Rattus norvegicus

0 known processes

Metap2

methionyl aminopeptidase 2

(Aliases: Amp2,Mnpep,p67)

Metap2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of metabolic process GO:0009892 331 0.251
protein complex biogenesis GO:0070271 263 0.205
negative regulation of apoptotic process GO:0043066 181 0.199
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.195
regulation of nucleic acid templated transcription GO:1903506 380 0.188
negative regulation of macromolecule metabolic process GO:0010605 260 0.179
regulation of molecular function GO:0065009 398 0.172
rna biosynthetic process GO:0032774 380 0.160
regulation of rna biosynthetic process GO:2001141 381 0.158
reproductive process GO:0022414 372 0.158
macromolecular complex subunit organization GO:0043933 339 0.152
response to peptide hormone GO:0043434 278 0.133
cellular component biogenesis GO:0044085 368 0.129
protein complex subunit organization GO:0071822 302 0.127
cellular response to peptide GO:1901653 133 0.124
cellular response to nitrogen compound GO:1901699 210 0.114
negative regulation of cellular protein metabolic process GO:0032269 106 0.109
negative regulation of biosynthetic process GO:0009890 168 0.108
response to peptide GO:1901652 292 0.104
positive regulation of cell proliferation GO:0008284 249 0.104
organelle organization GO:0006996 266 0.102
nucleic acid templated transcription GO:0097659 379 0.099
single organism reproductive process GO:0044702 297 0.099
negative regulation of cellular metabolic process GO:0031324 281 0.095
mitotic spindle organization GO:0007052 2 0.093
negative regulation of cellular biosynthetic process GO:0031327 161 0.092
protein complex assembly GO:0006461 263 0.090
negative regulation of programmed cell death GO:0043069 183 0.089
cell cycle GO:0007049 101 0.084
negative regulation of gene expression GO:0010629 199 0.082
programmed cell death GO:0012501 392 0.079
reproduction GO:0000003 245 0.078
regulation of signal transduction GO:0009966 318 0.076
cellular amino acid metabolic process GO:0006520 107 0.075
insulin receptor signaling pathway GO:0008286 24 0.073
cellular response to endogenous stimulus GO:0071495 377 0.070
regulation of catalytic activity GO:0050790 304 0.070
transcription from rna polymerase ii promoter GO:0006366 252 0.069
rna metabolic process GO:0016070 406 0.067
mitotic cell cycle GO:0000278 49 0.067
macromolecular complex assembly GO:0065003 273 0.066
mitotic cell cycle process GO:1903047 35 0.066
regulation of programmed cell death GO:0043067 341 0.064
negative regulation of cellular response to insulin stimulus GO:1900077 11 0.061
regulation of transcription dna templated GO:0006355 374 0.059
response to temperature stimulus GO:0009266 94 0.058
response to heat GO:0009408 60 0.057
regulation of protein metabolic process GO:0051246 289 0.057
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.054
transcription dna templated GO:0006351 377 0.052
apoptotic process GO:0006915 381 0.051
anatomical structure morphogenesis GO:0009653 298 0.050
negative regulation of cell death GO:0060548 229 0.050
multi organism reproductive process GO:0044703 262 0.049
cell cell recognition GO:0009988 1 0.046
enzyme linked receptor protein signaling pathway GO:0007167 116 0.046
regulation of intracellular signal transduction GO:1902531 218 0.046
negative regulation of protein metabolic process GO:0051248 114 0.044
positive regulation of nucleic acid templated transcription GO:1903508 197 0.042
organ morphogenesis GO:0009887 75 0.042
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.041
positive regulation of biosynthetic process GO:0009891 319 0.041
regulation of cell proliferation GO:0042127 359 0.041
negative regulation of nucleic acid templated transcription GO:1903507 117 0.041
toxin transport GO:1901998 3 0.040
positive regulation of rna metabolic process GO:0051254 203 0.040
cytoskeleton organization GO:0007010 111 0.039
multicellular organismal reproductive process GO:0048609 233 0.039
positive regulation of gene expression GO:0010628 244 0.039
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.039
multicellular organism reproduction GO:0032504 233 0.038
translation GO:0006412 35 0.038
negative regulation of rna metabolic process GO:0051253 123 0.038
regulation of apoptotic process GO:0042981 335 0.037
defense response GO:0006952 194 0.036
regulation of cellular amine metabolic process GO:0033238 8 0.036
response to oxygen levels GO:0070482 265 0.036
cellular response to insulin stimulus GO:0032869 81 0.036
cellular component assembly GO:0022607 360 0.035
regulation of transforming growth factor beta3 production GO:0032910 2 0.035
regulation of hydrolase activity GO:0051336 143 0.034
positive regulation of transport GO:0051050 245 0.033
protein maturation GO:0051604 68 0.033
organic substance catabolic process GO:1901575 316 0.032
single organism intracellular transport GO:1902582 166 0.032
positive regulation of rna biosynthetic process GO:1902680 197 0.032
negative regulation of insulin receptor signaling pathway GO:0046627 10 0.032
chromosome segregation GO:0007059 2 0.032
cellular response to stress GO:0033554 269 0.031
sexual reproduction GO:0019953 148 0.031
single fertilization GO:0007338 3 0.031
proteolysis GO:0006508 175 0.030
cell cycle g1 s phase transition GO:0044843 13 0.030
cellular component morphogenesis GO:0032989 155 0.030
positive regulation of cellular biosynthetic process GO:0031328 295 0.030
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.030
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.030
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.029
cellular response to peptide hormone stimulus GO:0071375 120 0.029
response to carbohydrate GO:0009743 183 0.029
cellular catabolic process GO:0044248 295 0.028
negative regulation of transcription dna templated GO:0045892 116 0.028
ion transmembrane transport GO:0034220 365 0.028
intracellular signal transduction GO:0035556 314 0.028
regulation of cellular amino acid metabolic process GO:0006521 2 0.028
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.027
chromatin assembly or disassembly GO:0006333 1 0.027
purine nucleotide biosynthetic process GO:0006164 83 0.027
smad protein complex assembly GO:0007183 1 0.027
regulation of anatomical structure morphogenesis GO:0022603 141 0.026
neuron projection morphogenesis GO:0048812 122 0.026
spindle organization GO:0007051 2 0.026
response to decreased oxygen levels GO:0036293 237 0.026
peptidyl amino acid modification GO:0018193 126 0.026
cellular response to hormone stimulus GO:0032870 247 0.025
positive regulation of cellular component organization GO:0051130 200 0.025
response to hypoxia GO:0001666 231 0.024
regulation of immune response GO:0050776 55 0.024
cell cycle phase transition GO:0044770 21 0.024
regulation of cellular ketone metabolic process GO:0010565 27 0.023
neuron differentiation GO:0030182 368 0.023
protein transport GO:0015031 132 0.023
ribose phosphate metabolic process GO:0019693 235 0.022
regulation of neuron projection development GO:0010975 161 0.021
neuron development GO:0048666 286 0.021
cell cycle checkpoint GO:0000075 2 0.021
cation transmembrane transport GO:0098655 263 0.021
response to cytokine GO:0034097 215 0.020
positive regulation of developmental process GO:0051094 283 0.020
synaptic transmission GO:0007268 235 0.020
nucleobase containing small molecule metabolic process GO:0055086 316 0.019
blood circulation GO:0008015 183 0.019
negative regulation of rna biosynthetic process GO:1902679 118 0.019
response to other organism GO:0051707 220 0.019
cellular amine metabolic process GO:0044106 38 0.019
response to nutrient levels GO:0031667 370 0.019
negative regulation of signaling GO:0023057 157 0.019
regulation of cellular protein metabolic process GO:0032268 267 0.019
cellular response to oxygen containing compound GO:1901701 386 0.018
single organism organelle organization GO:1902589 180 0.018
nucleotide metabolic process GO:0009117 279 0.018
purine containing compound biosynthetic process GO:0072522 85 0.018
regulation of vesicle mediated transport GO:0060627 81 0.018
positive regulation of cellular amine metabolic process GO:0033240 3 0.018
regulation of cell cycle GO:0051726 73 0.018
central nervous system development GO:0007417 311 0.018
negative regulation of cell communication GO:0010648 158 0.018
negative regulation of cell cycle phase transition GO:1901988 4 0.017
organophosphate metabolic process GO:0019637 370 0.017
metal ion homeostasis GO:0055065 186 0.017
regulation of membrane potential GO:0042391 110 0.017
regulation of neurogenesis GO:0050767 247 0.017
cellular homeostasis GO:0019725 252 0.017
cation transport GO:0006812 382 0.017
protein oligomerization GO:0051259 191 0.017
transforming growth factor beta3 production GO:0032907 2 0.017
positive regulation of response to stimulus GO:0048584 285 0.017
behavior GO:0007610 205 0.016
response to glucose GO:0009749 136 0.016
cellular response to organonitrogen compound GO:0071417 197 0.016
response to corticosteroid GO:0031960 235 0.016
response to growth factor GO:0070848 189 0.016
vesicle mediated transport GO:0016192 181 0.016
cellular protein complex assembly GO:0043623 44 0.016
secretion GO:0046903 307 0.016
developmental process involved in reproduction GO:0003006 159 0.016
response to estrogen GO:0043627 232 0.016
positive regulation of cell death GO:0010942 184 0.016
positive regulation of cell projection organization GO:0031346 111 0.016
gtp catabolic process GO:0006184 71 0.015
cytoskeleton dependent cytokinesis GO:0061640 2 0.015
regulation of phosphate metabolic process GO:0019220 349 0.015
regulation of cell development GO:0060284 263 0.015
cellular protein catabolic process GO:0044257 19 0.015
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.015
regulation of cellular component organization GO:0051128 368 0.015
positive regulation of bone mineralization GO:0030501 4 0.015
negative regulation of response to stimulus GO:0048585 155 0.015
negative regulation of signal transduction GO:0009968 83 0.015
tissue development GO:0009888 252 0.015
response to nutrient GO:0007584 248 0.015
neurological system process GO:0050877 219 0.015
response to monosaccharide GO:0034284 159 0.015
regulation of cellular response to insulin stimulus GO:1900076 16 0.015
dna packaging GO:0006323 4 0.015
response to external biotic stimulus GO:0043207 221 0.015
mitotic dna damage checkpoint GO:0044773 1 0.014
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.014
regulation of protein processing GO:0070613 50 0.014
amine metabolic process GO:0009308 38 0.014
negative regulation of proteolysis GO:0045861 41 0.014
regulation of rna metabolic process GO:0051252 391 0.014
protein phosphorylation GO:0006468 345 0.014
cell morphogenesis involved in differentiation GO:0000904 119 0.014
cellular ketone metabolic process GO:0042180 51 0.014
cell cycle process GO:0022402 57 0.014
spermatogenesis GO:0007283 99 0.014
dendrite development GO:0016358 72 0.014
chromatin remodeling GO:0006338 3 0.014
carbohydrate derivative metabolic process GO:1901135 346 0.014
regulation of response to external stimulus GO:0032101 106 0.014
wound healing GO:0042060 122 0.014
gamete generation GO:0007276 124 0.013
regulation of phosphorus metabolic process GO:0051174 349 0.013
macromolecule catabolic process GO:0009057 58 0.013
cell projection morphogenesis GO:0048858 123 0.013
oxoacid metabolic process GO:0043436 290 0.013
protein processing GO:0016485 68 0.013
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.013
circulatory system process GO:0003013 183 0.013
cellular macromolecular complex assembly GO:0034622 58 0.013
establishment of protein localization GO:0045184 141 0.013
male gamete generation GO:0048232 99 0.013
golgi vesicle transport GO:0048193 22 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 19 0.013
dephosphorylation GO:0016311 98 0.013
development of primary sexual characteristics GO:0045137 107 0.013
response to extracellular stimulus GO:0009991 380 0.013
positive regulation of transcription dna templated GO:0045893 197 0.013
response to wounding GO:0009611 254 0.013
neuron projection development GO:0031175 273 0.012
nucleotide biosynthetic process GO:0009165 98 0.012
inorganic ion transmembrane transport GO:0098660 229 0.012
halogenated hydrocarbon metabolic process GO:0042197 4 0.012
mitochondrion organization GO:0007005 35 0.012
positive regulation of signal transduction GO:0009967 175 0.012
muscle structure development GO:0061061 87 0.012
regulation of neuron differentiation GO:0045664 208 0.012
regulation of cell differentiation GO:0045595 320 0.012
positive regulation of molecular function GO:0044093 230 0.012
regulation of protein modification process GO:0031399 194 0.012
catabolic process GO:0009056 351 0.012
regulation of transferase activity GO:0051338 123 0.012
negative regulation of catalytic activity GO:0043086 103 0.011
negative regulation of intracellular signal transduction GO:1902532 38 0.011
modification dependent macromolecule catabolic process GO:0043632 14 0.011
inflammatory response GO:0006954 150 0.011
nucleosome organization GO:0034728 1 0.011
muscle organ development GO:0007517 50 0.011
cell part morphogenesis GO:0032990 123 0.011
sex differentiation GO:0007548 113 0.011
mapk cascade GO:0000165 140 0.011
immune response GO:0006955 104 0.011
regulation of mitotic cell cycle phase transition GO:1901990 11 0.011
positive regulation of protein metabolic process GO:0051247 178 0.011
regulation of protein phosphorylation GO:0001932 183 0.010
embryonic pattern specification GO:0009880 1 0.010
developmental growth GO:0048589 100 0.010
single organism catabolic process GO:0044712 283 0.010
positive regulation of phosphorus metabolic process GO:0010562 262 0.010
response to insulin GO:0032868 133 0.010
cation homeostasis GO:0055080 195 0.010
regulation of cellular localization GO:0060341 263 0.010

Metap2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
muscular disease DOID:0080000 0 0.026
disease of anatomical entity DOID:7 0 0.026
musculoskeletal system disease DOID:17 0 0.026