Rattus norvegicus

307 known processes

Smad3

SMAD family member 3

(Aliases: Madh3)

Smad3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
enzyme linked receptor protein signaling pathway GO:0007167 116 0.725
regulation of cell proliferation GO:0042127 359 0.659
positive regulation of cell migration GO:0030335 96 0.511
regulation of nucleic acid templated transcription GO:1903506 380 0.506
protein phosphorylation GO:0006468 345 0.474
Human
mapk cascade GO:0000165 140 0.455
Rat
regulation of lipid metabolic process GO:0019216 68 0.444
epithelial cell proliferation GO:0050673 54 0.425
Mouse
positive regulation of signaling GO:0023056 270 0.419
striated muscle contraction GO:0006941 44 0.372
regulation of cell motility GO:2000145 131 0.342
regulation of cellular localization GO:0060341 263 0.330
Human
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.325
positive regulation of cell communication GO:0010647 271 0.312
positive regulation of developmental process GO:0051094 283 0.308
heart development GO:0007507 72 0.304
Mouse
regulation of locomotion GO:0040012 148 0.302
cell motility GO:0048870 202 0.286
single organism biosynthetic process GO:0044711 342 0.280
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.277
response to estrogen GO:0043627 232 0.277
Rat
multi multicellular organism process GO:0044706 138 0.276
regulation of apoptotic process GO:0042981 335 0.275
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.274
response to carbohydrate GO:0009743 183 0.260
apoptotic process GO:0006915 381 0.258
negative regulation of metabolic process GO:0009892 331 0.248
regulation of cell migration GO:0030334 128 0.247
blood circulation GO:0008015 183 0.247
neuron development GO:0048666 286 0.244
Rat
intracellular signal transduction GO:0035556 314 0.244
Human Rat
response to corticosteroid GO:0031960 235 0.243
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 51 0.239
positive regulation of cell motility GO:2000147 97 0.239
regulation of phosphate metabolic process GO:0019220 349 0.237
nucleic acid templated transcription GO:0097659 379 0.233
regulation of molecular function GO:0065009 398 0.226
positive regulation of cell proliferation GO:0008284 249 0.220
regulation of anatomical structure morphogenesis GO:0022603 141 0.216
Human Rat
positive regulation of phosphate metabolic process GO:0045937 262 0.213
negative regulation of rna biosynthetic process GO:1902679 118 0.213
cellular response to endogenous stimulus GO:0071495 377 0.212
positive regulation of nucleic acid templated transcription GO:1903508 197 0.211
regulation of cell development GO:0060284 263 0.210
Human Rat
regulation of cellular component movement GO:0051270 150 0.208
positive regulation of locomotion GO:0040017 102 0.207
regulation of rna metabolic process GO:0051252 391 0.206
regulation of synaptic transmission GO:0050804 141 0.206
positive regulation of biosynthetic process GO:0009891 319 0.205
cellular ketone metabolic process GO:0042180 51 0.205
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.204
cellular amino acid metabolic process GO:0006520 107 0.203
negative regulation of cell death GO:0060548 229 0.202
cardiovascular system development GO:0072358 134 0.200
Mouse
lipid metabolic process GO:0006629 283 0.199
positive regulation of cellular component movement GO:0051272 102 0.199
positive regulation of phosphorus metabolic process GO:0010562 262 0.189
regulation of postsynaptic membrane potential GO:0060078 25 0.186
regulation of peptide transport GO:0090087 87 0.180
synaptic transmission GO:0007268 235 0.178
regulation of phosphorus metabolic process GO:0051174 349 0.173
anatomical structure morphogenesis GO:0009653 298 0.167
Human Mouse Rat
organonitrogen compound biosynthetic process GO:1901566 167 0.167
regulation of programmed cell death GO:0043067 341 0.167
positive regulation of secretion by cell GO:1903532 128 0.165
regulation of tube size GO:0035150 89 0.162
positive regulation of protein kinase activity GO:0045860 73 0.158
rhythmic process GO:0048511 156 0.155
tissue development GO:0009888 252 0.154
positive regulation of cellular biosynthetic process GO:0031328 295 0.152
negative regulation of apoptotic process GO:0043066 181 0.151
regulation of neurogenesis GO:0050767 247 0.150
Rat
homeostatic process GO:0042592 331 0.148
positive regulation of transport GO:0051050 245 0.143
Human
single organism reproductive process GO:0044702 297 0.141
Rat
regulation of protein phosphorylation GO:0001932 183 0.141
Human
transcription from rna polymerase ii promoter GO:0006366 252 0.140
organic acid metabolic process GO:0006082 292 0.138
multicellular organism growth GO:0035264 1 0.138
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.138
regulation of system process GO:0044057 208 0.135
multicellular organismal reproductive process GO:0048609 233 0.135
negative regulation of programmed cell death GO:0043069 183 0.133
rna metabolic process GO:0016070 406 0.132
regulation of phosphorylation GO:0042325 248 0.129
Human
negative regulation of biosynthetic process GO:0009890 168 0.128
regulation of neuron death GO:1901214 115 0.127
cellular component movement GO:0006928 248 0.126
regulation of secretion by cell GO:1903530 208 0.124
regulation of blood vessel size GO:0050880 89 0.124
response to insulin GO:0032868 133 0.122
regulation of transcription dna templated GO:0006355 374 0.121
secretion GO:0046903 307 0.120
glycogen metabolic process GO:0005977 23 0.120
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.118
secretion by cell GO:0032940 248 0.117
regulation of cellular ketone metabolic process GO:0010565 27 0.117
regulation of protein kinase activity GO:0045859 105 0.116
central nervous system development GO:0007417 311 0.115
cognition GO:0050890 92 0.115
regulation of dopamine secretion GO:0014059 15 0.114
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.113
carboxylic acid metabolic process GO:0019752 289 0.113
response to ethanol GO:0045471 162 0.112
synaptic transmission glutamatergic GO:0035249 33 0.111
positive regulation of signal transduction GO:0009967 175 0.111
cellular response to oxygen containing compound GO:1901701 386 0.110
smooth muscle cell migration GO:0014909 36 0.109
response to toxic substance GO:0009636 133 0.105
multi organism reproductive process GO:0044703 262 0.105
cellular response to growth factor stimulus GO:0071363 162 0.104
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.103
programmed cell death GO:0012501 392 0.103
response to mechanical stimulus GO:0009612 134 0.103
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.102
positive regulation of cell differentiation GO:0045597 217 0.102
Human Mouse Rat
negative regulation of cell proliferation GO:0008285 119 0.100
muscle structure development GO:0061061 87 0.099
Mouse
regulation of signal transduction GO:0009966 318 0.098
regulation of homeostatic process GO:0032844 101 0.098
positive regulation of cell development GO:0010720 176 0.097
Human Rat
response to inorganic substance GO:0010035 377 0.097
monoamine transport GO:0015844 43 0.096
regulation of growth GO:0040008 105 0.095
Human
neuron differentiation GO:0030182 368 0.095
Rat
positive regulation of multicellular organismal process GO:0051240 387 0.094
regulation of anatomical structure size GO:0090066 135 0.093
cellular response to hormone stimulus GO:0032870 247 0.093
regulation of hormone secretion GO:0046883 106 0.092
amine metabolic process GO:0009308 38 0.092
rna biosynthetic process GO:0032774 380 0.091
regulation of transferase activity GO:0051338 123 0.091
regulation of cell growth GO:0001558 85 0.091
Human
cellular carbohydrate metabolic process GO:0044262 72 0.090
positive regulation of secretion GO:0051047 140 0.089
dopamine secretion GO:0014046 15 0.088
regulation of mesenchymal cell proliferation GO:0010464 4 0.088
cell migration GO:0016477 197 0.087
behavior GO:0007610 205 0.087
regulation of intracellular signal transduction GO:1902531 218 0.086
peptidyl amino acid modification GO:0018193 126 0.085
muscle cell proliferation GO:0033002 84 0.084
positive regulation of kinase activity GO:0033674 77 0.084
regulation of blood circulation GO:1903522 110 0.084
positive regulation of protein phosphorylation GO:0001934 135 0.084
regulation of catecholamine secretion GO:0050433 32 0.084
calcium ion homeostasis GO:0055074 162 0.083
negative regulation of transport GO:0051051 136 0.082
response to peptide GO:1901652 292 0.082
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.082
regulation of rna biosynthetic process GO:2001141 381 0.082
regulation of peptide hormone secretion GO:0090276 80 0.081
regulation of mapk cascade GO:0043408 116 0.081
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.081
negative regulation of gene expression GO:0010629 199 0.081
response to estradiol GO:0032355 164 0.081
response to ammonium ion GO:0060359 71 0.081
chemical homeostasis GO:0048878 292 0.081
oxidation reduction process GO:0055114 304 0.080
aging GO:0007568 241 0.080
single organism behavior GO:0044708 130 0.080
regulation of kinase activity GO:0043549 117 0.079
response to peptide hormone GO:0043434 278 0.079
cation transport GO:0006812 382 0.079
positive regulation of neurogenesis GO:0050769 165 0.078
Rat
adenylate cyclase inhibiting g protein coupled receptor signaling pathway GO:0007193 19 0.078
vascular process in circulatory system GO:0003018 96 0.078
regulation of multicellular organismal development GO:2000026 376 0.078
positive regulation of behavior GO:0048520 38 0.077
response to wounding GO:0009611 254 0.077
Mouse Rat
muscle contraction GO:0006936 88 0.076
cell morphogenesis involved in differentiation GO:0000904 119 0.075
Human Rat
cellular glucan metabolic process GO:0006073 23 0.075
response to ketone GO:1901654 182 0.075
regulation of epithelial cell proliferation GO:0050678 49 0.075
Mouse
developmental process involved in reproduction GO:0003006 159 0.075
Rat
negative regulation of cellular metabolic process GO:0031324 281 0.075
negative regulation of macromolecule metabolic process GO:0010605 260 0.074
mesenchymal cell proliferation GO:0010463 4 0.074
regulation of smooth muscle cell migration GO:0014910 36 0.074
monocarboxylic acid metabolic process GO:0032787 152 0.073
hepaticobiliary system development GO:0061008 90 0.073
Mouse
nitrogen compound transport GO:0071705 229 0.073
positive regulation of growth GO:0045927 55 0.072
positive regulation of nervous system development GO:0051962 178 0.072
Rat
negative regulation of nucleic acid templated transcription GO:1903507 117 0.072
circulatory system development GO:0072359 134 0.072
Mouse
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.072
synaptic transmission gabaergic GO:0051932 22 0.071
negative regulation of growth GO:0045926 37 0.071
Human
polysaccharide metabolic process GO:0005976 25 0.071
localization of cell GO:0051674 202 0.071
negative regulation of signaling GO:0023057 157 0.071
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.071
Human Rat
regulation of cell differentiation GO:0045595 320 0.070
Human Mouse Rat
female pregnancy GO:0007565 122 0.070
ribose phosphate metabolic process GO:0019693 235 0.070
cellular component biogenesis GO:0044085 368 0.069
regulation of neuron projection development GO:0010975 161 0.069
Rat
regulation of membrane potential GO:0042391 110 0.069
astrocyte development GO:0014002 4 0.069
cell cell signaling GO:0007267 335 0.069
muscle cell migration GO:0014812 36 0.069
positive regulation of rna metabolic process GO:0051254 203 0.069
regulation of monooxygenase activity GO:0032768 8 0.069
actin filament based process GO:0030029 86 0.068
single organism catabolic process GO:0044712 283 0.068
energy derivation by oxidation of organic compounds GO:0015980 46 0.068
response to dexamethasone GO:0071548 49 0.068
negative regulation of rna metabolic process GO:0051253 123 0.068
regulation of peptide secretion GO:0002791 82 0.068
catecholamine transport GO:0051937 37 0.067
response to monosaccharide GO:0034284 159 0.067
cation homeostasis GO:0055080 195 0.066
circulatory system process GO:0003013 183 0.066
positive regulation of response to stimulus GO:0048584 285 0.066
regulation of cellular amine metabolic process GO:0033238 8 0.066
hormone transport GO:0009914 121 0.065
striated muscle tissue development GO:0014706 58 0.064
Mouse
response to nutrient levels GO:0031667 370 0.064
tube development GO:0035295 89 0.063
Mouse
regulation of dendrite development GO:0050773 59 0.063
Rat
response to hypoxia GO:0001666 231 0.063
Human
activation of protein kinase activity GO:0032147 47 0.062
positive regulation of cell projection organization GO:0031346 111 0.062
Rat
single organism membrane organization GO:0044802 74 0.062
regulation of cellular component organization GO:0051128 368 0.062
reproduction GO:0000003 245 0.062
cellular response to insulin stimulus GO:0032869 81 0.061
positive regulation of gene expression GO:0010628 244 0.061
cellular lipid metabolic process GO:0044255 208 0.061
cellular response to stress GO:0033554 269 0.061
organic hydroxy compound transport GO:0015850 77 0.061
muscle system process GO:0003012 115 0.060
positive regulation of chemotaxis GO:0050921 23 0.060
macromolecular complex assembly GO:0065003 273 0.060
regulation of ion transport GO:0043269 245 0.059
response to vitamin GO:0033273 131 0.059
sexual reproduction GO:0019953 148 0.059
ensheathment of neurons GO:0007272 40 0.058
positive regulation of amine transport GO:0051954 26 0.058
regulation of body fluid levels GO:0050878 90 0.058
purine ribonucleotide biosynthetic process GO:0009152 81 0.057
blood vessel development GO:0001568 69 0.057
vasoconstriction GO:0042310 54 0.057
glial cell differentiation GO:0010001 65 0.056
digestive system development GO:0055123 41 0.056
Mouse
artery smooth muscle contraction GO:0014824 4 0.056
reproductive process GO:0022414 372 0.056
Rat
muscle tissue development GO:0060537 58 0.056
Mouse
response to extracellular stimulus GO:0009991 380 0.056
response to cocaine GO:0042220 39 0.055
cellular component morphogenesis GO:0032989 155 0.055
Human Rat
small molecule biosynthetic process GO:0044283 124 0.055
regulation of protein modification process GO:0031399 194 0.055
Human
negative regulation of neuron death GO:1901215 69 0.054
cell projection organization GO:0030030 302 0.054
Rat
positive regulation of phosphorylation GO:0042327 177 0.052
regulation of cellular amino acid metabolic process GO:0006521 2 0.052
cellular amine metabolic process GO:0044106 38 0.052
locomotion GO:0040011 237 0.050
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.050
regulation of nervous system development GO:0051960 264 0.050
Rat
regulation of secretion GO:0051046 224 0.050
ribose phosphate biosynthetic process GO:0046390 87 0.049
cyclic purine nucleotide metabolic process GO:0052652 62 0.049
regulation of catalytic activity GO:0050790 304 0.049
regulation of nucleotide biosynthetic process GO:0030808 47 0.049
regulation of nitric oxide synthase activity GO:0050999 8 0.048
regulation of smooth muscle cell proliferation GO:0048660 75 0.048
neuron projection development GO:0031175 273 0.048
Rat
protein heterooligomerization GO:0051291 89 0.048
negative regulation of transcription dna templated GO:0045892 116 0.048
gliogenesis GO:0042063 93 0.047
regulation of lipid biosynthetic process GO:0046890 38 0.047
response to decreased oxygen levels GO:0036293 237 0.047
Human
positive regulation of molecular function GO:0044093 230 0.047
positive regulation of mapk cascade GO:0043410 92 0.047
negative regulation of multicellular organismal process GO:0051241 203 0.046
Mouse
positive regulation of neuron projection development GO:0010976 99 0.046
Rat
positive regulation of immune system process GO:0002684 90 0.046
ras protein signal transduction GO:0007265 29 0.045
endocytosis GO:0006897 84 0.045
regulation of stem cell proliferation GO:0072091 14 0.045
regulation of amine transport GO:0051952 54 0.045
cellular polysaccharide metabolic process GO:0044264 23 0.044
response to acid chemical GO:0001101 222 0.044
regulation of systemic arterial blood pressure by norepinephrine epinephrine GO:0001993 2 0.044
hormone secretion GO:0046879 115 0.044
protein complex assembly GO:0006461 263 0.044
catecholamine secretion GO:0050432 33 0.043
dendrite development GO:0016358 72 0.043
Rat
regulation of carbohydrate metabolic process GO:0006109 41 0.043
amine transport GO:0015837 57 0.043
positive regulation of rna biosynthetic process GO:1902680 197 0.043
lipid oxidation GO:0034440 30 0.043
head development GO:0060322 247 0.042
multicellular organism reproduction GO:0032504 233 0.042
forebrain development GO:0030900 98 0.042
behavioral response to nicotine GO:0035095 2 0.042
positive regulation of apoptotic process GO:0043065 154 0.042
reactive oxygen species metabolic process GO:0072593 37 0.042
response to glucose GO:0009749 136 0.042
regulation of blood pressure GO:0008217 83 0.041
regulation of cellular component biogenesis GO:0044087 86 0.041
oxoacid metabolic process GO:0043436 290 0.041
response to cytokine GO:0034097 215 0.041
cytosolic calcium ion homeostasis GO:0051480 140 0.041
regulation of sodium ion transport GO:0002028 21 0.041
monovalent inorganic cation transport GO:0015672 172 0.040
nuclear transport GO:0051169 49 0.040
Human
heterocycle catabolic process GO:0046700 167 0.040
transcription dna templated GO:0006351 377 0.040
cellular response to nitrogen compound GO:1901699 210 0.040
actin filament bundle assembly GO:0051017 19 0.040
cell growth GO:0016049 104 0.040
Human
cell activation GO:0001775 97 0.040
Mouse
brain development GO:0007420 247 0.039
positive regulation of the force of heart contraction by epinephrine norepinephrine GO:0001997 2 0.039
smooth muscle cell proliferation GO:0048659 77 0.039
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 27 0.039
single organism carbohydrate metabolic process GO:0044723 118 0.039
regulation of response to external stimulus GO:0032101 106 0.039
cell part morphogenesis GO:0032990 123 0.039
Rat
signal transduction by phosphorylation GO:0023014 144 0.038
Rat
negative regulation of cellular biosynthetic process GO:0031327 161 0.038
signal release GO:0023061 145 0.038
membrane organization GO:0061024 94 0.038
peptidyl serine phosphorylation GO:0018105 33 0.038
regulation of catabolic process GO:0009894 113 0.038
Human
regulation of hormone levels GO:0010817 187 0.038
cellular component assembly GO:0022607 360 0.038
ameboidal type cell migration GO:0001667 26 0.038
actomyosin structure organization GO:0031032 22 0.038
positive regulation of catalytic activity GO:0043085 184 0.038
astrocyte activation GO:0048143 4 0.037
serotonin receptor signaling pathway GO:0007210 10 0.037
negative regulation of cell differentiation GO:0045596 99 0.037
Mouse
muscle cell differentiation GO:0042692 52 0.037
circadian rhythm GO:0007623 88 0.037
estrous cycle phase GO:0060206 15 0.037
positive regulation of cellular amine metabolic process GO:0033240 3 0.036
neuron projection morphogenesis GO:0048812 122 0.036
Rat
generation of precursor metabolites and energy GO:0006091 62 0.036
cellular response to steroid hormone stimulus GO:0071383 93 0.036
vesicle mediated transport GO:0016192 181 0.035
positive regulation of transcription dna templated GO:0045893 197 0.035
divalent metal ion transport GO:0070838 132 0.035
negative regulation of developmental process GO:0051093 125 0.035
Mouse
divalent inorganic cation transport GO:0072511 134 0.035
glucose metabolic process GO:0006006 52 0.035
protein complex biogenesis GO:0070271 263 0.035
positive regulation of epithelial cell proliferation GO:0050679 32 0.035
positive regulation of neuron differentiation GO:0045666 126 0.035
Rat
single organism cellular localization GO:1902580 102 0.035
Human
g protein coupled receptor signaling pathway GO:0007186 242 0.035
regulation of vasculature development GO:1901342 44 0.034
macromolecular complex subunit organization GO:0043933 339 0.034
ion homeostasis GO:0050801 212 0.034
gland development GO:0048732 155 0.034
Mouse
ribonucleotide metabolic process GO:0009259 231 0.034
regulation of synaptic transmission gabaergic GO:0032228 17 0.034
gamete generation GO:0007276 124 0.034
positive regulation of the force of heart contraction by norepinephrine GO:0003061 1 0.034
calcium ion transport GO:0006816 131 0.034
cellular chemical homeostasis GO:0055082 247 0.034
negative regulation of secretion GO:0051048 82 0.033
regulation of cellular protein metabolic process GO:0032268 267 0.033
metal ion transport GO:0030001 289 0.033
positive regulation of blood circulation GO:1903524 65 0.033
lipid biosynthetic process GO:0008610 128 0.033
positive regulation of protein modification process GO:0031401 142 0.033
neuron neuron synaptic transmission GO:0007270 60 0.033
response to glucocorticoid GO:0051384 223 0.032
positive regulation of mesenchymal cell proliferation GO:0002053 4 0.032
energy reserve metabolic process GO:0006112 25 0.032
regulation of fat cell differentiation GO:0045598 3 0.032
regulation of cell projection organization GO:0031344 175 0.032
Rat
peptidyl tyrosine phosphorylation GO:0018108 72 0.031
steroid biosynthetic process GO:0006694 48 0.031
organic substance catabolic process GO:1901575 316 0.031
Human
cellular homeostasis GO:0019725 252 0.031
regulation of neuron differentiation GO:0045664 208 0.031
Rat
cell morphogenesis GO:0000902 142 0.031
Human Rat
organic acid catabolic process GO:0016054 49 0.031
negative regulation of molecular function GO:0044092 133 0.031
steroid metabolic process GO:0008202 73 0.030
cellular cation homeostasis GO:0030003 180 0.030
positive regulation of transferase activity GO:0051347 81 0.030
positive regulation of hormone secretion GO:0046887 65 0.030
memory GO:0007613 54 0.030
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.030
regulation of muscle system process GO:0090257 79 0.030
positive regulation of cellular component organization GO:0051130 200 0.030
negative regulation of synaptic transmission glutamatergic GO:0051967 8 0.029
learning or memory GO:0007611 90 0.029
cellular protein localization GO:0034613 122 0.029
Human
regulation of muscle organ development GO:0048634 26 0.029
Mouse
peptide hormone secretion GO:0030072 84 0.029
regulation of actin filament based process GO:0032970 42 0.029
blood vessel morphogenesis GO:0048514 58 0.029
regulation of lipid catabolic process GO:0050994 12 0.029
wound healing GO:0042060 122 0.029
Mouse Rat
positive regulation of long term synaptic potentiation GO:1900273 4 0.029
positive regulation of blood pressure by epinephrine norepinephrine GO:0003321 2 0.029
vasculature development GO:0001944 70 0.029
intracellular transport GO:0046907 185 0.029
Human
axon development GO:0061564 96 0.028
insulin like growth factor receptor signaling pathway GO:0048009 3 0.028
dephosphorylation GO:0016311 98 0.028
response to nutrient GO:0007584 248 0.028
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.028
negative regulation of synaptic transmission GO:0050805 29 0.028
peptide transport GO:0015833 97 0.028
mammary gland morphogenesis GO:0060443 6 0.028
axon ensheathment GO:0008366 40 0.028
renal system process GO:0003014 40 0.028
regulation of behavior GO:0050795 61 0.028
regulation of epithelial cell differentiation GO:0030856 12 0.028
positive regulation of vasodilation GO:0045909 29 0.028
positive regulation of protein serine threonine kinase activity GO:0071902 52 0.028
negative regulation of cell communication GO:0010648 158 0.028
cardiac muscle tissue growth GO:0055017 20 0.028
negative regulation of secretion by cell GO:1903531 72 0.027
transforming growth factor beta receptor signaling pathway GO:0007179 18 0.027
adenylate cyclase activating g protein coupled receptor signaling pathway GO:0007189 24 0.027
carboxylic acid catabolic process GO:0046395 49 0.027
regulation of actin cytoskeleton organization GO:0032956 30 0.027
erk1 and erk2 cascade GO:0070371 48 0.027
negative regulation of homeostatic process GO:0032845 47 0.027
embryonic pattern specification GO:0009880 1 0.027
Mouse
regulation of camp metabolic process GO:0030814 43 0.027
neuron death GO:0070997 127 0.027
regulation of cell cycle GO:0051726 73 0.027
Human
monosaccharide metabolic process GO:0005996 61 0.027
respiratory gaseous exchange GO:0007585 4 0.027
positive regulation of protein metabolic process GO:0051247 178 0.027
response to molecule of bacterial origin GO:0002237 194 0.027
multicellular organismal signaling GO:0035637 44 0.026
negative regulation of uterine smooth muscle contraction GO:0070473 2 0.026
sulfur compound metabolic process GO:0006790 70 0.026
cellular calcium ion homeostasis GO:0006874 160 0.026
peptidyl serine modification GO:0018209 34 0.026
regulation of response to wounding GO:1903034 69 0.026
Mouse
metal ion homeostasis GO:0055065 186 0.026
regulation of cardiac muscle tissue development GO:0055024 12 0.026
organ regeneration GO:0031100 101 0.026
glial cell development GO:0021782 19 0.026
response to external biotic stimulus GO:0043207 221 0.026
Human
regulation of excitatory postsynaptic membrane potential GO:0060079 18 0.025
regulation of anion transport GO:0044070 43 0.025
cellular ion homeostasis GO:0006873 184 0.025
renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressure GO:0001999 1 0.025
organelle organization GO:0006996 266 0.025
regulation of muscle cell apoptotic process GO:0010660 26 0.025
Rat
ribonucleoside triphosphate metabolic process GO:0009199 141 0.025
protein oligomerization GO:0051259 191 0.025
regulation of heart contraction GO:0008016 48 0.025
developmental growth GO:0048589 100 0.025
Mouse
amide transport GO:0042886 105 0.025
respiratory system process GO:0003016 3 0.025
chemotaxis GO:0006935 66 0.025
regulation of synaptic plasticity GO:0048167 70 0.024
neuronal action potential GO:0019228 35 0.024
regulation of cytoskeleton organization GO:0051493 49 0.024
regulation of smooth muscle contraction GO:0006940 29 0.024
small gtpase mediated signal transduction GO:0007264 36 0.024
regulation of renin secretion into blood stream GO:1900133 1 0.024
purine nucleotide biosynthetic process GO:0006164 83 0.024
nucleoside phosphate metabolic process GO:0006753 283 0.024
purine nucleotide catabolic process GO:0006195 136 0.024
carbohydrate metabolic process GO:0005975 130 0.024
organ induction GO:0001759 1 0.024
gastrulation GO:0007369 2 0.023
Mouse
transmission of nerve impulse GO:0019226 42 0.023
response to metal ion GO:0010038 253 0.023
carbohydrate derivative biosynthetic process GO:1901137 124 0.023
glucan metabolic process GO:0044042 23 0.023
autonomic nervous system development GO:0048483 3 0.023
cellular divalent inorganic cation homeostasis GO:0072503 162 0.023
synapse organization GO:0050808 46 0.023
regulation of wound healing GO:0061041 14 0.023
Mouse
protein localization to membrane GO:0072657 36 0.023
positive regulation of renin secretion into blood stream GO:1900135 1 0.023
regulation of synaptic transmission glutamatergic GO:0051966 26 0.023
regulation of the force of heart contraction by chemical signal GO:0003057 2 0.023
camp biosynthetic process GO:0006171 47 0.023
gland morphogenesis GO:0022612 12 0.023
t cell homeostasis GO:0043029 2 0.023
organic hydroxy compound metabolic process GO:1901615 115 0.023
lymphocyte homeostasis GO:0002260 2 0.022
regulation of protein serine threonine kinase activity GO:0071900 64 0.022
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.022
coagulation GO:0050817 28 0.022
transmembrane transport GO:0055085 412 0.022

Smad3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.029
central nervous system disease DOID:331 0 0.023
disease of anatomical entity DOID:7 0 0.023
nervous system disease DOID:863 0 0.023