Rattus norvegicus

51 known processes

Tjp1

tight junction protein 1

(Aliases: ZO-1)

Tjp1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
neuron apoptotic process GO:0051402 88 0.270
regulation of intracellular signal transduction GO:1902531 218 0.132
phosphatidylethanolamine metabolic process GO:0046337 1 0.100
programmed cell death GO:0012501 392 0.076
cell type specific apoptotic process GO:0097285 134 0.071
cellular response to stress GO:0033554 269 0.070
positive regulation of apoptotic process GO:0043065 154 0.065
regulation of transcription dna templated GO:0006355 374 0.057
intracellular signal transduction GO:0035556 314 0.057
macromolecule localization GO:0033036 252 0.055
organophosphate metabolic process GO:0019637 370 0.055
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.055
negative regulation of multicellular organismal process GO:0051241 203 0.053
regulation of apoptotic process GO:0042981 335 0.052
ribose phosphate metabolic process GO:0019693 235 0.051
response to reactive oxygen species GO:0000302 120 0.051
synaptic transmission GO:0007268 235 0.051
response to decreased oxygen levels GO:0036293 237 0.050
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.049
ras protein signal transduction GO:0007265 29 0.048
response to inorganic substance GO:0010035 377 0.048
nucleoside phosphate metabolic process GO:0006753 283 0.048
carbohydrate derivative metabolic process GO:1901135 346 0.044
apoptotic process GO:0006915 381 0.044
ribonucleoside metabolic process GO:0009119 174 0.043
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.043
cell cell signaling GO:0007267 335 0.041
nucleotide metabolic process GO:0009117 279 0.039
regulation of molecular function GO:0065009 398 0.039
single organism catabolic process GO:0044712 283 0.039
regulation of cell differentiation GO:0045595 320 0.039
cellular response to oxygen containing compound GO:1901701 386 0.039
response to hydrogen peroxide GO:0042542 89 0.037
positive regulation of cell development GO:0010720 176 0.037
response to hypoxia GO:0001666 231 0.037
positive regulation of cellular component movement GO:0051272 102 0.037
neuron death GO:0070997 127 0.037
cell projection morphogenesis GO:0048858 123 0.037
neuron development GO:0048666 286 0.036
cellular nitrogen compound catabolic process GO:0044270 163 0.036
negative regulation of neuron apoptotic process GO:0043524 45 0.035
positive regulation of cell death GO:0010942 184 0.035
macromolecular complex subunit organization GO:0043933 339 0.035
response to oxygen levels GO:0070482 265 0.034
protein modification by small protein conjugation GO:0032446 31 0.034
single organism biosynthetic process GO:0044711 342 0.034
purine nucleoside triphosphate metabolic process GO:0009144 141 0.034
purine ribonucleotide metabolic process GO:0009150 227 0.033
gap junction assembly GO:0016264 2 0.033
cell projection organization GO:0030030 302 0.033
regulation of canonical wnt signaling pathway GO:0060828 4 0.033
regulation of cell projection organization GO:0031344 175 0.032
calcium ion homeostasis GO:0055074 162 0.032
ribonucleoside triphosphate metabolic process GO:0009199 141 0.032
response to estrogen GO:0043627 232 0.032
aromatic compound catabolic process GO:0019439 168 0.031
regulation of establishment of planar polarity GO:0090175 2 0.031
small gtpase mediated signal transduction GO:0007264 36 0.031
positive regulation of molecular function GO:0044093 230 0.031
multicellular organismal reproductive process GO:0048609 233 0.030
positive regulation of nucleotide metabolic process GO:0045981 91 0.030
neuron differentiation GO:0030182 368 0.030
establishment of protein localization GO:0045184 141 0.030
cellular divalent inorganic cation homeostasis GO:0072503 162 0.030
non canonical wnt signaling pathway GO:0035567 3 0.030
regulation of neuron death GO:1901214 115 0.029
organophosphate catabolic process GO:0046434 148 0.029
organic substance catabolic process GO:1901575 316 0.029
wnt signaling pathway planar cell polarity pathway GO:0060071 2 0.029
regulation of purine nucleotide metabolic process GO:1900542 115 0.029
ribonucleotide metabolic process GO:0009259 231 0.028
cellular protein localization GO:0034613 122 0.028
negative regulation of cellular metabolic process GO:0031324 281 0.028
regulation of signal transduction GO:0009966 318 0.028
multicellular organismal signaling GO:0035637 44 0.027
response to metal ion GO:0010038 253 0.026
lipid metabolic process GO:0006629 283 0.026
purine nucleotide metabolic process GO:0006163 229 0.026
positive regulation of phosphate metabolic process GO:0045937 262 0.026
regulation of neurogenesis GO:0050767 247 0.026
regulation of catalytic activity GO:0050790 304 0.026
positive regulation of cell proliferation GO:0008284 249 0.026
positive regulation of rho gtpase activity GO:0032321 13 0.025
regulation of nervous system development GO:0051960 264 0.025
organic cyclic compound catabolic process GO:1901361 175 0.025
positive regulation of cellular biosynthetic process GO:0031328 295 0.025
cellular component biogenesis GO:0044085 368 0.025
ribonucleoside catabolic process GO:0042454 126 0.025
regulation of nucleotide metabolic process GO:0006140 117 0.025
wnt signaling pathway calcium modulating pathway GO:0007223 1 0.024
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.024
negative regulation of developmental process GO:0051093 125 0.024
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.024
ribose phosphate biosynthetic process GO:0046390 87 0.023
regulation of cell development GO:0060284 263 0.023
negative regulation of apoptotic process GO:0043066 181 0.023
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.023
cellular amine metabolic process GO:0044106 38 0.023
regulation of neuron projection development GO:0010975 161 0.023
metal ion homeostasis GO:0055065 186 0.023
alcohol metabolic process GO:0006066 77 0.022
purine ribonucleoside metabolic process GO:0046128 168 0.022
synaptic vesicle endocytosis GO:0048488 4 0.022
double strand break repair GO:0006302 1 0.022
nucleobase containing small molecule metabolic process GO:0055086 316 0.022
protein phosphorylation GO:0006468 345 0.022
divalent inorganic cation homeostasis GO:0072507 165 0.021
cell part morphogenesis GO:0032990 123 0.021
ossification GO:0001503 70 0.021
positive regulation of cell communication GO:0010647 271 0.021
glycosyl compound metabolic process GO:1901657 182 0.021
cellular response to oxidative stress GO:0034599 76 0.021
negative regulation of transport GO:0051051 136 0.021
cellular cation homeostasis GO:0030003 180 0.021
regulation of phosphorus metabolic process GO:0051174 349 0.021
reproduction GO:0000003 245 0.021
positive regulation of phosphorus metabolic process GO:0010562 262 0.021
amine metabolic process GO:0009308 38 0.020
protein localization GO:0008104 191 0.020
negative regulation of macromolecule metabolic process GO:0010605 260 0.020
anatomical structure morphogenesis GO:0009653 298 0.020
Mouse
chemical homeostasis GO:0048878 292 0.019
cellular lipid metabolic process GO:0044255 208 0.019
purine containing compound metabolic process GO:0072521 253 0.019
regulation of catabolic process GO:0009894 113 0.019
response to estradiol GO:0032355 164 0.019
neurological system process GO:0050877 219 0.019
Mouse
protein complex subunit organization GO:0071822 302 0.019
regulation of protein phosphorylation GO:0001932 183 0.019
cellular response to reactive oxygen species GO:0034614 55 0.019
epithelial cell differentiation GO:0030855 71 0.019
organic hydroxy compound metabolic process GO:1901615 115 0.019
regulation of phosphate metabolic process GO:0019220 349 0.019
g protein coupled receptor signaling pathway GO:0007186 242 0.019
regulation of cellular amino acid metabolic process GO:0006521 2 0.019
regulation of cellular protein metabolic process GO:0032268 267 0.019
cellular component movement GO:0006928 248 0.019
regulation of synaptic transmission GO:0050804 141 0.019
cellular component assembly GO:0022607 360 0.019
epithelium development GO:0060429 96 0.018
cellular homeostasis GO:0019725 252 0.018
cardiac ventricle development GO:0003231 1 0.018
cytosolic calcium ion homeostasis GO:0051480 140 0.018
homeostatic process GO:0042592 331 0.018
brain development GO:0007420 247 0.018
positive regulation of catalytic activity GO:0043085 184 0.018
rhythmic process GO:0048511 156 0.018
carboxylic acid metabolic process GO:0019752 289 0.018
positive regulation of developmental process GO:0051094 283 0.018
regulation of locomotion GO:0040012 148 0.018
organic acid metabolic process GO:0006082 292 0.018
reproductive process GO:0022414 372 0.018
positive regulation of gtpase activity GO:0043547 47 0.018
regulation of neuron apoptotic process GO:0043523 83 0.017
reproductive structure development GO:0048608 128 0.017
positive regulation of rna metabolic process GO:0051254 203 0.017
rho protein signal transduction GO:0007266 11 0.017
regulation of membrane potential GO:0042391 110 0.017
regulation of cell proliferation GO:0042127 359 0.017
response to growth factor GO:0070848 189 0.017
positive regulation of biosynthetic process GO:0009891 319 0.017
neuron projection morphogenesis GO:0048812 122 0.017
nucleobase containing compound catabolic process GO:0034655 152 0.017
positive regulation of transcription dna templated GO:0045893 197 0.017
regulation of neuron differentiation GO:0045664 208 0.016
cellular chemical homeostasis GO:0055082 247 0.016
proteolysis GO:0006508 175 0.016
purine nucleoside metabolic process GO:0042278 169 0.016
reproductive system development GO:0061458 128 0.016
regulation of phosphorylation GO:0042325 248 0.016
transmembrane transport GO:0055085 412 0.016
cell morphogenesis involved in differentiation GO:0000904 119 0.016
single organism reproductive process GO:0044702 297 0.016
multicellular organism reproduction GO:0032504 233 0.016
regulation of cell morphogenesis GO:0022604 77 0.016
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.016
regulation of purine nucleotide catabolic process GO:0033121 65 0.016
tissue remodeling GO:0048771 40 0.016
protein complex assembly GO:0006461 263 0.016
carbohydrate derivative biosynthetic process GO:1901137 124 0.016
circulatory system process GO:0003013 183 0.015
negative regulation of cell death GO:0060548 229 0.015
single organism organelle organization GO:1902589 180 0.015
single organism cellular localization GO:1902580 102 0.015
oxoacid metabolic process GO:0043436 290 0.015
cellular response to growth factor stimulus GO:0071363 162 0.015
regulation of anatomical structure morphogenesis GO:0022603 141 0.015
protein modification by small protein conjugation or removal GO:0070647 35 0.015
regulation of multicellular organismal development GO:2000026 376 0.015
locomotion GO:0040011 237 0.015
negative regulation of neuron death GO:1901215 69 0.015
salivary gland morphogenesis GO:0007435 1 0.015
establishment of tissue polarity GO:0007164 2 0.015
cellular metal ion homeostasis GO:0006875 172 0.014
regulation of rna metabolic process GO:0051252 391 0.014
secretion GO:0046903 307 0.014
phospholipid metabolic process GO:0006644 61 0.014
rna metabolic process GO:0016070 406 0.014
regulation of embryonic development GO:0045995 2 0.014
macromolecular complex assembly GO:0065003 273 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
positive regulation of cell differentiation GO:0045597 217 0.014
intracellular protein transport GO:0006886 79 0.014
embryonic pattern specification GO:0009880 1 0.014
positive regulation of nucleic acid templated transcription GO:1903508 197 0.014
positive regulation of signaling GO:0023056 270 0.014
axis specification GO:0009798 4 0.014
aging GO:0007568 241 0.014
organophosphate biosynthetic process GO:0090407 143 0.014
cation homeostasis GO:0055080 195 0.014
regulation of gtp catabolic process GO:0033124 58 0.014
chromosome segregation GO:0007059 2 0.014
regulation of growth GO:0040008 105 0.013
signal release GO:0023061 145 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.013
regulation of hormone secretion GO:0046883 106 0.013
purine nucleoside catabolic process GO:0006152 124 0.013
positive regulation of locomotion GO:0040017 102 0.013
positive regulation of programmed cell death GO:0043068 157 0.013
neuronal action potential GO:0019228 35 0.013
wnt signaling pathway GO:0016055 17 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
ion homeostasis GO:0050801 212 0.013
positive regulation of catabolic process GO:0009896 78 0.013
positive regulation of nucleoside metabolic process GO:0045979 55 0.013
negative regulation of programmed cell death GO:0043069 183 0.013
neuron projection development GO:0031175 273 0.013
sex differentiation GO:0007548 113 0.013
anterior posterior pattern specification GO:0009952 1 0.013
gtp metabolic process GO:0046039 72 0.013
regulation of cellular component movement GO:0051270 150 0.013
cellular response to hydroperoxide GO:0071447 2 0.013
regulation of developmental growth GO:0048638 45 0.013
positive regulation of cellular protein metabolic process GO:0032270 167 0.013
regulation of nucleoside metabolic process GO:0009118 66 0.013
regulation of cellular amine metabolic process GO:0033238 8 0.013
female sex differentiation GO:0046660 59 0.013
cellular response to nitrogen compound GO:1901699 210 0.013
regulation of hormone levels GO:0010817 187 0.013
neural crest cell development GO:0014032 2 0.013
purine ribonucleoside catabolic process GO:0046130 124 0.013
negative regulation of cell projection organization GO:0031345 50 0.013
regulation of vasculature development GO:1901342 44 0.012
axon development GO:0061564 96 0.012
cellular protein complex assembly GO:0043623 44 0.012
nucleoside phosphate biosynthetic process GO:1901293 102 0.012
cellular calcium ion homeostasis GO:0006874 160 0.012
positive regulation of gene expression GO:0010628 244 0.012
positive regulation of nucleotide catabolic process GO:0030813 53 0.012
catabolic process GO:0009056 351 0.012
regulation of protein metabolic process GO:0051246 289 0.012
synaptic growth at neuromuscular junction GO:0051124 1 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.012
developmental growth GO:0048589 100 0.012
head development GO:0060322 247 0.012
positive regulation of multicellular organismal process GO:0051240 387 0.012
glycosyl compound catabolic process GO:1901658 126 0.012
regulation of rho gtpase activity GO:0032319 17 0.012
cellular catabolic process GO:0044248 295 0.012
regulation of programmed cell death GO:0043067 341 0.012
negative regulation of neuron projection development GO:0010977 46 0.012
organonitrogen compound catabolic process GO:1901565 179 0.012
purine containing compound catabolic process GO:0072523 138 0.012
response to nutrient levels GO:0031667 370 0.012
heart morphogenesis GO:0003007 3 0.012
syncytium formation GO:0006949 4 0.012
vasodilation GO:0042311 44 0.012
oxidation reduction process GO:0055114 304 0.011
small molecule catabolic process GO:0044282 59 0.011
regulation of nucleic acid templated transcription GO:1903506 380 0.011
positive regulation of cellular amine metabolic process GO:0033240 3 0.011
myoblast fusion GO:0007520 2 0.011
positive regulation of neurogenesis GO:0050769 165 0.011
cellular response to endogenous stimulus GO:0071495 377 0.011
response to increased oxygen levels GO:0036296 45 0.011
protein complex biogenesis GO:0070271 263 0.011
response to extracellular stimulus GO:0009991 380 0.011
endomembrane system organization GO:0010256 48 0.011
motor neuron axon guidance GO:0008045 1 0.011
action potential GO:0001508 54 0.011
nucleoside catabolic process GO:0009164 126 0.011
hormone secretion GO:0046879 115 0.011
positive regulation of cellular component organization GO:0051130 200 0.011
cell morphogenesis GO:0000902 142 0.011
phototransduction visible light GO:0007603 2 0.011
cell motility GO:0048870 202 0.011
macromolecule catabolic process GO:0009057 58 0.011
cardiac chamber development GO:0003205 1 0.011
cellular response to hydrogen peroxide GO:0070301 42 0.011
regulation of cellular ketone metabolic process GO:0010565 27 0.011
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.011
response to purine containing compound GO:0014074 126 0.011
negative regulation of metabolic process GO:0009892 331 0.011
positive regulation of cell migration GO:0030335 96 0.010
establishment of planar polarity GO:0001736 1 0.010
female gonad development GO:0008585 53 0.010
protein transport GO:0015031 132 0.010
regulation of protein modification process GO:0031399 194 0.010
carboxylic acid transport GO:0046942 115 0.010
cellular macromolecular complex assembly GO:0034622 58 0.010
cellular amino acid metabolic process GO:0006520 107 0.010
regulation of cellular localization GO:0060341 263 0.010
organonitrogen compound biosynthetic process GO:1901566 167 0.010
nucleoside metabolic process GO:0009116 179 0.010

Tjp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.024
nervous system disease DOID:863 0 0.024
cardiovascular system disease DOID:1287 0 0.016
central nervous system disease DOID:331 0 0.015