process GO:0010656 21 0.024
response to acid chemical GO:0001101 222 0.024
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.023
positive regulation of ion transport GO:0043270 94 0.023
lymphocyte migration GO:0072676 3 0.023
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.023
response to nutrient levels GO:0031667 370 0.023
cytokine production GO:0001816 61 0.022
cellular macromolecule localization GO:0070727 122 0.022
Rat
lipid metabolic process GO:0006629 283 0.022
vasculature development GO:0001944 70 0.022
urogenital system development GO:0001655 78 0.022
neural crest cell migration GO:0001755 1 0.022
regulation of intracellular signal transduction GO:1902531 218 0.022
Mouse
calcium mediated signaling GO:0019722 23 0.022
tube development GO:0035295 89 0.022
behavioral response to ethanol GO:0048149 1 0.022
autonomic nervous system development GO:0048483 3 0.022
purine ribonucleotide biosynthetic process GO:0009152 81 0.022
Rat
positive regulation of programmed cell death GO:0043068 157 0.022
g protein coupled receptor signaling pathway GO:0007186 242 0.022
muscle cell apoptotic process GO:0010657 30 0.021
growth GO:0040007 165 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.021
Rat
positive regulation of immune system process GO:0002684 90 0.021
regulation of epithelial cell differentiation GO:0030856 12 0.021
vesicle mediated transport GO:0016192 181 0.021
axis specification GO:0009798 4 0.021
cellular modified amino acid biosynthetic process GO:0042398 18 0.021
immune system development GO:0002520 41 0.021
nitrogen compound transport GO:0071705 229 0.021
muscle tissue development GO:0060537 58 0.020
regulation of homeostatic process GO:0032844 101 0.020
negative regulation of signal transduction GO:0009968 83 0.020
cell cycle process GO:0022402 57 0.020
positive regulation of cellular amine metabolic process GO:0033240 3 0.020
response to extracellular stimulus GO:0009991 380 0.020
skeletal muscle tissue development GO:0007519 31 0.020
regulation of calcium ion transmembrane transport GO:1903169 18 0.020
maintenance of location GO:0051235 17 0.020
protein oligomerization GO:0051259 191 0.020
response to camp GO:0051591 91 0.020
regulation of hormone levels GO:0010817 187 0.020
regulation of response to external stimulus GO:0032101 106 0.020
regulation of striated muscle contraction GO:0006942 21 0.020
Mouse
tissue morphogenesis GO:0048729 22 0.020
myeloid leukocyte differentiation GO:0002573 20 0.019
cellular response to insulin stimulus GO:0032869 81 0.019
axonogenesis GO:0007409 71 0.019
multicellular organismal reproductive process GO:0048609 233 0.019
Mouse
regulation of cellular amino acid metabolic process GO:0006521 2 0.019
regulation of growth GO:0040008 105 0.019
regulation of leukocyte migration GO:0002685 24 0.019
tissue remodeling GO:0048771 40 0.019
protein kinase c activating g protein coupled receptor signaling pathway GO:0007205 12 0.019
negative regulation of neuron death GO:1901215 69 0.019
peptidyl amino acid modification GO:0018193 126 0.018
negative regulation of neutrophil apoptotic process GO:0033030 3 0.018
positive regulation of transferase activity GO:0051347 81 0.018
Mouse
cellular response to peptide hormone stimulus GO:0071375 120 0.018
negative regulation of protein metabolic process GO:0051248 114 0.018
nucleobase containing small molecule metabolic process GO:0055086 316 0.018
Human Mouse Rat Fly
negative regulation of cell cycle phase transition GO:1901988 4 0.018
salivary gland development GO:0007431 3 0.018
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.018
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.018
release of sequestered calcium ion into cytosol GO:0051209 25 0.018
organonitrogen compound biosynthetic process GO:1901566 167 0.018
Rat
regulation of stem cell proliferation GO:0072091 14 0.018
renal filtration GO:0097205 10 0.017
small gtpase mediated signal transduction GO:0007264 36 0.017
multicellular organism reproduction GO:0032504 233 0.017
Mouse
mitotic cell cycle GO:0000278 49 0.017
organonitrogen compound catabolic process GO:1901565 179 0.017
Human Mouse Rat
leukocyte chemotaxis GO:0030595 22 0.017
embryonic pattern specification GO:0009880 1 0.017
positive regulation of gene expression GO:0010628 244 0.017
regulation of protein localization GO:0032880 81 0.017
negative regulation of osteoblast differentiation GO:0045668 2 0.017
response to ethanol GO:0045471 162 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
response to dexamethasone GO:0071548 49 0.017
negative regulation of nucleic acid templated transcription GO:1903507 117 0.017
cellular nitrogen compound catabolic process GO:0044270 163 0.017
Human Mouse Rat
angioblast cell migration GO:0035476 1 0.016
developmental process involved in reproduction GO:0003006 159 0.016
Mouse
leukocyte mediated immunity GO:0002443 28 0.016
peptidyl tyrosine phosphorylation GO:0018108 72 0.016
response to reactive oxygen species GO:0000302 120 0.016
kidney development GO:0001822 67 0.016
macromolecular complex assembly GO:0065003 273 0.016
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.016
response to transition metal nanoparticle GO:1990267 122 0.016
hematopoietic or lymphoid organ development GO:0048534 36 0.016
cell morphogenesis involved in differentiation GO:0000904 119 0.016
response to antibiotic GO:0046677 39 0.016
positive regulation of neuron projection development GO:0010976 99 0.016
muscle structure development GO:0061061 87 0.016
cellular response to cytokine stimulus GO:0071345 127 0.016
sensory organ development GO:0007423 74 0.015
gland development GO:0048732 155 0.015
sodium ion transport GO:0006814 82 0.015
sequestering of calcium ion GO:0051208 8 0.015
calcium ion transport from endoplasmic reticulum to cytosol GO:1903514 4 0.015
regulation of jnk cascade GO:0046328 19 0.015
regulation of cellular ketone metabolic process GO:0010565 27 0.015
cardiac muscle cell contraction GO:0086003 10 0.015
muscle organ development GO:0007517 50 0.015
sensory perception of pain GO:0019233 73 0.015
positive regulation of neural precursor cell proliferation GO:2000179 10 0.015
mitotic cell cycle phase transition GO:0044772 20 0.015
skin morphogenesis GO:0043589 2 0.015
cell cycle checkpoint GO:0000075 2 0.015
cytokine biosynthetic process GO:0042089 3 0.015
regulation of cytokine production GO:0001817 56 0.015
calcium ion transport into cytosol GO:0060402 38 0.015
eye morphogenesis GO:0048592 4 0.015
dna integrity checkpoint GO:0031570 2 0.015
embryonic skeletal system development GO:0048706 3 0.015
negative regulation of neuron projection development GO:0010977 46 0.015
signal transduction by phosphorylation GO:0023014 144 0.015
Mouse
cell growth GO:0016049 104 0.015
male gamete generation GO:0048232 99 0.015
anatomical structure formation involved in morphogenesis GO:0048646 83 0.015
mesoderm development GO:0007498 2 0.015
reactive nitrogen species metabolic process GO:2001057 1 0.014
cardiac conduction GO:0061337 2 0.014
response to calcium ion GO:0051592 59 0.014
organophosphate catabolic process GO:0046434 148 0.014
Human Mouse Rat
regulation of smooth muscle cell proliferation GO:0048660 75 0.014
cellular protein localization GO:0034613 122 0.014
Rat
positive regulation of cell motility GO:2000147 97 0.014
motor neuron axon guidance GO:0008045 1 0.014
protein complex biogenesis GO:0070271 263 0.014
single organismal cell cell adhesion GO:0016337 42 0.014
camp metabolic process GO:0046058 63 0.014
Rat Fly
negative regulation of long term synaptic potentiation GO:1900272 1 0.014
protein transport GO:0015031 132 0.014
Rat
positive regulation of stem cell proliferation GO:2000648 13 0.014
dendrite development GO:0016358 72 0.014
actin cytoskeleton organization GO:0030036 73 0.014
response to monosaccharide GO:0034284 159 0.014
cytosolic calcium ion transport GO:0060401 39 0.014
sexual reproduction GO:0019953 148 0.014
Mouse
macromolecule localization GO:0033036 252 0.014
Rat
positive regulation of cell migration GO:0030335 96 0.014
alcohol metabolic process GO:0006066 77 0.013
regulation of secretion by cell GO:1903530 208 0.013
positive regulation of calcium ion transport GO:0051928 36 0.013
acute inflammatory response GO:0002526 58 0.013
negative regulation of homeostatic process GO:0032845 47 0.013
erk1 and erk2 cascade GO:0070371 48 0.013
regulation of vesicle mediated transport GO:0060627 81 0.013
steroid biosynthetic process GO:0006694 48 0.013
purine nucleotide metabolic process GO:0006163 229 0.013
Human Mouse Rat Fly
regulation of lipid metabolic process GO:0019216 68 0.013
ion transmembrane transport GO:0034220 365 0.013
negative regulation of secretion by cell GO:1903531 72 0.013
regulation of intracellular transport GO:0032386 65 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.013
learning or memory GO:0007611 90 0.013
positive regulation of cell death GO:0010942 184 0.013
negative regulation of biosynthetic process GO:0009890 168 0.013
Rat
regulation of cell cycle phase transition GO:1901987 12 0.013
positive regulation of map kinase activity GO:0043406 46 0.013
Mouse
muscle cell proliferation GO:0033002 84 0.013
cellular response to steroid hormone stimulus GO:0071383 93 0.013
protein autophosphorylation GO:0046777 66 0.013
camera type eye development GO:0043010 48 0.013
actin filament based movement GO:0030048 16 0.013
carbohydrate derivative catabolic process GO:1901136 147 0.012
Human Mouse Rat
transmission of nerve impulse GO:0019226 42 0.012
glycoprotein biosynthetic process GO:0009101 19 0.012
salivary gland morphogenesis GO:0007435 1 0.012
hormone biosynthetic process GO:0042446 25 0.012

Pde5a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.064
nervous system disease DOID:863 0 0.064
central nervous system disease DOID:331 0 0.061
disease of metabolism DOID:0014667 0 0.030
inherited metabolic disorder DOID:655 0 0.030
brain disease DOID:936 0 0.018