Rattus norvegicus

65 known processes

Tnfsf11

tumor necrosis factor (ligand) superfamily, member 11

(Aliases: RANKL)

Tnfsf11 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of response to stimulus GO:0048584 285 0.181
Human Rat
response to nutrient levels GO:0031667 370 0.171
Rat
regulation of programmed cell death GO:0043067 341 0.157
Rat
cellular response to endogenous stimulus GO:0071495 377 0.149
regulation of apoptotic process GO:0042981 335 0.133
Rat
cellular response to stress GO:0033554 269 0.130
positive regulation of multicellular organismal process GO:0051240 387 0.128
programmed cell death GO:0012501 392 0.122
Rat
cellular response to organic cyclic compound GO:0071407 202 0.115
response to extracellular stimulus GO:0009991 380 0.107
Rat
response to ketone GO:1901654 182 0.106
response to cytokine GO:0034097 215 0.101
Human
intracellular signal transduction GO:0035556 314 0.095
Human Rat
apoptotic process GO:0006915 381 0.093
Rat
multicellular organismal reproductive process GO:0048609 233 0.091
response to lipopolysaccharide GO:0032496 191 0.089
Rat
reproductive process GO:0022414 372 0.085
Rat
positive regulation of signaling GO:0023056 270 0.079
Human Rat
positive regulation of apoptotic process GO:0043065 154 0.079
Rat
regulation of catalytic activity GO:0050790 304 0.074
Human Rat
single organism reproductive process GO:0044702 297 0.072
Rat
cellular ketone metabolic process GO:0042180 51 0.071
cellular response to hormone stimulus GO:0032870 247 0.070
neuron death GO:0070997 127 0.069
Rat
neuron development GO:0048666 286 0.068
defense response GO:0006952 194 0.068
Rat
positive regulation of cell differentiation GO:0045597 217 0.068
positive regulation of cell development GO:0010720 176 0.065
Rat
macromolecular complex subunit organization GO:0043933 339 0.065
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.061
Human Rat
response to radiation GO:0009314 137 0.061
positive regulation of biosynthetic process GO:0009891 319 0.061
Human Rat
positive regulation of cell death GO:0010942 184 0.056
Rat
regulation of cell differentiation GO:0045595 320 0.056
positive regulation of immune system process GO:0002684 90 0.055
cellular response to lipid GO:0071396 201 0.054
multicellular organism reproduction GO:0032504 233 0.053
cell projection organization GO:0030030 302 0.053
regulation of cellular ketone metabolic process GO:0010565 27 0.053
positive regulation of protein phosphorylation GO:0001934 135 0.052
Human
regulation of intracellular signal transduction GO:1902531 218 0.052
Human Rat
tube development GO:0035295 89 0.051
regulation of multicellular organismal development GO:2000026 376 0.049
g protein coupled receptor signaling pathway GO:0007186 242 0.049
cell type specific apoptotic process GO:0097285 134 0.049
Rat
response to estrogen GO:0043627 232 0.047
response to external biotic stimulus GO:0043207 221 0.047
Rat
regulation of phosphate metabolic process GO:0019220 349 0.047
Human
response to other organism GO:0051707 220 0.046
Rat
cellular response to external stimulus GO:0071496 118 0.046
nucleobase containing small molecule metabolic process GO:0055086 316 0.046
regulation of neurogenesis GO:0050767 247 0.045
Rat
regulation of neuron death GO:1901214 115 0.045
Rat
jak stat cascade GO:0007259 26 0.045
cellular catabolic process GO:0044248 295 0.044
positive regulation of cell communication GO:0010647 271 0.044
Human Rat
inflammatory response GO:0006954 150 0.043
Rat
regulation of protein modification process GO:0031399 194 0.043
Human
brain development GO:0007420 247 0.042
single organism biosynthetic process GO:0044711 342 0.042
response to estradiol GO:0032355 164 0.041
cellular response to organonitrogen compound GO:0071417 197 0.041
carboxylic acid metabolic process GO:0019752 289 0.041
positive regulation of rna biosynthetic process GO:1902680 197 0.040
Human
protein phosphorylation GO:0006468 345 0.040
Human
positive regulation of developmental process GO:0051094 283 0.040
cell activation GO:0001775 97 0.039
Human Rat
renal system development GO:0072001 67 0.039
positive regulation of transcription dna templated GO:0045893 197 0.039
Human
cellular response to cytokine stimulus GO:0071345 127 0.039
Human
immune system process GO:0002376 204 0.038
cellular response to oxygen containing compound GO:1901701 386 0.038
macromolecular complex assembly GO:0065003 273 0.038
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 51 0.038
multi organism reproductive process GO:0044703 262 0.038
single organism cell adhesion GO:0098602 46 0.037
Human
regulation of nucleotide metabolic process GO:0006140 117 0.037
sexual reproduction GO:0019953 148 0.037
regulation of phosphorylation GO:0042325 248 0.037
Human
protein complex subunit organization GO:0071822 302 0.035
positive regulation of rna metabolic process GO:0051254 203 0.035
Human
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.034
Human
neuron projection development GO:0031175 273 0.034
positive regulation of molecular function GO:0044093 230 0.034
Human Rat
regeneration GO:0031099 163 0.034
response to growth factor GO:0070848 189 0.033
Rat
positive regulation of neurogenesis GO:0050769 165 0.033
Rat
development of primary sexual characteristics GO:0045137 107 0.033
Rat
rhythmic process GO:0048511 156 0.033
response to nutrient GO:0007584 248 0.033
Rat
positive regulation of cell proliferation GO:0008284 249 0.033
Rat
neuron differentiation GO:0030182 368 0.032
response to ethanol GO:0045471 162 0.032
cellular response to extracellular stimulus GO:0031668 73 0.032
organonitrogen compound catabolic process GO:1901565 179 0.031
cellular component biogenesis GO:0044085 368 0.031
positive regulation of protein metabolic process GO:0051247 178 0.031
Human Rat
positive regulation of phosphate metabolic process GO:0045937 262 0.031
Human
response to peptide GO:1901652 292 0.031
Rat
calcium ion transport GO:0006816 131 0.031
positive regulation of phosphorus metabolic process GO:0010562 262 0.031
Human
macromolecule localization GO:0033036 252 0.030
Rat
positive regulation of jak stat cascade GO:0046427 19 0.030
positive regulation of nervous system development GO:0051962 178 0.030
Rat
regulation of cellular amine metabolic process GO:0033238 8 0.030
nucleoside phosphate metabolic process GO:0006753 283 0.029
divalent inorganic cation transport GO:0072511 134 0.029
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.029
Rat
gamete generation GO:0007276 124 0.029
activation of janus kinase activity GO:0042976 5 0.029
regulation of phosphorus metabolic process GO:0051174 349 0.029
Human
homeostatic process GO:0042592 331 0.028
regulation of cellular protein metabolic process GO:0032268 267 0.028
Human Rat
protein localization GO:0008104 191 0.028
Rat
positive regulation of phosphorylation GO:0042327 177 0.028
Human
positive regulation of catalytic activity GO:0043085 184 0.028
Human Rat
positive regulation of programmed cell death GO:0043068 157 0.028
Rat
steroid metabolic process GO:0008202 73 0.028
response to ionizing radiation GO:0010212 59 0.027
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.027
Human
regulation of protein metabolic process GO:0051246 289 0.027
Human Rat
response to oxygen levels GO:0070482 265 0.027
Rat
protein complex assembly GO:0006461 263 0.026
response to wounding GO:0009611 254 0.026
Rat
vitamin d metabolic process GO:0042359 4 0.026
cell adhesion GO:0007155 110 0.025
Human
protein complex biogenesis GO:0070271 263 0.025
neuron apoptotic process GO:0051402 88 0.025
Rat
reproduction GO:0000003 245 0.025
cellular homeostasis GO:0019725 252 0.025
Rat
positive regulation of gene expression GO:0010628 244 0.025
Human
neuropeptide signaling pathway GO:0007218 29 0.024
regulation of hormone levels GO:0010817 187 0.024
response to corticosteroid GO:0031960 235 0.024
wound healing GO:0042060 122 0.024
positive regulation of intracellular signal transduction GO:1902533 138 0.024
Human Rat
regulation of jak stat cascade GO:0046425 21 0.024
catabolic process GO:0009056 351 0.024
carbohydrate derivative catabolic process GO:1901136 147 0.024
purine containing compound metabolic process GO:0072521 253 0.024
camp metabolic process GO:0046058 63 0.023
cellular response to ammonium ion GO:0071242 17 0.023
gonad development GO:0008406 104 0.023
Rat
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.023
central nervous system development GO:0007417 311 0.023
proteolysis GO:0006508 175 0.023
Rat
gastrulation GO:0007369 2 0.022
ribose phosphate metabolic process GO:0019693 235 0.022
organic cyclic compound catabolic process GO:1901361 175 0.022
positive regulation of hydrolase activity GO:0051345 86 0.022
Rat
response to alkaloid GO:0043279 132 0.022
glycosyl compound metabolic process GO:1901657 182 0.022
organic substance catabolic process GO:1901575 316 0.022
positive regulation of neuron differentiation GO:0045666 126 0.022
amine metabolic process GO:0009308 38 0.022
cellular cation homeostasis GO:0030003 180 0.022
Rat
metal ion transport GO:0030001 289 0.022
response to glucocorticoid GO:0051384 223 0.022
spermatogenesis GO:0007283 99 0.022
cellular component movement GO:0006928 248 0.022
Human
negative regulation of metabolic process GO:0009892 331 0.021
immune system development GO:0002520 41 0.021
positive regulation of cellular component organization GO:0051130 200 0.021
Rat
chemical homeostasis GO:0048878 292 0.021
Rat
regulation of transferase activity GO:0051338 123 0.021
Human
positive regulation of neuron projection development GO:0010976 99 0.021
regulation of cell proliferation GO:0042127 359 0.021
Rat
liver development GO:0001889 90 0.021
positive regulation of blood pressure by epinephrine norepinephrine GO:0003321 2 0.021
cellular amine metabolic process GO:0044106 38 0.021
adenylate cyclase inhibiting g protein coupled receptor signaling pathway GO:0007193 19 0.020
aromatic compound catabolic process GO:0019439 168 0.020
purine nucleotide metabolic process GO:0006163 229 0.020
localization of cell GO:0051674 202 0.020
Human
regulation of anatomical structure size GO:0090066 135 0.020
appendage morphogenesis GO:0035107 4 0.020
secretion by cell GO:0032940 248 0.020
Rat
organophosphate catabolic process GO:0046434 148 0.020
response to molecule of bacterial origin GO:0002237 194 0.020
Rat
regulation of leukocyte proliferation GO:0070663 26 0.020
Rat
antigen receptor mediated signaling pathway GO:0050851 1 0.020
cytosolic calcium ion homeostasis GO:0051480 140 0.020
positive regulation of cellular protein metabolic process GO:0032270 167 0.020
Human Rat
regulation of rna biosynthetic process GO:2001141 381 0.020
Human
anatomical structure morphogenesis GO:0009653 298 0.020
divalent inorganic cation homeostasis GO:0072507 165 0.020
aging GO:0007568 241 0.019
response to monosaccharide GO:0034284 159 0.019
gland development GO:0048732 155 0.019
response to peptide hormone GO:0043434 278 0.019
Rat
regulation of protein phosphorylation GO:0001932 183 0.019
Human
single organism catabolic process GO:0044712 283 0.019
immune response GO:0006955 104 0.019
Rat
cation transport GO:0006812 382 0.019
carbohydrate derivative metabolic process GO:1901135 346 0.019
regulation of cellular component organization GO:0051128 368 0.019
Rat
ovulation cycle GO:0042698 67 0.019
hepaticobiliary system development GO:0061008 90 0.018
nucleotide metabolic process GO:0009117 279 0.018
cellular component assembly GO:0022607 360 0.018
cation homeostasis GO:0055080 195 0.018
Rat
cellular nitrogen compound catabolic process GO:0044270 163 0.018
forebrain development GO:0030900 98 0.018
divalent metal ion transport GO:0070838 132 0.018
purine ribonucleotide biosynthetic process GO:0009152 81 0.018
positive regulation of protein modification process GO:0031401 142 0.018
Human
regulation of response to stress GO:0080134 126 0.018
Rat
secretion GO:0046903 307 0.017
Rat
regulation of neuron differentiation GO:0045664 208 0.017
regulation of signal transduction GO:0009966 318 0.017
Human Rat
head development GO:0060322 247 0.017
negative regulation of developmental process GO:0051093 125 0.017
response to toxic substance GO:0009636 133 0.017
positive regulation of cell projection organization GO:0031346 111 0.017
regulation of cell development GO:0060284 263 0.017
Rat
regulation of kinase activity GO:0043549 117 0.017
Human
response to dexamethasone GO:0071548 49 0.017
multicellular organismal homeostasis GO:0048871 49 0.017
positive regulation of signal transduction GO:0009967 175 0.017
Human Rat
ribonucleotide metabolic process GO:0009259 231 0.017
regulation of hormone secretion GO:0046883 106 0.017
regulation of cellular amino acid metabolic process GO:0006521 2 0.017
nucleoside catabolic process GO:0009164 126 0.016
regulation of secretion by cell GO:1903530 208 0.016
Rat
mononuclear cell proliferation GO:0032943 29 0.016
Rat
ribonucleotide biosynthetic process GO:0009260 85 0.016
limb morphogenesis GO:0035108 4 0.016
negative regulation of biosynthetic process GO:0009890 168 0.016
ras protein signal transduction GO:0007265 29 0.016
regulation of body fluid levels GO:0050878 90 0.016
positive regulation of calcium ion transport GO:0051928 36 0.016
negative regulation of cellular biosynthetic process GO:0031327 161 0.016
urogenital system development GO:0001655 78 0.016
calcium ion homeostasis GO:0055074 162 0.016
embryonic appendage morphogenesis GO:0035113 4 0.016
peptidyl amino acid modification GO:0018193 126 0.015
organonitrogen compound biosynthetic process GO:1901566 167 0.015
temperature homeostasis GO:0001659 17 0.015
regulation of system process GO:0044057 208 0.015
cell growth GO:0016049 104 0.015
heterocycle catabolic process GO:0046700 167 0.015
regulation of neuron projection development GO:0010975 161 0.015
positive regulation of protein kinase activity GO:0045860 73 0.015
Human
protein homooligomerization GO:0051260 91 0.015
female pregnancy GO:0007565 122 0.015
regulation of cellular extravasation GO:0002691 2 0.015
nucleotide biosynthetic process GO:0009165 98 0.015
negative regulation of nervous system development GO:0051961 79 0.015
response to hexose GO:0009746 144 0.014
nucleobase containing compound catabolic process GO:0034655 152 0.014
leukocyte activation GO:0045321 76 0.014
Human Rat
dendrite morphogenesis GO:0048813 43 0.014
neural crest cell development GO:0014032 2 0.014
regulation of ion transport GO:0043269 245 0.014
Rat
small gtpase mediated signal transduction GO:0007264 36 0.014
activation of protein kinase activity GO:0032147 47 0.014
cellular response to nitrogen compound GO:1901699 210 0.014
gtp catabolic process GO:0006184 71 0.014
regulation of lipid biosynthetic process GO:0046890 38 0.014
cellular divalent inorganic cation homeostasis GO:0072503 162 0.014
regulation of camp biosynthetic process GO:0030817 38 0.014
cellular amino acid metabolic process GO:0006520 107 0.014
regulation of nervous system development GO:0051960 264 0.014
Rat
male gamete generation GO:0048232 99 0.014
glutamate receptor signaling pathway GO:0007215 43 0.014
response to hypoxia GO:0001666 231 0.014
Rat
cellular macromolecule catabolic process GO:0044265 29 0.014
regulation of protein kinase activity GO:0045859 105 0.014
Human
cellular response to nutrient levels GO:0031669 60 0.014
organic hydroxy compound metabolic process GO:1901615 115 0.014
establishment of protein localization GO:0045184 141 0.014
Rat
protein oligomerization GO:0051259 191 0.014
oxoacid metabolic process GO:0043436 290 0.014
purine ribonucleotide metabolic process GO:0009150 227 0.014
nucleoside triphosphate catabolic process GO:0009143 123 0.014
developmental process involved in reproduction GO:0003006 159 0.014
Rat
cerebral cortex tangential migration GO:0021800 1 0.014
ribose phosphate biosynthetic process GO:0046390 87 0.014
cytokine production GO:0001816 61 0.014
Rat
negative regulation of cellular component organization GO:0051129 83 0.013
regulation of cell projection organization GO:0031344 175 0.013
camp biosynthetic process GO:0006171 47 0.013
behavior GO:0007610 205 0.013
response to ammonium ion GO:0060359 71 0.013
innate immune response GO:0045087 35 0.013
axis specification GO:0009798 4 0.013
cellular chemical homeostasis GO:0055082 247 0.013
Rat
cellular response to alcohol GO:0097306 87 0.013
embryonic limb morphogenesis GO:0030326 4 0.013
cellular response to growth factor stimulus GO:0071363 162 0.013
cell part morphogenesis GO:0032990 123 0.013
cellular response to oxygen levels GO:0071453 60 0.013
regulation of lipid metabolic process GO:0019216 68 0.013
positive regulation of mononuclear cell proliferation GO:0032946 20 0.013
Rat
sex differentiation GO:0007548 113 0.013
Rat
purine nucleoside metabolic process GO:0042278 169 0.013
synaptic transmission GO:0007268 235 0.013
Rat
organophosphate metabolic process GO:0019637 370 0.012
transcription dna templated GO:0006351 377 0.012
Human
dendrite development GO:0016358 72 0.012
positive regulation of transport GO:0051050 245 0.012
Rat
response to amine GO:0014075 46 0.012
response to glucose GO:0009749 136 0.012
embryonic hindlimb morphogenesis GO:0035116 2 0.012
saliva secretion GO:0046541 3 0.012
positive regulation of lymphocyte proliferation GO:0050671 20 0.012
Rat
regulation of ossification GO:0030278 32 0.012
motor neuron axon guidance GO:0008045 1 0.012
ion homeostasis GO:0050801 212 0.012
Rat
positive regulation of transferase activity GO:0051347 81 0.012
Human
rna metabolic process GO:0016070 406 0.012
Human
organic acid metabolic process GO:0006082 292 0.012
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.012
cell morphogenesis GO:0000902 142 0.012
feeding behavior GO:0007631 53 0.012
biological adhesion GO:0022610 110 0.012
Human
peptidyl tyrosine phosphorylation GO:0018108 72 0.012
carbohydrate derivative biosynthetic process GO:1901137 124 0.012
nucleoside metabolic process GO:0009116 179 0.012
regulation of epithelial cell proliferation GO:0050678 49 0.012
negative regulation of cell death GO:0060548 229 0.012
hormone metabolic process GO:0042445 69 0.011
inorganic ion transmembrane transport GO:0098660 229 0.011
cellular response to corticosteroid stimulus GO:0071384 69 0.011
purine nucleoside triphosphate metabolic process GO:0009144 141 0.011
nucleoside triphosphate metabolic process GO:0009141 144 0.011
salivary gland development GO:0007431 3 0.011
ribonucleoside metabolic process GO:0009119 174 0.011
cellular response to starvation GO:0009267 27 0.011
mapk cascade GO:0000165 140 0.011
Human
response to light stimulus GO:0009416 52 0.011
protein modification by small protein conjugation GO:0032446 31 0.011
cation transmembrane transport GO:0098655 263 0.011
positive regulation of cellular biosynthetic process GO:0031328 295 0.011
Human
nucleic acid templated transcription GO:0097659 379 0.011
Human
cytoplasmic transport GO:0016482 115 0.011
positive regulation of cellular catabolic process GO:0031331 71 0.011
purine ribonucleotide catabolic process GO:0009154 136 0.011
negative regulation of neuron differentiation GO:0045665 62 0.011
regulation of purine nucleotide catabolic process GO:0033121 65 0.011
purine containing compound biosynthetic process GO:0072522 85 0.011
urinary tract smooth muscle contraction GO:0014848 4 0.011
regulation of cell growth GO:0001558 85 0.011
negative regulation of uterine smooth muscle contraction GO:0070473 2 0.011
regulation of catabolic process GO:0009894 113 0.011
epithelial cell proliferation GO:0050673 54 0.011
hormone transport GO:0009914 121 0.011
regulation of nucleoside metabolic process GO:0009118 66 0.011
maintenance of location GO:0051235 17 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.011
positive regulation of cellular amine metabolic process GO:0033240 3 0.011
purine nucleoside catabolic process GO:0006152 124 0.011
monovalent inorganic cation transport GO:0015672 172 0.010
response to biotic stimulus GO:0009607 226 0.010
Rat
negative regulation of signaling GO:0023057 157 0.010
regulation of dendrite development GO:0050773 59 0.010
regulation of gluconeogenesis GO:0006111 4 0.010
purine containing compound catabolic process GO:0072523 138 0.010
autophagic cell death GO:0048102 4 0.010
purine nucleotide catabolic process GO:0006195 136 0.010
transcription from rna polymerase ii promoter GO:0006366 252 0.010
Human
multicellular organismal catabolic process GO:0044243 2 0.010
protein modification by small protein conjugation or removal GO:0070647 35 0.010
regulation of secretion GO:0051046 224 0.010
Rat
response to cocaine GO:0042220 39 0.010
cytokine mediated signaling pathway GO:0019221 43 0.010
Human
single organismal cell cell adhesion GO:0016337 42 0.010
Human
response to heat GO:0009408 60 0.010
female gonad development GO:0008585 53 0.010
regulation of nucleotide biosynthetic process GO:0030808 47 0.010
negative regulation of multicellular organismal process GO:0051241 203 0.010
reproductive system development GO:0061458 128 0.010
Rat

Tnfsf11 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.016
Human
cardiovascular system disease DOID:1287 0 0.016
nervous system disease DOID:863 0 0.015
musculoskeletal system disease DOID:17 0 0.015
Human
connective tissue disease DOID:65 0 0.015
Human
hypertension DOID:10763 0 0.011
artery disease DOID:0050828 0 0.011
vascular disease DOID:178 0 0.011
immune system disease DOID:2914 0 0.011
bone disease DOID:0080001 0 0.011
Human
central nervous system disease DOID:331 0 0.010