Rattus norvegicus

0 known processes

Np4

defensin NP-4 precursor

(Aliases: NP-4)

Np4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
response to other organism GO:0051707 220 0.516
response to external biotic stimulus GO:0043207 221 0.482
response to extracellular stimulus GO:0009991 380 0.452
response to bacterium GO:0009617 200 0.347
response to lipopolysaccharide GO:0032496 191 0.319
regulation of rna biosynthetic process GO:2001141 381 0.283
transcription dna templated GO:0006351 377 0.253
rna biosynthetic process GO:0032774 380 0.201
rna metabolic process GO:0016070 406 0.196
regulation of nucleic acid templated transcription GO:1903506 380 0.152
response to biotic stimulus GO:0009607 226 0.147
regulation of transcription dna templated GO:0006355 374 0.145
negative regulation of multicellular organismal process GO:0051241 203 0.128
positive regulation of multicellular organismal process GO:0051240 387 0.125
response to ethanol GO:0045471 162 0.111
organ regeneration GO:0031100 101 0.110
regulation of protein metabolic process GO:0051246 289 0.107
positive regulation of gene expression GO:0010628 244 0.101
positive regulation of developmental process GO:0051094 283 0.100
positive regulation of biosynthetic process GO:0009891 319 0.099
response to decreased oxygen levels GO:0036293 237 0.098
response to nutrient levels GO:0031667 370 0.097
response to oxygen levels GO:0070482 265 0.093
regulation of rna metabolic process GO:0051252 391 0.090
response to cytokine GO:0034097 215 0.090
response to nutrient GO:0007584 248 0.089
response to peptide GO:1901652 292 0.089
regulation of cell differentiation GO:0045595 320 0.087
blood circulation GO:0008015 183 0.083
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.082
response to hypoxia GO:0001666 231 0.081
cation transport GO:0006812 382 0.079
reproductive process GO:0022414 372 0.078
biological adhesion GO:0022610 110 0.077
nucleic acid templated transcription GO:0097659 379 0.077
negative regulation of metabolic process GO:0009892 331 0.076
response to amino acid GO:0043200 75 0.075
cell adhesion GO:0007155 110 0.075
response to growth factor GO:0070848 189 0.074
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.074
defense response GO:0006952 194 0.073
aging GO:0007568 241 0.071
regulation of molecular function GO:0065009 398 0.070
response to estrogen GO:0043627 232 0.069
cellular ion homeostasis GO:0006873 184 0.067
cellular response to oxygen containing compound GO:1901701 386 0.066
cellular component movement GO:0006928 248 0.065
cellular amino acid metabolic process GO:0006520 107 0.065
regulation of cellular localization GO:0060341 263 0.064
single organism biosynthetic process GO:0044711 342 0.063
intracellular transport GO:0046907 185 0.062
cellular cation homeostasis GO:0030003 180 0.061
positive regulation of protein modification process GO:0031401 142 0.060
regulation of cell development GO:0060284 263 0.060
negative regulation of cellular metabolic process GO:0031324 281 0.057
response to molecule of bacterial origin GO:0002237 194 0.057
defense response to other organism GO:0098542 17 0.056
negative regulation of cell death GO:0060548 229 0.056
positive regulation of protein metabolic process GO:0051247 178 0.055
nucleoside monophosphate metabolic process GO:0009123 93 0.054
organic substance catabolic process GO:1901575 316 0.053
regulation of multicellular organismal development GO:2000026 376 0.053
multi organism reproductive process GO:0044703 262 0.053
cellular component biogenesis GO:0044085 368 0.053
negative regulation of macromolecule metabolic process GO:0010605 260 0.053
carboxylic acid metabolic process GO:0019752 289 0.052
ion homeostasis GO:0050801 212 0.051
regulation of system process GO:0044057 208 0.051
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.050
response to monosaccharide GO:0034284 159 0.050
regulation of anatomical structure morphogenesis GO:0022603 141 0.050
female pregnancy GO:0007565 122 0.050
positive regulation of phosphate metabolic process GO:0045937 262 0.050
positive regulation of cell development GO:0010720 176 0.050
regulation of protein phosphorylation GO:0001932 183 0.049
response to mechanical stimulus GO:0009612 134 0.048
lipid metabolic process GO:0006629 283 0.047
regulation of phosphate metabolic process GO:0019220 349 0.047
protein phosphorylation GO:0006468 345 0.047
transcription from rna polymerase ii promoter GO:0006366 252 0.046
regeneration GO:0031099 163 0.046
neurological system process GO:0050877 219 0.046
response to organophosphorus GO:0046683 102 0.046
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.045
peptidyl amino acid modification GO:0018193 126 0.045
muscle tissue development GO:0060537 58 0.044
cellular response to peptide hormone stimulus GO:0071375 120 0.043
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.043
regulation of intracellular signal transduction GO:1902531 218 0.043
response to peptide hormone GO:0043434 278 0.042
cellular component assembly GO:0022607 360 0.042
cellular calcium ion homeostasis GO:0006874 160 0.041
cellular catabolic process GO:0044248 295 0.041
positive regulation of rna biosynthetic process GO:1902680 197 0.041
response to glucocorticoid GO:0051384 223 0.041
response to acid chemical GO:0001101 222 0.040
purine containing compound catabolic process GO:0072523 138 0.040
positive regulation of neurogenesis GO:0050769 165 0.039
response to carbohydrate GO:0009743 183 0.039
cytosolic calcium ion homeostasis GO:0051480 140 0.038
heterocycle catabolic process GO:0046700 167 0.038
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.038
response to starvation GO:0042594 59 0.037
regulation of neuron death GO:1901214 115 0.037
nucleoside catabolic process GO:0009164 126 0.037
positive regulation of nervous system development GO:0051962 178 0.036
nucleoside metabolic process GO:0009116 179 0.036
ribose phosphate metabolic process GO:0019693 235 0.036
nucleotide metabolic process GO:0009117 279 0.036
positive regulation of nucleic acid templated transcription GO:1903508 197 0.036
tissue development GO:0009888 252 0.036
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.036
growth GO:0040007 165 0.035
wound healing GO:0042060 122 0.035
regulation of cellular amino acid metabolic process GO:0006521 2 0.035
cellular response to hormone stimulus GO:0032870 247 0.035
cellular ketone metabolic process GO:0042180 51 0.035
regulation of catalytic activity GO:0050790 304 0.035
anatomical structure morphogenesis GO:0009653 298 0.035
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.035
nucleobase containing small molecule metabolic process GO:0055086 316 0.035
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.035
cardiovascular system development GO:0072358 134 0.035
regulation of membrane potential GO:0042391 110 0.034
nucleoside phosphate biosynthetic process GO:1901293 102 0.034
ribonucleoside monophosphate metabolic process GO:0009161 88 0.034
positive regulation of cellular amine metabolic process GO:0033240 3 0.033
regulation of phosphorus metabolic process GO:0051174 349 0.033
purine containing compound metabolic process GO:0072521 253 0.033
positive regulation of cell differentiation GO:0045597 217 0.033
negative regulation of cellular biosynthetic process GO:0031327 161 0.033
purine ribonucleotide metabolic process GO:0009150 227 0.033
cell migration GO:0016477 197 0.033
cellular chemical homeostasis GO:0055082 247 0.032
cellular response to mechanical stimulus GO:0071260 48 0.032
purine nucleoside monophosphate metabolic process GO:0009126 84 0.032
cellular homeostasis GO:0019725 252 0.032
cellular response to cytokine stimulus GO:0071345 127 0.032
cellular response to organic cyclic compound GO:0071407 202 0.032
inflammatory response GO:0006954 150 0.032
response to inorganic substance GO:0010035 377 0.031
macromolecular complex subunit organization GO:0043933 339 0.031
negative regulation of rna metabolic process GO:0051253 123 0.031
purine nucleotide metabolic process GO:0006163 229 0.030
immune response GO:0006955 104 0.030
regulation of cellular ketone metabolic process GO:0010565 27 0.030
nucleoside triphosphate metabolic process GO:0009141 144 0.030
proteolysis GO:0006508 175 0.030
cellular divalent inorganic cation homeostasis GO:0072503 162 0.030
negative regulation of gene expression GO:0010629 199 0.029
aromatic compound catabolic process GO:0019439 168 0.029
glycosyl compound metabolic process GO:1901657 182 0.029
adult locomotory behavior GO:0008344 4 0.028
organophosphate metabolic process GO:0019637 370 0.028
metal ion transport GO:0030001 289 0.028
single organism catabolic process GO:0044712 283 0.028
muscle structure development GO:0061061 87 0.028
response to oxidative stress GO:0006979 186 0.027
regulation of transferase activity GO:0051338 123 0.027
positive regulation of cellular biosynthetic process GO:0031328 295 0.027
amine metabolic process GO:0009308 38 0.027
cardiac muscle contraction GO:0060048 27 0.027
regulation of catabolic process GO:0009894 113 0.027
single organism intracellular transport GO:1902582 166 0.027
regulation of blood pressure GO:0008217 83 0.027
response to retinoic acid GO:0032526 63 0.026
positive regulation of protein phosphorylation GO:0001934 135 0.026
ribonucleotide metabolic process GO:0009259 231 0.026
organic cyclic compound catabolic process GO:1901361 175 0.026
divalent metal ion transport GO:0070838 132 0.026
heart contraction GO:0060047 57 0.025
actin mediated cell contraction GO:0070252 12 0.025
macromolecular complex assembly GO:0065003 273 0.025
cellular response to nitrogen compound GO:1901699 210 0.025
purine ribonucleoside metabolic process GO:0046128 168 0.025
response to glucose GO:0009749 136 0.025
cellular response to acid chemical GO:0071229 75 0.025
metal ion homeostasis GO:0055065 186 0.025
ribonucleotide catabolic process GO:0009261 136 0.025
muscle system process GO:0003012 115 0.024
regulation of apoptotic process GO:0042981 335 0.024
positive regulation of cell proliferation GO:0008284 249 0.024
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.024
behavior GO:0007610 205 0.024
cellular response to organonitrogen compound GO:0071417 197 0.024
catabolic process GO:0009056 351 0.023
regulation of cellular amine metabolic process GO:0033238 8 0.023
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.023
organic acid metabolic process GO:0006082 292 0.023
carbohydrate derivative metabolic process GO:1901135 346 0.023
regulation of ion transport GO:0043269 245 0.023
positive regulation of cellular protein metabolic process GO:0032270 167 0.023
cellular response to external stimulus GO:0071496 118 0.023
jak stat cascade GO:0007259 26 0.022
positive regulation of molecular function GO:0044093 230 0.022
regulation of phosphorylation GO:0042325 248 0.022
regulation of nervous system development GO:0051960 264 0.022
negative regulation of programmed cell death GO:0043069 183 0.022
response to camp GO:0051591 91 0.022
neuron differentiation GO:0030182 368 0.022
regulation of protein modification process GO:0031399 194 0.022
cellular metal ion homeostasis GO:0006875 172 0.022
regulation of vasculature development GO:1901342 44 0.022
purine ribonucleoside catabolic process GO:0046130 124 0.022
cytokine production GO:0001816 61 0.022
response to hexose GO:0009746 144 0.022
positive regulation of rna metabolic process GO:0051254 203 0.021
regulation of homotypic cell cell adhesion GO:0034110 4 0.021
organelle organization GO:0006996 266 0.021
response to purine containing compound GO:0014074 126 0.021
carbohydrate derivative catabolic process GO:1901136 147 0.021
atp catabolic process GO:0006200 54 0.021
response to tumor necrosis factor GO:0034612 56 0.021
regulation of metanephros development GO:0072215 4 0.021
acute inflammatory response GO:0002526 58 0.021
immune system process GO:0002376 204 0.021
positive regulation of transcription dna templated GO:0045893 197 0.021
locomotion GO:0040011 237 0.021
nucleoside phosphate catabolic process GO:1901292 140 0.021
programmed cell death GO:0012501 392 0.021
oxoacid metabolic process GO:0043436 290 0.021
cellular nitrogen compound catabolic process GO:0044270 163 0.020
cellular response to endogenous stimulus GO:0071495 377 0.020
bmp signaling pathway GO:0030509 4 0.020
homeostatic process GO:0042592 331 0.020
negative regulation of nucleic acid templated transcription GO:1903507 117 0.020
protein oligomerization GO:0051259 191 0.020
neuron death GO:0070997 127 0.020
regulation of immune response GO:0050776 55 0.020
ribonucleoside triphosphate metabolic process GO:0009199 141 0.020
response to transition metal nanoparticle GO:1990267 122 0.020
regulation of protein localization GO:0032880 81 0.019
striated muscle tissue development GO:0014706 58 0.019
positive regulation of ion transport GO:0043270 94 0.019
response to estradiol GO:0032355 164 0.019
negative regulation of biosynthetic process GO:0009890 168 0.019
regulation of signal transduction GO:0009966 318 0.019
positive regulation of phosphorylation GO:0042327 177 0.019
cellular response to growth factor stimulus GO:0071363 162 0.019
protein complex biogenesis GO:0070271 263 0.019
ribonucleoside catabolic process GO:0042454 126 0.019
response to metal ion GO:0010038 253 0.019
multi multicellular organism process GO:0044706 138 0.019
cellular amine metabolic process GO:0044106 38 0.018
regulation of blood circulation GO:1903522 110 0.018
protein complex assembly GO:0006461 263 0.018
cell projection organization GO:0030030 302 0.018
nucleoside monophosphate catabolic process GO:0009125 56 0.018
negative regulation of developmental process GO:0051093 125 0.018
monovalent inorganic cation transport GO:0015672 172 0.018
nucleotide catabolic process GO:0009166 139 0.018
secretion GO:0046903 307 0.018
purine nucleoside catabolic process GO:0006152 124 0.017
circulatory system development GO:0072359 134 0.017
purine nucleoside triphosphate metabolic process GO:0009144 141 0.017
circadian rhythm GO:0007623 88 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.017
negative regulation of signaling GO:0023057 157 0.017
taxis GO:0042330 67 0.017
embryonic pattern specification GO:0009880 1 0.017
protein localization GO:0008104 191 0.017
limb morphogenesis GO:0035108 4 0.017
skeletal muscle organ development GO:0060538 33 0.017
transmembrane transport GO:0055085 412 0.017
axis specification GO:0009798 4 0.017
small gtpase mediated signal transduction GO:0007264 36 0.017
ribonucleoside metabolic process GO:0009119 174 0.017
positive regulation of phosphorus metabolic process GO:0010562 262 0.017
response to temperature stimulus GO:0009266 94 0.016
localization of cell GO:0051674 202 0.016
regulation of cellular catabolic process GO:0031329 101 0.016
muscle organ development GO:0007517 50 0.016
cellular response to oxidative stress GO:0034599 76 0.016
negative regulation of apoptotic process GO:0043066 181 0.016
calcium ion transport GO:0006816 131 0.016
cardiac ventricle development GO:0003231 1 0.016
positive regulation of cell projection organization GO:0031346 111 0.016
regulation of programmed cell death GO:0043067 341 0.016
response to calcium ion GO:0051592 59 0.016
intracellular signal transduction GO:0035556 314 0.016
response to wounding GO:0009611 254 0.016
anterior posterior pattern specification GO:0009952 1 0.016
developmental process involved in reproduction GO:0003006 159 0.015
organonitrogen compound catabolic process GO:1901565 179 0.015
epithelial cell differentiation GO:0030855 71 0.015
purine ribonucleoside monophosphate catabolic process GO:0009169 55 0.015
calcium ion homeostasis GO:0055074 162 0.015
inorganic ion transmembrane transport GO:0098660 229 0.015
response to corticosteroid GO:0031960 235 0.015
regulation of immune system process GO:0002682 123 0.015
neuron projection morphogenesis GO:0048812 122 0.015
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.015
cell growth GO:0016049 104 0.014
cellular response to tumor necrosis factor GO:0071356 46 0.014
cellular response to stress GO:0033554 269 0.014
regulation of response to external stimulus GO:0032101 106 0.014
protein autophosphorylation GO:0046777 66 0.014
actin filament based movement GO:0030048 16 0.014
purine nucleoside metabolic process GO:0042278 169 0.014
purine nucleotide biosynthetic process GO:0006164 83 0.014
regulation of hydrolase activity GO:0051336 143 0.014
ribonucleoside triphosphate catabolic process GO:0009203 122 0.014
macromolecule localization GO:0033036 252 0.014
smooth muscle cell proliferation GO:0048659 77 0.014
regulation of cellular protein metabolic process GO:0032268 267 0.014
regulation of metal ion transport GO:0010959 118 0.014
regulation of muscle system process GO:0090257 79 0.014
divalent inorganic cation transport GO:0072511 134 0.014
chemical homeostasis GO:0048878 292 0.013
response to zinc ion GO:0010043 39 0.013
cytoplasmic transport GO:0016482 115 0.013
negative regulation of response to stimulus GO:0048585 155 0.013
organophosphate biosynthetic process GO:0090407 143 0.013
positive regulation of transferase activity GO:0051347 81 0.013
cardiac muscle cell contraction GO:0086003 10 0.013
nucleoside triphosphate catabolic process GO:0009143 123 0.013
regulation of hormone levels GO:0010817 187 0.013
leukocyte activation GO:0045321 76 0.013
regulation of neuron projection development GO:0010975 161 0.013
positive regulation of neuron differentiation GO:0045666 126 0.013
regulation of angiogenesis GO:0045765 39 0.013
regulation of cell proliferation GO:0042127 359 0.013
synaptic transmission GO:0007268 235 0.013
vasodilation GO:0042311 44 0.013
multicellular organismal reproductive process GO:0048609 233 0.013
purine nucleoside triphosphate catabolic process GO:0009146 122 0.013
negative regulation of transcription dna templated GO:0045892 116 0.013
neutrophil chemotaxis GO:0030593 11 0.013
regulation of neuron differentiation GO:0045664 208 0.013
single organism reproductive process GO:0044702 297 0.013
cyclic purine nucleotide metabolic process GO:0052652 62 0.013
cellular macromolecule localization GO:0070727 122 0.013
purine ribonucleotide catabolic process GO:0009154 136 0.012
transmission of nerve impulse GO:0019226 42 0.012
negative regulation of rna biosynthetic process GO:1902679 118 0.012
cell motility GO:0048870 202 0.012
skeletal muscle tissue development GO:0007519 31 0.012
nucleobase containing compound catabolic process GO:0034655 152 0.012
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.012
regulation of cell morphogenesis GO:0022604 77 0.012
response to hydrogen peroxide GO:0042542 89 0.012
negative regulation of muscle organ development GO:0048635 8 0.012
single organism cell adhesion GO:0098602 46 0.012
negative regulation of cell communication GO:0010648 158 0.012
n methyl d aspartate receptor clustering GO:0097114 2 0.012
gliogenesis GO:0042063 93 0.012
positive regulation of response to stimulus GO:0048584 285 0.012
odontogenesis GO:0042476 32 0.012
innate immune response GO:0045087 35 0.012
epithelial cell proliferation GO:0050673 54 0.012
cellular component morphogenesis GO:0032989 155 0.012
regulation of cell motility GO:2000145 131 0.012
regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003339 2 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
peptidyl tyrosine phosphorylation GO:0018108 72 0.012
neurotransmitter gated ion channel clustering GO:0072578 3 0.012
neuron projection development GO:0031175 273 0.012
positive regulation of immune system process GO:0002684 90 0.012
negative regulation of molecular function GO:0044092 133 0.012
action potential GO:0001508 54 0.011
single organism carbohydrate metabolic process GO:0044723 118 0.011
organophosphate catabolic process GO:0046434 148 0.011
heart process GO:0003015 57 0.011
regulation of response to stress GO:0080134 126 0.011
respiratory gaseous exchange GO:0007585 4 0.011
cytosolic calcium ion transport GO:0060401 39 0.011
regulation of bmp signaling pathway GO:0030510 2 0.011
negative regulation of neuron death GO:1901215 69 0.011
glycosyl compound catabolic process GO:1901658 126 0.011
muscle cell proliferation GO:0033002 84 0.011
positive regulation of catalytic activity GO:0043085 184 0.011
skeletal muscle cell differentiation GO:0035914 2 0.011
nitrogen compound transport GO:0071705 229 0.011
embryonic axis specification GO:0000578 1 0.011
regulation of kinase activity GO:0043549 117 0.011
regulation of muscle organ development GO:0048634 26 0.011
protein heterooligomerization GO:0051291 89 0.011
purine nucleoside monophosphate catabolic process GO:0009128 55 0.011
t cell activation GO:0042110 29 0.011
necroptotic process GO:0070266 2 0.011
multicellular organism reproduction GO:0032504 233 0.011
rhythmic process GO:0048511 156 0.011
regulation of neurogenesis GO:0050767 247 0.011
hormone metabolic process GO:0042445 69 0.011
purine nucleotide catabolic process GO:0006195 136 0.011
ras protein signal transduction GO:0007265 29 0.011
regulation of homeostatic process GO:0032844 101 0.011
cellular response to insulin stimulus GO:0032869 81 0.011
cellular response to peptide GO:1901653 133 0.010
circulatory system process GO:0003013 183 0.010
rho protein signal transduction GO:0007266 11 0.010
regulation of platelet activation GO:0010543 2 0.010
negative regulation of cell differentiation GO:0045596 99 0.010
negative regulation of organ growth GO:0046621 3 0.010
response to cgmp GO:0070305 3 0.010
positive regulation of kinase activity GO:0033674 77 0.010
sodium ion transport GO:0006814 82 0.010
regulation of nucleoside metabolic process GO:0009118 66 0.010
response to ketone GO:1901654 182 0.010
regulation of heart contraction GO:0008016 48 0.010
digestive system development GO:0055123 41 0.010
vascular process in circulatory system GO:0003018 96 0.010

Np4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.024
musculoskeletal system disease DOID:17 0 0.024
nervous system disease DOID:863 0 0.022