Rattus norvegicus

43 known processes

Ptgis

prostaglandin I2 (prostacyclin) synthase

(Aliases: PGIS)

Ptgis biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular component assembly GO:0022607 360 0.348
cellular response to cytokine stimulus GO:0071345 127 0.218
Human
macromolecular complex assembly GO:0065003 273 0.150
protein complex subunit organization GO:0071822 302 0.147
macromolecular complex subunit organization GO:0043933 339 0.141
regulation of multicellular organismal development GO:2000026 376 0.139
Human
cellular component biogenesis GO:0044085 368 0.130
carboxylic acid metabolic process GO:0019752 289 0.125
response to inorganic substance GO:0010035 377 0.125
protein oligomerization GO:0051259 191 0.122
programmed cell death GO:0012501 392 0.119
Human
cellular response to endogenous stimulus GO:0071495 377 0.118
response to nutrient GO:0007584 248 0.113
protein complex assembly GO:0006461 263 0.109
response to oxygen levels GO:0070482 265 0.104
response to other organism GO:0051707 220 0.102
response to biotic stimulus GO:0009607 226 0.097
anatomical structure morphogenesis GO:0009653 298 0.097
Human
response to extracellular stimulus GO:0009991 380 0.096
cellular response to oxygen containing compound GO:1901701 386 0.091
protein complex biogenesis GO:0070271 263 0.081
response to mechanical stimulus GO:0009612 134 0.081
single organism biosynthetic process GO:0044711 342 0.079
regulation of system process GO:0044057 208 0.078
circulatory system development GO:0072359 134 0.077
Human
response to nutrient levels GO:0031667 370 0.075
intracellular signal transduction GO:0035556 314 0.074
oxoacid metabolic process GO:0043436 290 0.068
regulation of cell proliferation GO:0042127 359 0.067
regulation of programmed cell death GO:0043067 341 0.062
Human
positive regulation of cell death GO:0010942 184 0.061
Human
response to lipopolysaccharide GO:0032496 191 0.061
positive regulation of multicellular organismal process GO:0051240 387 0.061
Human
response to monosaccharide GO:0034284 159 0.060
response to external biotic stimulus GO:0043207 221 0.060
multi multicellular organism process GO:0044706 138 0.059
response to vitamin GO:0033273 131 0.059
blood circulation GO:0008015 183 0.057
cellular ketone metabolic process GO:0042180 51 0.055
secretion GO:0046903 307 0.055
response to hexose GO:0009746 144 0.055
response to bacterium GO:0009617 200 0.054
cellular response to hormone stimulus GO:0032870 247 0.054
organic acid biosynthetic process GO:0016053 83 0.053
cellular response to external stimulus GO:0071496 118 0.053
cellular response to organic cyclic compound GO:0071407 202 0.053
cellular amide metabolic process GO:0043603 44 0.052
reproductive process GO:0022414 372 0.052
organic acid metabolic process GO:0006082 292 0.051
positive regulation of cell proliferation GO:0008284 249 0.050
response to molecule of bacterial origin GO:0002237 194 0.049
neuron development GO:0048666 286 0.047
response to hydrogen peroxide GO:0042542 89 0.047
response to oxidative stress GO:0006979 186 0.047
gland development GO:0048732 155 0.045
homeostatic process GO:0042592 331 0.045
regulation of transcription dna templated GO:0006355 374 0.045
Human
response to glucose GO:0009749 136 0.045
neuron projection development GO:0031175 273 0.045
rhythmic process GO:0048511 156 0.045
Rat
response to peptide GO:1901652 292 0.044
response to glucocorticoid GO:0051384 223 0.044
cellular ion homeostasis GO:0006873 184 0.044
aging GO:0007568 241 0.043
cell adhesion GO:0007155 110 0.043
cellular amino acid metabolic process GO:0006520 107 0.042
positive regulation of response to stimulus GO:0048584 285 0.041
Human
enzyme linked receptor protein signaling pathway GO:0007167 116 0.041
regulation of cellular localization GO:0060341 263 0.041
response to hyperoxia GO:0055093 45 0.039
organophosphate metabolic process GO:0019637 370 0.039
response to cytokine GO:0034097 215 0.037
Human
inflammatory response GO:0006954 150 0.036
Human
apoptotic process GO:0006915 381 0.036
Human
organonitrogen compound biosynthetic process GO:1901566 167 0.036
small molecule biosynthetic process GO:0044283 124 0.036
cellular chemical homeostasis GO:0055082 247 0.036
multicellular organismal reproductive process GO:0048609 233 0.036
response to reactive oxygen species GO:0000302 120 0.035
negative regulation of multicellular organismal process GO:0051241 203 0.035
regulation of cellular component organization GO:0051128 368 0.035
response to transforming growth factor beta GO:0071559 46 0.035
response to wounding GO:0009611 254 0.035
Human
cellular amine metabolic process GO:0044106 38 0.035
chemical homeostasis GO:0048878 292 0.035
positive regulation of gene expression GO:0010628 244 0.035
response to vitamin d GO:0033280 34 0.034
response to organophosphorus GO:0046683 102 0.034
Rat
neuron differentiation GO:0030182 368 0.034
cell morphogenesis GO:0000902 142 0.034
head development GO:0060322 247 0.034
tissue development GO:0009888 252 0.034
cardiovascular system development GO:0072358 134 0.034
Human
kidney development GO:0001822 67 0.034
positive regulation of rna biosynthetic process GO:1902680 197 0.034
reproduction GO:0000003 245 0.033
response to ketone GO:1901654 182 0.033
response to decreased oxygen levels GO:0036293 237 0.033
response to peptide hormone GO:0043434 278 0.032
response to corticosteroid GO:0031960 235 0.032
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.031
brain development GO:0007420 247 0.031
regulation of cell migration GO:0030334 128 0.031
carbohydrate derivative metabolic process GO:1901135 346 0.031
regulation of cellular ketone metabolic process GO:0010565 27 0.031
amine metabolic process GO:0009308 38 0.031
regulation of neurogenesis GO:0050767 247 0.031
response to temperature stimulus GO:0009266 94 0.031
response to growth factor GO:0070848 189 0.030
renal system development GO:0072001 67 0.030
oxidation reduction process GO:0055114 304 0.030
Rat
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.030
response to tumor necrosis factor GO:0034612 56 0.029
cellular calcium ion homeostasis GO:0006874 160 0.029
regulation of secretion by cell GO:1903530 208 0.029
positive regulation of phosphorus metabolic process GO:0010562 262 0.028
cell projection organization GO:0030030 302 0.028
defense response GO:0006952 194 0.028
Human
response to carbohydrate GO:0009743 183 0.028
positive regulation of biosynthetic process GO:0009891 319 0.027
response to metal ion GO:0010038 253 0.027
blood vessel development GO:0001568 69 0.027
Human
regulation of cell activation GO:0050865 50 0.027
cellular metal ion homeostasis GO:0006875 172 0.027
regulation of phosphorus metabolic process GO:0051174 349 0.027
regulation of rna metabolic process GO:0051252 391 0.027
Human
response to estrogen GO:0043627 232 0.027
regulation of cell differentiation GO:0045595 320 0.027
biological adhesion GO:0022610 110 0.027
vasculature development GO:0001944 70 0.027
Human
positive regulation of developmental process GO:0051094 283 0.026
Human
regulation of cell development GO:0060284 263 0.026
peptide metabolic process GO:0006518 32 0.026
response to hypoxia GO:0001666 231 0.026
negative regulation of apoptotic process GO:0043066 181 0.026
response to ethanol GO:0045471 162 0.026
reproductive structure development GO:0048608 128 0.026
cellular cation homeostasis GO:0030003 180 0.026
regulation of protein metabolic process GO:0051246 289 0.026
cellular homeostasis GO:0019725 252 0.026
response to camp GO:0051591 91 0.026
Rat
female pregnancy GO:0007565 122 0.026
regulation of molecular function GO:0065009 398 0.026
Human
multicellular organism reproduction GO:0032504 233 0.025
locomotion GO:0040011 237 0.025
cellular lipid metabolic process GO:0044255 208 0.025
positive regulation of transport GO:0051050 245 0.025
response to amino acid GO:0043200 75 0.025
positive regulation of rna metabolic process GO:0051254 203 0.024
regulation of hormone levels GO:0010817 187 0.024
regulation of response to stress GO:0080134 126 0.024
Human
regulation of nervous system development GO:0051960 264 0.024
cellular response to abiotic stimulus GO:0071214 85 0.024
positive regulation of cellular biosynthetic process GO:0031328 295 0.024
protein homooligomerization GO:0051260 91 0.024
positive regulation of cell differentiation GO:0045597 217 0.024
cell migration GO:0016477 197 0.024
sexual reproduction GO:0019953 148 0.024
cellular modified amino acid metabolic process GO:0006575 61 0.023
regulation of cellular amino acid metabolic process GO:0006521 2 0.023
secretion by cell GO:0032940 248 0.023
catabolic process GO:0009056 351 0.023
ion homeostasis GO:0050801 212 0.023
regulation of cellular amine metabolic process GO:0033238 8 0.023
response to estradiol GO:0032355 164 0.023
positive regulation of apoptotic process GO:0043065 154 0.023
Human
cellular response to growth factor stimulus GO:0071363 162 0.023
rna biosynthetic process GO:0032774 380 0.023
Human
positive regulation of molecular function GO:0044093 230 0.023
divalent inorganic cation homeostasis GO:0072507 165 0.023
protein phosphorylation GO:0006468 345 0.023
wound healing GO:0042060 122 0.022
positive regulation of nervous system development GO:0051962 178 0.022
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.022
negative regulation of developmental process GO:0051093 125 0.022
regulation of apoptotic process GO:0042981 335 0.022
Human
cytosolic calcium ion homeostasis GO:0051480 140 0.022
cellular response to mechanical stimulus GO:0071260 48 0.022
response to purine containing compound GO:0014074 126 0.022
Rat
circulatory system process GO:0003013 183 0.022
regulation of secretion GO:0051046 224 0.022
positive regulation of cell development GO:0010720 176 0.022
negative regulation of cell proliferation GO:0008285 119 0.022
nucleoside phosphate metabolic process GO:0006753 283 0.022
epithelium development GO:0060429 96 0.022
cellular component movement GO:0006928 248 0.021
positive regulation of secretion by cell GO:1903532 128 0.021
protein heterooligomerization GO:0051291 89 0.021
regulation of blood circulation GO:1903522 110 0.021
negative regulation of cell differentiation GO:0045596 99 0.021
carboxylic acid biosynthetic process GO:0046394 83 0.021
cell type specific apoptotic process GO:0097285 134 0.021
gastrulation GO:0007369 2 0.020
cellular divalent inorganic cation homeostasis GO:0072503 162 0.020
positive regulation of cell communication GO:0010647 271 0.020
Human
metal ion homeostasis GO:0055065 186 0.020
regulation of locomotion GO:0040012 148 0.020
response to toxic substance GO:0009636 133 0.020
positive regulation of cellular amine metabolic process GO:0033240 3 0.020
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.020
cellular response to lipid GO:0071396 201 0.020
response to increased oxygen levels GO:0036296 45 0.020
regulation of blood vessel size GO:0050880 89 0.020
regulation of cell motility GO:2000145 131 0.020
negative regulation of nervous system development GO:0051961 79 0.020
organelle organization GO:0006996 266 0.020
positive regulation of cellular component organization GO:0051130 200 0.019
cell growth GO:0016049 104 0.019
growth GO:0040007 165 0.019
single organismal cell cell adhesion GO:0016337 42 0.019
cation homeostasis GO:0055080 195 0.019
nucleic acid templated transcription GO:0097659 379 0.019
Human
cellular response to nitrogen compound GO:1901699 210 0.019
neuronal action potential GO:0019228 35 0.019
cellular response to tumor necrosis factor GO:0071356 46 0.019
vascular process in circulatory system GO:0003018 96 0.018
single organism organelle organization GO:1902589 180 0.018
regulation of tube size GO:0035150 89 0.018
metal ion transport GO:0030001 289 0.018
anion transport GO:0006820 178 0.018
response to alkaloid GO:0043279 132 0.018
single organism cell adhesion GO:0098602 46 0.018
central nervous system development GO:0007417 311 0.018
multi organism reproductive process GO:0044703 262 0.018
axis specification GO:0009798 4 0.018
macromolecule localization GO:0033036 252 0.018
regulation of immune system process GO:0002682 123 0.018
formation of primary germ layer GO:0001704 1 0.018
response to transition metal nanoparticle GO:1990267 122 0.018
cellular amino acid biosynthetic process GO:0008652 32 0.017
negative regulation of metabolic process GO:0009892 331 0.017
Human
extracellular matrix organization GO:0030198 13 0.017
single organism reproductive process GO:0044702 297 0.017
calcium ion homeostasis GO:0055074 162 0.017
positive regulation of programmed cell death GO:0043068 157 0.017
Human
rna metabolic process GO:0016070 406 0.017
Human
regulation of g0 to g1 transition GO:0070316 3 0.017
nucleotide metabolic process GO:0009117 279 0.017
cellular response to stress GO:0033554 269 0.017
Human
response to interleukin 1 GO:0070555 55 0.017
Human
cellular response to alcohol GO:0097306 87 0.017
organophosphate biosynthetic process GO:0090407 143 0.017
heart morphogenesis GO:0003007 3 0.017
multicellular organismal signaling GO:0035637 44 0.016
small gtpase mediated signal transduction GO:0007264 36 0.016
immune system process GO:0002376 204 0.016
artery development GO:0060840 3 0.016
positive regulation of transcription dna templated GO:0045893 197 0.016
urogenital system development GO:0001655 78 0.016
positive regulation of hydrolase activity GO:0051345 86 0.016
eye morphogenesis GO:0048592 4 0.016
regulation of phosphate metabolic process GO:0019220 349 0.016
gamete generation GO:0007276 124 0.016
positive regulation of hepatocyte differentiation GO:0070368 2 0.016
response to radiation GO:0009314 137 0.016
signal release GO:0023061 145 0.016
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.016
elastic fiber assembly GO:0048251 1 0.016
cellular response to nutrient levels GO:0031669 60 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.016
positive regulation of phosphate metabolic process GO:0045937 262 0.015
cellular response to interleukin 1 GO:0071347 37 0.015
Human
cellular response to peptide GO:1901653 133 0.015
embryonic appendage morphogenesis GO:0035113 4 0.015
regulation of cellular component biogenesis GO:0044087 86 0.015
signal transduction by phosphorylation GO:0023014 144 0.015
regulation of mapk cascade GO:0043408 116 0.015
cell cell signaling GO:0007267 335 0.015
muscle system process GO:0003012 115 0.015
ribose phosphate metabolic process GO:0019693 235 0.015
cellular response to peptide hormone stimulus GO:0071375 120 0.015
intracellular transport GO:0046907 185 0.015
tissue remodeling GO:0048771 40 0.014
organic substance catabolic process GO:1901575 316 0.014
cation transport GO:0006812 382 0.014
positive regulation of secretion GO:0051047 140 0.014
transmission of nerve impulse GO:0019226 42 0.014
odontogenesis GO:0042476 32 0.014
neurological system process GO:0050877 219 0.014
Rat
embryonic skeletal system morphogenesis GO:0048704 3 0.014
ras protein signal transduction GO:0007265 29 0.014
negative regulation of programmed cell death GO:0043069 183 0.014
fatty acid metabolic process GO:0006631 99 0.014
hematopoietic progenitor cell differentiation GO:0002244 2 0.014
organic anion transport GO:0015711 132 0.014
single organism catabolic process GO:0044712 283 0.014
regulation of phosphorylation GO:0042325 248 0.014
cartilage development GO:0051216 22 0.014
transcription dna templated GO:0006351 377 0.014
Human
nucleobase containing small molecule metabolic process GO:0055086 316 0.014
response to acid chemical GO:0001101 222 0.014
negative regulation of macromolecule metabolic process GO:0010605 260 0.014
peptidyl amino acid modification GO:0018193 126 0.014
positive regulation of cell motility GO:2000147 97 0.014
female sex differentiation GO:0046660 59 0.013
response to testosterone GO:0033574 55 0.013
carbohydrate derivative biosynthetic process GO:1901137 124 0.013
positive regulation of phosphorylation GO:0042327 177 0.013
regulation of cellular protein metabolic process GO:0032268 267 0.013
regulation of anatomical structure size GO:0090066 135 0.013
actin filament based process GO:0030029 86 0.013
cellular component morphogenesis GO:0032989 155 0.013
carbohydrate metabolic process GO:0005975 130 0.013
proteolysis GO:0006508 175 0.013
cytoplasmic transport GO:0016482 115 0.013
unsaturated fatty acid metabolic process GO:0033559 39 0.013
localization of cell GO:0051674 202 0.013
positive regulation of signal transduction GO:0009967 175 0.013
Human
response to heat GO:0009408 60 0.013
positive regulation of protein metabolic process GO:0051247 178 0.013
dna metabolic process GO:0006259 96 0.013
embryonic skeletal system development GO:0048706 3 0.013
purine nucleotide metabolic process GO:0006163 229 0.013
regulation of neuron projection development GO:0010975 161 0.013
negative regulation of cellular biosynthetic process GO:0031327 161 0.013
Human
single organism cellular localization GO:1902580 102 0.013
anterior posterior pattern specification GO:0009952 1 0.013
lipid metabolic process GO:0006629 283 0.012
response to calcium ion GO:0051592 59 0.012
regeneration GO:0031099 163 0.012
positive regulation of neuron differentiation GO:0045666 126 0.012
g protein coupled receptor signaling pathway GO:0007186 242 0.012
positive regulation of blood circulation GO:1903524 65 0.012
regulation of cellular component movement GO:0051270 150 0.012
limb morphogenesis GO:0035108 4 0.012
developmental process involved in reproduction GO:0003006 159 0.012
transmembrane transport GO:0055085 412 0.012
embryonic pattern specification GO:0009880 1 0.012
negative regulation of cell development GO:0010721 82 0.012
cellular response to extracellular stimulus GO:0031668 73 0.012
action potential GO:0001508 54 0.012
female gonad development GO:0008585 53 0.012
regulation of muscle system process GO:0090257 79 0.012
positive regulation of catalytic activity GO:0043085 184 0.012
establishment of protein localization GO:0045184 141 0.012
positive regulation of cellular protein metabolic process GO:0032270 167 0.012
response to fatty acid GO:0070542 65 0.012
response to fibroblast growth factor GO:0071774 29 0.012
regulation of neuron apoptotic process GO:0043523 83 0.011
cytokine mediated signaling pathway GO:0019221 43 0.011
ovulation cycle GO:0042698 67 0.011
positive regulation of nucleic acid templated transcription GO:1903508 197 0.011
axon ensheathment GO:0008366 40 0.011
organonitrogen compound catabolic process GO:1901565 179 0.011
sex differentiation GO:0007548 113 0.011
cellular response to metal ion GO:0071248 55 0.011
cellular response to oxygen levels GO:0071453 60 0.011
Human
collagen fibril organization GO:0030199 1 0.011
purine ribonucleotide metabolic process GO:0009150 227 0.011
positive regulation of protein transport GO:0051222 41 0.011
regulation of blood pressure GO:0008217 83 0.011
leukotriene biosynthetic process GO:0019370 3 0.011
protein localization GO:0008104 191 0.011
transforming growth factor beta receptor signaling pathway GO:0007179 18 0.011
glycosyl compound metabolic process GO:1901657 182 0.011
purine containing compound metabolic process GO:0072521 253 0.011
response to mineralocorticoid GO:0051385 49 0.011
regulation of cell adhesion GO:0030155 52 0.011
positive regulation of protein modification process GO:0031401 142 0.011
nitrogen compound transport GO:0071705 229 0.011
cellular catabolic process GO:0044248 295 0.011
glucose homeostasis GO:0042593 75 0.011
sequestering of metal ion GO:0051238 9 0.011
regulation of cell growth GO:0001558 85 0.011
tube development GO:0035295 89 0.010
retinal metabolic process GO:0042574 3 0.010
regulation of nucleic acid templated transcription GO:1903506 380 0.010
Human
protein transport GO:0015031 132 0.010
synaptic transmission GO:0007268 235 0.010
cellular response to inorganic substance GO:0071241 65 0.010
rho protein signal transduction GO:0007266 11 0.010
cell part morphogenesis GO:0032990 123 0.010
response to retinoic acid GO:0032526 63 0.010
positive regulation of protein phosphorylation GO:0001934 135 0.010
single organism carbohydrate metabolic process GO:0044723 118 0.010
regulation of response to wounding GO:1903034 69 0.010
Human
nucleoside metabolic process GO:0009116 179 0.010
regulation of rna biosynthetic process GO:2001141 381 0.010
Human
vesicle mediated transport GO:0016192 181 0.010
positive regulation of signaling GO:0023056 270 0.010
Human

Ptgis disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.058
Human
musculoskeletal system disease DOID:17 0 0.058
nervous system disease DOID:863 0 0.017
bone disease DOID:0080001 0 0.012
connective tissue disease DOID:65 0 0.012
osteochondrodysplasia DOID:2256 0 0.012
bone development disease DOID:0080006 0 0.012