Rattus norvegicus

44 known processes

Ctsh

cathepsin H

Ctsh biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oxoacid metabolic process GO:0043436 290 0.323
carboxylic acid metabolic process GO:0019752 289 0.142
organic substance catabolic process GO:1901575 316 0.138
Human
organic acid metabolic process GO:0006082 292 0.124
response to metal ion GO:0010038 253 0.123
regulation of cell proliferation GO:0042127 359 0.107
Mouse
regulation of body fluid levels GO:0050878 90 0.096
single organism catabolic process GO:0044712 283 0.091
response to peptide hormone GO:0043434 278 0.084
response to wounding GO:0009611 254 0.084
monocarboxylic acid metabolic process GO:0032787 152 0.084
response to nutrient levels GO:0031667 370 0.083
regulation of tolerance induction to nonself antigen GO:0002655 1 0.079
response to glucocorticoid GO:0051384 223 0.072
positive regulation of multicellular organismal process GO:0051240 387 0.069
Mouse
negative regulation of response to wounding GO:1903035 23 0.068
negative regulation of multicellular organismal process GO:0051241 203 0.062
response to external biotic stimulus GO:0043207 221 0.062
response to carbohydrate GO:0009743 183 0.061
regeneration GO:0031099 163 0.061
cellular amino acid metabolic process GO:0006520 107 0.060
growth GO:0040007 165 0.060
negative regulation of response to external stimulus GO:0032102 37 0.059
negative regulation of immune system process GO:0002683 39 0.058
single organism reproductive process GO:0044702 297 0.056
multi organism reproductive process GO:0044703 262 0.055
t cell tolerance induction GO:0002517 3 0.054
reproductive process GO:0022414 372 0.052
wound healing GO:0042060 122 0.051
protein maturation GO:0051604 68 0.050
Human Mouse
programmed cell death GO:0012501 392 0.050
Human Mouse
catabolic process GO:0009056 351 0.050
Human
carbohydrate derivative metabolic process GO:1901135 346 0.050
proteolysis GO:0006508 175 0.050
response to inorganic substance GO:0010035 377 0.049
response to extracellular stimulus GO:0009991 380 0.048
positive regulation of response to stimulus GO:0048584 285 0.048
Mouse
regulation of multicellular organismal development GO:2000026 376 0.047
Mouse
negative regulation of cell death GO:0060548 229 0.045
Mouse
cellular response to external stimulus GO:0071496 118 0.043
tissue development GO:0009888 252 0.043
Mouse
regulation of protein metabolic process GO:0051246 289 0.041
Human Mouse
response to ketone GO:1901654 182 0.041
cell activation GO:0001775 97 0.041
regulation of hormone levels GO:0010817 187 0.039
immune system process GO:0002376 204 0.038
Human Mouse
regulation of protein maturation GO:1903317 50 0.038
lipid biosynthetic process GO:0008610 128 0.037
positive regulation of cell proliferation GO:0008284 249 0.036
Mouse
regulation of response to external stimulus GO:0032101 106 0.036
positive regulation of immune response GO:0050778 42 0.035
aging GO:0007568 241 0.034
regulation of cellular protein metabolic process GO:0032268 267 0.034
Human Mouse
positive regulation of cell projection organization GO:0031346 111 0.034
secretion GO:0046903 307 0.033
response to peptide GO:1901652 292 0.033
locomotion GO:0040011 237 0.032
Human Mouse
blood coagulation GO:0007596 26 0.032
response to other organism GO:0051707 220 0.031
immune response GO:0006955 104 0.031
Human Mouse
regulation of cell differentiation GO:0045595 320 0.031
negative regulation of response to stimulus GO:0048585 155 0.031
localization of cell GO:0051674 202 0.031
Human Mouse
peptidyl glutamic acid modification GO:0018200 1 0.030
negative regulation of defense response GO:0031348 19 0.030
macromolecule catabolic process GO:0009057 58 0.030
behavior GO:0007610 205 0.030
cellular component movement GO:0006928 248 0.030
Human Mouse
homeostatic process GO:0042592 331 0.030
Human
isoprenoid metabolic process GO:0006720 45 0.029
cellular response to stress GO:0033554 269 0.029
lipid metabolic process GO:0006629 283 0.029
negative regulation of vasculature development GO:1901343 11 0.029
negative regulation of protein maturation GO:1903318 47 0.029
nucleobase containing small molecule metabolic process GO:0055086 316 0.028
response to estradiol GO:0032355 164 0.028
defense response GO:0006952 194 0.028
cell cell signaling GO:0007267 335 0.028
cellular response to endogenous stimulus GO:0071495 377 0.028
cellular amide metabolic process GO:0043603 44 0.028
Human
positive regulation of cell differentiation GO:0045597 217 0.027
positive regulation of nervous system development GO:0051962 178 0.027
signal release GO:0023061 145 0.026
regulation of neuron differentiation GO:0045664 208 0.026
regulation of immune system process GO:0002682 123 0.026
Human
ion homeostasis GO:0050801 212 0.026
antigen processing and presentation of peptide antigen GO:0048002 2 0.026
regulation of catalytic activity GO:0050790 304 0.025
Human Mouse
regulation of neurogenesis GO:0050767 247 0.025
head development GO:0060322 247 0.025
positive regulation of developmental process GO:0051094 283 0.025
Mouse
neuron projection development GO:0031175 273 0.024
developmental growth GO:0048589 100 0.024
regulation of cellular component movement GO:0051270 150 0.024
Human Mouse
cell projection organization GO:0030030 302 0.024
regulation of apoptotic process GO:0042981 335 0.024
Human Mouse
response to estrogen GO:0043627 232 0.024
multicellular organismal reproductive process GO:0048609 233 0.024
response to hexose GO:0009746 144 0.023
reproductive system development GO:0061458 128 0.023
response to amine GO:0014075 46 0.023
thyroid hormone generation GO:0006590 3 0.023
regulation of epithelial cell proliferation GO:0050678 49 0.022
response to corticosteroid GO:0031960 235 0.022
cellular catabolic process GO:0044248 295 0.022
Human
response to monosaccharide GO:0034284 159 0.022
regulation of immune response GO:0050776 55 0.022
Human
synaptic transmission GO:0007268 235 0.021
positive regulation of cellular component movement GO:0051272 102 0.021
Human Mouse
hexose metabolic process GO:0019318 58 0.021
cell motility GO:0048870 202 0.021
Human Mouse
regulation of hydrolase activity GO:0051336 143 0.021
Human Mouse
epithelial cell differentiation GO:0030855 71 0.020
leukocyte mediated immunity GO:0002443 28 0.020
Mouse
positive regulation of neuron projection development GO:0010976 99 0.020
male sex differentiation GO:0046661 64 0.020
immune effector process GO:0002252 53 0.020
Mouse
spermatogenesis GO:0007283 99 0.020
single organism biosynthetic process GO:0044711 342 0.020
response to acid chemical GO:0001101 222 0.019
Mouse
positive regulation of signal transduction GO:0009967 175 0.019
Mouse
epithelial cell proliferation GO:0050673 54 0.019
regulation of programmed cell death GO:0043067 341 0.019
Human Mouse
positive regulation of locomotion GO:0040017 102 0.019
Human Mouse
cellular response to alcohol GO:0097306 87 0.019
cellular modified amino acid metabolic process GO:0006575 61 0.019
response to molecule of bacterial origin GO:0002237 194 0.019
positive regulation of neurogenesis GO:0050769 165 0.019
monovalent inorganic cation transport GO:0015672 172 0.019
positive regulation of camp metabolic process GO:0030816 31 0.019
negative regulation of peptidase activity GO:0010466 38 0.019
positive regulation of signaling GO:0023056 270 0.018
Mouse
multicellular organism reproduction GO:0032504 233 0.018
positive regulation of tolerance induction GO:0002645 1 0.018
response to starvation GO:0042594 59 0.018
cellular response to lipid GO:0071396 201 0.018
regulation of cell development GO:0060284 263 0.018
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 2 0.018
regulation of locomotion GO:0040012 148 0.018
Human Mouse
response to axon injury GO:0048678 59 0.018
tissue regeneration GO:0042246 36 0.018
cell migration GO:0016477 197 0.018
Human Mouse
positive regulation of cellular amine metabolic process GO:0033240 3 0.017
regulation of bmp signaling pathway GO:0030510 2 0.017
lymphocyte activation GO:0046649 43 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
positive regulation of cell development GO:0010720 176 0.017
negative regulation of cell proliferation GO:0008285 119 0.016
carbohydrate derivative catabolic process GO:1901136 147 0.016
response to ethanol GO:0045471 162 0.016
cellular response to iron ion starvation GO:0010106 1 0.016
negative regulation of programmed cell death GO:0043069 183 0.016
Mouse
gland development GO:0048732 155 0.016
monosaccharide metabolic process GO:0005996 61 0.016
multi multicellular organism process GO:0044706 138 0.016
response to glucose GO:0009749 136 0.016
multicellular organismal catabolic process GO:0044243 2 0.016
organelle inheritance GO:0048308 2 0.016
response to camp GO:0051591 91 0.016
regulation of response to stress GO:0080134 126 0.016
immune system development GO:0002520 41 0.016
protein processing GO:0016485 68 0.015
Human Mouse
negative regulation of innate immune response GO:0045824 4 0.015
regulation of phosphorylation GO:0042325 248 0.015
negative regulation of molecular function GO:0044092 133 0.015
positive regulation of tolerance induction to nonself antigen GO:0002657 1 0.015
regulation of nervous system development GO:0051960 264 0.015
cellular ketone metabolic process GO:0042180 51 0.015
bmp signaling pathway GO:0030509 4 0.015
regulation of molecular function GO:0065009 398 0.015
Human Mouse
negative regulation of apoptotic process GO:0043066 181 0.015
Mouse
leukocyte differentiation GO:0002521 30 0.015
macromolecule localization GO:0033036 252 0.015
regulation of cellular component organization GO:0051128 368 0.014
reproduction GO:0000003 245 0.014
regulation of immune effector process GO:0002697 32 0.014
ion transmembrane transport GO:0034220 365 0.014
neuron development GO:0048666 286 0.014
reproductive structure development GO:0048608 128 0.014
positive regulation of cell communication GO:0010647 271 0.014
Mouse
metal ion transport GO:0030001 289 0.014
cell type specific apoptotic process GO:0097285 134 0.014
male gamete generation GO:0048232 99 0.014
regulation of tolerance induction dependent upon immune response GO:0002652 1 0.014
glycosyl compound metabolic process GO:1901657 182 0.014
response to nutrient GO:0007584 248 0.014
positive regulation of neuron differentiation GO:0045666 126 0.014
dendritic spine development GO:0060996 20 0.014
single organism carbohydrate catabolic process GO:0044724 40 0.014
regulation of lipid biosynthetic process GO:0046890 38 0.014
terpenoid metabolic process GO:0006721 37 0.014
negative regulation of protein metabolic process GO:0051248 114 0.014
organic acid biosynthetic process GO:0016053 83 0.014
positive regulation of tolerance induction dependent upon immune response GO:0002654 1 0.014
male gonad development GO:0008584 59 0.014
sensory organ development GO:0007423 74 0.013
t cell mediated cytotoxicity GO:0001913 5 0.013
Mouse
regulation of blood coagulation GO:0030193 9 0.013
secretion by cell GO:0032940 248 0.013
coagulation GO:0050817 28 0.013
apoptotic process GO:0006915 381 0.013
Human Mouse
organic cyclic compound catabolic process GO:1901361 175 0.013
cellular component assembly GO:0022607 360 0.013
regulation of defense response GO:0031347 68 0.013
chemical homeostasis GO:0048878 292 0.013
Human
positive regulation of cellular component organization GO:0051130 200 0.013
positive regulation of t cell mediated cytotoxicity GO:0001916 4 0.013
regulation of ion transport GO:0043269 245 0.013
regulation of adaptive immune response GO:0002819 8 0.013
cellular amine metabolic process GO:0044106 38 0.012
reactive oxygen species metabolic process GO:0072593 37 0.012
hemostasis GO:0007599 26 0.012
dicarboxylic acid metabolic process GO:0043648 42 0.012
negative regulation of proteolysis GO:0045861 41 0.012
organophosphate metabolic process GO:0019637 370 0.012
regulation of cellular response to growth factor stimulus GO:0090287 15 0.012
regulation of signal transduction GO:0009966 318 0.012
Mouse
tolerance induction dependent upon immune response GO:0002461 2 0.012
cellular response to oxygen containing compound GO:1901701 386 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
positive regulation of protein metabolic process GO:0051247 178 0.011
Human Mouse
gliogenesis GO:0042063 93 0.011
anatomical structure morphogenesis GO:0009653 298 0.011
Mouse
positive regulation of transport GO:0051050 245 0.011
regulation of cellular amine metabolic process GO:0033238 8 0.011
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.011
cellular response to starvation GO:0009267 27 0.011
defense response to virus GO:0051607 9 0.011
sex differentiation GO:0007548 113 0.011
regulation of proteolysis GO:0030162 66 0.011
Human Mouse
positive regulation of cellular protein metabolic process GO:0032270 167 0.011
Human Mouse
positive regulation of phosphorylation GO:0042327 177 0.011
response to vitamin GO:0033273 131 0.010
negative regulation of gene expression GO:0010629 199 0.010
t cell mediated immunity GO:0002456 7 0.010
Mouse
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.010
regulation of tolerance induction GO:0002643 2 0.010
positive regulation of cell migration GO:0030335 96 0.010
Human Mouse

Ctsh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.401
inherited metabolic disorder DOID:655 0 0.401
sensory system disease DOID:0050155 0 0.216
disease of anatomical entity DOID:7 0 0.216
eye and adnexa disease DOID:1492 0 0.216
nervous system disease DOID:863 0 0.216
eye disease DOID:5614 0 0.216
retinal disease DOID:5679 0 0.181
retinal degeneration DOID:8466 0 0.181
lysosomal storage disease DOID:3211 0 0.157
central nervous system disease DOID:331 0 0.069
brain disease DOID:936 0 0.069
degeneration of macula and posterior pole DOID:2007 0 0.027
macular degeneration DOID:4448 0 0.027
age related macular degeneration DOID:10871 0 0.027
lipid storage disease DOID:9455 0 0.019
blood protein disease DOID:620 0 0.013
immune system disease DOID:2914 0 0.013
hematopoietic system disease DOID:74 0 0.013
skin disease DOID:37 0 0.010
integumentary system disease DOID:16 0 0.010