Rattus norvegicus

0 known processes

Mecom

MDS1 and EVI1 complex locus

(Aliases: Evi1,Mds1)

Mecom biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.050
regulation of cell proliferation GO:0042127 359 0.048
regulation of rna biosynthetic process GO:2001141 381 0.048
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.042
positive regulation of multicellular organismal process GO:0051240 387 0.041
regulation of transcription dna templated GO:0006355 374 0.039
regulation of rna metabolic process GO:0051252 391 0.039
positive regulation of biosynthetic process GO:0009891 319 0.038
intracellular signal transduction GO:0035556 314 0.037
positive regulation of rna biosynthetic process GO:1902680 197 0.037
transmembrane transport GO:0055085 412 0.037
lipid metabolic process GO:0006629 283 0.036
nucleobase containing small molecule metabolic process GO:0055086 316 0.036
regulation of system process GO:0044057 208 0.035
response to wounding GO:0009611 254 0.035
metal ion transport GO:0030001 289 0.034
response to inorganic substance GO:0010035 377 0.034
central nervous system development GO:0007417 311 0.034
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.033
positive regulation of nucleic acid templated transcription GO:1903508 197 0.032
cellular response to oxygen containing compound GO:1901701 386 0.031
carbohydrate derivative metabolic process GO:1901135 346 0.031
positive regulation of transcription dna templated GO:0045893 197 0.031
regulation of nucleic acid templated transcription GO:1903506 380 0.030
transcription dna templated GO:0006351 377 0.030
regulation of molecular function GO:0065009 398 0.030
response to decreased oxygen levels GO:0036293 237 0.029
cell cell signaling GO:0007267 335 0.029
cation transport GO:0006812 382 0.029
cellular response to stress GO:0033554 269 0.029
regulation of multicellular organismal development GO:2000026 376 0.028
regulation of signal transduction GO:0009966 318 0.028
cellular response to endogenous stimulus GO:0071495 377 0.028
circulatory system process GO:0003013 183 0.028
positive regulation of cell differentiation GO:0045597 217 0.028
response to peptide GO:1901652 292 0.027
organophosphate metabolic process GO:0019637 370 0.027
regulation of phosphorus metabolic process GO:0051174 349 0.027
positive regulation of phosphorus metabolic process GO:0010562 262 0.026
apoptotic process GO:0006915 381 0.026
positive regulation of cellular biosynthetic process GO:0031328 295 0.026
cellular homeostasis GO:0019725 252 0.026
rna biosynthetic process GO:0032774 380 0.026
response to oxygen levels GO:0070482 265 0.025
neuron differentiation GO:0030182 368 0.025
negative regulation of multicellular organismal process GO:0051241 203 0.025
regulation of catalytic activity GO:0050790 304 0.025
cell projection organization GO:0030030 302 0.025
purine nucleoside catabolic process GO:0006152 124 0.025
nucleoside phosphate metabolic process GO:0006753 283 0.024
positive regulation of phosphate metabolic process GO:0045937 262 0.024
negative regulation of cardiac muscle tissue development GO:0055026 3 0.024
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.024
small gtpase mediated signal transduction GO:0007264 36 0.024
response to acid chemical GO:0001101 222 0.024
positive regulation of rna metabolic process GO:0051254 203 0.024
anatomical structure morphogenesis GO:0009653 298 0.023
rna metabolic process GO:0016070 406 0.023
ion transmembrane transport GO:0034220 365 0.023
chemical homeostasis GO:0048878 292 0.023
inorganic ion transmembrane transport GO:0098660 229 0.023
single organism biosynthetic process GO:0044711 342 0.023
programmed cell death GO:0012501 392 0.023
peptidyl amino acid modification GO:0018193 126 0.022
ribonucleotide metabolic process GO:0009259 231 0.022
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.022
cellular component biogenesis GO:0044085 368 0.022
regulation of nervous system development GO:0051960 264 0.022
homeostatic process GO:0042592 331 0.022
nucleoside metabolic process GO:0009116 179 0.022
positive regulation of developmental process GO:0051094 283 0.022
ribonucleoside metabolic process GO:0009119 174 0.022
response to hypoxia GO:0001666 231 0.021
negative regulation of macromolecule metabolic process GO:0010605 260 0.021
regulation of phosphate metabolic process GO:0019220 349 0.021
nucleotide metabolic process GO:0009117 279 0.021
purine nucleoside metabolic process GO:0042278 169 0.021
ribose phosphate metabolic process GO:0019693 235 0.021
regulation of apoptotic process GO:0042981 335 0.020
regulation of cellular protein metabolic process GO:0032268 267 0.020
negative regulation of cellular metabolic process GO:0031324 281 0.020
organic acid metabolic process GO:0006082 292 0.020
negative regulation of apoptotic process GO:0043066 181 0.020
positive regulation of gene expression GO:0010628 244 0.019
catabolic process GO:0009056 351 0.019
organic cyclic compound catabolic process GO:1901361 175 0.019
ion homeostasis GO:0050801 212 0.019
purine nucleotide metabolic process GO:0006163 229 0.019
nucleic acid templated transcription GO:0097659 379 0.019
g protein coupled receptor signaling pathway GO:0007186 242 0.019
cellular component assembly GO:0022607 360 0.019
protein complex biogenesis GO:0070271 263 0.019
positive regulation of cell proliferation GO:0008284 249 0.019
response to nutrient levels GO:0031667 370 0.019
neurological system process GO:0050877 219 0.019
cellular catabolic process GO:0044248 295 0.018
purine nucleoside triphosphate metabolic process GO:0009144 141 0.018
response to estrogen GO:0043627 232 0.018
organic substance catabolic process GO:1901575 316 0.018
purine ribonucleoside metabolic process GO:0046128 168 0.018
intracellular transport GO:0046907 185 0.018
regulation of hormone levels GO:0010817 187 0.018
cytosolic calcium ion homeostasis GO:0051480 140 0.018
negative regulation of metabolic process GO:0009892 331 0.018
positive regulation of catalytic activity GO:0043085 184 0.018
negative regulation of response to stimulus GO:0048585 155 0.018
cation homeostasis GO:0055080 195 0.018
purine containing compound metabolic process GO:0072521 253 0.018
protein complex subunit organization GO:0071822 302 0.018
reproductive process GO:0022414 372 0.018
purine containing compound catabolic process GO:0072523 138 0.018
cellular cation homeostasis GO:0030003 180 0.017
regeneration GO:0031099 163 0.017
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.017
neuron projection development GO:0031175 273 0.017
ras protein signal transduction GO:0007265 29 0.017
organelle organization GO:0006996 266 0.017
response to extracellular stimulus GO:0009991 380 0.017
purine ribonucleotide metabolic process GO:0009150 227 0.017
cellular ion homeostasis GO:0006873 184 0.017
vasculogenesis GO:0001570 3 0.017
protein phosphorylation GO:0006468 345 0.016
protein oligomerization GO:0051259 191 0.016
regulation of cellular amino acid metabolic process GO:0006521 2 0.016
regulation of ion transport GO:0043269 245 0.016
neural crest cell differentiation GO:0014033 2 0.016
glycosyl compound catabolic process GO:1901658 126 0.016
neuron development GO:0048666 286 0.016
purine nucleotide catabolic process GO:0006195 136 0.016
cardiac muscle cell contraction GO:0086003 10 0.016
blood circulation GO:0008015 183 0.016
heterocycle catabolic process GO:0046700 167 0.016
cellular component movement GO:0006928 248 0.016
single organism reproductive process GO:0044702 297 0.016
negative regulation of cellular biosynthetic process GO:0031327 161 0.016
positive regulation of response to stimulus GO:0048584 285 0.016
single organism catabolic process GO:0044712 283 0.016
cellular response to organonitrogen compound GO:0071417 197 0.016
multicellular organismal reproductive process GO:0048609 233 0.016
regulation of cell differentiation GO:0045595 320 0.016
erk1 and erk2 cascade GO:0070371 48 0.015
regulation of protein metabolic process GO:0051246 289 0.015
circulatory system development GO:0072359 134 0.015
developmental process involved in reproduction GO:0003006 159 0.015
cellular divalent inorganic cation homeostasis GO:0072503 162 0.015
anion transport GO:0006820 178 0.015
response to purine containing compound GO:0014074 126 0.015
positive regulation of phosphorylation GO:0042327 177 0.015
protein complex assembly GO:0006461 263 0.015
cellular response to hormone stimulus GO:0032870 247 0.015
negative regulation of cell communication GO:0010648 158 0.015
locomotion GO:0040011 237 0.015
localization of cell GO:0051674 202 0.015
carboxylic acid metabolic process GO:0019752 289 0.015
urogenital system development GO:0001655 78 0.015
negative regulation of programmed cell death GO:0043069 183 0.015
anion transmembrane transport GO:0098656 77 0.015
macromolecular complex subunit organization GO:0043933 339 0.015
nucleobase containing compound catabolic process GO:0034655 152 0.015
purine nucleoside triphosphate catabolic process GO:0009146 122 0.015
muscle system process GO:0003012 115 0.015
positive regulation of protein modification process GO:0031401 142 0.015
regulation of blood circulation GO:1903522 110 0.015
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.015
secretion by cell GO:0032940 248 0.014
amine metabolic process GO:0009308 38 0.014
positive regulation of molecular function GO:0044093 230 0.014
calcium ion transport GO:0006816 131 0.014
gliogenesis GO:0042063 93 0.014
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.014
muscle cell proliferation GO:0033002 84 0.014
cellular amine metabolic process GO:0044106 38 0.014
cardiac chamber development GO:0003205 1 0.014
brain development GO:0007420 247 0.014
response to metal ion GO:0010038 253 0.014
cellular component morphogenesis GO:0032989 155 0.014
response to peptide hormone GO:0043434 278 0.014
negative regulation of cell death GO:0060548 229 0.014
glycosyl compound metabolic process GO:1901657 182 0.014
cellular amino acid metabolic process GO:0006520 107 0.014
potassium ion transport GO:0006813 97 0.014
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
synaptic transmission GO:0007268 235 0.014
regulation of protein phosphorylation GO:0001932 183 0.014
nitrogen compound transport GO:0071705 229 0.014
neuronal action potential GO:0019228 35 0.014
response to insulin GO:0032868 133 0.014
calcium ion homeostasis GO:0055074 162 0.013
ribonucleoside catabolic process GO:0042454 126 0.013
regulation of protein modification process GO:0031399 194 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.013
regulation of hydrolase activity GO:0051336 143 0.013
negative regulation of cardiac muscle tissue growth GO:0055022 3 0.013
positive regulation of signaling GO:0023056 270 0.013
organ regeneration GO:0031100 101 0.013
macromolecular complex assembly GO:0065003 273 0.013
negative regulation of heart growth GO:0061117 3 0.013
regulation of cellular amine metabolic process GO:0033238 8 0.013
growth GO:0040007 165 0.013
purine ribonucleotide catabolic process GO:0009154 136 0.013
positive regulation of nucleotide catabolic process GO:0030813 53 0.013
negative regulation of gene expression GO:0010629 199 0.013
head development GO:0060322 247 0.013
negative regulation of organ growth GO:0046621 3 0.013
divalent inorganic cation homeostasis GO:0072507 165 0.013
proteolysis GO:0006508 175 0.013
negative regulation of cell proliferation GO:0008285 119 0.013
carbohydrate derivative biosynthetic process GO:1901137 124 0.013
regulation of catabolic process GO:0009894 113 0.013
cardiac conduction GO:0061337 2 0.013
regulation of cellular catabolic process GO:0031329 101 0.013
regulation of phosphorylation GO:0042325 248 0.013
positive regulation of nucleotide metabolic process GO:0045981 91 0.013
response to growth factor GO:0070848 189 0.013
regulation of membrane potential GO:0042391 110 0.013
metal ion homeostasis GO:0055065 186 0.013
regulation of neurogenesis GO:0050767 247 0.013
cell morphogenesis GO:0000902 142 0.013
organonitrogen compound catabolic process GO:1901565 179 0.013
regulation of purine nucleotide metabolic process GO:1900542 115 0.012
response to ketone GO:1901654 182 0.012
positive regulation of protein metabolic process GO:0051247 178 0.012
regulation of body fluid levels GO:0050878 90 0.012
muscle contraction GO:0006936 88 0.012
cardiac ventricle development GO:0003231 1 0.012
regulation of cellular component movement GO:0051270 150 0.012
monovalent inorganic cation transport GO:0015672 172 0.012
positive regulation of cell communication GO:0010647 271 0.012
regulation of secretion by cell GO:1903530 208 0.012
secretion GO:0046903 307 0.012
positive regulation of cellular protein metabolic process GO:0032270 167 0.012
cardiovascular system development GO:0072358 134 0.012
cellular calcium ion homeostasis GO:0006874 160 0.012
regulation of muscle system process GO:0090257 79 0.012
mapk cascade GO:0000165 140 0.012
multicellular organism reproduction GO:0032504 233 0.012
transcription from rna polymerase ii promoter GO:0006366 252 0.012
cellular metal ion homeostasis GO:0006875 172 0.012
regulation of canonical wnt signaling pathway GO:0060828 4 0.012
regulation of cellular localization GO:0060341 263 0.012
multi organism reproductive process GO:0044703 262 0.012
positive regulation of catabolic process GO:0009896 78 0.012
regulation of intracellular signal transduction GO:1902531 218 0.012
eye morphogenesis GO:0048592 4 0.012
cellular chemical homeostasis GO:0055082 247 0.012
transmission of nerve impulse GO:0019226 42 0.012
cellular response to nitrogen compound GO:1901699 210 0.012
regulation of nucleotide metabolic process GO:0006140 117 0.012
cellular ketone metabolic process GO:0042180 51 0.012
inorganic cation transmembrane transport GO:0098662 202 0.012
adult locomotory behavior GO:0008344 4 0.012
positive regulation of protein phosphorylation GO:0001934 135 0.012
axis specification GO:0009798 4 0.012
hormone secretion GO:0046879 115 0.012
cell type specific apoptotic process GO:0097285 134 0.012
oxoacid metabolic process GO:0043436 290 0.011
neural crest cell development GO:0014032 2 0.011
positive regulation of hydrolase activity GO:0051345 86 0.011
aromatic compound catabolic process GO:0019439 168 0.011
action potential GO:0001508 54 0.011
response to hexose GO:0009746 144 0.011
organophosphate catabolic process GO:0046434 148 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.011
reproductive structure development GO:0048608 128 0.011
reproductive system development GO:0061458 128 0.011
regulation of stem cell differentiation GO:2000736 2 0.011
regulation of secretion GO:0051046 224 0.011
regulation of cellular ketone metabolic process GO:0010565 27 0.011
regulation of cellular component organization GO:0051128 368 0.011
nucleoside triphosphate metabolic process GO:0009141 144 0.011
regulation of blood vessel size GO:0050880 89 0.011
camera type eye morphogenesis GO:0048593 2 0.011
regulation of cell development GO:0060284 263 0.011
nucleoside triphosphate catabolic process GO:0009143 123 0.011
negative regulation of signaling GO:0023057 157 0.011
sex differentiation GO:0007548 113 0.011
regulation of programmed cell death GO:0043067 341 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
response to estradiol GO:0032355 164 0.011
signal release GO:0023061 145 0.011
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.011
vesicle mediated transport GO:0016192 181 0.010
anterior posterior pattern specification GO:0009952 1 0.010
blood vessel morphogenesis GO:0048514 58 0.010
positive regulation of transport GO:0051050 245 0.010
rho protein signal transduction GO:0007266 11 0.010
sensory perception GO:0007600 101 0.010
regulation of neuron death GO:1901214 115 0.010
maintenance of location GO:0051235 17 0.010
oxidation reduction process GO:0055114 304 0.010
multicellular organismal signaling GO:0035637 44 0.010
positive regulation of cellular component organization GO:0051130 200 0.010
hormone transport GO:0009914 121 0.010
regulation of homeostatic process GO:0032844 101 0.010
gastrulation GO:0007369 2 0.010
response to oxidative stress GO:0006979 186 0.010
gland development GO:0048732 155 0.010
regulation of response to wounding GO:1903034 69 0.010
regulation of neuron differentiation GO:0045664 208 0.010
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.010
protein heterooligomerization GO:0051291 89 0.010
nucleoside catabolic process GO:0009164 126 0.010

Mecom disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025
nervous system disease DOID:863 0 0.025
sensory system disease DOID:0050155 0 0.016
eye and adnexa disease DOID:1492 0 0.016
eye disease DOID:5614 0 0.016