Rattus norvegicus

16 known processes

Ctsk

cathepsin K

Ctsk biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to nutrient GO:0007584 248 0.319
cellular response to endogenous stimulus GO:0071495 377 0.294
response to inorganic substance GO:0010035 377 0.244
response to cytokine GO:0034097 215 0.225
cellular response to oxygen containing compound GO:1901701 386 0.225
response to estrogen GO:0043627 232 0.217
locomotion GO:0040011 237 0.215
response to wounding GO:0009611 254 0.202
tissue development GO:0009888 252 0.192
Rat
response to estradiol GO:0032355 164 0.188
cellular response to cytokine stimulus GO:0071345 127 0.181
cellular response to peptide hormone stimulus GO:0071375 120 0.163
response to corticosteroid GO:0031960 235 0.157
Rat
cellular response to hormone stimulus GO:0032870 247 0.144
cellular response to organic cyclic compound GO:0071407 202 0.135
macromolecular complex subunit organization GO:0043933 339 0.126
response to metal ion GO:0010038 253 0.126
response to molecule of bacterial origin GO:0002237 194 0.121
cellular response to peptide GO:1901653 133 0.120
cellular response to external stimulus GO:0071496 118 0.119
Rat
kidney development GO:0001822 67 0.118
response to peptide hormone GO:0043434 278 0.117
cellular response to lipid GO:0071396 201 0.109
response to biotic stimulus GO:0009607 226 0.108
cell motility GO:0048870 202 0.107
cellular response to tumor necrosis factor GO:0071356 46 0.105
embryonic skeletal system development GO:0048706 3 0.104
cellular component assembly GO:0022607 360 0.103
urogenital system development GO:0001655 78 0.103
response to peptide GO:1901652 292 0.103
response to mechanical stimulus GO:0009612 134 0.096
Zebrafish
reproductive process GO:0022414 372 0.096
Rat
response to tumor necrosis factor GO:0034612 56 0.096
response to vitamin GO:0033273 131 0.094
response to nutrient levels GO:0031667 370 0.093
Rat
response to lipopolysaccharide GO:0032496 191 0.091
wound healing GO:0042060 122 0.090
positive regulation of multicellular organismal process GO:0051240 387 0.089
renal system development GO:0072001 67 0.088
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.088
aging GO:0007568 241 0.088
Rat
regulation of cell motility GO:2000145 131 0.087
growth GO:0040007 165 0.085
cellular response to growth factor stimulus GO:0071363 162 0.085
positive regulation of cellular biosynthetic process GO:0031328 295 0.084
response to acid chemical GO:0001101 222 0.083
cellular component biogenesis GO:0044085 368 0.080
response to amino acid GO:0043200 75 0.077
protein complex subunit organization GO:0071822 302 0.076
response to bacterium GO:0009617 200 0.076
protein complex assembly GO:0006461 263 0.076
developmental process involved in reproduction GO:0003006 159 0.074
Rat
localization of cell GO:0051674 202 0.072
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.072
response to transition metal nanoparticle GO:1990267 122 0.071
cellular component movement GO:0006928 248 0.071
circulatory system development GO:0072359 134 0.071
cellular response to organonitrogen compound GO:0071417 197 0.070
cardiovascular system development GO:0072358 134 0.070
blood vessel development GO:0001568 69 0.066
response to growth factor GO:0070848 189 0.065
reproductive system development GO:0061458 128 0.065
Rat
positive regulation of biosynthetic process GO:0009891 319 0.061
peptide cross linking GO:0018149 1 0.060
positive regulation of gene expression GO:0010628 244 0.060
response to purine containing compound GO:0014074 126 0.059
macromolecular complex assembly GO:0065003 273 0.058
response to oxidative stress GO:0006979 186 0.058
intracellular signal transduction GO:0035556 314 0.058
programmed cell death GO:0012501 392 0.056
Rat
protein complex biogenesis GO:0070271 263 0.054
anatomical structure morphogenesis GO:0009653 298 0.054
brain development GO:0007420 247 0.053
eye development GO:0001654 50 0.053
skeletal system development GO:0001501 41 0.052
organic acid metabolic process GO:0006082 292 0.051
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.050
cellular response to nitrogen compound GO:1901699 210 0.049
reproductive structure development GO:0048608 128 0.049
Rat
eye morphogenesis GO:0048592 4 0.048
response to camp GO:0051591 91 0.048
regulation of phosphate metabolic process GO:0019220 349 0.047
response to fibroblast growth factor GO:0071774 29 0.046
tube development GO:0035295 89 0.045
neuron death GO:0070997 127 0.044
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.044
response to extracellular stimulus GO:0009991 380 0.044
Rat
apoptotic process GO:0006915 381 0.043
response to monosaccharide GO:0034284 159 0.042
Rat
response to transforming growth factor beta GO:0071559 46 0.042
oxoacid metabolic process GO:0043436 290 0.042
regulation of catalytic activity GO:0050790 304 0.042
cellular response to ketone GO:1901655 51 0.042
gastrulation GO:0007369 2 0.042
response to ketone GO:1901654 182 0.041
cellular homeostasis GO:0019725 252 0.041
non canonical wnt signaling pathway GO:0035567 3 0.041
neurological system process GO:0050877 219 0.041
carbohydrate derivative metabolic process GO:1901135 346 0.041
cell migration GO:0016477 197 0.040
response to glucose GO:0009749 136 0.039
Rat
regulation of cell proliferation GO:0042127 359 0.039
central nervous system development GO:0007417 311 0.039
organ morphogenesis GO:0009887 75 0.039
regulation of cell development GO:0060284 263 0.038
collagen fibril organization GO:0030199 1 0.038
vasculature development GO:0001944 70 0.038
response to organophosphorus GO:0046683 102 0.038
regulation of phosphorus metabolic process GO:0051174 349 0.038
positive regulation of phosphorylation GO:0042327 177 0.038
response to retinoic acid GO:0032526 63 0.038
negative regulation of multicellular organismal process GO:0051241 203 0.037
positive regulation of developmental process GO:0051094 283 0.037
protein phosphorylation GO:0006468 345 0.037
response to glucocorticoid GO:0051384 223 0.037
Rat
positive regulation of cellular component movement GO:0051272 102 0.037
positive regulation of response to stimulus GO:0048584 285 0.037
artery development GO:0060840 3 0.036
single organism reproductive process GO:0044702 297 0.036
Rat
rna metabolic process GO:0016070 406 0.036
response to radiation GO:0009314 137 0.036
negative regulation of gene expression GO:0010629 199 0.036
positive regulation of rna biosynthetic process GO:1902680 197 0.036
cellular catabolic process GO:0044248 295 0.035
Human
positive regulation of cell differentiation GO:0045597 217 0.035
carboxylic acid metabolic process GO:0019752 289 0.035
regulation of signal transduction GO:0009966 318 0.035
protein transport GO:0015031 132 0.035
aorta development GO:0035904 2 0.035
homeostatic process GO:0042592 331 0.034
regulation of hormone levels GO:0010817 187 0.034
regeneration GO:0031099 163 0.034
protein oligomerization GO:0051259 191 0.034
odontogenesis GO:0042476 32 0.034
response to hexose GO:0009746 144 0.033
Rat
cellular ion homeostasis GO:0006873 184 0.033
rhythmic process GO:0048511 156 0.033
ossification GO:0001503 70 0.033
multi organism reproductive process GO:0044703 262 0.032
Rat
regulation of molecular function GO:0065009 398 0.032
cellular response to steroid hormone stimulus GO:0071383 93 0.032
reproduction GO:0000003 245 0.032
Rat
developmental growth GO:0048589 100 0.031
regulation of phosphorylation GO:0042325 248 0.031
regulation of cellular component movement GO:0051270 150 0.031
transcription dna templated GO:0006351 377 0.031
positive regulation of molecular function GO:0044093 230 0.031
regulation of protein modification process GO:0031399 194 0.031
transforming growth factor beta receptor signaling pathway GO:0007179 18 0.031
positive regulation of nucleic acid templated transcription GO:1903508 197 0.030
positive regulation of phosphate metabolic process GO:0045937 262 0.030
regulation of apoptotic process GO:0042981 335 0.030
chemical homeostasis GO:0048878 292 0.030
extracellular matrix organization GO:0030198 13 0.029
regulation of nervous system development GO:0051960 264 0.029
regulation of rna biosynthetic process GO:2001141 381 0.029
connective tissue development GO:0061448 33 0.029
cartilage development GO:0051216 22 0.028
establishment of protein localization GO:0045184 141 0.028
cell cell signaling GO:0007267 335 0.028
transcription from rna polymerase ii promoter GO:0006366 252 0.027
response to carbohydrate GO:0009743 183 0.027
Rat
single organism biosynthetic process GO:0044711 342 0.027
oxidation reduction process GO:0055114 304 0.027
positive regulation of cell death GO:0010942 184 0.027
negative regulation of programmed cell death GO:0043069 183 0.027
head development GO:0060322 247 0.026
formation of primary germ layer GO:0001704 1 0.026
cellular ketone metabolic process GO:0042180 51 0.026
negative regulation of response to stimulus GO:0048585 155 0.026
response to oxygen levels GO:0070482 265 0.026
sex differentiation GO:0007548 113 0.026
Rat
lipid biosynthetic process GO:0008610 128 0.026
regulation of multicellular organismal development GO:2000026 376 0.025
response to hydrogen peroxide GO:0042542 89 0.025
positive regulation of cell communication GO:0010647 271 0.025
ras protein signal transduction GO:0007265 29 0.025
tissue remodeling GO:0048771 40 0.025
immune system process GO:0002376 204 0.025
response to interleukin 1 GO:0070555 55 0.025
female pregnancy GO:0007565 122 0.025
Rat
positive regulation of nervous system development GO:0051962 178 0.024
negative regulation of macromolecule metabolic process GO:0010605 260 0.024
alcohol metabolic process GO:0006066 77 0.024
cell projection organization GO:0030030 302 0.024
small gtpase mediated signal transduction GO:0007264 36 0.024
positive regulation of signal transduction GO:0009967 175 0.024
regulation of programmed cell death GO:0043067 341 0.023
organic substance catabolic process GO:1901575 316 0.023
Human
behavior GO:0007610 205 0.023
regulation of neuron death GO:1901214 115 0.023
neuron differentiation GO:0030182 368 0.023
embryo development GO:0009790 49 0.023
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.023
inflammatory response GO:0006954 150 0.023
gonad development GO:0008406 104 0.022
Rat
catabolic process GO:0009056 351 0.022
Human
positive regulation of transcription dna templated GO:0045893 197 0.022
positive regulation of non canonical wnt signaling pathway GO:2000052 1 0.022
cellular response to retinoic acid GO:0071300 27 0.022
cellular amino acid metabolic process GO:0006520 107 0.022
response to reactive oxygen species GO:0000302 120 0.022
regulation of cell differentiation GO:0045595 320 0.021
receptor mediated endocytosis GO:0006898 42 0.021
positive regulation of rna metabolic process GO:0051254 203 0.021
regulation of cellular component organization GO:0051128 368 0.021
heart morphogenesis GO:0003007 3 0.021
regulation of nucleic acid templated transcription GO:1903506 380 0.021
regulation of locomotion GO:0040012 148 0.021
purine ribonucleotide metabolic process GO:0009150 227 0.021
organic hydroxy compound metabolic process GO:1901615 115 0.021
peptidyl amino acid modification GO:0018193 126 0.021
regulation of neurogenesis GO:0050767 247 0.021
response to hyperoxia GO:0055093 45 0.020
negative regulation of biosynthetic process GO:0009890 168 0.020
regulation of cellular ketone metabolic process GO:0010565 27 0.020
intracellular transport GO:0046907 185 0.020
enzyme linked receptor protein signaling pathway GO:0007167 116 0.020
negative regulation of cell proliferation GO:0008285 119 0.020
wnt signaling pathway planar cell polarity pathway GO:0060071 2 0.020
calcium ion transport from endoplasmic reticulum to cytosol GO:1903514 4 0.020
sulfur compound metabolic process GO:0006790 70 0.020
cellular response to vitamin GO:0071295 21 0.020
cellular chemical homeostasis GO:0055082 247 0.020
cellular response to metal ion GO:0071248 55 0.020
nucleic acid templated transcription GO:0097659 379 0.020
anatomical structure formation involved in morphogenesis GO:0048646 83 0.019
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.019
negative regulation of metabolic process GO:0009892 331 0.019
cation homeostasis GO:0055080 195 0.019
neuron projection development GO:0031175 273 0.019
respiratory system development GO:0060541 45 0.019
sensory organ development GO:0007423 74 0.019
positive regulation of neurogenesis GO:0050769 165 0.019
proteolysis GO:0006508 175 0.019
Human Rat
response to x ray GO:0010165 15 0.019
positive regulation of protein metabolic process GO:0051247 178 0.018
cellular amine metabolic process GO:0044106 38 0.018
positive regulation of phosphorus metabolic process GO:0010562 262 0.018
negative regulation of cellular biosynthetic process GO:0031327 161 0.018
cellular response to vitamin e GO:0071306 3 0.018
ribonucleotide metabolic process GO:0009259 231 0.018
blood circulation GO:0008015 183 0.018
organophosphate metabolic process GO:0019637 370 0.018
response to alkaloid GO:0043279 132 0.018
small molecule biosynthetic process GO:0044283 124 0.018
secretion by cell GO:0032940 248 0.018
mast cell migration GO:0097531 4 0.018
negative regulation of innate immune response GO:0045824 4 0.018
cellular response to stress GO:0033554 269 0.018
Rat
rna biosynthetic process GO:0032774 380 0.018
negative regulation of signaling GO:0023057 157 0.017
cellular response to glucocorticoid stimulus GO:0071385 68 0.017
cellular hormone metabolic process GO:0034754 49 0.017
response to temperature stimulus GO:0009266 94 0.017
multi multicellular organism process GO:0044706 138 0.017
Rat
regulation of canonical wnt signaling pathway GO:0060828 4 0.017
positive regulation of signaling GO:0023056 270 0.017
negative regulation of cell death GO:0060548 229 0.017
positive regulation of intracellular signal transduction GO:1902533 138 0.017
response to external biotic stimulus GO:0043207 221 0.017
cellular response to alcohol GO:0097306 87 0.017
single organism intracellular transport GO:1902582 166 0.017
sequestering of metal ion GO:0051238 9 0.017
gland development GO:0048732 155 0.017
amine metabolic process GO:0009308 38 0.017
response to increased oxygen levels GO:0036296 45 0.017
digestive tract development GO:0048565 39 0.017
organic acid biosynthetic process GO:0016053 83 0.017
positive regulation of neuron differentiation GO:0045666 126 0.017
positive regulation of programmed cell death GO:0043068 157 0.016
positive regulation of cell development GO:0010720 176 0.016
regulation of rna metabolic process GO:0051252 391 0.016
embryonic skeletal system morphogenesis GO:0048704 3 0.016
positive regulation of cell proliferation GO:0008284 249 0.016
circulatory system process GO:0003013 183 0.016
respiratory tube development GO:0030323 43 0.016
cellular response to nutrient GO:0031670 30 0.016
regulation of cytokine production GO:0001817 56 0.016
calcium ion homeostasis GO:0055074 162 0.015
response to zinc ion GO:0010043 39 0.015
negative regulation of molecular function GO:0044092 133 0.015
organonitrogen compound catabolic process GO:1901565 179 0.015
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 27 0.015
camera type eye morphogenesis GO:0048593 2 0.015
development of primary sexual characteristics GO:0045137 107 0.015
Rat
multicellular organismal reproductive process GO:0048609 233 0.015
Rat
regulation of growth GO:0040008 105 0.015
cellular response to nutrient levels GO:0031669 60 0.015
Rat
cellular metal ion homeostasis GO:0006875 172 0.015
response to ionizing radiation GO:0010212 59 0.015
negative regulation of cellular metabolic process GO:0031324 281 0.015
positive regulation of cellular component organization GO:0051130 200 0.014
rho protein signal transduction GO:0007266 11 0.014
regulation of cellular protein metabolic process GO:0032268 267 0.014
cellular response to fibroblast growth factor stimulus GO:0044344 24 0.014
cartilage development involved in endochondral bone morphogenesis GO:0060351 3 0.014
endocrine system development GO:0035270 30 0.014
positive regulation of cell migration GO:0030335 96 0.014
response to nicotine GO:0035094 51 0.014
regulation of response to stress GO:0080134 126 0.014
regulation of homeostatic process GO:0032844 101 0.014
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.014
negative regulation of cell communication GO:0010648 158 0.014
regulation of cellular amino acid metabolic process GO:0006521 2 0.014
cellular response to alkaloid GO:0071312 25 0.014
vesicle mediated transport GO:0016192 181 0.014
cellular response to lipopolysaccharide GO:0071222 55 0.014
positive regulation of cytokine production GO:0001819 42 0.014
positive regulation of stem cell differentiation GO:2000738 2 0.014
regulation of transcription dna templated GO:0006355 374 0.014
cellular response to acid chemical GO:0071229 75 0.014
striated muscle tissue development GO:0014706 58 0.014
positive regulation of apoptotic process GO:0043065 154 0.014
cellular cation homeostasis GO:0030003 180 0.014
cellular calcium ion homeostasis GO:0006874 160 0.013
cellular response to interleukin 1 GO:0071347 37 0.013
negative regulation of apoptotic process GO:0043066 181 0.013
neuron apoptotic process GO:0051402 88 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.013
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 4 0.013
regulation of intracellular signal transduction GO:1902531 218 0.013
cation transport GO:0006812 382 0.013
forebrain development GO:0030900 98 0.013
regulation of mapk cascade GO:0043408 116 0.013
positive regulation of cellular protein metabolic process GO:0032270 167 0.013
regulation of protein transport GO:0051223 68 0.013
regulation of metanephros development GO:0072215 4 0.013
renin secretion into blood stream GO:0002001 1 0.013
response to other organism GO:0051707 220 0.013
cellular response to hexose stimulus GO:0071331 65 0.013
circadian rhythm GO:0007623 88 0.013
positive regulation of neuron projection development GO:0010976 99 0.013
regulation of cellular localization GO:0060341 263 0.013
positive regulation of catalytic activity GO:0043085 184 0.013
salivary gland development GO:0007431 3 0.013
negative regulation of rna biosynthetic process GO:1902679 118 0.013
regulation of neuron projection development GO:0010975 161 0.013
mapk cascade GO:0000165 140 0.013
purine containing compound biosynthetic process GO:0072522 85 0.013
cell adhesion GO:0007155 110 0.012
response to dexamethasone GO:0071548 49 0.012
multicellular organism reproduction GO:0032504 233 0.012
Rat
positive regulation of locomotion GO:0040017 102 0.012
nucleotide metabolic process GO:0009117 279 0.012
regulation of protein phosphorylation GO:0001932 183 0.012
macromolecule localization GO:0033036 252 0.012
sexual reproduction GO:0019953 148 0.012
Rat
elastic fiber assembly GO:0048251 1 0.012
galactolipid catabolic process GO:0019376 1 0.012
camera type eye development GO:0043010 48 0.012
nucleobase containing small molecule metabolic process GO:0055086 316 0.012
secretion GO:0046903 307 0.012
negative regulation of protein metabolic process GO:0051248 114 0.012
negative regulation of neurogenesis GO:0050768 78 0.012
cellular response to molecule of bacterial origin GO:0071219 56 0.012
organelle localization GO:0051640 55 0.012
regulation of cell projection organization GO:0031344 175 0.012
response to vitamin a GO:0033189 36 0.012
synaptic transmission GO:0007268 235 0.012
cyclic nucleotide metabolic process GO:0009187 80 0.012
regulation of transferase activity GO:0051338 123 0.012
response to insulin GO:0032868 133 0.011
positive regulation of protein transport GO:0051222 41 0.011
cellular response to interleukin 2 GO:0071352 1 0.011
cellular response to inorganic substance GO:0071241 65 0.011
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.011
axon development GO:0061564 96 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
regulation of embryonic development GO:0045995 2 0.011
ribose phosphate metabolic process GO:0019693 235 0.011
male gamete generation GO:0048232 99 0.011
Rat
regulation of cellular amine metabolic process GO:0033238 8 0.011
regulation of cellular catabolic process GO:0031329 101 0.011
proteoglycan metabolic process GO:0006029 3 0.011
heart development GO:0007507 72 0.011
cellular response to mechanical stimulus GO:0071260 48 0.011
response to hypoxia GO:0001666 231 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.011
organonitrogen compound biosynthetic process GO:1901566 167 0.011
cellular response to reactive oxygen species GO:0034614 55 0.011
muscle organ development GO:0007517 50 0.011
cell growth GO:0016049 104 0.011
sequestering of calcium ion GO:0051208 8 0.011
cellular response to biotic stimulus GO:0071216 59 0.011
ion homeostasis GO:0050801 212 0.011
response to activity GO:0014823 73 0.011
cytoplasmic transport GO:0016482 115 0.011
multicellular organism growth GO:0035264 1 0.011
positive regulation of immune system process GO:0002684 90 0.011
cellular response to glucose stimulus GO:0071333 65 0.011
purine containing compound metabolic process GO:0072521 253 0.011
ribonucleotide biosynthetic process GO:0009260 85 0.010
digestive system development GO:0055123 41 0.010
intracellular protein transport GO:0006886 79 0.010
axis elongation GO:0003401 2 0.010
regulation of cell growth GO:0001558 85 0.010
action potential GO:0001508 54 0.010
morphogenesis of a polarized epithelium GO:0001738 1 0.010
hormone secretion GO:0046879 115 0.010
hematopoietic progenitor cell differentiation GO:0002244 2 0.010
response to ethanol GO:0045471 162 0.010
cytokine production GO:0001816 61 0.010
signal release GO:0023061 145 0.010
steroid metabolic process GO:0008202 73 0.010
transmission of nerve impulse GO:0019226 42 0.010
lung development GO:0030324 43 0.010
multicellular organismal signaling GO:0035637 44 0.010
regulation of stem cell differentiation GO:2000736 2 0.010
neuron development GO:0048666 286 0.010

Ctsk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.074
musculoskeletal system disease DOID:17 0 0.074
retinal disease DOID:5679 0 0.030
retinal degeneration DOID:8466 0 0.030
sensory system disease DOID:0050155 0 0.030
eye and adnexa disease DOID:1492 0 0.030
nervous system disease DOID:863 0 0.030
eye disease DOID:5614 0 0.030
cancer DOID:162 0 0.014
disease of cellular proliferation DOID:14566 0 0.014
organ system cancer DOID:0050686 0 0.014
connective tissue disease DOID:65 0 0.013