Rattus norvegicus

0 known processes

Spc25

SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)

(Aliases: RGD1307811,MGC108932,Spbc25)

Spc25 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of chromosome segregation GO:0051983 1 0.265
ventricular cardiac muscle cell development GO:0055015 2 0.173
double strand break repair GO:0006302 1 0.167
protein localization to chromosome centromeric region GO:0071459 1 0.155
metaphase anaphase transition of mitotic cell cycle GO:0007091 1 0.126
chromosome segregation GO:0007059 2 0.123
cell cycle checkpoint GO:0000075 2 0.122
regulation of cell proliferation GO:0042127 359 0.118
mitotic sister chromatid separation GO:0051306 1 0.096
dna packaging GO:0006323 4 0.085
response to estrogen GO:0043627 232 0.084
regulation of cellular component organization GO:0051128 368 0.081
positive regulation of cardiac muscle cell proliferation GO:0060045 4 0.081
response to ddt GO:0046680 1 0.075
mitotic cell cycle phase transition GO:0044772 20 0.075
regulation of organelle organization GO:0033043 80 0.070
organic substance catabolic process GO:1901575 316 0.069
macromolecular complex subunit organization GO:0043933 339 0.064
regulation of proteasomal protein catabolic process GO:0061136 4 0.064
metaphase anaphase transition of cell cycle GO:0044784 1 0.062
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.061
cellular component assembly GO:0022607 360 0.061
multi organism reproductive process GO:0044703 262 0.060
multicellular organismal reproductive process GO:0048609 233 0.060
cellular response to iron iii ion GO:0071283 3 0.059
negative regulation of cell cycle phase transition GO:1901988 4 0.057
meiosis i GO:0007127 2 0.056
positive regulation of cell proliferation GO:0008284 249 0.055
single organism catabolic process GO:0044712 283 0.055
reproductive process GO:0022414 372 0.054
response to inorganic substance GO:0010035 377 0.052
single organism organelle organization GO:1902589 180 0.052
protein phosphorylation GO:0006468 345 0.051
sister chromatid segregation GO:0000819 1 0.050
regulation of mitotic sister chromatid segregation GO:0033047 1 0.049
regulation of sister chromatid segregation GO:0033045 1 0.048
cellular response to oxygen containing compound GO:1901701 386 0.048
multicellular organism reproduction GO:0032504 233 0.047
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.046
protein catabolic process GO:0030163 30 0.045
catabolic process GO:0009056 351 0.045
regulation of mitotic sister chromatid separation GO:0010965 1 0.045
nucleoside phosphate metabolic process GO:0006753 283 0.043
cellular response to endogenous stimulus GO:0071495 377 0.042
cellular component biogenesis GO:0044085 368 0.042
cell cycle GO:0007049 101 0.042
regulation of molecular function GO:0065009 398 0.042
histone phosphorylation GO:0016572 6 0.041
chromosome separation GO:0051304 1 0.041
mitotic cell cycle checkpoint GO:0007093 1 0.040
positive regulation of multicellular organismal process GO:0051240 387 0.040
cellular response to stress GO:0033554 269 0.039
positive regulation of gene expression GO:0010628 244 0.039
mitotic cell cycle GO:0000278 49 0.039
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 1 0.039
organelle organization GO:0006996 266 0.038
sexual reproduction GO:0019953 148 0.035
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.035
nucleobase containing small molecule metabolic process GO:0055086 316 0.035
negative regulation of metabolic process GO:0009892 331 0.034
cellular catabolic process GO:0044248 295 0.034
anterior posterior pattern specification GO:0009952 1 0.034
positive regulation of cellular biosynthetic process GO:0031328 295 0.034
organophosphate metabolic process GO:0019637 370 0.033
regulation of multicellular organismal development GO:2000026 376 0.033
histone serine phosphorylation GO:0035404 1 0.033
mitotic cell cycle process GO:1903047 35 0.032
regulation of rna biosynthetic process GO:2001141 381 0.032
regeneration GO:0031099 163 0.031
single organism reproductive process GO:0044702 297 0.031
heterocycle catabolic process GO:0046700 167 0.031
cellular nitrogen compound catabolic process GO:0044270 163 0.031
carbohydrate derivative metabolic process GO:1901135 346 0.031
positive regulation of rna metabolic process GO:0051254 203 0.031
cellular response to organonitrogen compound GO:0071417 197 0.030
positive regulation of triglyceride metabolic process GO:0090208 4 0.030
organic cyclic compound catabolic process GO:1901361 175 0.029
cellular amine metabolic process GO:0044106 38 0.029
mitotic sister chromatid segregation GO:0000070 1 0.029
regulation of phosphorus metabolic process GO:0051174 349 0.029
negative regulation of macromolecule metabolic process GO:0010605 260 0.029
protein complex subunit organization GO:0071822 302 0.028
cellular component movement GO:0006928 248 0.028
nucleotide metabolic process GO:0009117 279 0.028
cell cycle phase transition GO:0044770 21 0.028
regulation of nuclear cell cycle dna replication GO:0033262 1 0.028
macromolecule catabolic process GO:0009057 58 0.027
regulation of cellular localization GO:0060341 263 0.027
cellular amino acid metabolic process GO:0006520 107 0.027
cell cycle process GO:0022402 57 0.027
chromosome condensation GO:0030261 3 0.027
axis specification GO:0009798 4 0.027
cell cycle g1 s phase transition GO:0044843 13 0.026
regulation of protein metabolic process GO:0051246 289 0.026
response to decreased oxygen levels GO:0036293 237 0.026
regulation of cell cycle phase transition GO:1901987 12 0.026
transcription dna templated GO:0006351 377 0.026
regulation of apoptotic process GO:0042981 335 0.026
protein complex assembly GO:0006461 263 0.025
positive regulation of developmental process GO:0051094 283 0.025
negative regulation of apoptotic process GO:0043066 181 0.025
cardiac muscle cell development GO:0055013 16 0.024
regulation of protein modification process GO:0031399 194 0.024
dna metabolic process GO:0006259 96 0.024
response to purine containing compound GO:0014074 126 0.024
reproduction GO:0000003 245 0.024
protein complex biogenesis GO:0070271 263 0.024
macromolecular complex assembly GO:0065003 273 0.024
purine containing compound metabolic process GO:0072521 253 0.024
cellular process involved in reproduction in multicellular organism GO:0022412 35 0.023
negative regulation of cell death GO:0060548 229 0.023
regulation of phosphate metabolic process GO:0019220 349 0.023
cellular response to lipid GO:0071396 201 0.023
ribose phosphate metabolic process GO:0019693 235 0.023
cellular protein localization GO:0034613 122 0.023
cellular response to organic cyclic compound GO:0071407 202 0.023
aromatic compound catabolic process GO:0019439 168 0.023
positive regulation of biosynthetic process GO:0009891 319 0.023
ribonucleoside triphosphate metabolic process GO:0009199 141 0.023
mitotic spindle organization GO:0007052 2 0.023
negative regulation of chromosome organization GO:2001251 1 0.023
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.023
response to hypoxia GO:0001666 231 0.023
developmental process involved in reproduction GO:0003006 159 0.023
dna integrity checkpoint GO:0031570 2 0.023
meiotic cell cycle process GO:1903046 3 0.023
negative regulation of cellular metabolic process GO:0031324 281 0.022
purine ribonucleotide metabolic process GO:0009150 227 0.022
mitotic dna damage checkpoint GO:0044773 1 0.022
apoptotic process GO:0006915 381 0.022
dna conformation change GO:0071103 10 0.022
tissue development GO:0009888 252 0.022
developmental growth GO:0048589 100 0.022
response to metal ion GO:0010038 253 0.022
gamete generation GO:0007276 124 0.022
nucleoside triphosphate metabolic process GO:0009141 144 0.021
single organism biosynthetic process GO:0044711 342 0.021
hindbrain morphogenesis GO:0021575 2 0.021
programmed cell death GO:0012501 392 0.021
g1 s transition of mitotic cell cycle GO:0000082 12 0.021
ventricular cardiac muscle cell differentiation GO:0055012 2 0.021
response to transition metal nanoparticle GO:1990267 122 0.021
intracellular signal transduction GO:0035556 314 0.020
response to peptide hormone GO:0043434 278 0.020
nucleoside monophosphate metabolic process GO:0009123 93 0.020
purine ribonucleoside metabolic process GO:0046128 168 0.020
regulation of cellular protein metabolic process GO:0032268 267 0.020
spindle organization GO:0007051 2 0.020
nucleoside monophosphate catabolic process GO:0009125 56 0.020
negative regulation of molecular function GO:0044092 133 0.020
negative regulation of programmed cell death GO:0043069 183 0.019
regulation of phosphorylation GO:0042325 248 0.019
regulation of programmed cell death GO:0043067 341 0.019
negative regulation of gene expression GO:0010629 199 0.019
amine metabolic process GO:0009308 38 0.019
head development GO:0060322 247 0.019
brain development GO:0007420 247 0.019
regulation of heart growth GO:0060420 12 0.019
circulatory system development GO:0072359 134 0.019
neuron differentiation GO:0030182 368 0.019
regulation of catabolic process GO:0009894 113 0.019
aging GO:0007568 241 0.019
cell projection organization GO:0030030 302 0.018
negative regulation of transport GO:0051051 136 0.018
cerebellar purkinje cell layer development GO:0021680 2 0.018
central nervous system development GO:0007417 311 0.018
rna biosynthetic process GO:0032774 380 0.018
regulation of cellular amine metabolic process GO:0033238 8 0.018
muscle cell proliferation GO:0033002 84 0.018
response to oxygen levels GO:0070482 265 0.018
organonitrogen compound catabolic process GO:1901565 179 0.018
regulation of signal transduction GO:0009966 318 0.018
regulation of dna metabolic process GO:0051052 60 0.018
negative regulation of cellular protein metabolic process GO:0032269 106 0.017
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.017
purine nucleotide metabolic process GO:0006163 229 0.017
peptidyl amino acid modification GO:0018193 126 0.017
cellular response to purine containing compound GO:0071415 2 0.017
regulation of mrna 3 end processing GO:0031440 1 0.017
rna metabolic process GO:0016070 406 0.017
regulation of nucleic acid templated transcription GO:1903506 380 0.017
anatomical structure morphogenesis GO:0009653 298 0.017
cellular ketone metabolic process GO:0042180 51 0.017
purine ribonucleotide catabolic process GO:0009154 136 0.016
mrna metabolic process GO:0016071 20 0.016
negative regulation of microtubule depolymerization GO:0007026 3 0.016
cytokinetic process GO:0032506 1 0.016
nucleobase containing compound catabolic process GO:0034655 152 0.016
dephosphorylation GO:0016311 98 0.016
growth GO:0040007 165 0.016
regulation of chromosome organization GO:0033044 9 0.016
nucleotide catabolic process GO:0009166 139 0.016
purine containing compound catabolic process GO:0072523 138 0.016
response to mechanical stimulus GO:0009612 134 0.015
negative regulation of cellular component organization GO:0051129 83 0.015
cellular macromolecule catabolic process GO:0044265 29 0.015
regulation of cell differentiation GO:0045595 320 0.015
nucleoside phosphate catabolic process GO:1901292 140 0.015
cellular response to dna damage stimulus GO:0006974 19 0.015
cellular response to nitrogen compound GO:1901699 210 0.015
response to acid chemical GO:0001101 222 0.015
purine nucleoside metabolic process GO:0042278 169 0.014
proteolysis GO:0006508 175 0.014
negative regulation of response to stimulus GO:0048585 155 0.014
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 3 0.014
negative regulation of phosphate metabolic process GO:0045936 80 0.014
male gamete generation GO:0048232 99 0.014
positive regulation of nucleic acid templated transcription GO:1903508 197 0.014
negative regulation of cell division GO:0051782 1 0.014
response to peptide GO:1901652 292 0.014
nucleoside metabolic process GO:0009116 179 0.014
centrosome organization GO:0051297 1 0.014
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 1 0.014
positive regulation of rna biosynthetic process GO:1902680 197 0.014
reproductive structure development GO:0048608 128 0.014
purine nucleoside catabolic process GO:0006152 124 0.014
response to toxic substance GO:0009636 133 0.014
negative regulation of protein metabolic process GO:0051248 114 0.014
regulation of humoral immune response mediated by circulating immunoglobulin GO:0002923 1 0.014
neuron development GO:0048666 286 0.014
response to ethanol GO:0045471 162 0.014
cellular response to acid chemical GO:0071229 75 0.013
response to reactive oxygen species GO:0000302 120 0.013
regulation of response to stress GO:0080134 126 0.013
negative regulation of cellular biosynthetic process GO:0031327 161 0.013
regulation of cellular amino acid metabolic process GO:0006521 2 0.013
regulation of cell cycle GO:0051726 73 0.013
chromatin organization GO:0006325 34 0.013
cellular macromolecule localization GO:0070727 122 0.013
maintenance of location GO:0051235 17 0.013
cell growth GO:0016049 104 0.013
regulation of cell cycle process GO:0010564 31 0.013
positive regulation of lipid catabolic process GO:0050996 4 0.013
glycosyl compound metabolic process GO:1901657 182 0.013
reproductive system development GO:0061458 128 0.013
cytoskeleton organization GO:0007010 111 0.013
cellular response to oxidative stress GO:0034599 76 0.012
macromolecule localization GO:0033036 252 0.012
negative regulation of phosphorus metabolic process GO:0010563 80 0.012
response to wounding GO:0009611 254 0.012
protein localization to chromosome GO:0034502 1 0.012
positive regulation of phosphate metabolic process GO:0045937 262 0.012
cerebellar cortex morphogenesis GO:0021696 2 0.012
ubiquitin dependent protein catabolic process GO:0006511 14 0.012
negative regulation of cell communication GO:0010648 158 0.012
cerebellar purkinje cell differentiation GO:0021702 1 0.012
locomotion GO:0040011 237 0.012
regulation of mitotic cell cycle phase transition GO:1901990 11 0.012
ribonucleoside metabolic process GO:0009119 174 0.012
nucleic acid templated transcription GO:0097659 379 0.012
purine nucleoside monophosphate metabolic process GO:0009126 84 0.012
spermatogenesis GO:0007283 99 0.012
positive regulation of synaptic plasticity GO:0031915 3 0.012
response to amine GO:0014075 46 0.012
heart development GO:0007507 72 0.012
regulation of organ growth GO:0046620 13 0.011
regulation of transcription dna templated GO:0006355 374 0.011
chromatin modification GO:0016568 33 0.011
regulation of transferase activity GO:0051338 123 0.011
cellular cation homeostasis GO:0030003 180 0.011
cell cycle dna replication GO:0044786 1 0.011
organophosphate catabolic process GO:0046434 148 0.011
cytoplasmic transport GO:0016482 115 0.011
regulation of protein kinase activity GO:0045859 105 0.011
muscle tissue development GO:0060537 58 0.011
regulation of rna metabolic process GO:0051252 391 0.011
response to fatty acid GO:0070542 65 0.011
pyrimidine nucleobase metabolic process GO:0006206 8 0.011
positive regulation of dna metabolic process GO:0051054 39 0.011
positive regulation of cellular component organization GO:0051130 200 0.011
regulation of protein localization GO:0032880 81 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.011
endoplasmic reticulum to cytosol transport GO:1903513 4 0.011
cell cell signaling GO:0007267 335 0.011
response to estradiol GO:0032355 164 0.011
cellular response to hormone stimulus GO:0032870 247 0.011
cerebellar purkinje cell layer morphogenesis GO:0021692 1 0.011
regulation of catalytic activity GO:0050790 304 0.011
ribonucleoside catabolic process GO:0042454 126 0.011
modification dependent protein catabolic process GO:0019941 14 0.011
carboxylic acid metabolic process GO:0019752 289 0.011
chromosome organization GO:0051276 36 0.010
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.010
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.010
response to organophosphorus GO:0046683 102 0.010
dna replication GO:0006260 37 0.010
positive regulation of cellular protein metabolic process GO:0032270 167 0.010
ribonucleoside monophosphate metabolic process GO:0009161 88 0.010
response to nutrient levels GO:0031667 370 0.010
regulation of muscle tissue development GO:1901861 25 0.010
regulation of cardiac muscle tissue growth GO:0055021 12 0.010
response to glucocorticoid GO:0051384 223 0.010
development of primary sexual characteristics GO:0045137 107 0.010
carbohydrate derivative catabolic process GO:1901136 147 0.010
cell morphogenesis GO:0000902 142 0.010
organelle fission GO:0048285 25 0.010
asymmetric stem cell division GO:0098722 2 0.010
regulation of striated muscle tissue development GO:0016202 25 0.010
cytoskeleton dependent cytokinesis GO:0061640 2 0.010

Spc25 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
large intestine cancer DOID:5672 0 0.014
colon cancer DOID:219 0 0.014
gastrointestinal system cancer DOID:3119 0 0.014
intestinal cancer DOID:10155 0 0.014
cancer DOID:162 0 0.014
disease of cellular proliferation DOID:14566 0 0.014
organ system cancer DOID:0050686 0 0.014
colorectal cancer DOID:9256 0 0.014