Rattus norvegicus

7 known processes

Mmel1

membrane metallo-endopeptidase-like 1

(Aliases: NEP2,Mell1,NEPII)

Mmel1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to oxygen containing compound GO:1901701 386 0.171
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.082
Rat
oxoacid metabolic process GO:0043436 290 0.070
apoptotic process GO:0006915 381 0.069
Rat
positive regulation of cellular biosynthetic process GO:0031328 295 0.065
Rat
carbohydrate derivative metabolic process GO:1901135 346 0.065
Rat
brain development GO:0007420 247 0.064
carboxylic acid metabolic process GO:0019752 289 0.063
cellular response to stress GO:0033554 269 0.059
response to hexose GO:0009746 144 0.056
programmed cell death GO:0012501 392 0.055
Rat
regulation of apoptotic process GO:0042981 335 0.052
cellular ketone metabolic process GO:0042180 51 0.049
cellular amino acid metabolic process GO:0006520 107 0.049
central nervous system development GO:0007417 311 0.048
anatomical structure morphogenesis GO:0009653 298 0.048
regulation of cellular localization GO:0060341 263 0.047
regulation of ion transport GO:0043269 245 0.047
response to inorganic substance GO:0010035 377 0.045
Rat
cellular component morphogenesis GO:0032989 155 0.044
inorganic cation transmembrane transport GO:0098662 202 0.043
transmembrane transport GO:0055085 412 0.042
ion transmembrane transport GO:0034220 365 0.042
response to monosaccharide GO:0034284 159 0.042
positive regulation of biosynthetic process GO:0009891 319 0.041
Rat
neuron differentiation GO:0030182 368 0.040
regulation of phosphate metabolic process GO:0019220 349 0.039
Rat
response to acid chemical GO:0001101 222 0.039
organic acid metabolic process GO:0006082 292 0.038
regulation of hormone levels GO:0010817 187 0.037
purine containing compound metabolic process GO:0072521 253 0.037
Rat
single organism biosynthetic process GO:0044711 342 0.036
Rat
secretion GO:0046903 307 0.036
glutamate receptor signaling pathway GO:0007215 43 0.036
positive regulation of molecular function GO:0044093 230 0.035
regulation of programmed cell death GO:0043067 341 0.035
response to corticosteroid GO:0031960 235 0.035
response to carbohydrate GO:0009743 183 0.035
transcription dna templated GO:0006351 377 0.034
regulation of protein metabolic process GO:0051246 289 0.034
protein localization GO:0008104 191 0.034
regulation of nucleic acid templated transcription GO:1903506 380 0.033
hormone transport GO:0009914 121 0.033
macromolecular complex subunit organization GO:0043933 339 0.033
glycosyl compound metabolic process GO:1901657 182 0.032
regulation of rna biosynthetic process GO:2001141 381 0.032
negative regulation of macromolecule metabolic process GO:0010605 260 0.032
regulation of cellular ketone metabolic process GO:0010565 27 0.032
purine ribonucleotide metabolic process GO:0009150 227 0.032
Rat
positive regulation of nucleic acid templated transcription GO:1903508 197 0.031
catabolic process GO:0009056 351 0.031
positive regulation of rna biosynthetic process GO:1902680 197 0.030
regulation of secretion by cell GO:1903530 208 0.030
peptide hormone secretion GO:0030072 84 0.030
purine nucleotide metabolic process GO:0006163 229 0.030
Rat
response to oxygen levels GO:0070482 265 0.030
Rat
regulation of secretion GO:0051046 224 0.029
nucleotide metabolic process GO:0009117 279 0.028
Rat
amine metabolic process GO:0009308 38 0.028
head development GO:0060322 247 0.028
metal ion transport GO:0030001 289 0.028
positive regulation of protein phosphorylation GO:0001934 135 0.028
multicellular organismal signaling GO:0035637 44 0.028
macromolecular complex assembly GO:0065003 273 0.028
regulation of transcription dna templated GO:0006355 374 0.027
regulation of cellular amine metabolic process GO:0033238 8 0.027
regulation of molecular function GO:0065009 398 0.027
response to radiation GO:0009314 137 0.027
nucleic acid templated transcription GO:0097659 379 0.027
regulation of peptide transport GO:0090087 87 0.026
neuron projection development GO:0031175 273 0.026
nitrogen compound transport GO:0071705 229 0.025
cellular amine metabolic process GO:0044106 38 0.025
wound healing GO:0042060 122 0.025
regulation of cellular amino acid metabolic process GO:0006521 2 0.025
negative regulation of cell communication GO:0010648 158 0.025
protein phosphorylation GO:0006468 345 0.024
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.024
amino acid transport GO:0006865 70 0.024
regulation of phosphorus metabolic process GO:0051174 349 0.024
Rat
peptide transport GO:0015833 97 0.024
anion transport GO:0006820 178 0.024
rna biosynthetic process GO:0032774 380 0.023
regulation of rna metabolic process GO:0051252 391 0.023
organic anion transport GO:0015711 132 0.023
muscle structure development GO:0061061 87 0.023
cellular response to organic cyclic compound GO:0071407 202 0.023
response to peptide GO:1901652 292 0.023
inorganic ion transmembrane transport GO:0098660 229 0.023
nucleobase containing small molecule metabolic process GO:0055086 316 0.023
Rat
homeostatic process GO:0042592 331 0.023
regulation of catalytic activity GO:0050790 304 0.022
protein complex subunit organization GO:0071822 302 0.022
macromolecule localization GO:0033036 252 0.022
hormone secretion GO:0046879 115 0.022
negative regulation of metabolic process GO:0009892 331 0.022
reproductive process GO:0022414 372 0.022
positive regulation of protein metabolic process GO:0051247 178 0.022
response to external biotic stimulus GO:0043207 221 0.022
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.022
insulin secretion GO:0030073 69 0.021
proteolysis GO:0006508 175 0.021
regulation of insulin secretion GO:0050796 65 0.021
single organism reproductive process GO:0044702 297 0.021
response to decreased oxygen levels GO:0036293 237 0.021
Rat
ras protein signal transduction GO:0007265 29 0.021
cell morphogenesis GO:0000902 142 0.021
cellular response to lipid GO:0071396 201 0.021
purine ribonucleoside metabolic process GO:0046128 168 0.021
secretion by cell GO:0032940 248 0.021
organic acid transport GO:0015849 116 0.021
single organism catabolic process GO:0044712 283 0.021
positive regulation of signaling GO:0023056 270 0.021
Rat
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.020
negative regulation of cellular biosynthetic process GO:0031327 161 0.020
single organism organelle organization GO:1902589 180 0.020
negative regulation of programmed cell death GO:0043069 183 0.020
sodium ion transport GO:0006814 82 0.020
peptide secretion GO:0002790 86 0.020
rna metabolic process GO:0016070 406 0.020
regulation of peptide hormone secretion GO:0090276 80 0.020
regulation of cellular protein metabolic process GO:0032268 267 0.020
negative regulation of transport GO:0051051 136 0.020
positive regulation of phosphorus metabolic process GO:0010562 262 0.020
Rat
cellular catabolic process GO:0044248 295 0.019
regulation of protein kinase activity GO:0045859 105 0.019
defense response GO:0006952 194 0.019
positive regulation of protein modification process GO:0031401 142 0.019
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.019
Rat
response to ammonium ion GO:0060359 71 0.019
protein oligomerization GO:0051259 191 0.019
regulation of protein phosphorylation GO:0001932 183 0.019
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.019
positive regulation of transcription dna templated GO:0045893 197 0.019
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
synaptic transmission GO:0007268 235 0.019
regulation of peptide secretion GO:0002791 82 0.019
amide transport GO:0042886 105 0.019
regulation of cell proliferation GO:0042127 359 0.019
positive regulation of cell proliferation GO:0008284 249 0.019
organic substance catabolic process GO:1901575 316 0.019
positive regulation of transport GO:0051050 245 0.019
negative regulation of cellular metabolic process GO:0031324 281 0.019
regulation of nervous system development GO:0051960 264 0.018
positive regulation of rna metabolic process GO:0051254 203 0.018
positive regulation of cellular protein metabolic process GO:0032270 167 0.018
action potential GO:0001508 54 0.018
aging GO:0007568 241 0.018
response to metal ion GO:0010038 253 0.018
Rat
regulation of catabolic process GO:0009894 113 0.018
neuron development GO:0048666 286 0.018
protein complex biogenesis GO:0070271 263 0.018
positive regulation of catalytic activity GO:0043085 184 0.018
negative regulation of gene expression GO:0010629 199 0.018
establishment of protein localization GO:0045184 141 0.017
small gtpase mediated signal transduction GO:0007264 36 0.017
cation transport GO:0006812 382 0.017
regulation of phosphorylation GO:0042325 248 0.017
Rat
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
nucleoside phosphate metabolic process GO:0006753 283 0.017
Rat
positive regulation of phosphorylation GO:0042327 177 0.017
gastrulation GO:0007369 2 0.017
cell projection organization GO:0030030 302 0.017
positive regulation of response to stimulus GO:0048584 285 0.017
Rat
response to peptide hormone GO:0043434 278 0.017
multicellular organism reproduction GO:0032504 233 0.017
nucleoside metabolic process GO:0009116 179 0.016
cellular response to hexose stimulus GO:0071331 65 0.016
organ regeneration GO:0031100 101 0.016
negative regulation of multicellular organismal process GO:0051241 203 0.016
monovalent inorganic cation transport GO:0015672 172 0.016
intracellular signal transduction GO:0035556 314 0.016
Rat
positive regulation of phosphate metabolic process GO:0045937 262 0.016
Rat
transcription from rna polymerase ii promoter GO:0006366 252 0.016
regulation of membrane potential GO:0042391 110 0.016
single organism membrane organization GO:0044802 74 0.016
positive regulation of cellular component organization GO:0051130 200 0.016
signal release GO:0023061 145 0.016
response to extracellular stimulus GO:0009991 380 0.016
negative regulation of apoptotic process GO:0043066 181 0.016
positive regulation of gene expression GO:0010628 244 0.016
growth GO:0040007 165 0.016
multi organism reproductive process GO:0044703 262 0.016
negative regulation of signaling GO:0023057 157 0.016
regulation of cell development GO:0060284 263 0.016
regulation of hydrolase activity GO:0051336 143 0.015
regulation of calcium ion transport GO:0051924 77 0.015
response to glucocorticoid GO:0051384 223 0.015
positive regulation of apoptotic process GO:0043065 154 0.015
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.015
regulation of amine transport GO:0051952 54 0.015
nucleoside phosphate catabolic process GO:1901292 140 0.015
positive regulation of nervous system development GO:0051962 178 0.015
cellular chemical homeostasis GO:0055082 247 0.015
glucose homeostasis GO:0042593 75 0.015
response to nutrient levels GO:0031667 370 0.015
positive regulation of cell communication GO:0010647 271 0.015
Rat
regulation of hormone secretion GO:0046883 106 0.015
nucleoside catabolic process GO:0009164 126 0.014
negative regulation of rna biosynthetic process GO:1902679 118 0.014
negative regulation of biosynthetic process GO:0009890 168 0.014
gliogenesis GO:0042063 93 0.014
response to growth factor GO:0070848 189 0.014
regulation of neurogenesis GO:0050767 247 0.014
regulation of anion transport GO:0044070 43 0.014
ribonucleoside triphosphate metabolic process GO:0009199 141 0.014
axis specification GO:0009798 4 0.014
response to molecule of bacterial origin GO:0002237 194 0.014
regulation of protein transport GO:0051223 68 0.014
mapk cascade GO:0000165 140 0.014
Rat
negative regulation of response to stimulus GO:0048585 155 0.014
multicellular organismal reproductive process GO:0048609 233 0.014
cellular component movement GO:0006928 248 0.014
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.014
sensory perception of light stimulus GO:0050953 3 0.014
regulation of transferase activity GO:0051338 123 0.013
response to oxidative stress GO:0006979 186 0.013
response to glucose GO:0009749 136 0.013
positive regulation of nucleotide metabolic process GO:0045981 91 0.013
Rat
cellular response to carbohydrate stimulus GO:0071322 72 0.013
cellular component assembly GO:0022607 360 0.013
ribonucleotide metabolic process GO:0009259 231 0.013
Rat
organic cyclic compound catabolic process GO:1901361 175 0.013
regulation of intracellular signal transduction GO:1902531 218 0.013
Rat
carboxylic acid transport GO:0046942 115 0.013
regulation of transmembrane transport GO:0034762 122 0.013
cation transmembrane transport GO:0098655 263 0.013
sex differentiation GO:0007548 113 0.013
comma shaped body morphogenesis GO:0072049 2 0.013
regulation of protein modification process GO:0031399 194 0.013
metal ion homeostasis GO:0055065 186 0.013
regulation of cell projection organization GO:0031344 175 0.013
synaptic transmission glutamatergic GO:0035249 33 0.013
cellular response to acid chemical GO:0071229 75 0.013
nucleoside triphosphate catabolic process GO:0009143 123 0.013
positive regulation of programmed cell death GO:0043068 157 0.013
multicellular organism growth GO:0035264 1 0.013
regulation of nucleotide metabolic process GO:0006140 117 0.013
Rat
regulation of cellular component organization GO:0051128 368 0.013
protein complex assembly GO:0006461 263 0.013
single organism cellular localization GO:1902580 102 0.012
regulation of response to external stimulus GO:0032101 106 0.012
transmission of nerve impulse GO:0019226 42 0.012
carbohydrate homeostasis GO:0033500 75 0.012
neurological system process GO:0050877 219 0.012
response to amine GO:0014075 46 0.012
response to wounding GO:0009611 254 0.012
ribonucleoside metabolic process GO:0009119 174 0.012
regulation of response to stress GO:0080134 126 0.012
striated muscle contraction GO:0006941 44 0.012
development of primary sexual characteristics GO:0045137 107 0.012
purine nucleoside triphosphate metabolic process GO:0009144 141 0.012
response to biotic stimulus GO:0009607 226 0.012
aromatic compound catabolic process GO:0019439 168 0.012
spindle organization GO:0007051 2 0.012
organophosphate metabolic process GO:0019637 370 0.012
Rat
positive regulation of protein kinase activity GO:0045860 73 0.012
reproductive structure development GO:0048608 128 0.012
negative regulation of cellular protein metabolic process GO:0032269 106 0.012
purine ribonucleoside catabolic process GO:0046130 124 0.012
cellular homeostasis GO:0019725 252 0.012
purine nucleotide catabolic process GO:0006195 136 0.012
cell cycle GO:0007049 101 0.012
regulation of neuron death GO:1901214 115 0.012
negative regulation of neurogenesis GO:0050768 78 0.012
dna metabolic process GO:0006259 96 0.012
purine nucleoside metabolic process GO:0042278 169 0.012
protein transport GO:0015031 132 0.012
reproductive system development GO:0061458 128 0.012
chemical homeostasis GO:0048878 292 0.012
eye morphogenesis GO:0048592 4 0.012
positive regulation of cell death GO:0010942 184 0.011
negative regulation of cellular component organization GO:0051129 83 0.011
cellular response to abiotic stimulus GO:0071214 85 0.011
response to hypoxia GO:0001666 231 0.011
Rat
male gonad development GO:0008584 59 0.011
regulation of purine nucleotide metabolic process GO:1900542 115 0.011
Rat
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.011
regulation of kinase activity GO:0043549 117 0.011
response to bacterium GO:0009617 200 0.011
cellular component biogenesis GO:0044085 368 0.011
regulation of neuron differentiation GO:0045664 208 0.011
regulation of establishment of protein localization GO:0070201 69 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.011
cellular response to glucose stimulus GO:0071333 65 0.011
positive regulation of secretion by cell GO:1903532 128 0.011
negative regulation of secretion by cell GO:1903531 72 0.011
response to toxic substance GO:0009636 133 0.011
male gamete generation GO:0048232 99 0.011
nuclear transport GO:0051169 49 0.011
b cell differentiation GO:0030183 2 0.011
gamete generation GO:0007276 124 0.011
positive regulation of catabolic process GO:0009896 78 0.011
response to ethanol GO:0045471 162 0.011
cellular nitrogen compound catabolic process GO:0044270 163 0.011
nucleoside triphosphate metabolic process GO:0009141 144 0.011
heterocycle catabolic process GO:0046700 167 0.011
cellular response to monosaccharide stimulus GO:0071326 67 0.011
negative regulation of cell death GO:0060548 229 0.011
regulation of protein localization GO:0032880 81 0.011
regulation of cellular catabolic process GO:0031329 101 0.011
spermatogenesis GO:0007283 99 0.010
detection of visible light GO:0009584 3 0.010
cell morphogenesis involved in differentiation GO:0000904 119 0.010
cell growth GO:0016049 104 0.010
positive regulation of cell differentiation GO:0045597 217 0.010
cell part morphogenesis GO:0032990 123 0.010
negative regulation of cell differentiation GO:0045596 99 0.010
monocarboxylic acid transport GO:0015718 52 0.010
mitotic cell cycle GO:0000278 49 0.010
guanosine containing compound catabolic process GO:1901069 71 0.010
response to cytokine GO:0034097 215 0.010
carbohydrate derivative catabolic process GO:1901136 147 0.010
vesicle mediated transport GO:0016192 181 0.010
negative regulation of protein metabolic process GO:0051248 114 0.010
negative regulation of secretion GO:0051048 82 0.010
neuron apoptotic process GO:0051402 88 0.010

Mmel1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.040
nervous system disease DOID:863 0 0.040
sensory system disease DOID:0050155 0 0.032
eye and adnexa disease DOID:1492 0 0.032
eye disease DOID:5614 0 0.031
retinal disease DOID:5679 0 0.023
retinal degeneration DOID:8466 0 0.023