Rattus norvegicus

0 known processes

Adamts1

ADAM metallopeptidase with thrombospondin type 1 motif, 1

Adamts1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
apoptotic process GO:0006915 381 0.209
regulation of programmed cell death GO:0043067 341 0.140
response to extracellular stimulus GO:0009991 380 0.135
regulation of catalytic activity GO:0050790 304 0.126
regulation of phosphorylation GO:0042325 248 0.119
positive regulation of developmental process GO:0051094 283 0.098
cardiovascular system development GO:0072358 134 0.091
Mouse
neuron differentiation GO:0030182 368 0.085
programmed cell death GO:0012501 392 0.080
response to hydrogen peroxide GO:0042542 89 0.079
cellular response to growth factor stimulus GO:0071363 162 0.079
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.078
cellular response to oxygen containing compound GO:1901701 386 0.078
response to camp GO:0051591 91 0.077
oxoacid metabolic process GO:0043436 290 0.071
regulation of molecular function GO:0065009 398 0.071
reproductive process GO:0022414 372 0.069
Mouse
regulation of apoptotic process GO:0042981 335 0.069
cellular component biogenesis GO:0044085 368 0.068
regulation of system process GO:0044057 208 0.065
cell motility GO:0048870 202 0.065
cell migration GO:0016477 197 0.064
response to nutrient levels GO:0031667 370 0.063
positive regulation of cell differentiation GO:0045597 217 0.063
single organism reproductive process GO:0044702 297 0.062
Mouse
cell projection organization GO:0030030 302 0.062
locomotion GO:0040011 237 0.061
anatomical structure morphogenesis GO:0009653 298 0.061
Mouse
negative regulation of metabolic process GO:0009892 331 0.059
response to organophosphorus GO:0046683 102 0.057
cellular response to lipid GO:0071396 201 0.057
regulation of signal transduction GO:0009966 318 0.057
organ morphogenesis GO:0009887 75 0.056
Mouse
positive regulation of programmed cell death GO:0043068 157 0.056
organic acid metabolic process GO:0006082 292 0.055
carboxylic acid metabolic process GO:0019752 289 0.054
rna metabolic process GO:0016070 406 0.054
positive regulation of gene expression GO:0010628 244 0.053
regulation of intracellular signal transduction GO:1902531 218 0.053
organic substance catabolic process GO:1901575 316 0.051
negative regulation of macromolecule metabolic process GO:0010605 260 0.050
positive regulation of neurogenesis GO:0050769 165 0.049
response to inorganic substance GO:0010035 377 0.048
response to decreased oxygen levels GO:0036293 237 0.046
positive regulation of response to stimulus GO:0048584 285 0.046
multi multicellular organism process GO:0044706 138 0.046
regulation of multicellular organismal development GO:2000026 376 0.045
cellular component assembly GO:0022607 360 0.045
multicellular organism reproduction GO:0032504 233 0.044
Mouse
negative regulation of apoptotic process GO:0043066 181 0.044
regulation of transcription dna templated GO:0006355 374 0.043
carbohydrate derivative metabolic process GO:1901135 346 0.043
blood vessel morphogenesis GO:0048514 58 0.042
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.042
positive regulation of cell communication GO:0010647 271 0.041
neuron projection development GO:0031175 273 0.040
regulation of cell proliferation GO:0042127 359 0.040
regulation of cellular component organization GO:0051128 368 0.040
angiogenesis GO:0001525 53 0.040
homeostatic process GO:0042592 331 0.040
regulation of phosphorus metabolic process GO:0051174 349 0.039
regulation of protein metabolic process GO:0051246 289 0.039
single organism biosynthetic process GO:0044711 342 0.039
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.039
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.038
positive regulation of catalytic activity GO:0043085 184 0.038
positive regulation of cellular component organization GO:0051130 200 0.038
regulation of phosphate metabolic process GO:0019220 349 0.038
response to purine containing compound GO:0014074 126 0.037
positive regulation of biosynthetic process GO:0009891 319 0.037
regulation of rna biosynthetic process GO:2001141 381 0.037
cellular response to endogenous stimulus GO:0071495 377 0.035
response to oxygen levels GO:0070482 265 0.035
regulation of stress activated mapk cascade GO:0032872 23 0.035
response to lipopolysaccharide GO:0032496 191 0.034
negative regulation of gene expression GO:0010629 199 0.034
regulation of cell activation GO:0050865 50 0.034
positive regulation of cell death GO:0010942 184 0.034
negative regulation of cellular metabolic process GO:0031324 281 0.034
cellular component movement GO:0006928 248 0.034
circadian rhythm GO:0007623 88 0.033
response to growth factor GO:0070848 189 0.033
intracellular signal transduction GO:0035556 314 0.032
negative regulation of programmed cell death GO:0043069 183 0.032
amine metabolic process GO:0009308 38 0.032
cellular response to organonitrogen compound GO:0071417 197 0.032
positive regulation of signaling GO:0023056 270 0.032
response to wounding GO:0009611 254 0.031
positive regulation of apoptotic process GO:0043065 154 0.030
response to biotic stimulus GO:0009607 226 0.030
neurological system process GO:0050877 219 0.030
multicellular organismal reproductive process GO:0048609 233 0.030
Mouse
regulation of mapk cascade GO:0043408 116 0.030
cellular catabolic process GO:0044248 295 0.030
protein phosphorylation GO:0006468 345 0.030
rna biosynthetic process GO:0032774 380 0.030
localization of cell GO:0051674 202 0.030
regulation of nucleic acid templated transcription GO:1903506 380 0.030
ion transmembrane transport GO:0034220 365 0.030
neuron development GO:0048666 286 0.029
cellular amino acid metabolic process GO:0006520 107 0.029
regulation of cell development GO:0060284 263 0.029
transcription from rna polymerase ii promoter GO:0006366 252 0.029
regulation of response to stress GO:0080134 126 0.029
blood circulation GO:0008015 183 0.028
heart contraction GO:0060047 57 0.028
chemical homeostasis GO:0048878 292 0.028
positive regulation of immune system process GO:0002684 90 0.028
response to dexamethasone GO:0071548 49 0.028
response to carbohydrate GO:0009743 183 0.028
female pregnancy GO:0007565 122 0.028
response to peptide GO:1901652 292 0.028
regulation of cellular amino acid metabolic process GO:0006521 2 0.027
regulation of cell projection organization GO:0031344 175 0.027
positive regulation of cell proliferation GO:0008284 249 0.027
cellular ketone metabolic process GO:0042180 51 0.027
positive regulation of multicellular organismal process GO:0051240 387 0.027
regulation of protein phosphorylation GO:0001932 183 0.027
cellular response to organic cyclic compound GO:0071407 202 0.027
regulation of cellular ketone metabolic process GO:0010565 27 0.027
positive regulation of phosphate metabolic process GO:0045937 262 0.027
response to oxidative stress GO:0006979 186 0.027
negative regulation of rna biosynthetic process GO:1902679 118 0.027
central nervous system development GO:0007417 311 0.026
circulatory system development GO:0072359 134 0.026
Mouse
cellular response to stress GO:0033554 269 0.026
response to nutrient GO:0007584 248 0.026
immune system process GO:0002376 204 0.026
positive regulation of cell development GO:0010720 176 0.025
circulatory system process GO:0003013 183 0.025
single organism catabolic process GO:0044712 283 0.025
macromolecular complex subunit organization GO:0043933 339 0.025
regulation of membrane potential GO:0042391 110 0.025
regulation of g0 to g1 transition GO:0070316 3 0.025
action potential GO:0001508 54 0.025
negative regulation of cell proliferation GO:0008285 119 0.024
response to monosaccharide GO:0034284 159 0.024
response to reactive oxygen species GO:0000302 120 0.024
cation transport GO:0006812 382 0.024
mapk cascade GO:0000165 140 0.024
reproduction GO:0000003 245 0.024
Mouse
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.023
developmental process involved in reproduction GO:0003006 159 0.023
Mouse
stress activated protein kinase signaling cascade GO:0031098 37 0.023
positive regulation of neuron projection development GO:0010976 99 0.023
gland development GO:0048732 155 0.023
positive regulation of phosphorus metabolic process GO:0010562 262 0.023
cell morphogenesis GO:0000902 142 0.022
positive regulation of transcription dna templated GO:0045893 197 0.022
synaptic transmission GO:0007268 235 0.022
developmental growth GO:0048589 100 0.022
muscle system process GO:0003012 115 0.022
response to radiation GO:0009314 137 0.022
signal transduction by phosphorylation GO:0023014 144 0.022
cellular homeostasis GO:0019725 252 0.022
regulation of stress activated protein kinase signaling cascade GO:0070302 23 0.022
response to mechanical stimulus GO:0009612 134 0.022
response to hexose GO:0009746 144 0.022
muscle contraction GO:0006936 88 0.022
macromolecular complex assembly GO:0065003 273 0.021
brain development GO:0007420 247 0.021
intracellular transport GO:0046907 185 0.021
nucleic acid templated transcription GO:0097659 379 0.021
regulation of cellular protein metabolic process GO:0032268 267 0.021
jnk cascade GO:0007254 28 0.021
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.021
regulation of cellular component movement GO:0051270 150 0.021
regulation of cell differentiation GO:0045595 320 0.021
transcription dna templated GO:0006351 377 0.021
response to cytokine GO:0034097 215 0.021
head development GO:0060322 247 0.021
multicellular organismal signaling GO:0035637 44 0.021
ossification GO:0001503 70 0.020
growth GO:0040007 165 0.020
negative regulation of molecular function GO:0044092 133 0.020
cellular chemical homeostasis GO:0055082 247 0.020
enzyme linked receptor protein signaling pathway GO:0007167 116 0.020
cellular amine metabolic process GO:0044106 38 0.020
gastrulation GO:0007369 2 0.020
multi organism reproductive process GO:0044703 262 0.020
Mouse
nucleoside phosphate metabolic process GO:0006753 283 0.020
response to fluid shear stress GO:0034405 16 0.020
response to other organism GO:0051707 220 0.020
positive regulation of cell projection organization GO:0031346 111 0.020
positive regulation of g0 to g1 transition GO:0070318 2 0.020
tube development GO:0035295 89 0.019
positive regulation of fibroblast proliferation GO:0048146 15 0.019
regulation of rna metabolic process GO:0051252 391 0.019
regulation of neuron projection development GO:0010975 161 0.019
rhythmic process GO:0048511 156 0.019
Mouse
positive regulation of nucleic acid templated transcription GO:1903508 197 0.019
negative regulation of transport GO:0051051 136 0.019
regulation of cell migration GO:0030334 128 0.019
response to bacterium GO:0009617 200 0.019
negative regulation of nucleic acid templated transcription GO:1903507 117 0.019
response to hypoxia GO:0001666 231 0.019
cellular response to cycloheximide GO:0071409 4 0.019
response to glucose GO:0009749 136 0.019
positive regulation of stress activated protein kinase signaling cascade GO:0070304 17 0.019
regulation of cell motility GO:2000145 131 0.019
anion transport GO:0006820 178 0.019
heart morphogenesis GO:0003007 3 0.019
Mouse
response to ionizing radiation GO:0010212 59 0.019
negative regulation of biosynthetic process GO:0009890 168 0.018
positive regulation of phosphorylation GO:0042327 177 0.018
positive regulation of nervous system development GO:0051962 178 0.018
cell adhesion GO:0007155 110 0.018
response to alkaloid GO:0043279 132 0.018
cytoplasmic transport GO:0016482 115 0.018
lipid metabolic process GO:0006629 283 0.018
response to molecule of bacterial origin GO:0002237 194 0.018
positive regulation of rna metabolic process GO:0051254 203 0.018
regulation of immune system process GO:0002682 123 0.018
purine containing compound metabolic process GO:0072521 253 0.018
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.018
catabolic process GO:0009056 351 0.018
response to estradiol GO:0032355 164 0.018
cell activation GO:0001775 97 0.018
neuron apoptotic process GO:0051402 88 0.018
regulation of jnk cascade GO:0046328 19 0.018
response to estrogen GO:0043627 232 0.018
cellular response to hormone stimulus GO:0032870 247 0.018
dna metabolic process GO:0006259 96 0.017
regulation of blood circulation GO:1903522 110 0.017
positive regulation of neuron differentiation GO:0045666 126 0.017
negative regulation of cell death GO:0060548 229 0.017
nucleotide metabolic process GO:0009117 279 0.017
endothelial cell apoptotic process GO:0072577 3 0.017
heart process GO:0003015 57 0.016
regulation of cellular amine metabolic process GO:0033238 8 0.016
blood vessel development GO:0001568 69 0.016
membrane organization GO:0061024 94 0.016
anatomical structure formation involved in morphogenesis GO:0048646 83 0.016
Mouse
carbohydrate homeostasis GO:0033500 75 0.016
cell chemotaxis GO:0060326 31 0.016
regulation of neurogenesis GO:0050767 247 0.016
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.016
neuronal action potential GO:0019228 35 0.016
nitrogen compound transport GO:0071705 229 0.016
protein oligomerization GO:0051259 191 0.016
embryonic pattern specification GO:0009880 1 0.016
response to toxic substance GO:0009636 133 0.015
secretion GO:0046903 307 0.015
sex differentiation GO:0007548 113 0.015
Mouse
plasminogen activation GO:0031639 2 0.015
embryo development GO:0009790 49 0.015
negative regulation of cellular biosynthetic process GO:0031327 161 0.015
regulation of neuron differentiation GO:0045664 208 0.015
protein complex subunit organization GO:0071822 302 0.015
purine nucleoside triphosphate catabolic process GO:0009146 122 0.015
regulation of hormone levels GO:0010817 187 0.015
cellular metal ion homeostasis GO:0006875 172 0.015
liver development GO:0001889 90 0.015
single organism intracellular transport GO:1902582 166 0.015
neuron projection morphogenesis GO:0048812 122 0.015
protein complex assembly GO:0006461 263 0.015
single organism cellular localization GO:1902580 102 0.015
positive regulation of blood coagulation GO:0030194 4 0.015
positive regulation of locomotion GO:0040017 102 0.015
protein targeting GO:0006605 61 0.014
response to metal ion GO:0010038 253 0.014
regeneration GO:0031099 163 0.014
cellular response to follicle stimulating hormone stimulus GO:0071372 13 0.014
positive regulation of cellular biosynthetic process GO:0031328 295 0.014
eye morphogenesis GO:0048592 4 0.014
transmembrane transport GO:0055085 412 0.014
negative regulation of cellular protein metabolic process GO:0032269 106 0.014
negative regulation of cell communication GO:0010648 158 0.014
cell projection morphogenesis GO:0048858 123 0.014
ras protein signal transduction GO:0007265 29 0.014
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
negative regulation of cell development GO:0010721 82 0.014
regulation of response to external stimulus GO:0032101 106 0.014
regulation of peptide transport GO:0090087 87 0.014
regulation of protein modification process GO:0031399 194 0.014
positive regulation of cell motility GO:2000147 97 0.014
signal release GO:0023061 145 0.013
regulation of dna metabolic process GO:0051052 60 0.013
nucleobase containing small molecule metabolic process GO:0055086 316 0.013
positive regulation of cardiac muscle contraction GO:0060452 4 0.013
glycosyl compound metabolic process GO:1901657 182 0.013
positive regulation of mapk cascade GO:0043410 92 0.013
response to calcium ion GO:0051592 59 0.013
cell type specific apoptotic process GO:0097285 134 0.013
regulation of nervous system development GO:0051960 264 0.013
cellular response to steroid hormone stimulus GO:0071383 93 0.013
response to temperature stimulus GO:0009266 94 0.013
oxidation reduction process GO:0055114 304 0.013
secretion by cell GO:0032940 248 0.013
response to vitamin GO:0033273 131 0.013
organelle organization GO:0006996 266 0.013
ribose phosphate metabolic process GO:0019693 235 0.013
organophosphate metabolic process GO:0019637 370 0.013
synapse organization GO:0050808 46 0.013
purine nucleotide catabolic process GO:0006195 136 0.013
positive regulation of molecular function GO:0044093 230 0.012
male gamete generation GO:0048232 99 0.012
aging GO:0007568 241 0.012
negative regulation of protein metabolic process GO:0051248 114 0.012
cellular response to extracellular stimulus GO:0031668 73 0.012
cellular response to interleukin 1 GO:0071347 37 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.012
reactive nitrogen species metabolic process GO:2001057 1 0.012
metal ion homeostasis GO:0055065 186 0.012
tissue development GO:0009888 252 0.012
vasculature development GO:0001944 70 0.012
response to glucocorticoid GO:0051384 223 0.012
single organism organelle organization GO:1902589 180 0.012
cell cycle GO:0007049 101 0.012
response to fatty acid GO:0070542 65 0.012
organonitrogen compound biosynthetic process GO:1901566 167 0.012
carbohydrate derivative biosynthetic process GO:1901137 124 0.012
reproductive system development GO:0061458 128 0.012
Mouse
negative regulation of rna metabolic process GO:0051253 123 0.012
positive regulation of hydrolase activity GO:0051345 86 0.012
cellular divalent inorganic cation homeostasis GO:0072503 162 0.012
nucleoside phosphate catabolic process GO:1901292 140 0.012
nucleobase containing compound catabolic process GO:0034655 152 0.012
hair cell differentiation GO:0035315 2 0.012
positive regulation of jnk cascade GO:0046330 13 0.012
neuron projection regeneration GO:0031102 35 0.012
stress activated mapk cascade GO:0051403 35 0.012
cellular response to cytokine stimulus GO:0071345 127 0.012
vesicle mediated transport GO:0016192 181 0.012
cellular macromolecule localization GO:0070727 122 0.012
regulation of metalloenzyme activity GO:0048552 1 0.012
regulation of reactive oxygen species metabolic process GO:2000377 26 0.012
positive regulation of stress activated mapk cascade GO:0032874 17 0.012
cellular response to molecule of bacterial origin GO:0071219 56 0.012
respiratory system development GO:0060541 45 0.012
negative regulation of nervous system development GO:0051961 79 0.012
spermatogenesis GO:0007283 99 0.012
positive regulation of rna biosynthetic process GO:1902680 197 0.012
anion transmembrane transport GO:0098656 77 0.012
gamete generation GO:0007276 124 0.012
Mouse
metal ion transport GO:0030001 289 0.011
cellular response to nitrogen compound GO:1901699 210 0.011
neuron neuron synaptic transmission GO:0007270 60 0.011
purine ribonucleotide metabolic process GO:0009150 227 0.011
endocytosis GO:0006897 84 0.011
cell growth GO:0016049 104 0.011
positive regulation of protein phosphorylation GO:0001934 135 0.011
bmp signaling pathway GO:0030509 4 0.011
neuron death GO:0070997 127 0.011
positive regulation of cellular amine metabolic process GO:0033240 3 0.011
anterior posterior pattern specification GO:0009952 1 0.011
protein transport GO:0015031 132 0.011
negative regulation of viral process GO:0048525 4 0.011
ion homeostasis GO:0050801 212 0.011
regulation of neurological system process GO:0031644 43 0.011
regulation of endothelial cell apoptotic process GO:2000351 3 0.011
protein homooligomerization GO:0051260 91 0.011
cellular response to fluid shear stress GO:0071498 4 0.011
protein complex biogenesis GO:0070271 263 0.011
leukocyte cell cell adhesion GO:0007159 4 0.011
glucose homeostasis GO:0042593 75 0.011
wound healing GO:0042060 122 0.011
positive regulation of transport GO:0051050 245 0.011
regulation of erk1 and erk2 cascade GO:0070372 41 0.011
nucleocytoplasmic transport GO:0006913 48 0.011
negative regulation of phosphate metabolic process GO:0045936 80 0.011
reactive oxygen species metabolic process GO:0072593 37 0.011
lipid storage GO:0019915 1 0.011
protein localization GO:0008104 191 0.011
nucleoside metabolic process GO:0009116 179 0.011
small gtpase mediated signal transduction GO:0007264 36 0.011
collateral sprouting GO:0048668 2 0.011
cellular protein localization GO:0034613 122 0.011
response to tumor necrosis factor GO:0034612 56 0.011
cellular response to external stimulus GO:0071496 118 0.010
ribonucleotide catabolic process GO:0009261 136 0.010
positive regulation of intracellular signal transduction GO:1902533 138 0.010
mechanoreceptor differentiation GO:0042490 2 0.010
muscle cell proliferation GO:0033002 84 0.010
cellular response to carbohydrate stimulus GO:0071322 72 0.010
negative regulation of signal transduction GO:0009968 83 0.010
regulation of body fluid levels GO:0050878 90 0.010
reproductive structure development GO:0048608 128 0.010
Mouse
response to gonadotropin GO:0034698 34 0.010
regulation of cellular catabolic process GO:0031329 101 0.010
calcium ion homeostasis GO:0055074 162 0.010
cellular ion homeostasis GO:0006873 184 0.010
nucleoside triphosphate catabolic process GO:0009143 123 0.010
defense response to gram negative bacterium GO:0050829 3 0.010
cellular response to reactive oxygen species GO:0034614 55 0.010
inner ear receptor cell differentiation GO:0060113 2 0.010
response to activity GO:0014823 73 0.010
positive regulation of cellular component movement GO:0051272 102 0.010
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.010
cellular response to hexose stimulus GO:0071331 65 0.010

Adamts1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.036
cardiovascular system disease DOID:1287 0 0.036
nervous system disease DOID:863 0 0.015
disease of metabolism DOID:0014667 0 0.015
cancer DOID:162 0 0.014
disease of cellular proliferation DOID:14566 0 0.014
organ system cancer DOID:0050686 0 0.014
musculoskeletal system disease DOID:17 0 0.011