Rattus norvegicus

90 known processes

Col1a1

collagen, type I, alpha 1

(Aliases: COLIA1)

Col1a1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
endochondral bone morphogenesis GO:0060350 7 0.998
Mouse Rat
cellular response to nicotine GO:0071316 7 0.995
Rat
cartilage development involved in endochondral bone morphogenesis GO:0060351 3 0.992
Mouse Rat
endochondral bone growth GO:0003416 3 0.991
Rat
collagen fibril organization GO:0030199 1 0.991
Human
growth plate cartilage development GO:0003417 2 0.991
Rat
tooth eruption GO:0044691 1 0.984
extracellular fibril organization GO:0043206 1 0.974
aorta development GO:0035904 2 0.968
response to mechanical stimulus GO:0009612 134 0.962
cellular response to thyroid hormone stimulus GO:0097067 5 0.955
Rat
response to camp GO:0051591 91 0.943
skeletal system development GO:0001501 41 0.937
Human Mouse Rat
peptide cross linking GO:0018149 1 0.937
skeletal system morphogenesis GO:0048705 12 0.934
Mouse Rat
cartilage development GO:0051216 22 0.924
Mouse Rat
bone development GO:0060348 25 0.918
Mouse Rat
response to tumor necrosis factor GO:0034612 56 0.906
response to increased oxygen levels GO:0036296 45 0.905
response to transforming growth factor beta GO:0071559 46 0.894
odontogenesis GO:0042476 32 0.881
cellular response to tumor necrosis factor GO:0071356 46 0.859
response to estradiol GO:0032355 164 0.848
response to hyperoxia GO:0055093 45 0.837
cellular response to peptide hormone stimulus GO:0071375 120 0.806
Rat
response to norepinephrine GO:0071873 5 0.802
Rat
bone morphogenesis GO:0060349 11 0.789
Mouse Rat
cellular response to organic cyclic compound GO:0071407 202 0.786
transforming growth factor beta receptor signaling pathway GO:0007179 18 0.781
cellular response to hormone stimulus GO:0032870 247 0.780
Rat
connective tissue development GO:0061448 33 0.779
Mouse Rat
embryonic skeletal system development GO:0048706 3 0.774
Human
response to estrogen GO:0043627 232 0.750
response to cytokine GO:0034097 215 0.748
response to purine containing compound GO:0014074 126 0.727
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 27 0.720
tissue development GO:0009888 252 0.718
Human Zebrafish Mouse Rat
response to fibroblast growth factor GO:0071774 29 0.708
cellular response to alkaloid GO:0071312 25 0.698
Rat
response to organophosphorus GO:0046683 102 0.680
artery development GO:0060840 3 0.672
response to vitamin e GO:0033197 24 0.672
response to wounding GO:0009611 254 0.660
cellular response to cytokine stimulus GO:0071345 127 0.641
response to x ray GO:0010165 15 0.632
Rat
response to nutrient GO:0007584 248 0.631
cellular response to epidermal growth factor stimulus GO:0071364 12 0.620
response to oxygen levels GO:0070482 265 0.616
cellular response to endogenous stimulus GO:0071495 377 0.590
response to extracellular stimulus GO:0009991 380 0.567
protein heterotrimerization GO:0070208 2 0.555
Mouse
response to biotic stimulus GO:0009607 226 0.550
organ growth GO:0035265 24 0.548
Rat
response to retinoic acid GO:0032526 63 0.548
cellular response to vitamin e GO:0071306 3 0.536
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.527
chondrocyte differentiation GO:0002062 10 0.524
Rat
cellular response to peptide GO:1901653 133 0.524
Rat
response to corticosteroid GO:0031960 235 0.494
cellular response to lipid GO:0071396 201 0.491
cellular component assembly GO:0022607 360 0.486
Mouse
extracellular matrix organization GO:0030198 13 0.486
Human
macromolecular complex subunit organization GO:0043933 339 0.485
Human Mouse
response to peptide hormone GO:0043434 278 0.484
wound healing GO:0042060 122 0.483
response to nutrient levels GO:0031667 370 0.455
cellular response to organonitrogen compound GO:0071417 197 0.451
Mouse Rat
urogenital system development GO:0001655 78 0.446
cellular response to nitrogen compound GO:1901699 210 0.445
Mouse Rat
ossification GO:0001503 70 0.434
response to external biotic stimulus GO:0043207 221 0.422
aging GO:0007568 241 0.414
Rat
cellular response to growth factor stimulus GO:0071363 162 0.413
macromolecular complex assembly GO:0065003 273 0.404
Mouse
response to growth factor GO:0070848 189 0.404
cellular response to mechanical stimulus GO:0071260 48 0.396
protein complex subunit organization GO:0071822 302 0.385
Human Mouse
cellular response to oxygen containing compound GO:1901701 386 0.384
response to inorganic substance GO:0010035 377 0.382
response to reactive oxygen species GO:0000302 120 0.373
muscle tissue development GO:0060537 58 0.369
response to hydrogen peroxide GO:0042542 89 0.367
cardiovascular system development GO:0072358 134 0.365
Human Mouse
response to oxidative stress GO:0006979 186 0.360
response to peptide GO:1901652 292 0.352
developmental growth involved in morphogenesis GO:0060560 33 0.346
Rat
digestive system development GO:0055123 41 0.344
kidney development GO:0001822 67 0.330
cellular response to external stimulus GO:0071496 118 0.329
response to vitamin GO:0033273 131 0.320
organ morphogenesis GO:0009887 75 0.314
renal system development GO:0072001 67 0.311
response to molecule of bacterial origin GO:0002237 194 0.309
response to lipopolysaccharide GO:0032496 191 0.304
response to monoamine GO:0071867 17 0.290
Rat
cellular response to acid chemical GO:0071229 75 0.285
enzyme linked receptor protein signaling pathway GO:0007167 116 0.280
cellular response to nutrient GO:0031670 30 0.280
response to acid chemical GO:0001101 222 0.276
cellular component biogenesis GO:0044085 368 0.274
Mouse
muscle organ morphogenesis GO:0048644 1 0.254
blood vessel development GO:0001568 69 0.245
Human Mouse
cell adhesion GO:0007155 110 0.244
Mouse
vasculature development GO:0001944 70 0.230
Human Mouse
tissue remodeling GO:0048771 40 0.230
response to fluoride GO:1902617 3 0.229
response to nicotine GO:0035094 51 0.229
Rat
response to other organism GO:0051707 220 0.225
eye morphogenesis GO:0048592 4 0.220
cellular response to vitamin GO:0071295 21 0.219
response to ionizing radiation GO:0010212 59 0.207
Rat
tube development GO:0035295 89 0.206
cellular response to abiotic stimulus GO:0071214 85 0.206
protein complex assembly GO:0006461 263 0.197
Mouse
response to catecholamine GO:0071869 16 0.195
Rat
response to radiation GO:0009314 137 0.195
Rat
response to bacterium GO:0009617 200 0.185
muscle organ development GO:0007517 50 0.177
telencephalon development GO:0021537 62 0.175
response to glucocorticoid GO:0051384 223 0.162
skin morphogenesis GO:0043589 2 0.158
Human
response to epidermal growth factor GO:0070849 18 0.156
cellular response to retinoic acid GO:0071300 27 0.154
formation of primary germ layer GO:0001704 1 0.153
protein complex biogenesis GO:0070271 263 0.147
Mouse
protein oligomerization GO:0051259 191 0.147
Mouse
developmental growth GO:0048589 100 0.145
Zebrafish Rat
digestive tract development GO:0048565 39 0.144
anatomical structure morphogenesis GO:0009653 298 0.138
regulation of cell migration GO:0030334 128 0.138
Human
skin development GO:0043588 17 0.138
Human Mouse
growth GO:0040007 165 0.134
Zebrafish Rat
response to thyroid hormone GO:0097066 17 0.132
Rat
response to monosaccharide GO:0034284 159 0.132
gastrulation GO:0007369 2 0.130
cellular response to extracellular stimulus GO:0031668 73 0.127
regulation of proteasomal protein catabolic process GO:0061136 4 0.124
proteolysis GO:0006508 175 0.111
extracellular structure organization GO:0043062 13 0.110
Human
ras protein signal transduction GO:0007265 29 0.103
striated muscle tissue development GO:0014706 58 0.099
cellular response to nutrient levels GO:0031669 60 0.098
regulation of anatomical structure morphogenesis GO:0022603 141 0.096
Human
embryonic cranial skeleton morphogenesis GO:0048701 2 0.096
regeneration GO:0031099 163 0.095
Zebrafish
response to glucose GO:0009749 136 0.094
negative regulation of multicellular organismal process GO:0051241 203 0.094
positive regulation of gene expression GO:0010628 244 0.094
Human
embryonic morphogenesis GO:0048598 14 0.093
negative regulation of nervous system development GO:0051961 79 0.093
rna biosynthetic process GO:0032774 380 0.089
Human
positive regulation of cell motility GO:2000147 97 0.087
Human
reproductive process GO:0022414 372 0.086
small gtpase mediated signal transduction GO:0007264 36 0.083
eye development GO:0001654 50 0.082
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 5 0.080
positive regulation of developmental process GO:0051094 283 0.079
Human
circulatory system process GO:0003013 183 0.076
cellular component movement GO:0006928 248 0.075
Human
response to amino acid GO:0043200 75 0.074
Mouse
response to carbohydrate GO:0009743 183 0.073
cell migration GO:0016477 197 0.072
Human
developmental process involved in reproduction GO:0003006 159 0.071
head development GO:0060322 247 0.070
Mouse
response to alkaloid GO:0043279 132 0.069
Rat
regulation of blood pressure GO:0008217 83 0.068
negative regulation of cell differentiation GO:0045596 99 0.065
regulation of cell motility GO:2000145 131 0.065
Human
response to hexose GO:0009746 144 0.065
blood vessel morphogenesis GO:0048514 58 0.064
immune system process GO:0002376 204 0.064
female pregnancy GO:0007565 122 0.063
cellular response to glucocorticoid stimulus GO:0071385 68 0.062
intramembranous ossification GO:0001957 1 0.060
Mouse
transcription dna templated GO:0006351 377 0.060
Human
regulation of immune system process GO:0002682 123 0.059
cell cell signaling GO:0007267 335 0.059
camera type eye morphogenesis GO:0048593 2 0.059
negative regulation of cell proliferation GO:0008285 119 0.057
regulation of transcription dna templated GO:0006355 374 0.056
Human
single organism reproductive process GO:0044702 297 0.055
transcription from rna polymerase ii promoter GO:0006366 252 0.054
cell motility GO:0048870 202 0.053
Human
regulation of nucleic acid templated transcription GO:1903506 380 0.051
Human
muscle structure development GO:0061061 87 0.051
positive regulation of rna metabolic process GO:0051254 203 0.051
Human
forebrain development GO:0030900 98 0.050
negative regulation of developmental process GO:0051093 125 0.050
cell projection organization GO:0030030 302 0.047
positive regulation of non canonical wnt signaling pathway GO:2000052 1 0.045
cell matrix adhesion GO:0007160 19 0.045
reproductive system development GO:0061458 128 0.045
protein trimerization GO:0070206 16 0.044
Mouse
anatomical structure formation involved in morphogenesis GO:0048646 83 0.043
Mouse
protein heterooligomerization GO:0051291 89 0.043
Mouse
negative regulation of neurogenesis GO:0050768 78 0.042
response to metal ion GO:0010038 253 0.042
rna metabolic process GO:0016070 406 0.042
Human
intracellular signal transduction GO:0035556 314 0.041
positive regulation of phosphate metabolic process GO:0045937 262 0.040
regulation of cellular component organization GO:0051128 368 0.040
Human
muscle tissue morphogenesis GO:0060415 1 0.039
wound healing spreading of cells GO:0044319 2 0.039
blood circulation GO:0008015 183 0.037
regulation of protein metabolic process GO:0051246 289 0.037
response to transition metal nanoparticle GO:1990267 122 0.037
positive regulation of cellular biosynthetic process GO:0031328 295 0.037
Human
sensory organ development GO:0007423 74 0.036
positive regulation of cell death GO:0010942 184 0.035
circulatory system development GO:0072359 134 0.035
Human Mouse
c21 steroid hormone biosynthetic process GO:0006700 10 0.034
positive regulation of multicellular organismal process GO:0051240 387 0.034
Human
negative regulation of response to stimulus GO:0048585 155 0.034
epiboly GO:0090504 2 0.034
epithelial cell differentiation GO:0030855 71 0.033
regulation of secretion GO:0051046 224 0.033
brain development GO:0007420 247 0.032
protein phosphorylation GO:0006468 345 0.032
placenta development GO:0001890 22 0.032
regulation of nervous system development GO:0051960 264 0.031
aldosterone secretion GO:0035932 3 0.031
tissue morphogenesis GO:0048729 22 0.031
hormone metabolic process GO:0042445 69 0.030
apoptotic process GO:0006915 381 0.030
reproductive structure development GO:0048608 128 0.029
regulation of immune response GO:0050776 55 0.029
immune response GO:0006955 104 0.029
positive regulation of corticosteroid hormone secretion GO:2000848 4 0.029
cellular response to metal ion GO:0071248 55 0.028
positive regulation of nucleic acid templated transcription GO:1903508 197 0.028
Human
cellular response to iron iii ion GO:0071283 3 0.027
digestive tract morphogenesis GO:0048546 8 0.027
response to dexamethasone GO:0071548 49 0.027
regulation of rna biosynthetic process GO:2001141 381 0.026
Human
regulation of vasculature development GO:1901342 44 0.026
nucleic acid templated transcription GO:0097659 379 0.026
Human
embryonic skeletal system morphogenesis GO:0048704 3 0.026
cellular hormone metabolic process GO:0034754 49 0.026
positive regulation of cell communication GO:0010647 271 0.025
Human
organ regeneration GO:0031100 101 0.025
positive regulation of transcription dna templated GO:0045893 197 0.025
Human
positive regulation of endothelial cell migration GO:0010595 4 0.025
neuron differentiation GO:0030182 368 0.025
heart development GO:0007507 72 0.024
lipid biosynthetic process GO:0008610 128 0.024
negative regulation of immune system process GO:0002683 39 0.024
neuron projection development GO:0031175 273 0.024
cerebral cortex development GO:0021987 18 0.023
multicellular organismal catabolic process GO:0044243 2 0.022
cellular response to steroid hormone stimulus GO:0071383 93 0.022
regulation of embryonic development GO:0045995 2 0.022
negative regulation of cellular biosynthetic process GO:0031327 161 0.022
biological adhesion GO:0022610 110 0.022
Mouse
cellular ketone metabolic process GO:0042180 51 0.022
cellular response to corticosteroid stimulus GO:0071384 69 0.021
positive regulation of catalytic activity GO:0043085 184 0.021
positive regulation of signal transduction GO:0009967 175 0.021
Human
response to interleukin 2 GO:0070669 1 0.020
synaptic transmission GO:0007268 235 0.020
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.020
response to ketone GO:1901654 182 0.020
negative regulation of biosynthetic process GO:0009890 168 0.020
regulation of small gtpase mediated signal transduction GO:0051056 48 0.019
regulation of growth GO:0040008 105 0.019
limb morphogenesis GO:0035108 4 0.019
regulation of cell development GO:0060284 263 0.019
Human
locomotion GO:0040011 237 0.019
Human
membrane organization GO:0061024 94 0.019
response to hypoxia GO:0001666 231 0.019
central nervous system development GO:0007417 311 0.018
multi organism reproductive process GO:0044703 262 0.018
negative regulation of immune response GO:0050777 15 0.018
oxoacid metabolic process GO:0043436 290 0.018
single organism intracellular transport GO:1902582 166 0.018
response to starvation GO:0042594 59 0.018
reproduction GO:0000003 245 0.018
cellular macromolecule localization GO:0070727 122 0.018
Human
establishment of protein localization GO:0045184 141 0.018
Mouse
regulation of protein kinase activity GO:0045859 105 0.018
localization of cell GO:0051674 202 0.018
Human
cellular response to interleukin 2 GO:0071352 1 0.018
rho protein signal transduction GO:0007266 11 0.017
cellular response to fibroblast growth factor stimulus GO:0044344 24 0.017
semicircular canal development GO:0060872 1 0.017
negative regulation of cell development GO:0010721 82 0.017
skeletal muscle tissue development GO:0007519 31 0.017
regulation of hormone levels GO:0010817 187 0.017
intermediate filament organization GO:0045109 1 0.017
multicellular organism reproduction GO:0032504 233 0.016
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.016
positive regulation of synaptic plasticity GO:0031915 3 0.016
macromolecule localization GO:0033036 252 0.016
Human Mouse
multicellular organismal metabolic process GO:0044236 22 0.016
Human
regulation of synaptic transmission GO:0050804 141 0.016
cell substrate adhesion GO:0031589 29 0.016
Mouse
regulation of cellular localization GO:0060341 263 0.016
regulation of locomotion GO:0040012 148 0.016
Human
positive regulation of cell differentiation GO:0045597 217 0.015
Human
cell morphogenesis GO:0000902 142 0.015
Human
regulation of cell differentiation GO:0045595 320 0.015
Human
morphogenesis of an epithelium GO:0002009 20 0.015
carboxylic acid metabolic process GO:0019752 289 0.015
regulation of protein modification process GO:0031399 194 0.015
positive regulation of cellular protein metabolic process GO:0032270 167 0.015
cellular amine metabolic process GO:0044106 38 0.015
regulation of stem cell differentiation GO:2000736 2 0.014
Human
regulation of cellular component movement GO:0051270 150 0.014
Human
regulation of programmed cell death GO:0043067 341 0.014
positive regulation of dna metabolic process GO:0051054 39 0.014
multi multicellular organism process GO:0044706 138 0.014
regulation of epithelial to mesenchymal transition GO:0010717 2 0.014
Human
regulation of multicellular organismal development GO:2000026 376 0.014
Human
response to corticosterone GO:0051412 40 0.014
schwann cell migration GO:0036135 2 0.014
positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 2 0.014
positive regulation of stem cell differentiation GO:2000738 2 0.014
Human
organelle organization GO:0006996 266 0.013
epiboly involved in wound healing GO:0090505 2 0.013
cellular response to oxygen levels GO:0071453 60 0.013
regulation of system process GO:0044057 208 0.013
pallium development GO:0021543 42 0.013
cellular response to stress GO:0033554 269 0.013
positive regulation of protein phosphorylation GO:0001934 135 0.013
organic acid metabolic process GO:0006082 292 0.013
regulation of epithelial cell proliferation GO:0050678 49 0.013
neuron development GO:0048666 286 0.013
regulation of intracellular signal transduction GO:1902531 218 0.012
negative regulation of macromolecule metabolic process GO:0010605 260 0.012
regulation of cellular amine metabolic process GO:0033238 8 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
elastic fiber assembly GO:0048251 1 0.012
skeletal muscle organ development GO:0060538 33 0.012
sensory organ morphogenesis GO:0090596 7 0.012
peptidyl amino acid modification GO:0018193 126 0.012
endomembrane system organization GO:0010256 48 0.012
dna metabolic process GO:0006259 96 0.012
protein localization GO:0008104 191 0.012
Human Mouse
defense response to gram negative bacterium GO:0050829 3 0.012
regulation of cell projection organization GO:0031344 175 0.012
positive regulation of lipid biosynthetic process GO:0046889 25 0.012
triglyceride homeostasis GO:0070328 2 0.012
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.012
Human
response to ethanol GO:0045471 162 0.012
multicellular organismal reproductive process GO:0048609 233 0.012
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.012
Human
regulation of canonical wnt signaling pathway GO:0060828 4 0.012
Human
epithelial cell proliferation GO:0050673 54 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.012
positive regulation of secretion GO:0051047 140 0.012
neuronal action potential GO:0019228 35 0.011
regulation of transferase activity GO:0051338 123 0.011
synaptic vesicle localization GO:0097479 24 0.011
positive regulation of the force of heart contraction by chemical signal GO:0003099 2 0.011
response to decreased oxygen levels GO:0036293 237 0.011
cellular response to monosaccharide stimulus GO:0071326 67 0.011
wound healing spreading of epidermal cells GO:0035313 2 0.011
cytoplasmic transport GO:0016482 115 0.011
positive regulation of biosynthetic process GO:0009891 319 0.011
Human
regulation of cell proliferation GO:0042127 359 0.011
positive regulation of angiogenesis GO:0045766 28 0.011
cellular response to carbohydrate stimulus GO:0071322 72 0.011
hexose metabolic process GO:0019318 58 0.011
steroid metabolic process GO:0008202 73 0.011
synaptic growth at neuromuscular junction GO:0051124 1 0.011
maternal process involved in female pregnancy GO:0060135 38 0.011
regulation of molecular function GO:0065009 398 0.011
positive regulation of secretion by cell GO:1903532 128 0.010
thyroid gland development GO:0030878 1 0.010
endocrine system development GO:0035270 30 0.010
epithelium development GO:0060429 96 0.010
signal release GO:0023061 145 0.010

Col1a1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
osteochondrodysplasia DOID:2256 0 0.985
Human
osteogenesis imperfecta DOID:12347 0 0.985
Human
bone development disease DOID:0080006 0 0.985
Human
bone disease DOID:0080001 0 0.985
Human
disease of anatomical entity DOID:7 0 0.985
Human
musculoskeletal system disease DOID:17 0 0.985
Human
connective tissue disease DOID:65 0 0.985
Human
collagen disease DOID:854 0 0.214
Human
ehlers danlos syndrome DOID:13359 0 0.214
Human
myopathy DOID:423 0 0.107
muscular disease DOID:0080000 0 0.107
muscular dystrophy DOID:9884 0 0.107
muscle tissue disease DOID:66 0 0.107