Rattus norvegicus

92 known processes

Sik1

salt-inducible kinase 1

(Aliases: Sik,Snf1lk)

Sik1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
transcription from rna polymerase ii promoter GO:0006366 252 0.193
regulation of rna metabolic process GO:0051252 391 0.143
regulation of rna biosynthetic process GO:2001141 381 0.135
regulation of transcription dna templated GO:0006355 374 0.122
regulation of nucleic acid templated transcription GO:1903506 380 0.121
negative regulation of cellular biosynthetic process GO:0031327 161 0.115
rna metabolic process GO:0016070 406 0.110
negative regulation of metabolic process GO:0009892 331 0.108
response to inorganic substance GO:0010035 377 0.100
cellular response to stress GO:0033554 269 0.089
negative regulation of macromolecule metabolic process GO:0010605 260 0.085
anatomical structure morphogenesis GO:0009653 298 0.084
negative regulation of apoptotic process GO:0043066 181 0.081
rna biosynthetic process GO:0032774 380 0.079
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.079
transcription dna templated GO:0006351 377 0.077
positive regulation of biosynthetic process GO:0009891 319 0.074
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.072
response to camp GO:0051591 91 0.067
negative regulation of gene expression GO:0010629 199 0.066
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.065
nucleic acid templated transcription GO:0097659 379 0.063
regulation of apoptotic process GO:0042981 335 0.061
Human
neuron differentiation GO:0030182 368 0.060
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.060
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.060
negative regulation of transcription dna templated GO:0045892 116 0.060
positive regulation of nucleic acid templated transcription GO:1903508 197 0.058
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.057
negative regulation of cellular metabolic process GO:0031324 281 0.056
tissue development GO:0009888 252 0.055
Mouse
regulation of cellular protein metabolic process GO:0032268 267 0.055
response to growth factor GO:0070848 189 0.054
Worm
positive regulation of cellular biosynthetic process GO:0031328 295 0.053
negative regulation of rna metabolic process GO:0051253 123 0.053
carbohydrate derivative metabolic process GO:1901135 346 0.052
positive regulation of rna metabolic process GO:0051254 203 0.051
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.051
oxoacid metabolic process GO:0043436 290 0.051
organic acid metabolic process GO:0006082 292 0.051
negative regulation of signaling GO:0023057 157 0.050
organonitrogen compound biosynthetic process GO:1901566 167 0.047
sodium ion transport GO:0006814 82 0.045
carboxylic acid metabolic process GO:0019752 289 0.045
catabolic process GO:0009056 351 0.045
histone h3 acetylation GO:0043966 2 0.044
response to oxidative stress GO:0006979 186 0.043
organic substance catabolic process GO:1901575 316 0.041
apoptotic process GO:0006915 381 0.041
Human Mouse
positive regulation of gene expression GO:0010628 244 0.040
organelle organization GO:0006996 266 0.040
Rat
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.039
positive regulation of multicellular organismal process GO:0051240 387 0.039
Worm
regulation of phosphorus metabolic process GO:0051174 349 0.039
cellular ketone metabolic process GO:0042180 51 0.038
Mouse
negative regulation of rna biosynthetic process GO:1902679 118 0.037
cellular amino acid metabolic process GO:0006520 107 0.036
response to peptide hormone GO:0043434 278 0.036
response to peptide GO:1901652 292 0.036
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.035
regulation of molecular function GO:0065009 398 0.034
Mouse
negative regulation of protein metabolic process GO:0051248 114 0.034
cellular response to endogenous stimulus GO:0071495 377 0.032
Worm
programmed cell death GO:0012501 392 0.032
Human Mouse
regulation of protein metabolic process GO:0051246 289 0.032
cellular response to growth factor stimulus GO:0071363 162 0.031
Worm
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.031
Worm
negative regulation of cell communication GO:0010648 158 0.031
single organism biosynthetic process GO:0044711 342 0.031
Mouse
cellular response to hormone stimulus GO:0032870 247 0.030
cation transport GO:0006812 382 0.030
neuron development GO:0048666 286 0.029
response to metal ion GO:0010038 253 0.029
amine metabolic process GO:0009308 38 0.029
nucleobase containing small molecule metabolic process GO:0055086 316 0.029
organophosphate metabolic process GO:0019637 370 0.028
regulation of cell differentiation GO:0045595 320 0.028
Mouse
neuron projection development GO:0031175 273 0.028
entrainment of circadian clock GO:0009649 3 0.028
Mouse
chemical homeostasis GO:0048878 292 0.028
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.028
regulation of cellular component organization GO:0051128 368 0.028
Rat
positive regulation of rna biosynthetic process GO:1902680 197 0.028
organic cyclic compound catabolic process GO:1901361 175 0.027
central nervous system development GO:0007417 311 0.027
regulation of nervous system development GO:0051960 264 0.027
cellular homeostasis GO:0019725 252 0.027
regulation of phosphorylation GO:0042325 248 0.027
negative regulation of developmental process GO:0051093 125 0.027
response to hydrogen peroxide GO:0042542 89 0.027
response to purine containing compound GO:0014074 126 0.026
response to organophosphorus GO:0046683 102 0.026
regulation of cell proliferation GO:0042127 359 0.026
inactivation of mapk activity GO:0000188 2 0.026
macromolecular complex subunit organization GO:0043933 339 0.026
regulation of signal transduction GO:0009966 318 0.026
regulation of multicellular organismal development GO:2000026 376 0.026
negative regulation of nucleic acid templated transcription GO:1903507 117 0.025
cellular catabolic process GO:0044248 295 0.025
positive regulation of cell proliferation GO:0008284 249 0.025
cellular amine metabolic process GO:0044106 38 0.024
cell projection organization GO:0030030 302 0.024
protein maturation GO:0051604 68 0.024
regulation of intracellular signal transduction GO:1902531 218 0.024
negative regulation of cell death GO:0060548 229 0.024
cell part morphogenesis GO:0032990 123 0.024
organic acid biosynthetic process GO:0016053 83 0.024
regulation of cell projection organization GO:0031344 175 0.023
brain development GO:0007420 247 0.023
organic anion transport GO:0015711 132 0.023
response to other organism GO:0051707 220 0.023
regulation of cellular amine metabolic process GO:0033238 8 0.023
protein processing GO:0016485 68 0.022
cellular response to lipid GO:0071396 201 0.022
aging GO:0007568 241 0.022
response to bacterium GO:0009617 200 0.022
nucleobase containing compound catabolic process GO:0034655 152 0.022
negative regulation of biosynthetic process GO:0009890 168 0.021
cellular component movement GO:0006928 248 0.021
Rat
regulation of cellular amino acid metabolic process GO:0006521 2 0.021
single organism catabolic process GO:0044712 283 0.021
anion transport GO:0006820 178 0.021
regulation of cytokine production GO:0001817 56 0.021
nitrogen compound transport GO:0071705 229 0.021
reproductive process GO:0022414 372 0.021
defense response GO:0006952 194 0.020
chromatin organization GO:0006325 34 0.020
positive regulation of cellular component organization GO:0051130 200 0.020
single organism organelle organization GO:1902589 180 0.020
Rat
proteolysis GO:0006508 175 0.020
regulation of catalytic activity GO:0050790 304 0.020
purine containing compound metabolic process GO:0072521 253 0.020
nucleoside metabolic process GO:0009116 179 0.020
response to estradiol GO:0032355 164 0.019
regulation of neuron projection development GO:0010975 161 0.019
lipid metabolic process GO:0006629 283 0.019
Mouse
intracellular signal transduction GO:0035556 314 0.019
Human Mouse Rat
gland development GO:0048732 155 0.019
cellular ion homeostasis GO:0006873 184 0.019
cellular cation homeostasis GO:0030003 180 0.019
purine nucleotide metabolic process GO:0006163 229 0.018
photoperiodism GO:0009648 4 0.018
Mouse
cellular response to organic cyclic compound GO:0071407 202 0.018
cytokine production GO:0001816 61 0.018
cation transmembrane transport GO:0098655 263 0.018
head development GO:0060322 247 0.018
metal ion homeostasis GO:0055065 186 0.018
cell motility GO:0048870 202 0.018
Rat
circadian regulation of gene expression GO:0032922 3 0.018
negative regulation of programmed cell death GO:0043069 183 0.018
ribose phosphate metabolic process GO:0019693 235 0.018
regulation of cellular ketone metabolic process GO:0010565 27 0.018
Mouse
neurological system process GO:0050877 219 0.018
Worm
negative regulation of cellular protein metabolic process GO:0032269 106 0.018
cell cell signaling GO:0007267 335 0.018
negative regulation of signal transduction GO:0009968 83 0.018
positive regulation of molecular function GO:0044093 230 0.017
response to light stimulus GO:0009416 52 0.017
Mouse
response to external biotic stimulus GO:0043207 221 0.017
response to hypoxia GO:0001666 231 0.017
response to ketone GO:1901654 182 0.017
positive regulation of apoptotic process GO:0043065 154 0.017
Human
response to toxic substance GO:0009636 133 0.017
regulation of mapk cascade GO:0043408 116 0.017
macromolecular complex assembly GO:0065003 273 0.017
response to estrogen GO:0043627 232 0.017
response to nutrient levels GO:0031667 370 0.017
regulation of programmed cell death GO:0043067 341 0.017
Human
positive regulation of catalytic activity GO:0043085 184 0.017
positive regulation of programmed cell death GO:0043068 157 0.017
Human
regulation of anatomical structure morphogenesis GO:0022603 141 0.016
multicellular organism reproduction GO:0032504 233 0.016
response to glucocorticoid GO:0051384 223 0.016
positive regulation of transcription dna templated GO:0045893 197 0.016
nucleotide metabolic process GO:0009117 279 0.016
response to decreased oxygen levels GO:0036293 237 0.016
organonitrogen compound catabolic process GO:1901565 179 0.016
axon development GO:0061564 96 0.016
cellular response to cytokine stimulus GO:0071345 127 0.016
positive regulation of neurogenesis GO:0050769 165 0.016
protein complex subunit organization GO:0071822 302 0.016
response to cytokine GO:0034097 215 0.016
mapk cascade GO:0000165 140 0.016
ion homeostasis GO:0050801 212 0.016
regulation of cell development GO:0060284 263 0.015
purine ribonucleotide metabolic process GO:0009150 227 0.015
positive regulation of developmental process GO:0051094 283 0.015
Worm
peptidyl amino acid modification GO:0018193 126 0.015
dna metabolic process GO:0006259 96 0.015
organic acid transport GO:0015849 116 0.015
heterocycle catabolic process GO:0046700 167 0.015
nucleoside phosphate metabolic process GO:0006753 283 0.015
response to reactive oxygen species GO:0000302 120 0.015
positive regulation of cell projection organization GO:0031346 111 0.015
purine nucleotide catabolic process GO:0006195 136 0.015
cellular response to follicle stimulating hormone stimulus GO:0071372 13 0.015
cellular chemical homeostasis GO:0055082 247 0.015
response to oxygen levels GO:0070482 265 0.015
localization of cell GO:0051674 202 0.015
Rat
negative regulation of multicellular organismal process GO:0051241 203 0.015
positive regulation of neuron projection development GO:0010976 99 0.014
sensory organ development GO:0007423 74 0.014
response to calcium ion GO:0051592 59 0.014
aromatic compound catabolic process GO:0019439 168 0.014
alpha amino acid metabolic process GO:1901605 71 0.014
cellular response to oxygen containing compound GO:1901701 386 0.014
regulation of muscle system process GO:0090257 79 0.014
cellular component morphogenesis GO:0032989 155 0.014
positive regulation of neuron differentiation GO:0045666 126 0.014
ion transmembrane transport GO:0034220 365 0.014
bmp signaling pathway GO:0030509 4 0.014
cytokine biosynthetic process GO:0042089 3 0.014
cellular component biogenesis GO:0044085 368 0.014
anterior posterior pattern specification GO:0009952 1 0.014
multicellular organism growth GO:0035264 1 0.014
Worm
response to extracellular stimulus GO:0009991 380 0.014
regulation of response to stress GO:0080134 126 0.014
locomotion GO:0040011 237 0.014
Rat
regulation of phosphate metabolic process GO:0019220 349 0.014
regulation of metal ion transport GO:0010959 118 0.014
regulation of system process GO:0044057 208 0.014
cellular nitrogen compound catabolic process GO:0044270 163 0.014
developmental growth GO:0048589 100 0.014
Worm
posttranscriptional regulation of gene expression GO:0010608 37 0.013
regulation of cellular catabolic process GO:0031329 101 0.013
negative regulation of catalytic activity GO:0043086 103 0.013
cell migration GO:0016477 197 0.013
Rat
carbohydrate derivative biosynthetic process GO:1901137 124 0.013
cellular response to peptide GO:1901653 133 0.013
mesoderm development GO:0007498 2 0.013
cell projection morphogenesis GO:0048858 123 0.013
reactive oxygen species biosynthetic process GO:1903409 8 0.013
cell morphogenesis involved in differentiation GO:0000904 119 0.013
regulation of neurogenesis GO:0050767 247 0.013
regulation of dendrite development GO:0050773 59 0.013
cellular response to fluid shear stress GO:0071498 4 0.013
ras protein signal transduction GO:0007265 29 0.013
positive regulation of cellular amine metabolic process GO:0033240 3 0.013
organ regeneration GO:0031100 101 0.013
inner ear morphogenesis GO:0042472 1 0.013
negative regulation of phosphorus metabolic process GO:0010563 80 0.013
gastrulation GO:0007369 2 0.013
cellular component assembly GO:0022607 360 0.013
homeostatic process GO:0042592 331 0.013
reactive nitrogen species metabolic process GO:2001057 1 0.013
oxidation reduction process GO:0055114 304 0.013
cellular metal ion homeostasis GO:0006875 172 0.013
regulation of sodium ion transport GO:0002028 21 0.013
neuron death GO:0070997 127 0.012
embryonic skeletal system morphogenesis GO:0048704 3 0.012
axis specification GO:0009798 4 0.012
purine containing compound biosynthetic process GO:0072522 85 0.012
metal ion transport GO:0030001 289 0.012
positive regulation of cell death GO:0010942 184 0.012
Human
cation homeostasis GO:0055080 195 0.012
establishment of protein localization GO:0045184 141 0.012
cell type specific apoptotic process GO:0097285 134 0.012
regulation of blood pressure GO:0008217 83 0.012
macromolecule localization GO:0033036 252 0.012
response to testosterone GO:0033574 55 0.012
rhythmic process GO:0048511 156 0.012
Mouse
regulation of neuron differentiation GO:0045664 208 0.012
positive regulation of cell differentiation GO:0045597 217 0.012
negative regulation of response to stimulus GO:0048585 155 0.012
regulation of protein processing GO:0070613 50 0.012
regulation of cellular response to stress GO:0080135 49 0.012
negative regulation of molecular function GO:0044092 133 0.012
Mouse
positive regulation of phosphate metabolic process GO:0045937 262 0.012
reactive oxygen species metabolic process GO:0072593 37 0.012
cellular response to organonitrogen compound GO:0071417 197 0.012
response to alkaloid GO:0043279 132 0.012
male gamete generation GO:0048232 99 0.012
cellular response to molecule of bacterial origin GO:0071219 56 0.012
carboxylic acid biosynthetic process GO:0046394 83 0.012
blood circulation GO:0008015 183 0.012
muscle system process GO:0003012 115 0.012
regulation of dna metabolic process GO:0051052 60 0.012
positive regulation of cell development GO:0010720 176 0.012
organophosphate biosynthetic process GO:0090407 143 0.011
response to molecule of bacterial origin GO:0002237 194 0.011
synaptic transmission GO:0007268 235 0.011
signal transduction by phosphorylation GO:0023014 144 0.011
multicellular organismal reproductive process GO:0048609 233 0.011
negative regulation of protein maturation GO:1903318 47 0.011
ribonucleoside metabolic process GO:0009119 174 0.011
regulation of protein maturation GO:1903317 50 0.011
carbohydrate derivative catabolic process GO:1901136 147 0.011
regulation of nucleotide metabolic process GO:0006140 117 0.011
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.011
lipid localization GO:0010876 62 0.011
reproduction GO:0000003 245 0.011
Worm
cellular response to gonadotropin stimulus GO:0071371 17 0.011
cellular lipid metabolic process GO:0044255 208 0.011
Mouse
glycosyl compound metabolic process GO:1901657 182 0.011
divalent inorganic cation homeostasis GO:0072507 165 0.011
regulation of purine nucleotide metabolic process GO:1900542 115 0.011
gamete generation GO:0007276 124 0.011
small molecule biosynthetic process GO:0044283 124 0.011
chromatin modification GO:0016568 33 0.011
spermatogenesis GO:0007283 99 0.011
carbohydrate metabolic process GO:0005975 130 0.011
Mouse
cellular divalent inorganic cation homeostasis GO:0072503 162 0.011
erythrocyte differentiation GO:0030218 1 0.011
response to mechanical stimulus GO:0009612 134 0.011
regulation of membrane potential GO:0042391 110 0.011
response to hexose GO:0009746 144 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.011
response to retinoic acid GO:0032526 63 0.011
negative regulation of neuron apoptotic process GO:0043524 45 0.010
cellular amino acid biosynthetic process GO:0008652 32 0.010
respiratory gaseous exchange GO:0007585 4 0.010
regulation of neuron apoptotic process GO:0043523 83 0.010
positive regulation of cellular protein metabolic process GO:0032270 167 0.010
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.010
epithelium development GO:0060429 96 0.010
cell morphogenesis GO:0000902 142 0.010
neuron projection morphogenesis GO:0048812 122 0.010
endocytosis GO:0006897 84 0.010
positive regulation of biomineral tissue development GO:0070169 4 0.010
regulation of transferase activity GO:0051338 123 0.010
positive regulation of nervous system development GO:0051962 178 0.010
small gtpase mediated signal transduction GO:0007264 36 0.010
chromosome organization GO:0051276 36 0.010
regulation of reactive oxygen species metabolic process GO:2000377 26 0.010

Sik1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.013
cardiovascular system disease DOID:1287 0 0.013
nervous system disease DOID:863 0 0.013
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
organ system cancer DOID:0050686 0 0.013
disease of metabolism DOID:0014667 0 0.010